A Neuromedin U Receptor Acts with the Sensory System to Modulate Food Type-Dependent Effects on C. elegans Lifespan

Different food types modulate worm lifespan and involve the neuropeptide receptor NMUR-1, which acts with the sensory neurons in a bacterial lipopolysaccaharide structure-dependent manner.

• Publication year

  2010

• Venue

  PLoS Biology

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.1000376PMID 20520844PMCID 2876044
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Caenorhabditis elegans].

  2020cited by this paper
• Hox and a Newly Identified E2F Co-repress Cell Death in Caenorhabditis elegans

  2011cited by this paper
• The Influence of Bacterial Diet on Fat Storage in C. elegans

  2009cited by this paper
• Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans.

  2009cited by this paper
• Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

  2009cited by this paper
• A neuromedin-pyrokinin-like neuropeptide signaling system in Caenorhabditis elegans.

  2009cited by this paper
• Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

  2009cited by this paper
• Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

  2008cited by this paper
• A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues

  2008cited by this paper
• Transcriptional responses of Arabidopsis thaliana to the bacteria-derived PAMPs harpin and lipopolysaccharide.

  2008cited by this paper
• Adult‐Limited Dietary Restriction Slows Gompertzian Aging in Caenorhabditis elegans

  2007cited by this paper
• Two neurons mediate diet-restriction-induced longevity in C. elegans

  2007cited by this paper
• Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors

  2007influential reference
• Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans

  2007cited by this paper
• PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

  2007cited by this paper
• Neuropeptidergic signaling in the nematode Caenorhabditis elegans.

  2007cited by this paper
• The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival.

  2007cited by this paper
• Opposing Activities Protect Against Age-Onset Proteotoxicity

  2006cited by this paper
• Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity

  2006cited by this paper
• Neuromedin U and Its Putative Drosophila Homolog hugin

  2006cited by this paper
• Polygenic control of Caenorhabditis elegans fat storage

  2006cited by this paper
• A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue

  2006cited by this paper
• The Molecular Identities of the Caenorhabditis elegans Intraflagellar Transport Genes dyf-6, daf-10 and osm-1

  2006cited by this paper
• p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans

  2006cited by this paper
• Role of N-Acetylglucosamine within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209)1

  2006cited by this paper
• The Core Lipopolysaccharide of Escherichia coli Is a Ligand for the Dendritic-Cell-Specific Intercellular Adhesion Molecule Nonintegrin CD209 Receptor

  2005cited by this paper
• Sex and death: what is the connection?

  2005cited by this paper
• Candidate Gustatory Interneurons Modulating Feeding Behavior in the Drosophila Brain

  2005cited by this paper
• Understanding the odd science of aging.

  2005cited by this paper
• Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila

  2005cited by this paper
• The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.

  2004cited by this paper
• Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway

  2004cited by this paper
• Regulation of C. elegans longevity by specific gustatory and olfactory neurons.

  2004cited by this paper
• Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons

  2004cited by this paper
• Food transport in the C. elegans pharynx

  2003cited by this paper
• Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

  2003cited by this paper
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003cited by this paper
• DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

  2003cited by this paper
• Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

  2003cited by this paper
• Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.

  2003cited by this paper
• A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity

  2002cited by this paper
• The global regulator RNase III modulates translation repression by the transcription elongation factor N

  2002influential reference
• C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail.

  2002cited by this paper
• Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution

  2002cited by this paper
• Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans

  2002cited by this paper
• Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.

  2001cited by this paper
• The evolution and genetics of innate immunity

  2001cited by this paper
• Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species

  2001influential reference
• Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans.

  2001cited by this paper
• Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

  2000cited by this paper
• Identification of receptors for neuromedin U and its role in feeding

  2000influential reference
• C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.

  2000cited by this paper
• Regulation of lifespan by sensory perception in Caenorhabditis elegans

  1999cited by this paper
• Neuropeptide Gene Families in the Nematode Caenorhabditis elegans a

  1999cited by this paper
• Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron

  1999cited by this paper
• Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.

  1998cited by this paper
• Neurobiology of the Caenorhabditis elegans genome.

  1998cited by this paper
• Neuropeptides: Regulators of Physiological Processes

  1998cited by this paper
• Genetic uncoupling of the dsRNA‐binding and RNA cleavage activities of the Escherichia coli endoribonuclease RNase III — the effect of dsRNA binding on gene expression

  1998cited by this paper
• The genetics of caloric restriction in Caenorhabditis elegans.

  1998cited by this paper
• Survival analysis in public health research.

  1997cited by this paper
• The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

  1997cited by this paper
• daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

  1997cited by this paper
• daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

  1997cited by this paper
• odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl.

  1996cited by this paper
• Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans.

  1995cited by this paper
• Neural regulation of thermotaxis in Caenorhabditis elegans

  1995cited by this paper
• Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment.

