Biomaterial Approaches to Modulate Reactive Astroglial Response

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cells Tissues Organs

• Publication date

  2018-12-05

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1159/000494667PMID 30517922PMCID PMC6397084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2017cited by this paper
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• Astrocyte Aquaporin Dynamics in Health and Disease

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• Extracellular environment contribution to astrogliosis—lessons learned from a tissue engineered 3D model of the glial scar

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• Astrocytes alignment and reactivity on collagen hydrogels patterned with ECM proteins.

  2015influential reference
• White matter astrocytes in health and disease.

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• An in vitro spinal cord injury model to screen neuroregenerative materials.

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