The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Diabetologia

• Publication date

  2002-04-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-001-0766-5PMID 12107738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells.

  2002cited by this paper
• Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations.

  2002cited by this paper
• Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells.

  2002cited by this paper
• Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?

  2001cited by this paper
• Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9).

  2001cited by this paper
• Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes.

  2001cited by this paper
• Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese.

  2001cited by this paper
• Intensive insulin therapy in critically ill patients.

  2001cited by this paper
• Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin.

  2001cited by this paper
• Prevention of fat-induced insulin resistance by salicylate.

  2001cited by this paper
• Pravastatin and the Development of Diabetes Mellitus: Evidence for a Protective Treatment Effect in the West of Scotland Coronary Prevention Study

  2001cited by this paper
• Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

  2001cited by this paper
• Transcriptional regulation of plasminogen activator inhibitor type 1 gene by insulin: insights into the signaling pathway.

  2001cited by this paper
• Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells.

  2001cited by this paper
• C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.

  2001cited by this paper
• Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

  2001cited by this paper
• Effect of insulin on human aortic endothelial nitric oxide synthase.

  2000cited by this paper
• Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes.

  2000cited by this paper
• Troglitazone Reduces Reactive Oxygen Species Generation by Leukocytes and Lipid Peroxidation and Improves Flow-Mediated Vasodilatation in Obese Subjects

  2000cited by this paper
• Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells.

  2000cited by this paper
• Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial.

  2000cited by this paper
• Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.

  2000cited by this paper
• Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide.

  2000cited by this paper
• Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids.

  2000cited by this paper
• Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS).

  1999cited by this paper
• Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin‐10 concentrations: A pharmacodynamic study

  1999cited by this paper
• Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial.

  1999cited by this paper
• Meal-induced oxidative stress and low-density lipoprotein oxidation in diabetes: the possible role of hyperglycemia.

  1999cited by this paper
• Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection.

  1999cited by this paper
• Insulin-induced vasodilatation of internal carotid artery.

  1999cited by this paper
• Molecular Regulation of Cytokine Gene Expression During the Immune Response

  1999cited by this paper
• Effects of troglitazone on frequency of coronary vasospastic-induced angina pectoris in patients with diabetes mellitus.

  1999cited by this paper
• C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

  1999cited by this paper
• Effect of hydrocortisone on oxygen free radical generation by mononuclear cells.

  1998cited by this paper
• Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells.

  1998cited by this paper
• Chronic blockade of NO synthase activity induces a proinflammatory phenotype in the arterial wall: prevention by angiotensin II antagonism.

  1998cited by this paper
• Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes.

  1998cited by this paper
• What does insulin do to Ras?

  1998cited by this paper
• Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension.

  1998cited by this paper
• Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss.

  1998cited by this paper
• Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiológicos Latinoamérica) Collaborative Group.

  1998cited by this paper
• NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

  1997cited by this paper
• Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials.

  1997cited by this paper
• Increased arterial intima-media thickness in childhood-onset growth hormone deficiency.

  1997cited by this paper
• Endothelial cell adhesion molecule expression and lymphocyte adhesion to endothelial cells: effect of nitric oxide.

  1997cited by this paper
• Th1 and Th2 CD4+ Cells in the Pathogenesis of Allergic Diseases

  1997cited by this paper
• Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.

  1997cited by this paper
• NF-kappa B: ten years after.

  1996cited by this paper
• Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance.

  1996cited by this paper
• The NF-kappa B and I kappa B proteins: new discoveries and insights.

  1996cited by this paper
• Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

  1996cited by this paper
• Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

  1996cited by this paper
• Glucose and insulin independently reduce the fibrinolytic potential of human vascular smooth muscle cells in culture

  1996cited by this paper
• Is Insulin Really a Heart Disease Risk Factor?

  1995cited by this paper
• Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year.

  1995cited by this paper
• Insulin attenuates norepinephrine-induced venoconstriction. An ultrasonographic study.

  1995cited by this paper
• Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

  1994cited by this paper
• Nitric oxide release accounts for insulin's vascular effects in humans.

  1994cited by this paper
• Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

  1994cited by this paper
• Function and activation of NF-kappa B in the immune system.

