MAGUK-Controlled Ubiquitination of CARMA1 Modulates Lymphocyte NF-κB Activity

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular and Cellular Biology

• Publication date

  2009-12-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01129-09PMID 20008554PMCID PMC2815576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-κB Activation

  2007cited by this paper
• IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells

  2007cited by this paper
• Negative feedback loop in T cell activation through IκB kinase-induced phosphorylation and degradation of Bcl10

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• Post-translational modifications regulate distinct functions of CARMA1 and BCL10.

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• The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes

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• PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

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• Immunity by ubiquitylation: a reversible process of modification

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• Phosphorylation of the CARMA1 linker controls NF-kappaB activation.

  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

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  2003cited by this paper
• Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

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• Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

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• Differential requirement for Malt1 in T and B cell antigen receptor signaling.

  2003cited by this paper
• Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes.

  2003cited by this paper
• The MAGUK family protein CARD11 is essential for lymphocyte activation.

  2003cited by this paper
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• CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.

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• CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-κB*

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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway

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• Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

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  2018cites this paper
• CARD–BCL-10–MALT1 signalling in protective and pathological immunity

  2018cites this paper
• The E3 Ubiquitin Ligase RNF7 Negatively Regulates CARD14/CARMA2sh Signaling

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• Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

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• THE ROLES OF MALT1 IN NF-κB ACTIVATION AND SOLID TUMOR PROGRESSION

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  2015cites this paper
• A multi-omic analysis of human naïve CD4+ T cells

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  2014cites this paper
• The CBM signalosome: potential therapeutic target for aggressive lymphoma?

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• Identification of novel signaling pathways in T cells mediated by protein kinase C, Carma1, MALT1 and Bcl10

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