Pain modulation by release of the endogenous cannabinoid anandamide.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1999-10-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.96.21.12198PMID 10518599PMCID PMC18435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analgesic activity of δ9-tetrahydrocannabinol in the rat and mouse

  2004cited by this paper
• Dopamine activation of endogenous cannabinoid signaling in dorsal striatum

  1999cited by this paper
• Short communication Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections

  1999cited by this paper
• Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat.

  1999cited by this paper
• Kang tsou (1932-1999)

  1999cited by this paper
• A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.

  1998cited by this paper
• Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment.

  1998cited by this paper
• Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry.

  1998cited by this paper
• Control of pain initiation by endogenous cannabinoids

  1998cited by this paper
• Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2.

  1998cited by this paper
• Three times as many lamina I neurons project to the periaqueductal gray than to the thalamus: a retrograde tracing study in the cat.

  1998cited by this paper
• Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

  1998cited by this paper
• Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors

  1998cited by this paper
• Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity.

  1998cited by this paper
• SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice.

  1997cited by this paper
• Todd's achievement

  1997cited by this paper
• Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric determination of anandamide and its analogs in rat brain and peripheral tissues.

  1997cited by this paper
• Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists.

  1997cited by this paper
• Opioid-induced release of neurotensin in the periaqueductal gray matter of freely moving rats.

  1997cited by this paper
• Functional role of high-affinity anandamide transport, as revealed by selective inhibition.

  1997cited by this paper
• The perceived effects of smoked cannabis on patients with multiple sclerosis.

  1997cited by this paper
• Suppression of Noxious Stimulus-Evoked Activity in the Ventral Posterolateral Nucleus of the Thalamus by a Cannabinoid Agonist: Correlation between Electrophysiological and Antinociceptive Effects

  1996cited by this paper
• Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: a microdialysis study of antinociceptive circuits.

  1995cited by this paper
• Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist.

  1995cited by this paper
• Functional characteristics of the midbrain periaqueductal gray.

  1995cited by this paper
• Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2.

  1995cited by this paper
• An examination of the central sites of action of cannabinoid-induced antinociception in the rat.

  1995cited by this paper
• The striatonigral dynorphin pathway of the rat studied with in vivo microdialysis--II. Effects of dopamine D1 and D2 receptor agonists.

  1994cited by this paper
• SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

  1994cited by this paper
• Quantitative approaches to in vivo brain microdialysis.

  1994cited by this paper
• Deep and superficial noxious stimulation increases Fos-like immunoreactivity in different regions of the midbrain periaqueductal grey of the rat.

  1993cited by this paper
• Increases in rat striatal extracellular dopamine and vacuous chewing produced by two sigma receptor ligands.

  1993cited by this paper
• Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist.

  1993cited by this paper
• Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

  1992cited by this paper
• Spinal mechanisms of delta 9-tetrahydrocannabinol-induced analgesia.

  1992cited by this paper
• Spinal mechanisms ofΔ9-tetrahydrocannabinol-induced analgesia

  1992cited by this paper
• Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry.

  1992cited by this paper
• Naloxone blocks the release of opioid peptides in periaqueductal gray and N. accumbens induced by intra-amygdaloid injection of morphine.

  1991cited by this paper
• Functional activity mapping of the rat brainstem during formalin-induced noxious stimulation.

  1991cited by this paper
• Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

  1991cited by this paper
• Cannabinoid-induced antinociception is mediated by a spinal alpha 2-noradrenergic mechanism.

  1991cited by this paper
• Raphe magnus-induced descending inhibition of spinal nociceptive neurons is mediated through contralateral spinal pathways in the cat.

  1987cited by this paper
• Physiology and morphology of the lamina i spinomesencephalic projection

  1986cited by this paper
• Long ascending projections to the midbrain from cells of lamina I and nucleus of the dorsolateral funiculus of the rat spinal cord

  1985cited by this paper
• Bilateral lesions of the dorsolateral funiculus of the cat spinal cord: effects on basal nociceptive reflexes and nociceptive suppression produced by cholinergic activation of the pontine parabrachial region.

  1984cited by this paper
• A system of rat spinal cord lamina 1 cells projecting through the contralateral dorsolateral funiculus

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Cholinomimetic-induced co-release of prolactin and beta-endorphin in man.

  1982cited by this paper
• Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat.

  1982cited by this paper
• Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells

  1981cited by this paper
• Opioid and nonopioid mechanisms of stress analgesia.

  1980cited by this paper
• AChE-stained horizontal sections of the rat brain in stereotaxic coordinates.

  1980cited by this paper
• Analgesia from rostral brain stem stimulation in the rat.

  1978cited by this paper
• Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation.

  1978cited by this paper
• Psychological and physiological mechanisms of pain.

