Role of RNA methyltransferases in tissue renewal and pathology

Over the last five decades more than 100 types of RNA modifications have been identified in organism of all kingdoms of life, yet their function and biological relevance remain largely elusive. The recent development of transcriptome-wide techniques to detect RNA modifications such as N6-methyladenosine (m6A) and 5-methylcytidine (m5C) has not only created a new field of research ‘the epitranscriptome’ but also featured essential regulatory roles of RNA methylation in a wide range of fundamental cellular processes. Here, we discuss the current knowledge of m6A and m5C RNA methylation pathways and summarize how they impact normal tissues and contribute to human disease.

• Publication year

  2014

• Venue

  Current Opinion in Cell Biology

• Publication date

  2014-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ceb.2014.06.006PMID 25014650PMCID 4238901
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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