Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Developmental Biology

• Publication date

  2001-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/DBIO.2001.0346PMID 11476582
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell biology of limb patterning.

  2001cited by this paper
• WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.

  2001cited by this paper
• Some distal limb structures develop in mice lacking Sonic hedgehog signaling.

  2001cited by this paper
• Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development

  2000cited by this paper
• Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.

  2000cited by this paper
• Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development.

  2000cited by this paper
• Normal limb development in conditional mutants of Fgf4.

  2000cited by this paper
• The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.

  2000cited by this paper
• Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

  2000cited by this paper
• Fgf8 is required for outgrowth and patterning of the limbs

  2000cited by this paper
• Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly.

  2000cited by this paper
• Fgf8 signalling from the AER is essential for normal limb development

  2000cited by this paper
• Methods for manipulating the chick limb bud to study gene expression, tissue interactions, and patterning.

  2000cited by this paper
• Dorsoventral patterning of the vertebrate limb: a process governed by multiple events

  1999cited by this paper
• Molecular and cellular basis of pattern formation during vertebrate limb development.

  1999cited by this paper
• Hox genes in digit development and evolution

  1999cited by this paper
• Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

  1999cited by this paper
• Sonic hedgehog controls epaxial muscle determination through Myf5 activation.

  1999cited by this paper
• Disrupting the establishment of polarizing activity by teratogen exposure.

  1999cited by this paper
• Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death.

  1999cited by this paper
• Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity.

  1999cited by this paper
• Essential role for Sonic hedgehog during hair follicle morphogenesis.

  1999cited by this paper
• The roles of FGFs in the early development of vertebrate limbs.

  1998cited by this paper
• The molecular ZPA.

  1998cited by this paper
• Sonic hedgehog is essential to foregut development

  1998cited by this paper
• Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.

  1998cited by this paper
• Sonic hedgehog signaling is essential for hair development.

  1998cited by this paper
• Fins, limbs, and tails: outgrowths and axial patterning in vertebrate evolution

  1998cited by this paper
• Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud.

  1998cited by this paper
• Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications.

  1997cited by this paper
• Dorso-ventral limb polarity and origin of the ridge: on the fringe of independence?

  1997cited by this paper
• Molecular Models for Vertebrate Review Limb Development

  1997cited by this paper
• Hox9 genes and vertebrate limb specification

  1997cited by this paper
• Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.

  1997cited by this paper
• Fossils, genes and the evolution of animal limbs

  1997cited by this paper
• The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions.

  1996cited by this paper
• The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.

  1996cited by this paper
• Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

  1996cited by this paper
• Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.

  1996cited by this paper
• Analysis of Hox gene expression in the chick limb bud.

  1996cited by this paper
• Wound Repair, Regeneration and Artificial Tissues

  1996cited by this paper
• Gene expression in the limbless mutant: polarized gene expression in the absence of Shh and an AER.

  1996cited by this paper
• Surgical removal of limb bud Sonic hedgehog results in posterior skeletal defects.

  1996cited by this paper
• Retinoic acid is required for the initiation of outgrowth in the chick limb bud.

  1996cited by this paper
• Expression of a Delta homologue in prospective neurons in the chick

  1995cited by this paper
• Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.

  1995cited by this paper
• An additional limb can be induced from the flank of the chick embryo by FGF4.

  1995cited by this paper
• Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice.

  1995cited by this paper
• Fibroblast growth factors induce additional limb development from the flank of chick embryos.

  1995cited by this paper
• Hox gene expression in teleost fins and the origin of vertebrate digits

  1995cited by this paper
• Anterior duplication of the Sonic hedgehog expression pattern in the pectoral fin buds of zebrafish treated with retinoic acid.

  1995influential reference
• Initial limb budding is independent of apical ectodermal ridge activity; evidence from a limbless mutant.

  1988cited by this paper
• Posterior apical ectodermal ridge removal in the chick wing bud triggers a series of events resulting in defective anterior pattern formation.

  1987cited by this paper
• Ultrastructural analysis of the apical ectodermal ridge during vertebrate limb morphogenesis: II. Gap junctions as distinctive ridge structures common to birds and mammals

  1977cited by this paper
• Ultrastruct analysis of the apical ectodermal ridge duri;g vertebrate limb morphogenesis. II. Gap junctions as distinctive ridge structures common to birds and mammals.

  1977cited by this paper
• Ultrastructural analysis of the apical ectodermal ridge during vertebrate limb morphogenesis. 1. the human forelimb with special reference to gap junctions.

