Prevention of fat-induced insulin resistance by salicylate.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Clinical Investigation

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI11559PMID 11489937PMCID PMC209353
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.

  2009cited by this paper
• Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

  2001cited by this paper
• Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.

  2001cited by this paper
• Inhibition of IκB Kinase Activity by Sodium Salicylate in Vitro Does Not Reflect Its Inhibitory Mechanism in Intact Cells*

  2000cited by this paper
• Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice*

  2000cited by this paper
• Molecular mechanisms of insulin action in normal and insulin-resistant states.

  1999cited by this paper
• Mechanisms of TNF-alpha-induced insulin resistance.

  1999cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

  1999cited by this paper
• Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.

  1999cited by this paper
• Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.

  1999cited by this paper
• Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes.

  1999cited by this paper
• Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

  1998cited by this paper
• Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

  1998cited by this paper
• Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion.

  1998cited by this paper
• Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor.

  1998cited by this paper
• Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles*

  1998cited by this paper
• Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat.

  1998cited by this paper
• Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

  1997cited by this paper
• A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

  1997cited by this paper
• The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.

  1997cited by this paper
• The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

  1997cited by this paper
• Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.

  1997cited by this paper
• A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  1997cited by this paper
• Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

  1997cited by this paper
• Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.

  1997influential reference
• Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

  1997cited by this paper
• Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction*

  1997cited by this paper
• Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes (*)

  1996cited by this paper
• Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 (*)

  1996cited by this paper
• Plasma Free Fatty Acids Decrease Insulin-Stimulated Skeletal Muscle Glucose Uptake by Suppressing Glycolysis in Conscious Rats

  1996influential reference
• Mechanism of free fatty acid-induced insulin resistance in humans.

  1996cited by this paper
• Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

  1996cited by this paper
• IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

  1996cited by this paper
• Glucose-fatty acid cycle operates in humans at the levels of both whole body and skeletal muscle during low and high physiological plasma insulin concentrations.

  1994cited by this paper
• The Contribution of Insulin-Dependent and Insulin-Independent Glucose Uptake to Intravenous Glucose Tolerance in Healthy Human Subjects

  1994cited by this paper
• Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

  1994cited by this paper
• Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

  1994cited by this paper
• Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

  1993cited by this paper
• Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle.

  1993cited by this paper
• Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

  1991cited by this paper
• Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats.

  1990cited by this paper
• Banting lecture 1988. Role of insulin resistance in human disease.

  1988cited by this paper
• Role of Insulin Resistance in Human Disease

  1988cited by this paper
• The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

  1988cited by this paper
• Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding

  1988cited by this paper
• Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle.

  1985cited by this paper
• The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.

  1963cited by this paper
• Aspirin and Diabetes Mellitus

  1957cited by this paper
• On the Treatment of Glycosuria and Diabetes Mellitus with Sodium Salicylate

  1901cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin- Induced Insulin Receptor Substrate-1 Degradation in

  year unknowncited by this paper

• Immunometabolism in obesity: Understanding the beneficial and detrimental roles of inflammation

  2026cites this paper
• KBN2202 Suppresses Gonadal White Adipose Tissue Expansion in Female Mice Fed a High-Fat Diet

  2026cites this paper
• A Review on Comorbidity of Diabetes Mellitus

  2025cites this paper
• PLX3397-Induced Microglial Ablation Alters Adipose Tissue Accumulation in a Male–Female-Dependent Manner Under High-Energy-Diet Feeding

  2025cites this paper
• Beneficial effects of long-chain n-3 fatty acids on insulin-resistance: basic and clinical aspects.

  2025cites this paper
• Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer’s Disease

  2025cites this paper
• Muscle Cell Palmitate-Induced Insulin Resistance, JNK, IKK/NF-κB and STAT3 Activation are Attenuated by Carnosic and Rosmarinic Acid.

  2025cites this paper
• Understanding the peroxisome proliferator-activated receptor gamma (PPAR-γ) role in periodontitis and diabetes mellitus: A molecular perspective.

  2025cites this paper
• The Ancient Drug Salicylate Indirectly Targets Fructose‐1,6‐Bisphosphatase to Suppress Liver Glucose Production in Diet‐Induced Obese Mice

  2025influential citation
• Aspirin Inhibits the In Vitro Adipogenic Differentiation of Human Adipose Tissue-Derived Stem Cells in a Dose-Dependent Manner

  2025cites this paper
• Endoplasmic Reticulum Stress and Obesity.

