Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood-brain barrier.

Due to the impermeable structure and barrier function of the blood-brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.

• Publication year

  2018

• Venue

  Future Medicinal Chemistry

• Publication date

  2018-11-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.4155/fmc-2018-0208PMID 30499740
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dual-targeting for brain-specific liposomes drug delivery system: Synthesis and preliminary evaluation.

  2018cited by this paper
• Promoting neuroregeneration by applying dynamic magnetic fields to a novel nanomedicine: Superparamagnetic iron oxide (SPIO)-gold nanoparticles bounded with nerve growth factor (NGF).

  2018cited by this paper
• A brain targeting functionalized liposomes of the dopamine derivative N‐3,4‐bis(pivaloyloxy)‐dopamine for treatment of Parkinson's disease

  2018cited by this paper
• Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain

  2018cited by this paper
• Functionalised Carbon Nanotubes Enhance Brain Delivery of Amyloid-Targeting Pittsburgh Compound B (PiB)-Derived Ligands

  2018cited by this paper
• Rolipram-Loaded Polymeric Micelle Nanoparticle Reduces Secondary Injury after Rat Compression Spinal Cord Injury

  2018cited by this paper
• Artificial apolipoprotein corona enables nanoparticle brain targeting.

  2018cited by this paper
• Dual‐targeting immunoliposomes using angiopep‐2 and CD133 antibody for glioblastoma stem cells

  2018cited by this paper
• Amino acid conjugated chitosan nanoparticles for the brain targeting of a model dipeptidyl peptidase‐4 inhibitor

  2018cited by this paper
• Crossing the blood‐brain barrier with nanoparticles

  2018cited by this paper
• Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting

  2018cited by this paper
• Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

  2018cited by this paper
• Biocompatible and blood-brain barrier permeable carbon dots for inhibition of Aβ fibrillation and toxicity, and BACE1 activity.

  2017cited by this paper
• Brain-Targeted Polymers for Gene Delivery in the Treatment of Brain Diseases

  2017cited by this paper
• Poly((D,L)lactic-glycolic)acid–star glucose nanoparticles for glucose transporter and hypoglycemia-mediated tumor targeting

  2017cited by this paper
• Efficacy of NGR peptide-modified PEGylated quantum dots for crossing the blood-brain barrier and targeted fluorescence imaging of glioma and tumor vasculature.

  2017cited by this paper
• The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study.

  2017cited by this paper
• Glycol chitosan functionalized asenapine nanostructured lipid carriers for targeted brain delivery: Pharmacokinetic and teratogenic assessment.

  2017cited by this paper
• Blood brain barrier permeable gold nanocluster for targeted brain imaging and therapy: an in vitro and in vivo study.

  2017cited by this paper
• Functional single-walled carbon nanotubes 'CAR' for targeting dopamine delivery into the brain of parkinsonian mice.

  2017cited by this paper
• RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model.

  2017cited by this paper
• Strategies for transporting nanoparticles across the blood-brain barrier.

  2016cited by this paper
• Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma.

  2016cited by this paper
• Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis.

  2016cited by this paper
• Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice.

  2016cited by this paper
• Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.

  2016cited by this paper
• Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.

  2016cited by this paper
• Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance.

  2015cited by this paper
• Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases.

  2015cited by this paper
• Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles.

  2015cited by this paper
• Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation

  2015cited by this paper
• Drug and gene delivery across the blood-brain barrier with focused ultrasound.

  2015cited by this paper
• Combined Local Blood–Brain Barrier Opening and Systemic Methotrexate for the Treatment of Brain Tumors

  2015cited by this paper
• PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier.

  2015cited by this paper
• New findings about iron oxide nanoparticles and their different effects on murine primary brain cells

  2015cited by this paper
• The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo

  2015cited by this paper
• Nanoscale drug delivery systems and the blood–brain barrier

  2014cited by this paper
• Influence of Short-Chain Cell-Penetrating Peptides on Transport of Doxorubicin Encapsulating Receptor-Targeted Liposomes Across Brain Endothelial Barrier

  2014cited by this paper
• Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells

  2014cited by this paper
• In vivo imaging of brain cancer using epidermal growth factor single domain antibody bioconjugated to near-infrared quantum dots.

  2014cited by this paper
• Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?

  2014cited by this paper
• Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers.

  2014cited by this paper
• Blood–Brain Barrier Permeability and Brain Uptake Mechanism of Kainic Acid and Dihydrokainic Acid

  2014cited by this paper
• Treatment of cerebral ischemia‐reperfusion injury with PEGylated liposomes encapsulating FK506

  2013cited by this paper
• Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells.

  2013cited by this paper
• Quantum dot-based nanoprobes for in vivo targeted imaging.

  2013cited by this paper
• Glial influence on the Blood Brain Barrier

  2013cited by this paper
• Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas.

  2013cited by this paper
• Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

  2013cited by this paper
• Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

  2013cited by this paper
• Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

  2013cited by this paper
• Liposomes for brain delivery

  2013cited by this paper
• Nanoparticles for Brain Drug Delivery

  2013cited by this paper
• Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach

  2013cited by this paper
• Tuning the self-assembling of pyridinium cationic lipids for efficient gene delivery into neuronal cells.

  2013cited by this paper
• Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution.

  2013cited by this paper
• Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice.

  2013cited by this paper
• Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain

  2013cited by this paper
• Development, maintenance and disruption of the blood-brain barrier

  2013cited by this paper
• Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for protection against scopolamine-induced amnesia

  2013cited by this paper
• Nanotechnological advances for the delivery of CNS therapeutics.