  1976cited by this paper
• Normal development of the chick wing following removal of the polarizing zone.

  1975cited by this paper
• Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid.

  1973cited by this paper
• Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid.

  1973cited by this paper
• Ectodermal-mesodermal interactions in the growth of limb buds in the chick embryo: constancy and temporal limits of the ectodermal induction.

  1972cited by this paper
• DEVELOPMENT OF FRAGMENTED AND OF DISSOCIATED LIMB BUD MESODERM.

  1964cited by this paper
• Ectoderm — mesoderm relationship in the development of the chick embryo limb bud

  1955cited by this paper
• A series of normal stages in the development of the chick embryo

  1951cited by this paper

• Unveiling a New Link: Cholesterol Deficiency in Smith-Lemli-Opitz and Niemann-Pick C as a Driver of Ciliopathies.

  2026cites this paper
• The 3′ region of the ZPA regulatory sequence (ZRS) is required for activity and contains a critical E-box

  2025cites this paper
• Exploring the Pathways and Mechanisms of Evolutionary Transformation of Paired Appendages in Gnathostomes

  2025cites this paper
• Zic3 represses anterior digit development in tetrapods

  2025cites this paper
• Caudal fin shape imprinted during late zebrafish embryogenesis is re-patterned by the Sonic hedgehog pathway

  2025cites this paper
• Thalidomide-induced limb malformations: an update and reevaluation

  2025cites this paper
• The Unusual Effectiveness of Evolution in Systems Neuroscience.

  2025cites this paper
• Identification of non-coding elements associated with the evolutionary loss of digit 1

  2025cites this paper
• From the 1948 discovery of the apical ectodermal ridge in proximal-distal limb development to FGF molecular signals.

  2025cites this paper
• A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling

  2025cites this paper
• Molecular basis of positional memory in limb regeneration

  2025cites this paper
• Adult caudal fin shape is imprinted in the embryonic fin fold

  2024cites this paper
• Anterior-posterior constraint on Hedgehog signaling by hhip in teleost fin elaboration

  2024cites this paper
• Insights into digit evolution from a fate map study of the forearm using Chameleon, a new transgenic chicken line

  2024cites this paper
• Insights into Digit Evolution from a Fate Map Study of the Forearm

  2023cites this paper
• The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds

  2023cites this paper
• Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape

  2023cites this paper
• Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf

  2023cites this paper
• Molecular basis for positional memory and its reprogrammability in limb regeneration

  2023cites this paper
• The role of timing in the development and evolution of the limb

  2023cites this paper
• Hedgehog

  2023cites this paper
• Identification of Transcription Factor Networks during Mouse Hindlimb Development

  2022cites this paper
• A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2

  2022influential citation
• GLI transcriptional repression is inert prior to Hedgehog pathway activation

  2022cites this paper
• A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog

  2022cites this paper
• CDON contributes to Hedgehog-dependent patterning and growth of the developing limb.

  2022cites this paper
• A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog

  2022cites this paper
• Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling

  2022cites this paper
• Embryology and Classification of Congenital Upper Limb Anomalies

  2021cites this paper
• Anatomy and Development of the Pectoral Fin Vascular Network in the Zebrafish

  2021cites this paper
• Tgf‐β superfamily and limb regeneration: Tgf‐β to start and Bmp to end

  2021cites this paper
• Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction

  2021cites this paper
• GLI transcriptional repression is inert prior to Hedgehog pathway activation

  2021cites this paper
• The Pleiotropic Intricacies of Hedgehog Signaling: From Craniofacial Patterning to Carcinogenesis

  2021cites this paper
• Sonic hedgehog is Essential for Proximal-Distal Outgrowth of the Limb Bud in Salamanders

  2021influential citation
• Syndactyly

  2021cites this paper
• (Non)Parallel developmental mechanisms in vertebrate appendage reduction and loss

  2021influential citation
• HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly

  2021cites this paper
• A farewell to arms and legs: a review of limb reduction in squamates

  2021cites this paper
• Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook.

  2021cites this paper
• Multiscale modeling of vertebrate limb development

  2020influential citation
• Basal epidermis collective migration and local Sonic hedgehog signaling promote skeletal branching morphogenesis in zebrafish fins

  2020cites this paper
• In memory of John F. Fallon

  2020cites this paper
• The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits

  2020cites this paper
• Establishing the pattern of the vertebrate limb

  2020cites this paper
• HES1 is a Critical Mediator of the SHH-GLI3 Axis in Regulating Digit Number

  2020cites this paper
• Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits

  2020cites this paper
• The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13

  2020cites this paper
• Dynamic and self-regulatory interactions among gene regulatory networks control vertebrate limb bud morphogenesis.

