Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review

The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.

• Publication year

  2009

• Venue

  Vascular Health and Risk Management

• Publication date

  2009-02-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.2147/VHRM.S3402PMID 19436644PMCID 2672433
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ACTION TO CONTROL CARDIOVASCULAR RISK IN DIABETES STUDY GROUP. EFFECTS OF INTENSIVE GLUCOSE LOWERING IN TYPE 2 DIABETES

  2010cited by this paper
• Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review

  2009cited by this paper
• Glycaemic separation and risk factor control in the Veterans Affairs Diabetes Trial: an interim report

  2009cited by this paper
• Effects of Intensive Glucose Lowering in Type 2 Diabetes

  2009cited by this paper
• Glycemia management and cardiovascular risk in type 2 diabetes: an evolving perspective.

  2008cited by this paper
• The role of advanced glycation end products in progression and complications of diabetes

  2008cited by this paper
• Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.

  2008influential reference
• Effects of intensive glucose lowering in type 2 diabetes.

  2008cited by this paper
• Insulin Analog Preparations and Their Use in Children and Adolescents with Type 1 Diabetes Mellitus

  2008cited by this paper
• 10-year follow-up of intensive glucose control in type 2 diabetes.

  2008cited by this paper
• Reinventing type 2 diabetes: pathogenesis, treatment, and prevention.

  2008cited by this paper
• Intensive glycemic control in the ACCORD and ADVANCE trials.

  2008cited by this paper
• Defining the Role of Insulin Lispro in the Management of Postprandial Hyperglycaemia in Patients with Type 2 Diabetes Mellitus

  2008cited by this paper
• The insulin gradient phenomenon: a manifestation of the effects of body weight on blood pressure and insulin resistance.

  2008cited by this paper
• Can glycaemic variability, as calculated from blood glucose self-monitoring, predict the development of complications in type 1 diabetes over a decade?

  2008cited by this paper
• Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus.

  2008cited by this paper
• Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.

  2007cited by this paper
• Premeal insulin lispro plus bedtime NPH or twice-daily NPH in patients with type 2 diabetes: acute postprandial and chronic effects on glycemic control and cardiovascular risk factors.

  2007cited by this paper
• The effects of insulin on the endothelium.

  2007influential reference
• Insulin resistance and atherosclerosis.

  2006cited by this paper
• Relationship of left ventricular mass to insulin sensitivity and body mass index in healthy individuals

  2006cited by this paper
• The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus.

  2005cited by this paper
• Impact of insulin on microvascular blood flow and endothelial cell function in the postprandial state in patients with Type 1 diabetes.

  2005cited by this paper
• The effect of improved post-prandial blood glucose control on post-prandial metabolism and markers of vascular risk in people with Type 2 diabetes.

  2005cited by this paper
• Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes.

  2005cited by this paper
• Hyperglycemia and its effect after acute myocardial infarction on cardiovascular outcomes in patients with Type 2 diabetes mellitus (HEART2D) Study design.

  2005cited by this paper
• Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises.

  2004cited by this paper
• Anti-Inflammatory and Profibrinolytic Effect of Insulin in Acute ST-Segment–Elevation Myocardial Infarction

  2004cited by this paper
• Insulin resistance and cardiovascular events with low HDL cholesterol: the Veterans Affairs HDL Intervention Trial (VA-HIT).

  2003cited by this paper
• Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus.

  2003cited by this paper
• Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels.

  2003cited by this paper
• The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm

  2002cited by this paper
• Initial Management of Glycemia in Type 2 Diabetes Mellitus

  2002cited by this paper
• Inflammation and Atherosclerosis

  2002cited by this paper
• Clinical practice. Initial management of glycemia in type 2 diabetes mellitus.

  2002cited by this paper
• Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells.

  2001cited by this paper
• Insulin Inhibits NFκB and MCP-1 Expression in Human Aortic Endothelial Cells

  2001cited by this paper
• Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

  2001cited by this paper
• Insulin Inhibits Intranuclear Nuclear Factor κB and Stimulates IκB in Mononuclear Cells in Obese Subjects: Evidence for an Anti-inflammatory Effect?

  2001cited by this paper
• A randomized, controlled trial comparing insulin lispro with human soluble insulin in patients with Type 1 diabetes on intensified insulin therapy

  2000cited by this paper
• Effect of insulin on human aortic endothelial nitric oxide synthase.

  2000cited by this paper
• A randomized, controlled trial comparing insulin lispro with human soluble insulin in patients with Type 1 diabetes on intensified insulin therapy. The UK Trial Group.

  2000cited by this paper
• Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

  2000cited by this paper
• Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

  2000cited by this paper
• Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study.

  2000cited by this paper
• Elevated Concentrations of Soluble E-Selectin and Vascular Cell Adhesion Molecule-1 in NIDDM: Effect of intensive insulin treatment

  1998cited by this paper
• The postprandial state and risk of cardiovascular disease

  1998cited by this paper
• Case-control study of sudden infant death syndrome in Scotland, 1992-5

  1997cited by this paper
• Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.

  1997cited by this paper
• Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency.

  1996cited by this paper
• Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

  1996cited by this paper
• Insulin and the Vasculature—Old Actors, New Roles

  1996cited by this paper
• Hemodynamic actions of insulin.

  1994cited by this paper
• Clinical consequences of the Diabetes Control and Complications Trial.

  1994cited by this paper
• Absence of clinically overt atherosclerotic vascular disease and adverse changes in cardiovascular risk factors in 70 patients with insulinoma

  1993cited by this paper
• Insulin resistance, hyperinsulinemia, and obesity-associated hypertension.

  1992influential reference
• Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

  1980cited by this paper
• Vascular Health and Risk Management

  year unknowncited by this paper

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