  2012cited by this paper
• Methylmethacrylate-sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood-brain barrier.

  2012cited by this paper
• Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

  2012cited by this paper
• Target delivery of a gene into the brain using the RVG29-oligoarginine peptide.

  2012cited by this paper
• Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound.

  2012cited by this paper
• The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

  2012cited by this paper
• Brain delivery systems via mechanism independent of receptor-mediated endocytosis and adsorptive-mediated endocytosis.

  2012cited by this paper
• Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals.

  2011cited by this paper
• Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways.

  2011cited by this paper
• The use of myristic acid as a ligand of polyethylenimine/DNA nanoparticles for targeted gene therapy of glioblastoma

  2011cited by this paper
• Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System

  2011cited by this paper
• In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles.

  2011cited by this paper
• Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis

  2010cited by this paper
• Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.

  2010cited by this paper
• Pericytes are required for blood–brain barrier integrity during embryogenesis

  2010cited by this paper
• Myristic acid-conjugated polyethylenimine for brain-targeting delivery: in vivo and ex vivo imaging evaluation

  2010cited by this paper
• Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers.

  2010cited by this paper
• Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation.

  2010cited by this paper
• Structure and function of the blood-brain barrier.

  2010cited by this paper
• Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer.

  2009cited by this paper
• NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery.

  2009cited by this paper
• MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier.

  2009cited by this paper
• Uses of Nanoparticles for Central Nervous System Imaging and Therapy

  2009cited by this paper
• Differential receptor-mediated drug targeting to the diseased brain

  2009cited by this paper
• Cellular Elements of the Blood-Brain Barrier

  2009cited by this paper
• Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

  2009cited by this paper
• Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His.

  2009cited by this paper
• Transferrin-conjugated liposomal system for improved delivery of 5-fluorouracil to brain.

  2008cited by this paper
• Transferrin-conjugated liposomal system for improved delivery of 5-fluorouracil to brain

  2008cited by this paper
• Brain endothelial cells and the glio-vascular complex

  2008cited by this paper
• Physiology and pharmacological role of the blood-brain barrier.

  2008cited by this paper
• Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes.

  2008cited by this paper
• Brain Targeting Of Nerve Growth Factor Using Poly(Butylcyanoacrylate) Nanoparticles

  2004cited by this paper
• Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons.

  2004cited by this paper
• Chemotherapy of glioblastoma in rats using doxorubicin‐loaded nanoparticles

  2004cited by this paper
• Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles

  2003cited by this paper
• Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis.

  2003cited by this paper
• ABC transporters: physiology, structure and mechanism--an overview.

  2001cited by this paper
• HIV Infection and Dementia

  2000cited by this paper
• Mannose receptor is present in a functional state in rat microglial cells

  1999cited by this paper

• Smart responsive biomaterials for spatiotemporal modulation of functional tissue repair

  2025cites this paper
• Cell-Penetrating Peptides-Mediated Therapeutic Agents Delivery into the Central Nervous System

  2024cites this paper
• Peptide-based inhibitors and nanoparticles: Emerging therapeutics for Alzheimer's disease.

  2024cites this paper
• Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

  2024cites this paper
• Anti-Inflammatory Effects of Helminth-Derived Products: Potential Applications and Challenges in Diabetes Mellitus Management

  2024cites this paper
• Carbon Dots -A Turn-On Probe for Neurological Disorder

  2023cites this paper
• Advances in the research of nano delivery systems in ischemic stroke

  2022cites this paper
• Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

  2022cites this paper
• Comparative Evaluation of Engineered Polypeptide Scaffolds in HER2-Targeting Magnetic Nanocarrier Delivery

  2021cites this paper
• An Update on Actively Targeted Liposomes in Advanced Drug Delivery to Glioma.

  2021cites this paper
• Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

  2021cites this paper
• Therapeutic nanoparticles in the brain: a review of types, physicochemical properties and challenges.

  2021cites this paper
• Targeting the Brain Lesions Using Peptides: A Review Focused on the Possibility of Targeted Drug Delivery to Multiple Sclerosis Lesions.

  2021cites this paper
• Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases

  2021cites this paper
• Recent progress in therapeutic drug delivery systems for treatment of traumatic CNS injuries.

  2020cites this paper
• Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines.

  2020cites this paper
• Single enzyme nanoparticle, an effective tool for enzyme replacement therapy

  2020cites this paper
• Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease.

  2020cites this paper
• Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: A review.

  2020cites this paper
• Loading and Controlled Release of Poorly Water-Soluble Drug Telmisartan from Porous Silicon Microparticles

  2020cites this paper
• NEUROTOXICOLOGY OF NANOMATERIALS.

  2020cites this paper
• Functionalized PLGA nanoparticles prepared by nano-emulsion templating interact selectively with proteins involved in the transport through the blood-brain barrier.

  2020cites this paper
• The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

  2020cites this paper
• Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease.

  2019cites this paper
• Nanoparticle-mediated drug delivery: blood-brain barrier as the main obstacle to treat infectious diseases in CNS.

  2019cites this paper
• Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications

  2019cites this paper
• Preparation and evaluation of tacrolimus-loaded thermosensitive solid lipid nanoparticles for improved dermal distribution

  2019cites this paper
• Nanoneuromedicine for management of neurodegenerative disorder

  2019cites this paper
• Reply to the Reviewer’s Comments

  2018cites this paper