Biomarkers for bipolar disorder: current status and challenges ahead

ABSTRACT Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.

• Publication year

  2018

• Venue

  Expert Review of Neurotherapeutics

• Publication date

  2018-11-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1080/14737175.2019.1550361PMID 30451546
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Major depressive disorder

  2020cited by this paper
• Exosomal MicroRNAs as Potential Biomarkers in Neuropsychiatric Disorders.

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• The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review.

  2018cited by this paper
• TSPO expression and brain structure in the psychosis spectrum.

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• A longitudinal approach to biological psychiatric research: The PsyCourse study

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• Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses

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• Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

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• Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder

  2018cited by this paper
• The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine

  2018cited by this paper
• Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future

  2018cited by this paper
• The Emerging Neurobiology of Bipolar Disorder

  2018cited by this paper
• Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder

  2018cited by this paper
• Adiponectin is decreased in bipolar depression

  2018cited by this paper
• Are lithium effects dependent on genetic/epigenetic architecture?

  2018cited by this paper
• Precision Medicine and Global Health: The Good, the Bad, and the Ugly

  2018cited by this paper
• Systematic review of cognitive event related potentials in euthymic bipolar disorder.

  2018cited by this paper
• N6-Methyladenine DNA Modification in the Human Genome.

  2018cited by this paper
• Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta‐analysis

  2018cited by this paper
• Machine Learning Approaches for Clinical Psychology and Psychiatry.

  2018cited by this paper
• Biomarkers in cerebrospinal fluid of patients with bipolar disorder versus healthy individuals: A systematic review.

  2018cited by this paper
• Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function

  2018cited by this paper
• A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder

  2018cited by this paper
• Differential Abnormal Pattern of Anterior Cingulate Gyrus Activation in Unipolar and Bipolar Depression: an fMRI and Pattern Classification Approach

  2017cited by this paper
• Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis

  2017cited by this paper
• Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study

  2017cited by this paper
• Potential biomarkers for bipolar disorder: Where do we stand?

  2017cited by this paper
• A voxel‐based diffusion tensor imaging study in unipolar and bipolar depression

  2017cited by this paper
• Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

  2017cited by this paper
• Anatomical dysconnectivity in bipolar disorder compared with schizophrenia: A selective review of structural network analyses using diffusion MRI.

  2017cited by this paper
• Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder

  2017cited by this paper
• The putative role of neuronal network synchronization as a potential biomarker for bipolar disorder: A review of EEG studies.

  2017cited by this paper
• Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence

  2017cited by this paper
• The miRNome of bipolar disorder.

  2017cited by this paper
• Diffusion tensor imaging of cingulum bundle and corpus callosum in schizophrenia vs. bipolar disorder.

  2017cited by this paper
• Identification and individualized prediction of clinical phenotypes in bipolar disorders using neurocognitive data, neuroimaging scans and machine learning

  2017cited by this paper
• Personalized psychiatry: Promises and pitfalls.

  2017cited by this paper
• Identification of shared risk loci and pathways for bipolar disorder and schizophrenia

  2017cited by this paper
• Lithium, Stress, and Resilience in Bipolar Disorder: Deciphering this key homeostatic synaptic plasticity regulator.

  2017cited by this paper
• Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes.

  2017cited by this paper
• A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients.

  2017cited by this paper
• A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

  2017cited by this paper
• Biological hypotheses and biomarkers of bipolar disorder

  2017cited by this paper
• Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls

  2017cited by this paper
• Decreased S100B serum levels after treatment in bipolar patients in a manic phase.

  2017cited by this paper
• A preliminary study of bipolar disorder type I by mass spectrometry-based serum lipidomics.

  2017cited by this paper
• Personalized management of bipolar disorder.

  2017cited by this paper
• Cortical thickness in bipolar disorder: a systematic review

  2016cited by this paper
• Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

  2016cited by this paper
• State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis.

  2016cited by this paper
• Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

  2016cited by this paper
• Individualized Prediction and Clinical Staging of Bipolar Disorders using Neuroanatomical Biomarkers.

