The fat mass and obesity-associated (FTO) gene: Obesity and beyond?

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2014-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbadis.2014.01.017PMID 24518103
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Physiology of Will

  2015cited by this paper
• The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression

  2013cited by this paper
• Obesity and addiction: neurobiological overlaps

  2013cited by this paper
• FTO expression is regulated by availability of essential amino acids

  2013cited by this paper
• Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

  2013influential reference
• A link between FTO, ghrelin, and impaired brain food-cue responsivity.

  2013cited by this paper
• The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

  2013cited by this paper
• A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice

  2013cited by this paper
• FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes.

  2013influential reference
• Fat mass and obesity gene and cognitive decline

  2013influential reference
• Association between obesity‐related gene FTO and ADHD

  2013influential reference
• Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

  2013cited by this paper
• Role for the obesity-related FTO gene in the cellular sensing of amino acids

  2013influential reference
• Reversible RNA adenosine methylation in biological regulation.

  2013cited by this paper
• Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models

  2013cited by this paper
• Reduced memory in fat mass and obesity‐associated allele carriers among older adults with cardiovascular disease

  2013cited by this paper
• Global obesity: trends, risk factors and policy implications

  2013cited by this paper
• ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

  2013cited by this paper
• The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO

  2012cited by this paper
• FTO at rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in Preschool Children

  2012cited by this paper
• Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

  2012influential reference
• Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

  2012cited by this paper
• Genetic determinants of common obesity and their value in prediction.

  2012cited by this paper
• The medical care costs of obesity: an instrumental variables approach.

  2012cited by this paper
• Obesity and ADHD: clinical and neurobiological implications.

  2012cited by this paper
• FTO levels affect RNA modification and the transcriptome

  2012cited by this paper
• Depressive disorder moderates the effect of the FTO gene on body mass index

  2012cited by this paper
• Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate.

  2012cited by this paper
• Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

  2011cited by this paper
• N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

  2011influential reference
• Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence.

  2011cited by this paper
• Alström syndrome: insights into the pathogenesis of metabolic disorders

  2011cited by this paper
• The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men.

  2011cited by this paper
• Involvement of Leptin Receptor Long Isoform (LepRb)-STAT3 Signaling Pathway in Brain Fat Mass- and Obesity-Associated (FTO) Downregulation during Energy Restriction

  2011influential reference
• Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

  2011cited by this paper
• N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

  2011cited by this paper
• The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study

  2011cited by this paper
• The Physiology, Signaling, and Pharmacology of Dopamine Receptors

  2011cited by this paper
• FTO Is Expressed in Neurones throughout the Brain and Its Expression Is Unaltered by Fasting

  2011influential reference
• Regulation of FTO and FTM Expression During Human Preadipocyte Differentiation

  2010cited by this paper
• The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

  2010cited by this paper
• Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

  2010cited by this paper
• Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling*

  2010influential reference
• Development of hypothalamic neural networks controlling appetite.

  2010cited by this paper
• A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

  2010cited by this paper
• Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies.

  2010cited by this paper
• The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

  2010cited by this paper
• Nestin-Cre Mice Are Affected by Hypopituitarism, Which Is Not Due to Significant Activity of the Transgene in the Pituitary Gland

  2010cited by this paper
• Overexpression of Fto leads to increased food intake and results in obesity

  2010cited by this paper
• Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): Fine mapping and FTO gene expression study

  2010cited by this paper
• Crystal structure of the FTO protein reveals basis for its substrate specificity

  2010cited by this paper
• Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

  2009influential reference
• Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  2009cited by this paper
• The FTO gene and measured food intake in children

  2009cited by this paper
• 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders.

  2009cited by this paper
• Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.

  2009influential reference
• Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study

  2009cited by this paper
• FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity.

  2009cited by this paper
• Fatness-Associated FTO Gene Variant Increases Mortality Independent of Fatness – in Cohorts of Danish Men

  2009cited by this paper
• Inactivation of the Fto gene protects from obesity

  2009cited by this paper
• The FTO gene rs9939609 obesity-risk allele and loss of control over eating.

  2009cited by this paper
• Obesity, FTO gene variant, and energy intake in children.

  2009cited by this paper
• Annual medical spending attributable to obesity: payer-and service-specific estimates.

  2009cited by this paper
• CNS-targets in control of energy and glucose homeostasis.

  2009cited by this paper
• Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO.

  2009cited by this paper
• Depression, cortisol reactivity, and obesity in childhood and adolescence.

  2009cited by this paper
• Obesity associated genetic variation in FTO is associated with diminished satiety.