  2024cites this paper
• The Emerging Role of p21 in Diabetes and Related Metabolic Disorders

  2024cites this paper
• Cellular and Molecular Mechanisms of Insulin Resistance

  2024cites this paper
• Treatment with Gut-Specific Nonsteroidal Anti-Inflammatory Drug Attenuates Metabolic Inflammation but not Body Mass in Fattening Ground Squirrels.

  2023cites this paper
• What’s gut got to do with it? The role of the microbiota and inflammation in the development of adiposity and obesity

  2023cites this paper
• Thromboxane A2-TP axis promotes adipose tissue macrophages M1 polarization leading to insulin resistance in obesity.

  2023cites this paper
• FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m6A methylation of TNIP1

  2023cites this paper
• Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non‐alcoholic fatty liver disease

  2023cites this paper
• Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications

  2023cites this paper
• Comparison of the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) associated with periodontitis in Korean adults

  2022cites this paper
• The Effect of Healthy Lifestyle Strategies on the Management of Insulin Resistance in Children and Adolescents with Obesity: A Narrative Review

  2022cites this paper
• Convergent Molecular Pathways in Type 2 Diabetes Mellitus and Parkinson’s Disease: Insights into Mechanisms and Pathological Consequences

  2022cites this paper
• Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation.

  2022cites this paper
• Effect of acute TLR4 inhibition on insulin resistance in humans

  2022cites this paper
• Identification of a Multi-Messenger RNA Signature as Type 2 Diabetes Mellitus Candidate Genes Involved in Crosstalk between Inflammation and Insulin Resistance

  2022cites this paper
• Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

  2022cites this paper
• Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes

  2022cites this paper
• Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin sensitivity

  2022cites this paper
• Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

  2022cites this paper
• The Effects of Grape Seed Extract on Insulin, Adiponectin and Resistin Levels in Diabetic Rats

  2021cites this paper
• Sodium salicylate rewires hepatic metabolic pathways in obesity and attenuates IL-1β secretion from adipose tissue: The implications for obesity-impaired reverse cholesterol transport

  2021cites this paper
• The Cholesterol Metabolite Cholest-5-en-3-One Alleviates Hyperglycemia and Hyperinsulinemia in Obese (db/db) Mice

  2021cites this paper
• Recent Advances in Understanding the Role of IKKβ in Cardiometabolic Diseases

  2021cites this paper
• Gypenoside XLIX as a novel potential therapeutic agent against insulin resistance

  2021cites this paper
• Metformin Targets Foxo1 to Control Glucose Homeostasis

  2021cites this paper
• Modern computational intelligence based drug repurposing for diabetes epidemic.

  2021cites this paper
• Salsalate reduces atherosclerosis through AMPKβ1 in mice

  2021cites this paper
• Clinical overview of diabetes mellitus as a risk factor for cardiovascular death.

  2021cites this paper
• 4-Hydroxyisoleucine Alleviates Macrophage-Related Chronic Inflammation and Metabolic Syndrome in Mice Fed a High-Fat Diet

  2021cites this paper
• Synthetic Salicylates and / or Pioglitazone Ameliorative Effect in Type 2 Induced Diabetic Rats

  2020cites this paper
• ATIC as a link between antirheumatic drugs and regulation of energy metabolism in skeletal muscle

  2020cites this paper
• Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation

  2020cites this paper
• Autophagy-mediated metabolic effects of aspirin

  2020cites this paper
• Cyanidin-3-O-glucoside restores insulin signaling and reduces inflammation in hypertrophic adipocytes.

  2020cites this paper
• Basal insulin ameliorates post-breakfast hyperglycemia via suppression of post-breakfast proinsulin/C-peptide ratio and fasting serum free fatty acid levels in patients with type 2 diabetes

  2020cites this paper
• Ceramides in Adipose Tissue

  2020cites this paper
• Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

  2020cites this paper
• Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4

  2020cites this paper
• A possible Role of Salicylates in Diabetes Type II

  2020cites this paper
• Autophagy-mediated metabolic effects of aspirin

  2020cites this paper
• BTK targeting suppresses inflammatory genes and ameliorates insulin resistance

  2020cites this paper
• The Link of Nutrient Fluxes to Hepatic Insulin Resistance at Gene Expression

  2020cites this paper
• Lifestyle and Food Habits Impact on Chronic Diseases: Roles of PPARs

  2019cites this paper
• Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows.