  2016cited by this paper
• Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

  2016cited by this paper
• Differentiating unipolar and bipolar depression by alterations in large‐scale brain networks

  2016cited by this paper
• Dissecting bipolar disorder complexity through epigenomic approach

  2016cited by this paper
• Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

  2016cited by this paper
• Update on bipolar disorder biomarker candidates

  2016cited by this paper
• Aims and structure of the German Research Consortium BipoLife for the study of bipolar disorder

  2016cited by this paper
• The role of DNA methylation in the pathophysiology and treatment of bipolar disorder.

  2016cited by this paper
• Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

  2016cited by this paper
• Cognitive impairment in late‐life bipolar disorder is not associated with Alzheimer's disease pathological signature in the cerebrospinal fluid

  2016cited by this paper
• Blood lactate levels as a biomarker of antipsychotic side effects in patients with schizophrenia

  2016cited by this paper
• Major depressive disorder

  2016cited by this paper
• Unmet needs of bipolar disorder patients

  2016cited by this paper
• The potential association between obesity and bipolar disorder: A meta-analysis.

  2016cited by this paper
• New hope: the emerging role of 5-hydroxymethylcytosine in mental health and disease.

  2016cited by this paper
• Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis

  2016cited by this paper
• A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

  2016cited by this paper
• Detecting Neuroimaging Biomarkers for Schizophrenia: A Meta-Analysis of Multivariate Pattern Recognition Studies

  2015cited by this paper
• Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes.

  2015cited by this paper
• Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [(11)C]PBR28 PET Brain Imaging Study.

  2015cited by this paper
• Inflammatory monocyte gene expression: trait or state marker in bipolar disorder?

  2015cited by this paper
• Glucose metabolism alterations in patients with bipolar disorder.

  2015cited by this paper
• Individualized differential diagnosis of schizophrenia and mood disorders using neuroanatomical biomarkers.

  2015cited by this paper
• Fronto-limbic disconnection in bipolar disorder

  2015cited by this paper
• Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers

  2015cited by this paper
• The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders.

  2015cited by this paper
• Further neuroimaging evidence for the deficit subtype of schizophrenia: a cortical connectomics analysis.

  2015cited by this paper
• Elevated neurotrophin-3 and neurotrophin 4/5 levels in unmedicated bipolar depression and the effects of lithium.

  2015cited by this paper
• Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders

  2015cited by this paper
• Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At‐Risk Individuals

  2015cited by this paper
• Assessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatment.

  2015cited by this paper
• Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.

  2015cited by this paper
• Diagnostic and clinical implications of functional neuroimaging in bipolar disorder.

  2014cited by this paper
• An updated meta-analysis of oxidative stress markers in bipolar disorder.

  2014influential reference
• Brain morphometric biomarkers distinguishing unipolar and bipolar depression. A voxel-based morphometry-pattern classification approach.

  2014cited by this paper
• Structural abnormalities in bipolar euthymia: a multicontrast molecular diffusion imaging study.

  2014cited by this paper
• Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder

  2014cited by this paper
• Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: a study of two independent cohorts.

  2014cited by this paper
• Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies.

  2014cited by this paper
• Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression

  2014cited by this paper
• Glutamatergic dysregulation in pediatric psychiatric disorders: a systematic review of the magnetic resonance spectroscopy literature.

  2014cited by this paper
• The Immunology of Bipolar Disorder

  2014cited by this paper
• A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research.

  2014cited by this paper
• Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania.

  2014cited by this paper
• Cortical thickness differences between bipolar depression and major depressive disorder

  2014cited by this paper
• A genome‐wide linkage scan of bipolar disorder in Latino families identifies susceptibility loci at 8q24 and 14q32

  2014cited by this paper
• Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II.

  2014cited by this paper
• Genome-wide association study reveals two new risk loci for bipolar disorder

  2014cited by this paper
• Common and Rare Variant Analysis in Early-Onset Bipolar Disorder Vulnerability

  2014cited by this paper

• Psychoneuroimmunology of Mood Disorders.

