APOE4 Protects the Cognitive Development in Children with Heavy Diarrhea Burdens in Northeast Brazil

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Pediatric Research

• Publication date

  2005-02-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1203/01.PDR.0000148719.82468.CAPMID 15611352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The influence of neonatal nutrition on behavioral development: a critical appraisal.

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• Limitations in Verbal Fluency Following Heavy Burdens of Early Childhood Diarrhea in Brazilian Shantytown Children

  2005cited by this paper
• Apolipoprotein E Genotype Predicts 24-Month Bayley Scales Infant Development Score

  2003cited by this paper
• Long-term semantic memory versus contextual memory in unconscious number processing.

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• Effective warnings in the Deese-Roediger-McDermott false-memory paradigm: the role of identifiability.

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• Characteristics of telephone survey respondents according to willingness to participate.

  2003cited by this paper
• Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians.

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• Effects of acute diarrhea on linear growth in Peruvian children.

  2003cited by this paper
• Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse-glia affair.

  2002cited by this paper
• Effects of noradrenaline on cytosolic concentrations of Ca(2+) in cultured corpus cavernosum smooth muscle cells of the rabbit.

  2002cited by this paper
• Docosahexaenoic Acid-rich Phospholipid Supplementation: Effect on Behavior, Learning Ability, and Retinal Function in Control and n-3 Polyunsaturated Fatty Acid Deficient Old Mice

  2002cited by this paper
• Oxidized fat in the diet, postprandial lipaemia and cardiovascular disease

  2002cited by this paper
• Exploring insecticide resistance on the Web

  2002cited by this paper
• Effects of prenatal protein malnutrition on the hippocampal formation.

  2002cited by this paper
• Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy

  2002cited by this paper
• Influence of the apolipoprotein E ε4 allele on human embryonic development

  2002cited by this paper
• Lipid metabolism in mucous-dwelling amitochondriate protozoa.

  2002cited by this paper
• Early management of craniosynostosis using endoscopic-assisted strip craniectomies and cranial orthotic molding therapy.

  2002cited by this paper
• Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown.

  2002cited by this paper
• Defective neuronal sprouting by human apolipoprotein E4 is a gain‐of‐negative function

  2002cited by this paper
• Dietary Prenatal Lipids Affect Myelin Gene Expression in Postnatal Undernourished Rats

  2002cited by this paper
• Infant feeding and blood cholesterol: a study in adolescents and a systematic review.

  2002cited by this paper
• APOE genotype influences acquisition and recall following traumatic brain injury

  2002cited by this paper
• Differential asymmetries for recognizing nouns and verbs: where are they?

  2002cited by this paper
• Influence of Birth Weight on the Apo E Genetic Determinants of Plasma Lipid Levels in Children

  2002cited by this paper
• Diagnostic Utility of Letter Fluency, Category Fluency, and Fluency Difference Scores in Alzheimer's Disease

  2002cited by this paper
• Molecular biology of apolipoprotein E

  2002cited by this paper
• Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study.

  2002cited by this paper
• Influence of the apolipoprotein E epsilon4 allele on human embryonic development.

  2002cited by this paper
• Updating the DALYs for diarrhoeal disease.

  2002cited by this paper
• Organization of the neuronal circuits in the central nervous system during development

  2001influential reference
• Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering.

  2001cited by this paper
• Cerebral protein kinase C and its mRNA level in apolipoprotein E-deficient mice.

  2001cited by this paper
• Establishment of intestinal microbial functions at birth: bilirubin and bacteria

  2001cited by this paper
• Association between vitamin A status and lung function level in children aged 6--9 years in Wukro wereda, Northern Ethiopia.

  2001cited by this paper
• No association between apolipoprotein E polymorphisms and general cognitive ability in children.

  2001cited by this paper
• Interactions between Apolipoprotein E Gene and Dietary α-Tocopherol Influence Cerebral Oxidative Damage in Aged Mice

  2001cited by this paper
• CNS synaptogenesis promoted by glia-derived cholesterol.

  2001cited by this paper
• Cholesterol metabolism in the brain

  2001cited by this paper
• Malnutrition and mental development: is there a sensitive period? A nested case-control study.

  2001cited by this paper
• Dietary fats and cancer

  2001cited by this paper
• Collection of buccal cell DNA in seventh-grade children using water and a toothbrush.