  2019cites this paper
• Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism

  2019cites this paper
• Molecular Mechanisms of Insulin Resistance

  2019cites this paper
• The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila

  2019cites this paper
• Metabolic Messengers: ceramides

  2019cites this paper
• Effect of Salicylate on Albino Rats by Study of Serum Globulin pattern

  2019cites this paper
• Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes

  2019cites this paper
• Hepatic IKK epsilon expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance.

  2019cites this paper
• Deficiency of Adipocyte IKKβ Affects Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice

  2019cites this paper
• Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential.

  2019cites this paper
• Light at night exacerbates metabolic dysfunction in a polygenic mouse model of type 2 diabetes mellitus.

  2019cites this paper
• Inflammatory Muscle Diseases

  2019cites this paper
• Asprosin attenuates insulin signaling pathway through PKCδ‐activated ER stress and inflammation in skeletal muscle

  2019cites this paper
• Obesity as associated factors for Insulin, Fasting blood sugar, and Hemoglobin A1c in Korean adults

  2019cites this paper
• Early modification of the adipose tissue linking obesity and metaflammation

  2019cites this paper
• Associations between intra-pancreatic fat deposition and circulating levels of cytokines.

  2019cites this paper
• The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

  2018cites this paper
• Aspirin Recapitulates Features of Caloric Restriction

  2018cites this paper
• Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high‐fat diet

  2018cites this paper
• Argirein alleviates vascular endothelial insulin resistance through suppressing the activation of Nox4‐dependent O2‐ production in diabetic rats

  2018cites this paper
• Resolving the Paradox of Hepatic Insulin Resistance

  2018influential citation
• IKK b is a b-catenin kinase that regulates mesenchymal stem cell differentiation

  2018cites this paper
• A High Alanine Aminotransferase/Aspartate Aminotransferase Ratio Determines Insulin Resistance and Metabolically Healthy/Unhealthy Obesity in a General Adult Population in Korea: The Korean National Health and Nutritional Examination Survey 2007-2010.

  2018cites this paper
• The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila

  2018cites this paper
• PI 3 K rescues the detrimental effects of chronic Akt activation in the heart during ischemia / reperfusion injury

  2018cites this paper
• Hints for Therapeutic Interventions Through Exploring the Effects of Calorie Restriction on NAFLD by Mechanistic Approach

  2018cites this paper
• Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF‐κB p50 null mice to obesity

  2018cites this paper
• A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?

  2018cites this paper
• The Immune Deficiency Pathway Attenuates Insulin Signaling to Protect Against Infection

  2018cites this paper
• Conditional disruption of IkB kinase 2 fails to prevent obesity-induced insulin resistance

  2018cites this paper
• Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high-fat diet in lean mice.

  2018cites this paper
• METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice

  2018cites this paper
• Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians

  2018cites this paper
• FABP4 inhibitor BMS309403 decreases saturated-fatty-acid-induced endoplasmic reticulum stress-associated inflammation in skeletal muscle by reducing p38 MAPK activation.

  2018cites this paper
• Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice

  2018cites this paper
• Insulin resistance in obesity: an overview of fundamental alterations

  2018cites this paper
• Extra-Virgin Olive Oil and Type 2 Diabetes Mellitus

  2018cites this paper
• The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats.

  2018cites this paper
• IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.

  2018cites this paper
• Bovine α-Lactalbumin Hydrolysates (α-LAH) Ameliorate Adipose Insulin Resistance and Inflammation in High-Fat Diet-Fed C57BL/6J Mice

  2018cites this paper
• From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions

  2017cites this paper
• Skeletal muscle inflammation and insulin resistance in obesity

  2017cites this paper
• Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction

  2017cites this paper
• Influence of hyperglycemia on liver inflammatory conditions in the early phase of non‐alcoholic fatty liver disease in mice

  2017cites this paper
• Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice

  2017cites this paper
• Bone morphogenetic protein‐7 (BMP‐7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway

  2017cites this paper
• Linking Chronic Inflammation with Cardiovascular Disease: From Normal Aging to the Metabolic Syndrome.

  2017cites this paper