  2025cites this paper
• Long non-coding RNAs in bipolar disorder.

  2025cites this paper
• Near-infrared brain imaging study of depressive disorder with liver qi stagnation syndrome before and after treatment

  2025cites this paper
• Abnormal network homogeneity in patients with bipolar disorder in attention network

  2025cites this paper
• Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications.

  2025cites this paper
• SEDA-EEG: A semi-supervised emotion recognition network with domain adaptation for cross-subject EEG analysis

  2025cites this paper
• Special Issue “Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies”

  2025cites this paper
• Bioenergetic biomarkers as predictive indicators and their relationship with cognitive function in newly diagnosed, drug-naïve patients with bipolar disorder

  2025cites this paper
• Increased grey matter volumes in the temporal lobe and its relationship with cognitive functioning in euthymic patients with bipolar disorder.

  2024cites this paper
• Biomarkers of bipolar disorder based on metabolomics: A systematic review.

  2024cites this paper
• Mood Disorder Severity and Subtype Classification Using Multimodal Deep Neural Network Models

  2024cites this paper
• Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes Mellitus Among People With Mental Disorders

  2024cites this paper
• Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review

  2024cites this paper
• Unraveling the role of the renin-angiotensin system in severe mental illnesses: An insight into psychopathology and cognitive deficits.

  2024cites this paper
• Investigation of optical coherence tomography angiography findings in patients with bipolar disorder.

  2024cites this paper
• Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences.

  2024cites this paper
• Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth

  2024cites this paper
• Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review

  2024cites this paper
• Application of Lipidomics in Psychiatry: Plasma-Based Potential Biomarkers in Schizophrenia and Bipolar Disorder

  2023cites this paper
• Differential Expression of Proteins Associated with Bipolar Disorder as Identified Using the PeptideShaker Software

  2023cites this paper
• ECGPsychNet: an optimized hybrid ensemble model for automatic detection of psychiatric disorders using ECG signals

  2023cites this paper
• Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions

  2023cites this paper
• Candidate biomarkers in psychiatric disorders: state of the field

  2023cites this paper
• Mood Disorders in Youth: Complementary and Integrative Medicine.

  2023cites this paper
• Eveningness chronotype and depressive affective temperament associated with higher high-sensitivity C-Reactive Protein in Unipolar and Bipolar Depression

  2023cites this paper
• Optical coherence tomography angiography in patients with euthymic bipolar disorder.

  2022cites this paper
• Machine learning approaches for prediction of bipolar disorder based on biological, clinical and neuropsychological markers: a systematic review and meta-analysis.

  2022cites this paper
• TINY IN SIZE, BIG IN IMPACT: EXTRACELLULAR VESICLES AS MODULATORS OF MOOD, ANXIETY AND NEURODEVELOPMENTAL DISORDERS.

  2022cites this paper
• Biomarkers of mental illness and the human hand: A systematic review

  2022cites this paper
• Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders?

  2022cites this paper
• Proteomic Analysis of Plasma Markers in Patients Maintained on Antipsychotics: Comparison to Patients Off Antipsychotics and Normal Controls

  2022cites this paper
• Hsa-miR-19b-3p and Hsa-miR-23b-3P are the candidate biomarkers for bipolar disorder

  2022cites this paper
• Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder

  2022cites this paper
• Network Module analysis of bipolar disorder mechanism deciphers underlying pathways

  2022cites this paper
• Characteristics of prefrontal activity during emotional and cognitive processing in patients with bipolar disorder: A multi-channel functional near-infrared spectroscopy study

  2022cites this paper
• Neurovascular alterations in bipolar disorder: A review of perfusion weighted magnetic resonance imaging studies.

  2022cites this paper
• Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities.

  2022cites this paper
• The emergence of psychoanalytical electrochemistry: the translation of MDD biomarker discovery to diagnosis with electrochemical sensing

  2022cites this paper
• Disrupted network switching in euthymic bipolar disorder: Working memory and self-referential paradigms.