  2001cited by this paper
• Seismic Observations of Splitting of the Mid-Transition Zone Discontinuity in Earth's Mantle

  2001cited by this paper
• Total brain N-acetylaspartate

  2000cited by this paper
• Long-term effects of severe undernutrition during the first year of life on brain development and learning in Chilean high-school graduates.

  2000cited by this paper
• Apolipoprotein E: far more than a lipid transport protein.

  2000cited by this paper
• Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil.

  2000cited by this paper
• Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

  2000cited by this paper
• Lipoproteins in the Central Nervous System

  2000cited by this paper
• Different radiosensitivity of smooth muscle cells and endothelial cells in vitro as demonstrated by irradiation from a Re-188 filled balloon catheter.

  2000cited by this paper
• Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population.

  2000cited by this paper
• Apolipoprotein E4 phenotype increases non-fasting serum triglyceride concentration in infants - the STRIP study.

  2000cited by this paper
• Detailed haplotype analysis in Ashkenazi Jewish and non‐Jewish British dystonic patients carrying the GAG deletion in the DYT1 gene: evidence for a limited number of founder mutations

  1999cited by this paper
• Plasma electrolytes, total cholesterol, liver enzymes, and selected antioxidant status in protein energy malnutrition.

  1999cited by this paper
• Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury.

  1999cited by this paper
• Severity and timing of stunting in the first two years of life affect performance on cognitive tests in late childhood.

  1999cited by this paper
• Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil.

  1999cited by this paper
• Apolipoprotein E and the response of the brain to injury.

  1999cited by this paper
• Lipids, lipoproteins, and fatty acids during infantile marasmus in the Fès area of Morocco.

  1999cited by this paper
• Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury

  1999cited by this paper
• Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a ‘thrifty’ allele?

  1999cited by this paper
• Dietary long-chain (n-3) fatty acids facilitate immune cell activation in sedentary, but not exercise-trained rats.

  1998cited by this paper
• Effect of oxidative stress on brain damage detected by MRI and in vivo 31P-NMR.

  1998cited by this paper
• Pigs fed cholesterol neonatally have increased cerebrum cholesterol as young adults.

  1998cited by this paper
• Uptake and cellular localization of exogenous lipids by Giardia lamblia, a primitive eukaryote.

  1997cited by this paper
• Nutrition and cognitive function.

  1997cited by this paper
• Apolipoprotein E4 and Alzheimer's disease in São Paulo-Brazil.

  1997cited by this paper
• Optimization of Apolipoprotein E Genotyping.

  1997cited by this paper
• Evaluation of methodology for nutritional assessment in children: anthropometry, body composition, and energy expenditure.

  1997cited by this paper
• Malnutrition and reactivity to drugs acting in the central nervous system.

  1996cited by this paper
• Cholesterol starvation induces differentiation of the intestinal parasite Giardia lamblia.

  1996cited by this paper
• Apolipoprotein E alleles as risk factors in Alzheimer's disease.

  1996cited by this paper
• Motion perception: seeing and deciding.

  1996cited by this paper
• The importance of calcium in the control of salt intake.

  1996cited by this paper
• Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brain after dietary administration of cholesterol.

  1995cited by this paper
• The influence of apolipoprotein E polymorphism on plasma concentrations of apolipoprotein B and A-I during the first year of life.

  1994cited by this paper
• Fat and cholesterol in the diet of infants and young children: implications for growth, development, and long-term health.

  1994cited by this paper
• Growth in utero and serum cholesterol concentrations in adult life.

  1993cited by this paper
• Partial reconstruction of the adult Lurcher cerebellar circuitry by neural grafting.

  1993cited by this paper
• Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats.

  1993cited by this paper
• Long-term low-protein diet reduces the number of hippocampal mossy fiber synapses.

  1991cited by this paper
• Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

  1990influential reference
• Genetic heterogeneity in familial dysbetalipoproteinemia. The E2(lys146----gln) variant results in a dominant mode of inheritance.

  1990cited by this paper
• Comparative effects of postnatal undernutrition and methadone exposure on protein and nucleic acid contents of the brain and cerebellum in rats.

  1982influential reference

• Divergent Biological Consequences of APOE Isoforms Across Industrialized and Non-Industrial Environments

  2026cites this paper
• An evolutionary medicine and life history perspective on aging and disease: Trade-offs, hyperfunction, and mismatch

  2025cites this paper
• Biological constraint, evolutionary spandrels and antagonistic pleiotropy

  2024cites this paper
• More evidence for widespread antagonistic pleiotropy in polymorphic disease alleles

  2024cites this paper
• Apolipoprotein E4 and Alzheimer's disease causality under adverse environments and potential intervention by senolytic nutrients.

