Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  American Journal of Critical Care

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.4037/ajcc2014578PMID 24382617PMCID PMC4809634
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apolipoprotein E in Alzheimer's disease and other neurological disorders.

  2011cited by this paper
• Long-term complications of critical care

  2011cited by this paper
• A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfunction, and apolipoprotein E genotype following open aortic repair

  2011cited by this paper
• Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis

  2011cited by this paper
• Sedation, delirium and mechanical ventilation: the ‘ABCDE’ approach

  2011cited by this paper
• The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.

  2010cited by this paper
• Delirium in Intensive Care Unit Patients

  2010cited by this paper
• Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebo-controlled trial*

  2010cited by this paper
• The Apolipoprotein E-Mimetic Peptide COG112 Inhibits NF-κB Signaling, Proinflammatory Cytokine Expression, and Disease Activity in Murine Models of Colitis*

  2010cited by this paper
• Traumatic Brain Injury Exacerbates Neurodegenerative Pathology: Improvement with an Apolipoprotein E-Based Therapeutic

  2010cited by this paper
• Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis.

  2010cited by this paper
• The association between delirium and the apolipoprotein E epsilon 4 allele: new study results and a meta-analysis.

  2009cited by this paper
• APOE genotype-specific differences in the innate immune response.

  2009cited by this paper
• Chemokines are associated with delirium after cardiac surgery.

  2008cited by this paper
• The apolipoprotein E epsilon4 allele is not associated with cognitive dysfunction in cardiac surgery.

  2008cited by this paper
• The Role of Apolipoprotein E in Cognitive Decline and Delirium after Bypass Heart Operations

  2007cited by this paper
• APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients

  2007cited by this paper
• Delirium in older people

  2007cited by this paper
• Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients*

  2007cited by this paper
• Apolipoprotein E e4 Allele Increases the Risk of Early Postoperative Delirium in Older Patients Undergoing Noncardiac Surgery

  2007cited by this paper
• The association between delirium and the apolipoprotein E ϵ4 allele in the elderly

  2007cited by this paper
• Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation.

  2007cited by this paper
• Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-alpha and IL-6 in macrophages.

  2007cited by this paper
• A research algorithm to improve detection of delirium in the intensive care unit

  2006cited by this paper
• Incidence, risk factors and consequences of ICU delirium

  2006cited by this paper
• Neurotoxicity from innate immune response is greatest with targeted replacement of ε4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK

  2006cited by this paper
• A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

  2005cited by this paper
• APOE4 Protects the Cognitive Development in Children with Heavy Diarrhea Burdens in Northeast Brazil

  2005cited by this paper
• Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease.

  2003cited by this paper
• Apolipoprotein E Genotype Predicts 24-Month Bayley Scales Infant Development Score

  2003cited by this paper
• The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients.

  2002cited by this paper
• Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).

  2001cited by this paper
• The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults.

  1991cited by this paper
• Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

  1990cited by this paper
• A simple salting out procedure for extracting DNA from human nucleated cells.

  1988cited by this paper
• A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.

  1987cited by this paper

• Serum biomarkers of delirium in critical illness: a systematic review of mechanistic and diagnostic evidence

  2025cites this paper
• A Systems Biology Approach to Understanding Delirium Pathophysiology and Identifying Natural Compounds for Potential Therapeutic Purposes

  2025cites this paper
• Progress on the Assessment, Prediction and Intervention Measures of Postoperative Delirium in Elderly Patients

  2025cites this paper
• Apolipoprotein E4 allele is genetically associated with risk of the short- and medium-term postoperative cognitive dysfunction: A meta-analysis and trial sequential analysis

  2023cites this paper
• Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Biospecimens and Biomarkers

  2023cites this paper
• Exploring the Pathophysiology of Delirium: An Overview of Biomarker Studies, Animal Models, and Tissue-Engineered Models

  2023cites this paper
• Antipsychotic Use for ICU Delirium and Associated Inflammatory Markers

  2023cites this paper
• Meta-analysis of serological biomarkers at hospital admission for the likelihood of developing delirium during hospitalization

  2023cites this paper
• Nighttime medication administration and patient perception of sleep in the intensive care unit

  2023cites this paper
• Delirium risk factors in hospitalized patient: a comprehensive evaluation of underlying diseases and medications in different wards of a large Urban Hospital Center in Iran

  2022cites this paper
• The New Frontier of Perioperative Cognitive Medicine for Alzheimer’s Disease and Related Dementias

  2022cites this paper
• The complex interaction of genetics and delirium: a systematic review and meta-analysis

  2021cites this paper
• Depression and anxiety increase the odds of developing delirium in ICU patients; a prospective observational study

  2021cites this paper
• Biomarkers in delirium: A systematic review.

  2021cites this paper
• Six-month and 12-month patient outcomes based on inflammatory subphenotypes in sepsis-associated ARDS: secondary analysis of SAILS-ALTOS trial

  2021cites this paper
• Preoperative physical performance-related postoperative delirium in patients after cardiovascular surgery.

  2020cites this paper
• Delirium: Acute Brain Dysfunction in the Critically Ill

  2020cites this paper
• Inflammatory Biomarkers and Neurotransmitter Perturbations in Delirium

  2020cites this paper
• A retrospective observational study

  2020cites this paper
• Biomarkers of Delirium Duration and Delirium Severity in the ICU*

  2019cites this paper
• Apolipoprotein E genotype and the association between C‐reactive protein and postoperative delirium: Importance of gene‐protein interactions

  2019cites this paper
• A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes

  2019cites this paper
• Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

  2019influential citation
• Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study

  2018cites this paper
• Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

  2018cites this paper
• Delirium in the Critically Ill Patients

  2018cites this paper
• Development and validation of risk-stratification delirium prediction model for critically ill patients

  2017cites this paper
• Observational cohort study examining apolipoprotein E status and preoperative neuropsychological performance as predictors of post-operative delirium in an older elective arthroplasty population

  2017cites this paper
• A systematic review and meta-analysis of the association between the apolipoprotein E genotype and delirium

  2016influential citation
• Intimate Partner Violence and Traumatic Brain Injury: State of the Science and Next Steps

  2016cites this paper
• The American Geriatrics Society/National Institute on Aging Bedside‐to‐Bench Conference: Research Agenda on Delirium in Older Adults

  2015cites this paper
• Recent advances in multidisciplinary critical care.

  2015cites this paper
• Delirium in critically ill patients.

  2015cites this paper
• Interleukin 6 and cognitive dysfunction

  2014cites this paper