  2022cites this paper
• Is SARS-CoV-2 a Risk Factor of Bipolar Disorder?—A Narrative Review

  2022cites this paper
• Biomarkers and detection methods of bipolar disorder.

  2022cites this paper
• Utility of portable functional near-infrared spectroscopy (fNIRS) in patients with bipolar and unipolar disorders: A comparison with healthy controls.

  2022cites this paper
• Tercer Consenso Argentino sobre el manejo de los Trastornos Bipolares. Primera Parte: introducción, método de trabajo y generalidades

  2022cites this paper
• Neuroimaging Brain Inflammation in Mood Disorders

  2021cites this paper
• Nutrition-based interventions for mood disorders

  2021cites this paper
• Electrophysiological Biomarkers for Mood Disorders

  2021cites this paper
• Functional Near-Infrared Spectroscopy Studies in Mood Disorders

  2021cites this paper
• Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders

  2021cites this paper
• Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders

  2021cites this paper
• Effects of Lithium on Brain Structure in Bipolar Disorder

  2021cites this paper
• Resting-State Functional Connectivity in Unipolar Depression

  2021cites this paper
• Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder

  2021cites this paper
• Imaging Genetic and Epigenetic Markers in Mood Disorders

  2021cites this paper
• Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis

  2021cites this paper
• Lithium as a Neuroprotective Agent for Bipolar Disorder: An Overview

  2021cites this paper
• Manic Episode Induced by Lamotrigine in Rapid Cycling Bipolar Disorder

  2021cites this paper
• Automatic Diagnosis of Bipolar Disorder Using Optical Coherence Tomography Data and Artificial Intelligence

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• Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state

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• Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells

  2021cites this paper
• Is there a biosignature for lithium response in bipolar disorder? Evidence and implications

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• An Overview of Machine Learning Applications in Mood Disorders

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• Neuroimaging Biomarkers in Pediatric Mood Disorders

  2021cites this paper
• Neuroanatomical Findings in Bipolar Disorder

  2021cites this paper
• Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus

  2021cites this paper
• Brain Imaging Methods in Mood Disorders

  2021cites this paper
• Magnetoencephalography Studies in Mood Disorders

  2021cites this paper
• Neuroimaging Studies of Effects of Psychotherapy in Depression

  2021cites this paper
• Brain Imaging and the Mechanisms of Antidepressant Action

  2021cites this paper
• Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders

  2021cites this paper
• Functional Connectome in Bipolar Disorder

  2021cites this paper
• fMRI Neurofeedback as Treatment for Depression

  2021cites this paper
• Phosphoinositide-3-kinase regulatory subunit 1 gene polymorphisms are associated with schizophrenia and bipolar disorder in the Han Chinese population

  2020cites this paper
• Glial and neuronal markers in bipolar disorder: A meta-analysis testing S100B and NSE peripheral blood levels.

  2020cites this paper
• Changes in Non-Coding RNA in Depression and Bipolar Disorder: Can They Be Used as Diagnostic or Theranostic Biomarkers?

  2020cites this paper
• Eotaxin-1/CCL11 correlates with left superior temporal gyrus in bipolar disorder: A preliminary report suggesting accelerated brain aging.

  2020cites this paper
• Glutathione peroxidase-1 and neuromodulation: novel potentials of an old enzyme.

  2020cites this paper
• Neurocognitive Impairment in Bipolar Disorder and Associated Factors: Using Population-based Norms and a Strict Criterion for Impairment Definition

  2020cites this paper
• Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disorders

  2020cites this paper
• Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease

  2020cites this paper
• Protein kinase C isoforms as a target for manic-like behaviors and oxidative stress in a dopaminergic animal model of mania.

  2020cites this paper
• Exploring the clinical utility of two staging models for bipolar disorder

  2019cites this paper
• Preliminary investigation of peripheral extracellular vesicles' microRNAs in bipolar disorder.

  2019cites this paper
• The Role of Chemokines in the Pathophysiology of Major Depressive Disorder

  2019cites this paper
• Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

  2019cites this paper
• Accelerated hippocampal biological aging in bipolar disorder

  2019cites this paper