  1995influential reference
• A C. elegans mutant that lives twice as long as wild type

  1993cited by this paper
• The genetics of feeding in Caenorhabditis elegans.

  1993cited by this paper
• A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans.

  1993cited by this paper
• Odorant-selective genes and neurons mediate olfaction in C. elegans.

  1993cited by this paper
• Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12

  1992cited by this paper
• Structures of the rfaB, rfaI, rfaJ, and rfaS genes of Escherichia coli K-12 and their roles in assembly of the lipopolysaccharide core

  1992cited by this paper
• Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans.

  1991cited by this paper
• Control of larval development by chemosensory neurons in Caenorhabditis elegans.

  1991cited by this paper
• Use of T7 RNA polymerase to direct expression of cloned genes.

  1990influential reference
• Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.

  1990cited by this paper
• Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.

  1990cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989influential reference
• Genetic analysis of the rnc operon of Escherichia coli

  1989cited by this paper
• The Retardation of Aging and Disease by Dietary Restriction

  1988cited by this paper
• glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans.

  1987cited by this paper
• Mutant sensory cilia in the nematode Caenorhabditis elegans.

  1986influential reference
• The structure of the nervous system of the nematode Caenorhabditis elegans.

  1986influential reference
• Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span.

  1977influential reference
• The cell-wall lipopolysaccharide of Escherichia coli K-12. Structure and acceptor site for O-antigen and other substituents.

  1976cited by this paper
• Cell-wall lipopolysaccharide from Escherichia coli B.

  1975cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• A complementation analysis of the restriction and modification of DNA in Escherichia coli.

  1969influential reference

• RICTOR regulates an interspecies crosstalk that influences longevity through a novel methionine cycle-mitophagy axis

  2025cites this paper
• Context-dependent serotonin signaling links dietary quality to foraging decisions

  2025cites this paper
• THE NEUROPEPTIDE NEUROMEDIN U RECEPTOR NMUR-1 BUFFERS INSULIN RECEPTOR SIGNALING IN BACTERIA-DEPENDENT C. ELEGANS SURVIVAL

  2025cites this paper
• How to measure, analyze, and interpret age-related changes in Caenorhabditis elegans: lessons for mechanistic and evolutionary theories of aging.

  2025cites this paper
• GPCR Sense Communication Among Interaction Nematodes with Other Organisms

  2025influential citation
• Neuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance in C. elegans

  2025influential citation
• Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans

  2024influential citation
• Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans

  2024influential citation
• Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology

  2024cites this paper
• Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes

  2024cites this paper
• Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans

  2024cites this paper
• Monosaccharides improve symptoms of an animal model for type III galactosemia, through the activation of the insulin pathway.

  2024cites this paper
• Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction

  2023cites this paper
• Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans

  2023cites this paper
• Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans

  2023influential citation
• Serotonin and dopamine modulate aging in response to food odor and availability

  2022cites this paper
• Neuronal GPCR NMUR-1 regulates distinct immune responses to different pathogens

  2022cites this paper
• The neuropeptidergic connectome of C. elegans

  2022cites this paper
• Sensory perception of environmental cues as a modulator of aging and neurodegeneration: Insights from Caenorhabditis elegans

  2021influential citation
• Neuronal GPCR regulates the specificity of innate immunity against pathogen infection

  2021influential citation
• Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response

  2021cites this paper
• Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene‐diet interaction that ensures optimal life span

  2021cites this paper
• Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging

  2021cites this paper
• Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit

  2020cites this paper
• Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans

  2020cites this paper
• Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan

  2020cites this paper
• Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review.

  2020cites this paper
• UvrY is required for the full virulence of Aeromonas dhakensis

  2020cites this paper
• Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans

  2020cites this paper
• Ahr-bacterial diet interaction modulates aging and associated pathologies in C. elegans

  2020cites this paper
• Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales

  2019cites this paper
• Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans

  2019cites this paper
• Gut feelings: microRNAs tune protein quality control and ageing to odours

  2019cites this paper
• Using Bacterial Transcriptomics to Investigate Targets of Host-Bacterial Interactions in Caenorhabditis elegans

  2019cites this paper
• Bacterial diet and weak cadmium stress affect the survivability of Caenorhabditis elegans and its resistance to severe stress

  2019cites this paper
• A Comprehensive Understanding of Dietary Effects on C. elegans Physiology

  2019cites this paper
• Neuromedin U signaling regulates memory retrieval of learned salt avoidance in a C. elegans gustatory circuit

  2019cites this paper
• A novel gene-diet pair modulates C. elegans aging

  2018cites this paper
• Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling

  2018cites this paper
• CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans

  2017cites this paper
• Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans

  2017cites this paper
• Host-microbiota interactions in Caenorhabditis elegans and their significance.