  2008cited by this paper
• Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO

  2008influential reference
• The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis Published, JLR Papers in Press, November 29, 2007.

  2008cited by this paper
• An obesity-associated FTO gene variant and increased energy intake in children.

  2008cited by this paper
• BMC Biochemistry BioMed Central

  2008cited by this paper
• Overweight in Children and Adolescents in Relation to Attention-Deficit/Hyperactivity Disorder

  2008cited by this paper
• Polymorphisms of the FTO Gene Are Associated With Variation in Energy Intake, but not Energy Expenditure

  2008cited by this paper
• Variation in the FTO gene influences food intake but not energy expenditure.

  2008cited by this paper
• Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity.

  2008cited by this paper
• The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain.

  2008cited by this paper
• Regulation of Fto/Ftm gene expression in mice and humans.

  2008influential reference
• Overweight in Children and Adolescents in Relation to Attention-Deficit/Hyperactivity Disorder: Results From a National Sample

  2008cited by this paper
• The fat mass- and obesity-associated locus and dietary intake in children.

  2008cited by this paper
• Mutations in RPGRIP1L: extending the clinical spectrum of ciliopathies.

  2008cited by this paper
• Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans

  2008cited by this paper
• Variation in FTO contributes to childhood obesity and severe adult obesity

  2007cited by this paper
• Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.

  2007cited by this paper
• The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome

  2007cited by this paper
• The global epidemic of obesity: an overview.

  2007cited by this paper
• The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

  2007cited by this paper
• Ftm is a novel basal body protein of cilia involved in Shh signalling

  2007cited by this paper
• Depression

  2007cited by this paper
• A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

  2007cited by this paper
• Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

  2007cited by this paper
• WIP Regulates the Stability and Localization of WASP to Podosomes in Migrating Dendritic Cells

  2006cited by this paper
• Genetics of obesity in humans.

  2006cited by this paper
• Duplications of proximal 16q flanked by heterochromatin are not euchromatic variants and show no evidence of heterochromatic position effect

  2006cited by this paper
• Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

  2005cited by this paper
• Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome

  2003cited by this paper
• The association between childhood depression and adulthood body mass index.

  2001cited by this paper
• Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation

  1999cited by this paper
• Programmed cell death is affected in the novel mouse mutant Fused toes (Ft).

  1994cited by this paper
• Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells.

  1974cited by this paper

• An Investigation of the RNA Modification m6A and Its Regulatory Enzymes in Rat Brains Affected by Chronic Morphine Treatment and Withdrawal

  2025cites this paper
• Radicicol - A multifaceted natural product with promising anticancer and anti-inflammatory activities: Insights into its mechanisms and therapeutic perspectives.

  2025cites this paper
• Effect of Lekhan Basti and Navak Guggul on lipid markers and transcriptional effects of selected genes in obese patients: A single-centre, open-labelled, randomized, comparative, pilot study

  2025cites this paper
• Association of anthropometric indices with rs9939609 FTO gene polymorphism among overweight/obese women with breast cancer: a case-control study

  2025cites this paper
• Transdiagnostic Links Between Depression, Eating Behaviours, and Sleep: Phenotypic and Genetic Insights from the UK Biobank

  2025cites this paper
• Exploring the Genetic Contribution in Obesity: an overview of dopaminergic system genes.

  2024cites this paper
• Evaluation of Fat Mass and Obesity Associated (FTO) Gene Polymorphism in Male Androgentic Aloplecia Patients

  2024cites this paper
• Research Progress of Chronic Obstructive Pulmonary Disease Complicated with Sarcopenia in the Elderly

  2023cites this paper
• Association of the FTO gene with obesity and cancer in dogs

  2023cites this paper
• Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits

  2023cites this paper
• A comprehensive review of genetic causes of obesity

  2023cites this paper
• Revealing the Catalytic Strategy of FTO.

  2023cites this paper
• Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease

  2023cites this paper
• FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences

  2022cites this paper
• Fat mass and Obesity Associated (FTO) gene and polycystic ovary syndrome: Insight into pathogenesis and association with insulin resistance

  2022cites this paper
• Potential of Natural Honey in Controlling Obesity and its Related Complications

  2022cites this paper
• Body fat, cardiovascular risk factors and polymorphism in the FTO gene: randomized clinical trial and different physical exercise for adolescents

  2022influential citation
• The Association between FTO, MC4R Variants and Obesity in Different Populations and the Possible Reasons

  2022cites this paper
• FTO gene expression in diet-induced obesity is downregulated by Solanum fruit supplementation

  2022cites this paper
• NGHIÊN CỨU TỔNG QUAN VỀ MỐI LIÊN QUAN GIỮA GEN VÀ CÁC BỆNH CHUYỂN HÓA TRÊN CƠ SỞ XÉT NGHIỆM GEN CircleDNA

  2022cites this paper
• Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

  2021cites this paper
• Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract

  2021cites this paper
• The composite alliance of FTO locus with obesity‐related genetic variants

  2021cites this paper
• Regulation of Activating Transcription Factor 4 (ATF4) Expression by Fat Mass and Obesity-Associated (FTO) in Mouse Hepatocyte Cells.