  2024cites this paper
• Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention

  2024cites this paper
• Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer’s disease

  2024cites this paper
• Apolipoprotein-E4: risk of severe malaria and mortality and cognitive impairment in pediatric cerebral malaria

  2023cites this paper
• Re-mining serum proteomics data reveals extensive post-translational modifications upon Zika and dengue infection.

  2023cites this paper
• Lower mortality risk in APOE4 carriers with normal cognitive ageing

  2023cites this paper
• Apolipoprotein-ε4 is associated with higher fecundity in a natural fertility population

  2023cites this paper
• Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3

  2023cites this paper
• The Misguided Veneration of Averageness in Clinical Neuroscience: A Call to Value Diversity over Typicality

  2023cites this paper
• Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice

  2023cites this paper
• Apolipoprotein ɛ4-Associated Protection Against Pediatric Enteric Infections Is a Survival Advantage in Pre-Industrial Populations

  2023cites this paper
• ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers

  2023cites this paper
• Re-mining serum proteomics data reveals extensive post-translational modifications upon Zika and dengue infection

  2022cites this paper
• Impact of Shigella infections and inflammation early in life on child growth and school-aged cognitive outcomes: Findings from three birth cohorts over eight years

  2022cites this paper
• Evolution of Senescence in Humans-The Rift Between Lifespan and Healthspan

  2021cites this paper
• Immunoinflammatory role of apolipoprotein E4 in malnutrition and enteric infections and the increased risk for chronic diseases under adverse environments.

  2021cites this paper
• APOE genetics influence murine gut microbiome

  2021cites this paper
• Effect of Hydration Status of School Children on Cognitive Performance and Impact of Health Education on Their Drinking Behavior

  2021cites this paper
• Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers

  2021cites this paper
• The Evolutionary Optimality Challenge

  2021cites this paper
• APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

  2021cites this paper
• Murine Gut Microbiome Association With APOE Alleles

  2020cites this paper
• The Association of 3-Hydroxy-3-Methylglutaryl-CoA Reductase, Apolipoprotein E, and Solute Carrier Organic Anion Genetic Variants with Atorvastatin Response among Jordanian Patients with Type 2 Diabetes

  2020cites this paper
• Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank

  2020cites this paper
• Cost of illness for childhood diarrhea in low- and middle-income countries: a systematic review of evidence and modelled estimates

  2020cites this paper
• Apolipoprotein E, periodontal disease and the risk for atherosclerosis: a review.

  2019cites this paper
• Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress

  2019cites this paper
• Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

  2019cites this paper
• Cognitive Performance in Young APOE ε4 Carriers: A Latent Variable Approach for Assessing the Genotype–Phenotype Relationship

  2019cites this paper
• Responses to executive demand in young adulthood differ by APOE genotype

  2019cites this paper
• The Wisdom of Germline Editing: An Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos

  2019cites this paper
• 'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions.

  2018cites this paper
• The transition to modernity and chronic disease: mismatch and natural selection

  2018cites this paper
• The Myth of Optimality in Clinical Neuroscience.

  2018cites this paper
• The Wisdom of Nature: An Evolutionary Heuristic for Human Enhancement

  2017cites this paper
• Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes.

  2017cites this paper
• Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease

  2017cites this paper
• Neurodevelopment, Nutrition, and Inflammation: The Evolving Global Child Health Landscape

  2017cites this paper
• Cohort study of associations between intestinal protozoa infection and intestinal barrier funcion, nutritional status, and neurodevelopment in infants from Republic of São Tomé

  2017cites this paper
• Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors.

  2017cites this paper
• Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager‐horticulturalists with a high parasite burden

  2017cites this paper
• Chronic consequences on human health induced by microbial pathogens: Growth faltering among children in developing countries.

  2017cites this paper
• Chronic Health Consequences of Acute Enteric Infections in the Developed World

  2016cites this paper
• APOE genotype and stress response - a mini review

  2016cites this paper
• Environmental Enteropathy: Elusive but Significant Subclinical Abnormalities in Developing Countries

  2016cites this paper
• Early-life enteric infections: relation between chronic systemic inflammation and poor cognition in children.

  2016cites this paper
• Early Childhood Diarrhea Predicts Cognitive Delays in Later Childhood Independently of Malnutrition.

  2016cites this paper
• Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness

  2016cites this paper
• Mercury, APOE, and child behavior.

