Insulin-mediated vasodilation: impairment with increased blood pressure and body mass.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  The Lancet

• Publication date

  1993-09-18

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0140-6736(93)91708-TPMID 8103822
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The vasodilator action of insulin. Implications for the insulin hypothesis of hypertension.

  1993cited by this paper
• Diurnal Variation in Glucose Tolerance: Cyclic Suppression of Insulin Action and Insulin Secretion in Normal-Weight, But Not Obese, Subjects

  1992cited by this paper
• Insulin Increases Sympathetic Activity but Not Blood Pressure in Borderline Hypertensive Humans

  1992cited by this paper
• A Low‐Sodium Diet Corrects the Defect in β‐Adrenergic Response in Older Subjects

  1992cited by this paper
• Skeletal muscle is a primary site of insulin resistance in essential hypertension.

  1991cited by this paper
• Essential hypertension, metabolic disorders, and insulin resistance.

  1991cited by this paper
• Impaired Insulin Action on Skeletal Muscle Metabolism in Essential Hypertension

  1991cited by this paper
• Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

  1991cited by this paper
• Low sodium intake corrects abnormality in β‐receptor–mediated arterial vasodilation in patients with hypertension: Correlation with β‐receptor function in vitro

  1990cited by this paper
• Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

  1990cited by this paper
• Low sodium intake corrects abnormality in beta-receptor-mediated arterial vasodilation in patients with hypertension: correlation with beta-receptor function in vitro.

  1990cited by this paper
• Defective venous beta-adrenergic response in borderline hypertensive subjects is corrected by a low sodium diet.

  1990cited by this paper
• Low sodium diet corrects the defect in lymphocyte beta-adrenergic responsiveness in hypertensive subjects.

  1987cited by this paper
• Insulin resistance in essential hypertension.

  1987cited by this paper
• Salt and the glycaemic response.

  1986cited by this paper
• Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man.

  1986cited by this paper
• Beta adrenergic-mediated vasodilator response to insulin in the human forearm.

  1985cited by this paper
• The pathogenesis of hypertension: the Baker concerto.

  1984cited by this paper
• Age-related decrease in cardiac and peripheral vascular responsiveness to isoprenaline: studies in normal subjects.

  1981cited by this paper
• A new technique for recording compliance of human hand veins.

  1981cited by this paper
• Recent advances in the pathogenesis of hypertension: consideration of structural, functional, and metabolic vascular abnormalities resulting in elevated arterial resistance.

  1981cited by this paper
• Disorders in peripheral arterial system in asymptomatic elderly: plethysmographic semiology at rest, during postural, effort and pharmacological tests.

  1979cited by this paper
• Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics

  1977cited by this paper
• Diurnal variation in glucose tolerance.

  1967cited by this paper

• Sodium restriction and insulin resistance: A review of 23 clinical trials

  2023cites this paper
• Systematic review and meta-analysis examining the relationship between postprandial hypotension, cardiovascular events, and all-cause mortality

  2022cites this paper
• The role of metabolic syndrome in sudden cardiac death risk: Recent evidence and future directions

  2021cites this paper
• Hemostasis, endothelial stress, inflammation, and the metabolic syndrome

  2017cites this paper
• University of Groningen Improving metabolic control in NIDDM patients referred for insulin therapy

  2017cites this paper
• Dietary Polysaccharides in the Amelioration of Gut Microbiome Dysbiosis and Metabolic Diseases.

  2017cites this paper
• Blood pressure in Warmblood horses before and during a euglycemic-hyperinsulinemic clamp

  2016cites this paper
• Effects of cardiovascular risk factors on arterial stiffness and systemic hemodynamics

  2016cites this paper
• Effects of Low versus High Glycemic Index Sugar-Sweetened Beverages on Postprandial Vasodilatation and Inactivity-Induced Impairment of Glucose Metabolism in Healthy Men

  2016cites this paper
• Metabolic Syndrome Sinkholes: What to Do When Occam's Razor Gets Blunted.

  2015cites this paper
• Obesity and Antiphospholipid Syndrome: A Particular Challenge in Pregnancy

  2015cites this paper
• Blood pressure in Warmblood horses before and after a euglycemic-hyperinsulinemic clamp

  2015cites this paper
• Der Einfluss von Angiotensinrezeptor Blockade mit Irbesartan auf die Insulinsensitivität bei Patienten mit systolischer Herzinsuffizienz - Ergebnisse einer randomisierten, Placebo kontrollierten

  2015cites this paper
• New-Onset Diabetes in Heart Failure Patients: A Complex Relationship with Clinical Implications

  2014cites this paper
• Heat Shock Prevents Insulin Resistance–Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling

  2014influential citation
• Differential mechanisms for insulin-induced relaxations in mouse posterior tibial arteries and main mesenteric arteries.