  1994cited by this paper
• Insulin-mediated vasodilation: impairment with increased blood pressure and body mass.

  1993cited by this paper
• Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system.

  1993cited by this paper
• Absence of clinically overt atherosclerotic vascular disease and adverse changes in cardiovascular risk factors in 70 patients with insulinoma

  1993cited by this paper
• Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM

  1992cited by this paper
• Insulin and atherogenesis

  1992cited by this paper
• Muscle Blood Flow in Diabetes Mellitus: Evidence of Abnormality After Exercise

  1992cited by this paper
• Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults.

  1992cited by this paper
• Matrix metalloproteinases and their inhibitors in connective tissue remodeling

  1991cited by this paper
• Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type I: Implications for vascular disease in hyperinsulinemic states

  1991cited by this paper
• Transcutaneous Oxygen Tension in Legs and Feet of Diabetic Patients

  1988cited by this paper
• Insulin Stimulates the Synthesis of Plasminogen Activator Inhibitor 1 by the Human Hepatocellular Cell Line Hep G2

  1988cited by this paper
• Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity.

  1978cited by this paper
• The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

  1976cited by this paper

• The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update.

  2025cites this paper
• Dapagliflozin ameliorated retinal vascular permeability in diabetic retinopathy rats by suppressing inflammatory factors.

  2023cites this paper
• The effect of short‐term intensive insulin therapy on inflammatory cytokines in patients with newly diagnosed type 2 diabetes

  2022cites this paper
• Acute kidney injury and diabetic kidney disease in children with acute complications of diabetes

  2022cites this paper
• Intraoperative Hyperglycemia May Be Associated with an Increased Risk of Myocardial Injury after Non-Cardiac Surgery in Diabetic Patients

  2021cites this paper
• New insights and advances of sodium-glucose cotransporter 2 inhibitors in heart failure

  2021cites this paper
• Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?

  2020cites this paper
• A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications.

  2020cites this paper
• Lentivirus mediated pancreatic beta-cell specific insulin gene therapy for STZ-induced Diabetes.

  2020cites this paper
• Does control of glycemia regulate immunological parameters in insulin-treated persons with type 1 diabetes?

  2019cites this paper
• Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.

  2019cites this paper
• [A consensual therapeutic recommendation for type 2 diabetes mellitus by the Slovak Diabetes Society (2018)].

  2019cites this paper
• CONTROVERSIES IN TREATING DIABETES

  2018cites this paper
• Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?

  2017cites this paper
• Acute phase response in lactating dairy cows during hyperinsulinemic hypoglycaemic and hyperinsulinemic euglycaemic clamps and after intramammary LPS challenge

  2017cites this paper
• Traumatic brain injury and obesity induce persistent central insulin resistance

  2016cites this paper
• Prognostic significance of glycemic variability after cardiac surgery.

  2016cites this paper
• A STUDY OF RELATIONSHIP BETWEEN C - REACTIVE PROTEIN AND MICROALBUMINURIA IN DIABETIC PATIENTS -

  2016cites this paper
• Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications

  2016cites this paper
• Insulin resistance and chronic inflammation.

  2016cites this paper
• Blood levels of pro-inflammatory and anti-inflammatory cytokines in a patient with a flat glucose curve

  2016cites this paper
• Pathogenesis and Neuroendocrine Immunology

  2015cites this paper
• Assessing the correlation of trauma severity, blood sugar level, and neurologic outcomes in traumatic spinal cord injury patients

  2015cites this paper
• Role of neutrophil gelatinase -associated lipocalin-2 (NGAL) in poor wound healing in diabetes

  2015cites this paper
• Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control.

  2015cites this paper
• [Risk of cerebral edema in children with diabetic ketoacidosis in the course of type 1 diabetes].

