N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature Cell Biology

• Publication date

  2014-01-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb2902PMID 24394384PMCID PMC4640932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

  2013cited by this paper
• Reversible RNA adenosine methylation in biological regulation.

  2013cited by this paper
• Functional interplay between RNA-binding protein HuR and microRNAs.

  2012cited by this paper
• Protein Phylogenetic Analysis of Ca2+/cation Antiporters and Insights into their Evolution in Plants

  2012cited by this paper
• Cotton fiber: a powerful single-cell model for cell wall and cellulose research

  2012cited by this paper
• Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

  2012cited by this paper
• Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

  2012cited by this paper
• HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

  2012cited by this paper
• RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast

  2012cited by this paper
• Adenosine Methylation in Arabidopsis mRNA is Associated with the 3′ End and Reduced Levels Cause Developmental Defects

  2012cited by this paper
• Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.

  2011cited by this paper
• Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.

  2011cited by this paper
• A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

  2011cited by this paper
• N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

  2011cited by this paper
• Integrative Genomics Viewer

  2011cited by this paper
• Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs

  2011cited by this paper
• Reprogramming of mouse and human somatic cells by high‐performance engineered factors

  2011cited by this paper
• Cutadapt removes adapter sequences from high-throughput sequencing reads

  2011cited by this paper
• N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

  2011cited by this paper
• An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

  2010cited by this paper
• Genome-wide identification of polycomb-associated RNAs by RIP-seq.

  2010cited by this paper
• A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation

  2010cited by this paper
• Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

  2010cited by this paper
• Uncovering the Human Methyltransferasome*

  2010cited by this paper
• The Sequence Alignment/Map format and SAMtools

  2009cited by this paper
• Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

  2009cited by this paper
• Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

  2009cited by this paper
• TopHat: discovering splice junctions with RNA-Seq

  2009cited by this paper
• MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor[W][OA]

  2008cited by this paper
• Model-based Analysis of ChIP-Seq (MACS)

  2008cited by this paper
• Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

  2008cited by this paper
• Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

  2008cited by this paper
• Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

  2008cited by this paper
• Bioinformatics and Computational Biology Solutions Using R and Bioconductor

  2007cited by this paper
• Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis.

  2007cited by this paper
• Bioinformatics and Computational Biology Solutions Using R and Bioconductor

  2006cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• limma: Linear Models for Microarray Data

  2005cited by this paper
• Structure Prediction and Phylogenetic Analysis of a Functionally Diverse Family of Proteins Homologous to the MT-A70 Subunit of the Human mRNA:m6A Methyltransferase

  2002cited by this paper
• Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene.

  2002cited by this paper
• BIOINFORMATICS APPLICATIONS NOTE

  2001cited by this paper
• Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.

  1997cited by this paper
• Sequence specificity of the human mRNA N6-adenosine methylase in vitro.

  1990cited by this paper

• Mapping and visualization of global research progress on endocrine-disrupting chemicals and fetal development: a bibliometric analysis (2014–2024)

  2026cites this paper
• Comprehensive Profiling of N6-methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation.

  2026cites this paper
• Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation

  2026cites this paper
• A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease

  2026cites this paper
• Diapause termination alters the m6A methylation profiles and regulates gene expression associated with early embryonic development in the silkworm (Bombyx mori).

  2026cites this paper
• Mechanisms at the Intersection of lncRNA and m6A Biology.

  2026cites this paper
• m6A RNA modification and its emerging roles in diseases: recent advances and therapeutic implications.

  2026cites this paper
• Single-nucleotide resolution profiling reveals dynamic and site-specific m⁶A regulation during human myogenesis

  2026cites this paper
• RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia

  2026cites this paper
• Why does the m6A writer complex require so many proteins?

  2025cites this paper
• METTL3 safeguards cell identity and epigenome of human trophoblast stem cells

  2025cites this paper
• The m6A methyltransferase METTL3 regulates antimicrobial peptide expression via the Toll pathway in Eriocheir sinensis.

  2025cites this paper
• Unveiling the dynamics and therapeutic potential of m6A methyltransferases and demethylases in liver diseases

  2025cites this paper
• METTL3/METTL14‐mediated RNA m6A modification is involved in male reproductive development in Bactrocera dorsalis

  2025cites this paper
• HDAC2-mediated recruitment of METTL3 to chromatin regulates human embryonic stem cell differentiation.