  2014cites this paper
• Endothelial dysfunction in morbid obesity.

  2013cites this paper
• Evaluation of the potassium channel activator levcromakalim (BRL38227) on the lipid profile, electrolytes and blood glucose levels of streptozotocin‐diabetic rats (评估钾通道激活剂左克罗卡林（BRL38227）对链脲霉素‐糖尿病大鼠血脂谱、电解质以及血糖水平的影响)

  2013cites this paper
• Respostas metabólicas e inflamatórias após infusão de insulina para a avaliação endotelial venosa Metabolic and inflammatory response after insulin infusion for venous endothelial evaluation

  2013cites this paper
• Insulin treatment alters some biochemical parameters in potassium adapted streptozotocin-induced diabetic rats.

  2013cites this paper
• Equilibrio sodio-potasio en la regulación de la hipertensión arterial

  2012cites this paper
• [Heart failure and development of type 2 diabetes mellitus].

  2012cites this paper
• Sodium-potassium balance in the regulation of high blood pressure

  2012cites this paper
• High-fructose feeding impacts on the adrenergic control of renal haemodynamics in the rat

  2011cites this paper
• The effect of obesity on venous impedance and outflow measured by ultrasound

  2011cites this paper
• Systemic hemodynamics in relation to glucose tolerance: the Health 2000 Survey.

  2011cites this paper
• Systemic hemodynamics in young adults with the metabolic syndrome: The Cardiovascular Risk in Young Finns Study

  2010cites this paper
• New drugs and clinical trials in diabetes and hypertension.

  2009cites this paper
• Venous reserve capacity & autonomic function in formerly preeclamptic women

  2009cites this paper
• Blunted Autonomic Response to Volume Expansion in Formerly Preeclamptic Women with Low Plasma Volume

  2009cites this paper
• Multi-level regulation of argininosuccinate synthase: Significance for endothelial nitric oxide production

  2008cites this paper
• Obesity/Metabolic Syndrome Overview

  2007cites this paper
• Sodium and potassium in the pathogenesis of hypertension.

  2007cites this paper
• Update on G-protein polymorphisms in hypertension

  2006cites this paper
• Defective vasodilatory mechanisms in hypertension: a G-protein-coupled receptor perspective

  2006cites this paper
• Inhibitory effect of insulin on vasopressin-induced intracellular calcium response is blunted in hyperinsulinemic hypertensive patients: role of membrane fatty acid composition

  2006cites this paper
• Glucose uptake in skeletal muscle

  2006cites this paper
• Targeting postprandial hyperglycemia.

  2006cites this paper
• Effects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery.

  2005cites this paper
• Insulin‐mediated Venodilation is Impaired in Young, Healthy Carriers of the 825T Allele of the G‐protein β3 Subunit Gene (GNB3)

  2005cites this paper
• Penal Hemodynamics and Sodium Handling in Moderate Renal Insufficiency: The Role of Insulin Resistance and Dyslipidemia1’2

  2005cites this paper
• Effects of insulin on the acetylcholine-induced hyperpolarization in the guinea pig mesenteric arterioles.

  2004cites this paper
• Advances in diabetes for the millennium: diabetes and the endothelium.

  2004cites this paper
• Endothelial dysfunction and hypertension in diabetes mellitus.

  2004cites this paper
• Chronological Changes of a-Adrenoceptor-Mediated Vascular Constriction in Otsuka-Long-Evans- Tokushima Fatty Rats

  2003cites this paper
• Arterial wall stiffness is associated with peripheral circulation in patients with type 2 diabetes.

  2003cites this paper
• Regulation of the venous tone

  2003cites this paper
• Clinical Physiology of the Venous System

  2003cites this paper
• Effects of statins on the vasculature: Implications for aggressive lipid management in the cardiovascular metabolic syndrome.

  2003cites this paper
• Do effects on blood pressure contribute to improved clinical outcomes with metformin?

  2003cites this paper
• Vascular reactivity and thiazolidinediones.

  2003cites this paper
• Chronological changes of alpha-adrenoceptor-mediated vascular constriction in Otsuka-Long-Evans-Tokushima fatty rats.