  2015cites this paper
• Comparative cardiovascular morbidity and mortality in patients taking different insulin regimens for type 2 diabetes: a systematic review

  2015cites this paper
• Mikrobiologische Speichelbefunde bei jungen Erwachsenen aus Weißrussland in Abhängigkeit zum Rauchverhalten und der Mundgesundheit

  2015cites this paper
• Energy and Volume Regulation

  2015cites this paper
• Interaction of the endocrine system with inflammation: a function of energy and volume regulation

  2014cites this paper
• Postprandial response of plasma IL-6 to isoenergetic meals rich in casein or potato singly and combined in obese women

  2013cites this paper
• Oral but Not Intravenous Glucose Acutely Decreases Circulating Interleukin-6 Concentrations in Overweight Individuals

  2013cites this paper
• Impact of adipose tissue on endothelial cells: effect of metabolic disorders

  2013cites this paper
• Cardiovascular disease in childhood: the role of obesity

  2013cites this paper
• NMR-based metabonomic study of Chinese medicine Gegen Qinlian Decoction as an effective treatment for type 2 diabetes in rats

  2013cites this paper
• Importance of Perioperative Glycemic Control in General Surgery: A Report From the Surgical Care and Outcomes Assessment Program

  2013cites this paper
• Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease

  2013cites this paper
• Insulin and Insulin‐Like Growth Factor

  2012cites this paper
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  2012cites this paper
• Vascular inflammation is a missing link for diabetes-enhanced atherosclerotic cardiovascular diseases.

  2012cites this paper
• Trabalho organizado de acordo com as normas da revista

  2012cites this paper
• [Early insulin therapy in type 2 diabetes?].

  2012cites this paper
• A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis

  2012cites this paper
• Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM).

  2011cites this paper
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  2011cites this paper
• Insulin therapy during hospitalization.

  2011cites this paper
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  2011cites this paper
• Inflammatory and oxidative stress markers after intravenous insulin in percutaneous coronary intervention with stent in type 2 diabetes mellitus: a randomized controlled trial.

  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Contemporary Reviews in Cardiovascular Medicine

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?

  2009cites this paper
• Mitogenic potency of insulin glargine.

  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
• Effects of insulin therapy on inflammatory mediators in infants undergoing cardiac surgery with cardiopulmonary bypass.

  2008cites this paper
• The role of inflammation in metabolic syndrome

  2008cites this paper
• Physiopathologie du syndrome métabolique Pathogenesis of the metabolic syndrome

  2008cites this paper
• Postprandial Cytokine Concentrations and Meal Composition in Obese and Lean Women

  2008cites this paper
• [Pathogenesis of the metabolic syndrome].

  2008cites this paper
• Intensive Treatment and Complications of Diabetes

  2008cites this paper
• Cardiovascular events and insulin therapy: a retrospective cohort analysis.

  2008cites this paper
• N-3 Polyunsaturated Fatty Acids Modulate In-Vitro T Cell Function in Type I Diabetic Patients

  2008cites this paper
• Evaluation of Cytokine Production from Peripheral Blood Mononuclear Cells of Type 1 Diabetic Patients

  2008cites this paper
• Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitro

  2008cites this paper
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  2008influential citation
• Insulin inhibits tumor necrosis factor-α induction in myocardial ischemia/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation*

  2008cites this paper
• Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention).

  2008cites this paper
• Insulin resistance and obesity in childhood.

  2008cites this paper
• Sex-dependent role of glucocorticoids and androgens in the pathophysiology of human obesity

  2008cites this paper
• Tratamiento médico de los pacientes con diabetes mellitus durante el período perioperatorio

  2008cites this paper
• Effects of chronic hyperinsulinemia in insulin-resistant patients

  2008cites this paper
• Metabolic regulation of human vascular endothelial cell function in vitro

  2008cites this paper
• Effect of the glycemic control on intracellular cytokine production from peripheral blood mononuclear cells of type 1 and type 2 diabetic patients.

  2008cites this paper
• CHAPTER 19 – MEDICAL MANAGEMENT OF PATIENTS WITH DIABETES MELLITUS DURING THE PERIOPERATIVE PERIOD

  2008cites this paper
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  2007cites this paper
• Remodeling in the Transgenic ( mRen 2 ) Rat NADPH Oxidase Contributes to Vascular Inflammation

  2007cites this paper
• Oral Hypoglycemics: Increased Postoperative Mortality in Coronary Risk Patients

  2007cites this paper
• Revista Latinoamericana de Hipertensión

  2007cites this paper
• Glucose Control and Monitoring in the ICU

  2007cites this paper
• The effects of insulin on the endothelium.

  2007cites this paper