  2017cites this paper
• University of Southern Denmark HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1 Shamalnasab,

  2017influential citation
• Longevity Regulation by Insulin/IGF-1 Signalling

  2017cites this paper
• Integration of Metabolic Signals

  2017cites this paper
• Longevity control by the nervous system: Sensory perception, stress response and beyond

  2017cites this paper
• HIF-1–dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA–binding protein MAA-1

  2017influential citation
• Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans

  2017cites this paper
• A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism

  2017cites this paper
• Gene-diet interactions and aging in C. elegans.

  2016cites this paper
• Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides

  2016cites this paper
• Dietary and microbiome factors determine longevity in Caenorhabditis elegans

  2016influential citation
• Lipopolysaccharide of Klebsiella pneumoniae attenuates immunity of Caenorhabditis elegans and evades by altering its supramolecular structure

  2016cites this paper
• Lifespan-regulating genes in C. elegans

  2016cites this paper
• The Role of Neurosensory Systems in the Modulation of Aging

  2016cites this paper
• Synaptic transmission parallels neuromodulation in a central food-intake circuit

  2016cites this paper
• An optimised phylogenetic method sheds more light on the main branching events of rhodopsin-like superfamily.

  2016cites this paper
• Sensory systems: their impact on C. elegans survival.

  2015cites this paper
• RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans.

  2015influential citation
• Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans

  2015cites this paper
• The SKN-1 hunger games: May the odds be ever in your favor

  2015cites this paper
• What’s in a Choice: Linking Food Preference to Life History Outcomes in C. elegans

  2015cites this paper
• Genes and Pathways That Influence Longevity in Caenorhabditis elegans

  2015cites this paper
• The Influence of the Insulin-Like Gene Family and Diet-Drug Interactions on Caenorhabditis elegans Physiology: A Dissertation

  2015cites this paper
• Physiological roles for mafr-1 in reproduction and lipid homeostasis.

  2014cites this paper
• Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases

  2014cites this paper
• Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging

  2014cites this paper
• Molecular mechanisms of premature ageing in a worm model of human Werner syndrome

  2014cites this paper
• Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

  2014cites this paper
• Adaptive capacity to bacterial diet modulates aging in C. elegans.

  2014cites this paper
• Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis.

  2014cites this paper
• Testing the hyperfunction theory of ageing in Caenorhabditis elegans

  2014cites this paper
• mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

  2014cites this paper
• Durham E-Theses Excessive folate synthesis in Escherichia coli and its in uence on Caenorhabditis elegans ageing

  2014cites this paper
• The C. elegans lifespan assay toolkit.

  2014cites this paper
• Quantitative Behavioral Analysis of Thermal Nociception in Caenorhabditis elegans: Investigation of Neural Substrates Spatially Mediating the Noxious Response, and the Effects of Pharmacological Perturbations

  2014cites this paper
• Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling

  2014cites this paper
• An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

  2014cites this paper
• The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans

  2013cites this paper
• Molecular and Cellular Circuits Underlying Caenorhabditis elegans Olfactory Plasticity

  2013cites this paper
• Neuronal Inputs and Outputs of Aging and Longevity

  2013cites this paper
• Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

  2013cites this paper
• Influence of Steroid Hormone Signaling on Life Span Control by Caenorhabditis elegans Insulin-Like Signaling

  2013cites this paper
• Pseudomonas fluorescens NZI7 repels grazing by C. elegans, a natural predator

  2013cites this paper
• Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans

  2013cites this paper
• Bacteria and the aging and longevity of Caenorhabditis elegans.

  2013cites this paper
• Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

  2013cites this paper
• Feeding and the Rhodopsin Family G-Protein Coupled Receptors in Nematodes and Arthropods

  2012cites this paper
• Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging

  2012influential citation
• Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model

  2012cites this paper
• Caractérisation de voies impliquées dans la régulation neuroendocrine du métabolisme énergétique et de la reproduction chez l'huître creuse Crassostrea gigas : Thèse soutenue sur un ensemble de travaux

  2012cites this paper
• Mitochondrial SKN-1/Nrf mediates a conserved starvation response.

  2012cites this paper
• Neuropeptide GPCRs in C. elegans

  2012cites this paper
• Sensory perception and aging in model systems: from the outside in.

  2011influential citation
• A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans

  2011cites this paper
• Death and dessert: nutrient signalling pathways and ageing.

  2011cites this paper
• Isolation and Characterisation of Two cDNAs Encoding the Neuromedin U Receptor from Goldfish Brain

  2011cites this paper
• Signalling, Desensitization and Resensitization of Neuromedin U Receptors

  2011cites this paper
• The gustatory system influences "Drosophila" lifespan

  2011influential citation
• Durham E-Theses Excessive folate synthesis in Escherichia coli and its in(cid:29)uence on Caenorhabditis elegans ageing

  year unknowncites this paper