The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cell Host and Microbe

• Publication date

  2014-05-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.chom.2014.04.001PMID 24746552
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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  2011cited by this paper
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