  2003cites this paper
• Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications.

  2003cites this paper
• Insulin Inhibits Acetylcholine Responses in Rat Isolated Mesenteric Arteries via a Non-Nitric Oxide Nonprostanoid Pathway

  2002cites this paper
• Insulin - a vasoactive hormone

  2002cites this paper
• Vascular reactivity in diabetes mellitus

  2002influential citation
• Dermal neurovascular dysfunction in type 2 diabetes.

  2002cites this paper
• Quinapril Treatment Restores The Vasodilator Action Of Insulin In Fructose‐Hypertensive Rats

  2002cites this paper
• Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons.

  2002cites this paper
• Review INSULIN - A VASOACTIVE HORMONE

  2002cites this paper
• Altered renal microvascular response in Zucker obese rats.

  2002cites this paper
• The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm

  2002cites this paper
• Change in retinal arterial blood flow in the contralateral eye of retinal vein occlusion during glucose tolerance test

  2002cites this paper
• Cardiovascular implications of insulin resistance and non-insulin-dependent diabetes mellitus.

  2001cites this paper
• Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats.

  2001cites this paper
• Benefits of sustained moderate weight loss in obesity.

  2001cites this paper
• Modeling preclinical cardiovascular risk for use in epidemiologic studies: Miami community health study.

  2001cites this paper
• Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells.

  2001cites this paper
• Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

  2001cites this paper
• Insulin action on large artery stiffness in normal and insulin resistant subjects

  2001cites this paper
• Quinapril treatment enhances vascular sensitivity to insulin

  2001cites this paper
• Insulin-Induced Biphasic Responses in Rat Mesenteric Vascular Bed: Role of Endothelin

  2001influential citation
• Diameter, pressure and compliance relationships in dorsal hand veins

  2001cites this paper
• Insulin Inhibits Intranuclear Nuclear Factor κB and Stimulates IκB in Mononuclear Cells in Obese Subjects: Evidence for an Anti-inflammatory Effect?

  2001cites this paper
• Dermal Neurovascular Dysfunction in Type 2 Diabetes

  2001cites this paper
• The mechanism and change in the optic nerve head (ONH) circulation in rabbits after glucose loading

  2001cites this paper
• Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension

  2001cites this paper
• Diameter, pressure and compliance relationships in dorsal hand veins.

  2001cites this paper
• Defects in insulin action in chronic heart failure

  2000cites this paper
• Enhanced NO Inactivation and Hypertension Induced by a High-Fat, Refined-Carbohydrate Diet

  2000cites this paper
• Effect of insulin on human aortic endothelial nitric oxide synthase.

  2000cites this paper
• Inhibitory effect of insulin on bradykinin‐induced venodilation

  2000cites this paper
• Effect of plasma insulin level on myocardial blood flow and its mechanism of action.

  2000cites this paper
• Insulin stimulates both endothelin and nitric oxide activity in the human forearm.

  1999cites this paper
• Insulin Resistance, and Hypertension

  1999cites this paper
• The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats.

  1999cites this paper
• Moderate dietary salt restriction increases vascular and systemic insulin resistance.

  1999cites this paper
• The Fluid Retention Syndrome: Recognition, Risk Factors and Management

  1999cites this paper
• The haemodynamic response to hyperinsulinaemia in hypertensive subjects

  1999cites this paper
• Vanadate stimulation of adenylyl cyclase: An index of tyrosine kinase vascular effects

  1999cites this paper
• Does Nibbling or Grazing Protect the Peripheral Arteries from Atherosclerosis?

  1999cites this paper
• Endothelial membrane potential regulates production of both nitric oxide and superoxide--a fundamental determinant of vascular health.

  1999cites this paper
• Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.

  1999cites this paper
• Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk?

  1999cites this paper
• 10 INSULIN RESISTANCE, AND HYPERTENSION

  1999cites this paper
• Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm.

  1998cites this paper
• Enhanced responsiveness of blood pressure to sodium intake and to angiotensin II is associated with insulin resistance in IDDM patients with microalbuminuria.

  1998cites this paper
• Blood flow and glucose uptake in denervated, insulin-resistant muscles.

  1998cites this paper
• Blood flow and glucose uptake in denervated, insulin-resistant muscles.

  1998cites this paper
• Relation of insulin resistance to left ventricular hypertrophy and diastolic dysfunction in obesity

  1998cites this paper