  2015cites this paper
• Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

  2015cites this paper
• Herpes simplex-1 as an additive risk factor for cognitive decline in apolipoprotein E4 carriers

  2015cites this paper
• A global perspective on the influence of environmental exposures on the nervous system

  2015cites this paper
• Reducing neurodevelopmental disorders and disability through research and interventions

  2015cites this paper
• Sex, but not Apolipoprotein E Polymorphism, Differences in Spatial Performance in Young Adults

  2015cites this paper
• APOLIPOPROTEIN E AS PREDICTORS OF ACUTE BRAIN DYSFUNCTION AND SURVIVAL IN CRITICAL CARE PATIENTS

  2014cites this paper
• Cognitive decline and brain pathology in aging--need for a dimensional, lifespan and systems vulnerability view.

  2014cites this paper
• Apolipoprotein E Plays a Key Role against Cryptosporidial Infection in Transgenic Undernourished Mice

  2014cites this paper
• Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients.

  2014cites this paper
• Longitudinal change in working memory as a function of APOE genotype in midlife and old age.

  2014cites this paper
• Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.

  2014cites this paper
• Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4

  2014cites this paper
• Challenges in Enteric Epidemics: Barometers of Inadequate Water and Sanitation

  2013cites this paper
• Treating foodborne illness.

  2013cites this paper
• Diarrhea among children in developing countries.

  2013cites this paper
• Can infections cause Alzheimer's disease?

  2013cites this paper
• Immune responses and protection in children in developing countries induced by oral vaccines.

  2013cites this paper
• Apolipoprotein E (APOE) Genotype and Outcome in Infants with Hypoxic-Ischemic Encephalopathy (HIE)

  2013cites this paper
• Mercury, APOE, and children's neurodevelopment.

  2013cites this paper
• Apolipoprotein E4 influences growth and cognitive responses to micronutrient supplementation in shantytown children from northeast Brazil

  2012cites this paper
• Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?

  2012cites this paper
• Enteric pathogens through life stages

  2012cites this paper
• Trade‐off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan

  2011cites this paper
• NBER WORKING PAPER SERIES BIRTH COHORT AND THE BLACK-WHITE ACHIEVEMENT GAP: THE ROLES OF ACCESS AND HEALTH SOON AFTER BIRTH

  2011cites this paper
• Linking ecological immunology and evolutionary medicine: the case for apolipoprotein E

  2011cites this paper
• Interactions of diarrhea, pneumonia, and malnutrition in childhood: recent evidence from developing countries

  2011cites this paper
• Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain

  2011cites this paper
• Inflammatory Gene Variants in the Tsimane, an Indigenous Bolivian Population with a High Infectious Load

  2011cites this paper
• Enteric protozoa and human potential

  2011cites this paper
• IQ, Educational Attainment, Memory and Plasma Lipids: Associations with Apolipoprotein E Genotype in 5995 Children

  2011cites this paper
• DALYs and Diarrhea

  2010cites this paper
• Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history.

  2010cites this paper
• Apolipoprotein E genotype and cerebral palsy

  2010cites this paper
• Evolutionary perspectives on health and medicine

  2010cites this paper
• ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children.

  2010cites this paper
• Genetic Factors are Important Determinants of Impaired Growth Following Infant Cardiac Surgery

  2010cites this paper
• Apolipoprotein E genotype and cerebral palsy

  2010cites this paper
• APOE genotype is associated with left-handedness and visuospatial skills in children.

  2010influential citation
• Apolipoprotein E4 and Sex Affect Neurobehavioral Performance in Primary School Children

  2010cites this paper
• Genetic factors are important determinants of impaired growth after infant cardiac surgery.

  2010cites this paper
• Apolipoprotein E4 as a Predictor of Outcomes in Pediatric Mild Traumatic Brain Injury

  2009cites this paper
• Birth Cohort and the Black-White Achievement Gap: The Roles of Access and Health Soon after Birth

  2009cites this paper
• Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability—the VA Normative Aging Study

  2009cites this paper
• Semantic fluency: a sensitive marker for cognitive impairment in children with heavy diarrhea burdens?

  2009cites this paper
• Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition

  2009cites this paper
• Medical Genetic Polymorphisms as Markers of Evolutionary Forces Within the Human Genome: Hypotheses Focusing on Natural Selection in the Basque Population

  2009cites this paper
• Genome‐wide autozygosity mapping in human populations

  2009cites this paper