  1977cited by this paper
• The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

  1977cited by this paper
• Antagonism of stimulation‐produced analgesia by naloxone, a narcotic antagonist

  1976cited by this paper
• Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray

  1976cited by this paper
• Excitation of phasically firing supraoptic neurones during vasopressin release

  1975cited by this paper
• Ascending projections from marginal zone (Lamina I) neurons of the spinal dorsal horn

  1975cited by this paper
• The milk-ejection reflex of the rat: a 20- to 40-fold acceleration in the firing of paraventricular neurones during oxytocin release.

  1973cited by this paper
• Uses of Marijuana

  1972cited by this paper
• Analgesia from Electrical Stimulation in the Brainstem of the Rat

  1971cited by this paper
• STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION.

  1964cited by this paper

• Longitudinal analysis in Mecp2-het female mice reveals atypical nociceptive behaviours

  2026cites this paper
• Examining associations among daily discrimination, psychosocial risk factors, and pain outcomes in people with chronic low back pain

  2026cites this paper
• Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaqueductal gray.

  2025cites this paper
• Effects of fermentation, ripening and storage on endocannabinoids and endocannabinoid-like compounds in different cheeses.

  2025cites this paper
• Investigation of endocannabinoids in plasma and their correlation with physical fitness and resting state functional connectivity of the periaqueductal grey in women with fibromyalgia: An exploratory secondary study

  2025cites this paper
• Endocannabinoid and nitric oxide interactions in the brain.

  2025cites this paper
• Cannabinoids in neuropathic pain treatment: pharmacological insights and clinical outcomes from recent trials

  2025cites this paper
• UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain

  2025cites this paper
• PHARMACOLOGICAL CHARACTERIZATION OF A NEW SYNTHESIS COMPOUND WITH ANTAGONISTIC ACTION ON CB1 RECEPTORS: EVIDENCE FROM THE ANIMAL EXPERIMENTAL MODEL.

  2025cites this paper
• Exploring the Possible Role of Cannabinoids in Managing Post-cardiac Surgery Complications: A Narrative Review of Preclinical Evidence and a Call for Future Research Directions

  2024influential citation
• Exploring the Painless Nature and Potential Mechanisms of Asymptomatic Irreversible Pulpitis: A Narrative Review

  2024cites this paper
• Negative allosteric modulation of CB1 cannabinoid receptor signaling suppresses opioid-mediated tolerance and withdrawal without blocking opioid antinociception.

  2024cites this paper
• The endocannabinoid system as a therapeutic target in neuropathic pain: a review

  2024cites this paper
• Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality

  2024cites this paper
• Salivary Testosterone Levels and Pain Perception Exhibit Sex-Specific Association in Healthy Adults but Not in Patients with Migraine.

  2024cites this paper
• NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis

  2024cites this paper
• Study of effects of newly synthesised nociceptin analogues on the endocannabinoid system and pain after chronic immobilization stress

  2023cites this paper
• The Endogenous Cannabinoid and the Nitricoxidergic Systems in the Modulation of Stress Responses

  2023cites this paper
• NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis

  2023cites this paper
• Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation

  2023cites this paper
• Depth and hierarchies in the predictive brain: From reaction to action.

  2023cites this paper
• Overview: Chronic Pain and Cannabis-Based Medicines

  2023cites this paper
• Implementation and validation of a UHPLC-MS/MS method for quantification of the endocannabinoids AEA and 2-AG in cerebral interstitial fluid and plasma.

  2023cites this paper
• The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis

  2023cites this paper
• Unravelling the brain metabolome: A review of liquid chromatography - mass spectrometry strategies for extracellular brain metabolomics.

  2023cites this paper
• Persistent inflammation promotes endocannabinoid release and presynaptic cannabinoid 1 receptor desensitization

  2022cites this paper
• The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies

  2022cites this paper
• Sex‐specific cannabinoid 1 receptors on GABAergic neurons in the ventrolateral periaqueductal gray mediate analgesia in mice

  2022cites this paper
• Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia

  2022cites this paper
• Serum Concentrations of the Endocannabinoid, 2-Arachidonoylglycerol, in the Peri-Trauma Period Are Positively Associated with Chronic Pain Months Later

  2022cites this paper
• Sex‐specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord

  2022cites this paper
• Fatty acid amide hydrolase activity in the dorsal PAG attenuates neuropathic pain and associated dysautonomia.

  2022cites this paper
• Anandamide in the dorsal periaqueductal gray inhibits sensory input without a correlation to sympathoexcitation

  2022cites this paper
• Preclinical Studies of Posttraumatic Headache and the Potential Therapeutics

  2022cites this paper
• TRPV1: A Common Denominator Mediating Antinociceptive and Antiemetic Effects of Cannabinoids

  2022cites this paper
• Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

  2022cites this paper
• Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors.

  2021cites this paper
• Cannabinoids for Pain Management

  2021cites this paper
• A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo

  2021cites this paper
• Recent progress in natural product-based inhibitor screening with enzymatic fluorescent probes.

  2021cites this paper
• Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex

  2021cites this paper
• The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

  2021cites this paper
• A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice.