  2025cites this paper
• Epigenetic mechanisms linking environmental exposure to Parkinson's disease: A comprehensive review.

  2025cites this paper
• Genetic variants reshape the m6A epitranscriptome and drive transcriptomic reprogramming in colorectal cancer

  2025cites this paper
• NSUN-Mediated m5C RNA Modification in Stem Cell Regulation

  2025cites this paper
• The role of N6-methyladenosine (m6A) RNA methylation modification in kidney diseases: from mechanism to therapeutic potential

  2025cites this paper
• Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing

  2025cites this paper
• Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability

  2025cites this paper
• Comprehensive discovery of m6A sites in the human transcriptome at single-molecule resolution

  2025cites this paper
• The epigenetic landscape of brain metastasis

  2025cites this paper
• HuR-Targeted Small-Molecule Inhibitors─Beneficial Impact in Cancer Therapy.

  2025cites this paper
• N6-Methyladenosine: an RNA modification as a central regulator of cancer

  2025cites this paper
• Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation

  2025cites this paper
• Injecting structure-aware insights for the learning of RNA sequence representations to identify m6A modification sites

  2025cites this paper
• Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation.

  2025cites this paper
• Epigenetic regulation in female reproduction: the impact of m6A on maternal-fetal health

  2025cites this paper
• Interplay of m6A RNA methylation and gut microbiota in modulating gut injury

  2025cites this paper
• Single-cell multiomic analysis reveals methylome and transcriptome deviations following oocyte maturation in vitro

  2025cites this paper
• N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells

  2025cites this paper
• Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea

  2025influential citation
• Potential role of N6-methyladenosine modification in circular RNA biogenesis and function in the inflammatory responses

  2025cites this paper
• The RMaP challenge of predicting RNA modifications by nanopore sequencing

  2025cites this paper
• Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification.

  2025cites this paper
• N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection

  2025cites this paper
• Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole–nicotinamide chemotype

  2025cites this paper
• RNA modifications in plant pathogenic fungi: from epitranscriptomics to antifungal strategies.

  2025cites this paper
• Current Insights into Obesity and m6A Modification

  2025cites this paper
• Role of the epitranscriptome in viral infections: beneficial or detrimental?

  2025cites this paper
• Functional Nucleic Acid-Based Biosensing for m6A-modifying Enzyme Activity Monitoring

  2025cites this paper
• m6A RNA methylation regulator-associated genes drive metastasis and immune cell infiltration in skin cutaneous melanoma

  2025cites this paper
• Impact of N6-methyladenosine (m6A) machinery on HIV-1 replication in primary CD4+ T cells

  2025cites this paper
• Structural Control of RNA Demethylation: G-Quadruplex Proximity Suppresses ALKBH5 Activity.

  2025cites this paper
• The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification

  2025cites this paper
• N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling

  2025cites this paper
• The regulatory role of m6A in cancer metastasis

  2025cites this paper
• Cigarette smoking modulates m6A modification, affecting the induction of CYP1A1 mRNA by regulating human ARNT and AHRR in A549 cells.

  2025cites this paper
• Transcriptome-wide mapping of N3-methylcytidine modification at single-base resolution

  2025cites this paper
• Comprehensive characterization of lncRNA N6-methyladenosine modification dynamics throughout bovine skeletal muscle development

  2025cites this paper
• Targeting m6A RNA Modification in Tumor Therapeutics

  2025cites this paper
• RM2Target v2.0: an updated database for the target genes of writers, erasers, and readers of RNA modifications

  2025cites this paper
• Block sparse Bayes-based fuzzy system for RNA N6-methyladenosine sites prediction

  2025cites this paper
• Extractable organic matter from PM2.5 inhibits cardiomyocyte differentiation via AHR-mediated m6A RNA methylation.

  2025cites this paper
• O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation

  2025cites this paper
• Transcriptome-wide dynamics of m6A methylation in ISKNV and Siniperca chuatsi cells infected with ISKNV

  2025cites this paper
• METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression

  2025cites this paper
• Suppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse

  2025cites this paper
• Novel Insight of N6-Methyladenosine in Cardiovascular System

  2025cites this paper
• Decoding N6-methyladenosine's dynamic role in stem cell fate and early embryo development: insights into RNA-chromatin interactions.