  2021cites this paper
• Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies

  2020cites this paper
• RNA N6-methyladenosine: a promising molecular target in metabolic diseases

  2020cites this paper
• Epigenetic memory: gene writer, eraser and homocysteine

  2020cites this paper
• Characterization of the promoter region of the bovine IRX3 gene: Roles of SREBF2 and PPARG.

  2020cites this paper
• Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents

  2020cites this paper
• Genetic Polymorphisms, Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes can Predict Obesity in Childhood-Adolescence

  2020cites this paper
• Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity

  2020cites this paper
• Using Physiologic, Genetic, and Epigenetic Information to Provide Care to Clients Who Are Obese

  2019cites this paper
• Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective.

  2019cites this paper
• Fat mass and obesity-associated (FTO) and leptin receptor (LEPR) gene polymorphisms in Egyptian obese subjects

  2019cites this paper
• Adolescent obesity in the past decade: A systematic review of genetics and determinants of food choice

  2019cites this paper
• The influence of the fatty acid amide hydrolase 385C>A single nucleotide polymorphisms on obesity susceptibility

  2019cites this paper
• The association of the common fat mass and obesity associated gene polymorphisms with type 2 diabetes in obese Iraqi population.

  2019cites this paper
• Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study.

  2019cites this paper
• m6A mRNA Methylation in the Mammalian Brain: Distribution, Function and Implications for Brain Functions

  2019cites this paper
• Genetic Polymorphisms, Adherence to Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes: A Complex Cocktail to Predict the Obesity in Childhood-Adolescence

  2019cites this paper
• mRNA Translation Gone Awry: Translation Fidelity and Neurological Disease.

  2018cites this paper
• Interaction of two flavonols with fat mass and obesity-associated protein investigated by fluorescence quenching and molecular docking

  2018cites this paper
• Altering of FTO in the serum and livers of NAFLD patients : a correlation analysis

  2018cites this paper
• Epitranscriptomics: A New Regulatory Mechanism of Brain Development and Function

  2018cites this paper
• The Fat Mass‐ and Obesity‐Associated (FTO) Gene to Obesity: Lessons from Mouse Models

  2018cites this paper
• The m6A‐epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

  2018cites this paper
• Population differentiation in allele frequencies of obesity-associated SNPs

  2017cites this paper
• Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

  2017cites this paper
• DRD2: Bridging the Genome and Ingestive Behavior.

  2017cites this paper
• [Eating behavior in pediatric obesity: Of the advantages of combining the neurobiological and neuropsychological approaches].

  2017cites this paper
• Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues.

  2017cites this paper
• Deciphering the function of obesity-associated regulatory elements within FTO

  2017cites this paper
• Caractérisation fonctionnelle de la protéine ECT2 comme lecteur de la modification N6-méthyladénosine des ARN messagers chez la plante Arabidopsis thaliana

  2017cites this paper
• Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men.

  2017cites this paper
• FTO gene polymorphisms (rs9939609 and rs17817449) as predictors of Type 2 Diabetes Mellitus in obese Iraqi population.

  2017cites this paper
• FTO gene variant modulates the neural correlates of visual food perception

  2016cites this paper
• Metabolic mechanisms of the fat mass and obesity-associated (FTO) gene

  2016cites this paper
• N 6-Methyladenosine Methyltransferases and Demethylases: New Regulators of Stem Cell Pluripotency and Differentiation

  2016cites this paper
• Translating the epitranscriptome

  2016cites this paper
• An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning

  2015cites this paper
• FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice

  2015cites this paper
• Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index.

  2014cites this paper
• Human obesity: FTO, IRX3, or both?

  2014cites this paper
• The genome revolution and its role in understanding complex diseases.

  2014cites this paper
• Role of RNA methyltransferases in tissue renewal and pathology

  2014cites this paper
• Intron-specific Single Nucleotide Polymorphisms of Fat Mass and Obesity-Associated Gene in obese and overweight individuals of the Indian adult population- A pilot study.

  1969cites this paper