  2021cites this paper
• Electroacupuncture activates inhibitory neural circuits in the somatosensory cortex to relieve neuropathic pain

  2021cites this paper
• Antinociceptive effects of minor cannabinoids, terpenes and flavonoids in Cannabis

  2021cites this paper
• The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia

  2021cites this paper
• Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal

  2021cites this paper
• Mu-opioid and CB1 cannabinoid receptors of the dorsal periaqueductal gray interplay in the regulation of fear response, but not antinociception.

  2020cites this paper
• Visual high-throughput screening for developing fatty acid amide hydrolase natural inhibitor based on an enzyme-activated fluorescent probe.

  2020cites this paper
• Comparison of endometrial prostanoid profiles in three infertile subgroups: the missing part of receptivity?

  2020cites this paper
• Cannabinoids in the descending pain modulatory circuit: Role in inflammation.

  2020cites this paper
• Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain

  2020cites this paper
• Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson’s and Alzheimer’s Diseases: a Review

  2020cites this paper
• FAAH inhibition as a preventive treatment for migraine: A pre-clinical study.

  2020cites this paper
• The Brainstem and Nociceptive Modulation

  2020cites this paper
• Receptores cannabinoides y vías de modulación del dolor

  2020cites this paper
• Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.

  2020cites this paper
• Medicinal Applications of Cannabidiol from the Genus Cannabis L.

  2020cites this paper
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  2020cites this paper
• Mechanism of exercise-induced analgesia: what we can learn from physically active animals

  2020cites this paper
• Cannabinoid Receptor Type 1 and Its Role as an Analgesic: An Opioid Alternative?

  2020cites this paper
• Botanical Leads for Drug Discovery

  2020cites this paper
• Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

  2019cites this paper
• Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: the role of cannabinoid and opioid receptors.

  2019cites this paper
• Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

  2019cites this paper
• Investigation of the Involvement of the Endocannabinoid System in TENS-induced Antinociception.

  2019cites this paper
• Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation.

  2019cites this paper
• Tolerance to WIN55,212‐2 is delayed in desensitization‐resistant S426A/S430A mice

  2019cites this paper
• Diet, endocannabinoids, and health.

  2019cites this paper
• Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia

  2019cites this paper
• Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.

  2019influential citation
• Selective modulation of the cannabinoid type 1 (CB1) receptor as an emerging platform for the treatment of neuropathic pain.

  2019cites this paper
• The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray

  2019influential citation
• Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis.

  2019cites this paper
• Cannabinoide in der Schmerzmedizin

  2018cites this paper
• Cannabinoid disruption of learning mechanisms involved in reward processing

  2018cites this paper
• Mechanisms of placebo analgesia: A dual-process model informed by insights from cross-species comparisons.

  2018cites this paper
• The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse

  2018cites this paper
• “Brain over body”–A study on the willful regulation of autonomic function during cold exposure

  2018cites this paper
• The role of the endocannabinoid system in the emotional modulation of pain

  2018cites this paper
• Systematic Review and Meta‐Analysis on Neuropsychological Effects of Long‐Term Use of Opioids in Patients With Chronic Noncancer Pain

  2018cites this paper
• Tetrahydrocannabinol in Chronic Pain. Cortical Mechanisms of Pain and Analgesia

  2018cites this paper
• Heterómeros de receptores CB1, CB2 y GPR55 y su implicación en enfermedades neurodegenerativas y alcoholismo

  2018cites this paper
• Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis

  2017cites this paper
• Microdialysis Coupled with LC-MS/MS for In Vivo Neurochemical Monitoring

  2017cites this paper
• Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia.

  2017cites this paper
• A Genetic Component to National Differences in Happiness

  2017cites this paper
• Title Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor

  2017cites this paper
• Cannabinoid signaling in health and disease.

  2017cites this paper
• The cannabinoid system and pain

  2017cites this paper
• Perspectives in Pharmacology Mechanisms of Endocannabinoid Inactivation : Biochemistry and Pharmacology

  2017influential citation
• Plasma levels of the endocannabinoid anandamide, related N-acylethanolamines and linoleic acid-derived oxylipins in patients with migraine.

  2017cites this paper
• Cannabinoids and Pain: Sites and Mechanisms of Action.

  2017cites this paper
• Upregulation of fatty acid amide hydrolase in the dorsal periaqueductal gray is associated with neuropathic pain and reduced heart rate in rats.

  2017cites this paper
• Effects of alprazolam and cannabinoid‐related compounds in an animal model of panic attack

  2017cites this paper
• Design and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors

  2017cites this paper
• ALLOSTERIC INTERACTIONS WITHIN CANNABINOID RECEPTOR 1 (CB1) AND DOPAMINE RECEPTOR 2 LONG (D2L) HETEROMERS

  2017influential citation
• The Endocannabinoid System and Anxiety.

  2017cites this paper
• Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses

  2017cites this paper
• The Relaxation System Theoretical Construct

  2017cites this paper