  2020cites this paper
• Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by Sall4

  2020cites this paper
• Animal Models for Understanding Human Skeletal Defects.

  2020cites this paper
• Sonic Hedgehog is not a limb morphogen but acts as a trigger to specify all digits

  2020cites this paper
• Systems Biology Approach to the Origin of the Tetrapod Limb

  2019cites this paper
• The benefits differential equations bring to limb development

  2019cites this paper
• Proteostasis in the Hedgehog signaling pathway.

  2019cites this paper
• Positional information and tissue scaling during development and regeneration

  2019cites this paper
• Experimental evidence that preaxial polydactyly and forearm radial deficiencies may share a common developmental origin

  2019cites this paper
• GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

  2019cites this paper
• Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

  2019cites this paper
• Tbx5 inhibits hedgehog signaling in determination of digit identity.

  2019cites this paper
• Mutual transcriptional repression between Gli3 and Hox13 genes determines the anterior-posterior asymmetry of the autopod

  2018cites this paper
• Determinants of multi-scale patterning in growth plate cartilage

  2018cites this paper
• The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation

  2018cites this paper
• Role of Hox genes in regulating digit patterning.

  2018cites this paper
• Congenital absence of humerus with preaxial terminal longitudinal hemimelia and hypoplasia of the scapula in a dog: a case report.

  2018cites this paper
• Shh signaling influences the phenotype of Pitx1-/- hindlimbs.

  2018cites this paper
• Hyperinnervation improves Xenopus laevis limb regeneration.

  2018cites this paper
• Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates.

  2018cites this paper
• Hedgehog and Wnt Signaling Pathways Regulate Tail Regeneration

  2018cites this paper
• Osteoarthritic Synovial Fluid and TGF-β1 Induce Interleukin-18 in Articular Chondrocytes

  2018cites this paper
• Classification of congenital upper limb anomalies: towards improved communication, diagnosis, and discovery

  2018cites this paper
• LHX2 Mediates the FGF-to-SHH Regulatory Loop during Limb Development

  2018cites this paper
• Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings

  2018cites this paper
• The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies

  2017cites this paper
• Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumor suppressor

  2017cites this paper
• A rare case of partial paraxial radial hemimelia in a puppy

  2017cites this paper
• Genetics of clubfoot; recent progress and future perspectives.

  2017cites this paper
• SHH Protein Variance in the Limb Bud Is Constrained by Feedback Regulation and Correlates with Altered Digit Patterning

  2017cites this paper
• How do fins and limbs develop and evolve

  2017cites this paper
• IFT 56 regulates vertebrate developmental patterning by maintaining IFTB integrity and ciliary microtubule architecture

  2017cites this paper
• IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture

  2017cites this paper
• Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo

  2017cites this paper
• Can Long Bone Structural Variability Detect Among-Population Relationships?

  2017cites this paper
• Alternative applications of whole genome de novo assembly in animal genomics

  2017cites this paper
• Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery

  2017cites this paper
• John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?

  2017influential citation
• The origins, scaling and loss of tetrapod digits

  2017cites this paper
• Reduced β-catenin expression affects patterning of bone primordia, but not bone maturation

  2017cites this paper
• Does penile rehabilitation have a role in the treatment of erectile dysfunction following radical prostatectomy?

  2017cites this paper
• Upstream regulation for initiation of restricted Shh expression in the chick limb bud

  2017cites this paper
• Polydactyly: A Review

  2016cites this paper
• T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

  2016cites this paper
• Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway

  2016cites this paper
• Elucidating the genetic basis of an oligogenic birth defect using whole genome sequence data in a non-model organism, Bubalus bubalis

  2016cites this paper
• PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud

  2016influential citation
• Hedgehog inhibition causes complete loss of limb outgrowth and transformation of digit identity in Xenopus tropicalis.

  2016cites this paper
• Characterizing the Structure and Function of the Cytoplasmic Domains of Ptch1

  2016cites this paper
• Limb patterning genes and heterochronic development of the emu wing bud

  2016cites this paper
• Evolution: Enhanced Footing for Snake Limb Development

  2016cites this paper
• Crop Domestication: A Sneak-Peek into the Midpoint of Maize Evolution.

  2016cites this paper