  2025cites this paper
• Novel insights into the unique characterization of N6-methyladenosine RNA modification and regulating cold tolerance in winter Brassica rapa.

  2025cites this paper
• RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage.

  2025cites this paper
• Insights into the mechanism of METTL3-mediated m6A methylation in silicon dust-induced epithelial-mesenchymal transition

  2025cites this paper
• Emerging importance of m6A modification in liver cancer and its potential therapeutic role.

  2025cites this paper
• m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice.

  2025cites this paper
• METTL3, an Independent Adverse Prognostic Factor for AML, Promotes the Development of AML by Modulating the PGC‐1α–MAPK Pathway and PGC‐1α–Antioxidant System Axis

  2025cites this paper
• YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit

  2025cites this paper
• IGF2BP2: an m6A reader that affects cellular function and disease progression

  2025cites this paper
• The role of m6A RNA methylation in infectious diseases

  2025cites this paper
• Unraveling the Role of N6-Methylation Modification: From Bone Biology to Osteoporosis

  2025cites this paper
• Thermodynamic insights into N6-methyladenosine-modified ribonucleic acids and their interactions with the RNA recognition motif of heterogeneous nuclear ribonucleoprotein C.

  2025cites this paper
• Exercise induces Mettl14 in iWAT but regulates browning and metabolism independently of Mettl14

  2025cites this paper
• Tumor-associated macrophage-derived exosomes modulate the immunotherapeutic sensitivity of SHH-medulloblastoma by targeting m6A-modified FOXD1

  2025cites this paper
• RNA m6A modification: a key regulator in normal and malignant processes

  2025cites this paper
• Lack of mRNA Methylation in Schwann Cells Results in Demyelination and Regenerative Failure

  2025cites this paper
• Targeting RNA Adenosine Editing and Modification Enzymes for RNA therapeutics.

  2025cites this paper
• Insights into noncanonical and diversified functions of ABCF1: from health to disease.

  2025cites this paper
• Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases.

  2025cites this paper
• Clinical and prognostic significance of m6A hypomethylation and IGF2BP3 overexpression in gastric cancer: an integrated epigenomic-transcriptomic analysis

  2025cites this paper
• Structural and Functional Studies on Key Epigenetic Regulators in Asthma

  2025cites this paper
• RNA Modifications in Health and Disease

  2025cites this paper
• Mettl14 and Mettl3 Work Cooperatively to Regulate Retinal Development

  2024cites this paper
• N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions.

  2024cites this paper
• N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

  2024cites this paper
• Exploring methyl-verse: dynamic interplay of epigenome and m6A epitranscriptome.

  2024cites this paper
• mRNA m6A detection

  2024cites this paper
• m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs

  2024cites this paper
• A combined deep learning framework for mammalian m6A site prediction

  2024cites this paper
• A Demethylation-Switchable Aptamer Design Enables Lag-Free Monitoring of m6A Demethylase FTO with Energy Self-Sufficient and Structurally Integrated Features.

  2024cites this paper
• Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective

  2024cites this paper
• Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression

  2024cites this paper
• The Emerging Role of IGF2BP2 in Cancer Therapy Resistance: From Molecular Mechanism to Future Potential

  2024cites this paper
• PCBP1/2 and TDP43 Function as NAT10 Adaptors to Mediate mRNA ac4C Formation in Mammalian Cells

  2024cites this paper
• Global Co-regulatory Cross Talk Between m6A and m5C RNA Methylation Systems Coordinate Cellular Responses and Brain Disease Pathways

  2024cites this paper
• N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

  2024cites this paper
• An Investigation of RNA Methylations with Biophysical Approaches in a Cervical Cancer Cell Model

  2024cites this paper
• Fine particulate matter‑induced cardiac developmental toxicity (Review)

  2024cites this paper
• Transcriptome-wide methylated RNA immunoprecipitation sequencing profiling reveals m6A modification involved in response to heat stress in Apostichopus japonicus

  2024cites this paper
• Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders.

  2024cites this paper