Where it all starts: eukaryotic origins of DNA replication.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Cell Science

• Publication date

  2001-02-15

• Fields of study

  Biology, Medicine, Physics

• Identifiers
  PMID 11171369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.

  2000cited by this paper
• DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

  2000cited by this paper
• The Hexameric Eukaryotic MCM Helicase: Building Symmetry from Nonidentical Parts*

  2000cited by this paper
• The Cdt1 protein is required to license DNA for replication in fission yeast

  2000cited by this paper
• Uninterrupted MCM2-7 function required for DNA replication fork progression.

  2000cited by this paper
• Selection of homeotic proteins for binding to a human DNA replication origin.

  2000cited by this paper
• Initiation of eukaryotic DNA replication: conservative or liberal?

  2000cited by this paper
• Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

  2000cited by this paper
• Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M–G1 transition in mammals

  2000cited by this paper
• Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

  2000cited by this paper
• XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

  2000cited by this paper
• Major DNA replication initiation sites in the c‐myc locus in human cells

  2000cited by this paper
• CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis.

  2000cited by this paper
• A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase.

  2000cited by this paper
• Assembly of a Complex Containing Cdc45p, Replication Protein A, and Mcm2p at Replication Origins Controlled by S-Phase Cyclin-Dependent Kinases and Cdc7p-Dbf4p Kinase

  2000cited by this paper
• Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.

  2000cited by this paper
• Start sites of bidirectional DNA synthesis at the human lamin B2 origin.

  2000cited by this paper
• Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.

  2000cited by this paper
• Premature Structural Changes at Replication Origins in a Yeast Minichromosome Maintenance (MCM) Mutant*

  2000cited by this paper
• The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle.

  1999cited by this paper
• Short DNA fragments without sequence similarity are initiation sites for replication in the chromosome of the yeast Yarrowia lipolytica.

  1999cited by this paper
• Clustered Adenine/Thymine Stretches Are Essential for Function of a Fission Yeast Replication Origin

  1999cited by this paper
• Replication origins in metazoan chromosomes: fact or fiction?

  1999cited by this paper
• Chorion gene amplification in Drosophila: A model for metazoan origins of DNA replication and S-phase control.

  1999cited by this paper
• The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks.

  1999cited by this paper
• The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity.

  1999cited by this paper
• The regulation of replication origin activation.

  1999cited by this paper
• Chromosomal ARS1 has a single leading strand start site.

  1999cited by this paper
• Genetic methods for characterizing the cis-acting components of yeast DNA replication origins.

  1999cited by this paper
• The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin.

  1999cited by this paper
• Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication.

  1999cited by this paper
• Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element.

  1999cited by this paper
• Organization of DNA replication origins in the fission yeast genome

  1999cited by this paper
• ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.

  1999cited by this paper
• Methods to map origins of replication in eukaryotes

  1999cited by this paper
• Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity

  1999cited by this paper
• Activity of the c-myc Replicator at an Ectopic Chromosomal Location

  1999cited by this paper
• Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins.

  1999cited by this paper
• Association of Fission Yeast Orp1 and Mcm6 Proteins with Chromosomal Replication Origins

  1999cited by this paper
• Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin.

  1998cited by this paper
• Cdc7 is required throughout the yeast S phase to activate replication origins.

  1998cited by this paper
• Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos.

  1998cited by this paper
• The Cdc7 protein kinase is required for origin firing during S phase.

  1998cited by this paper
• AT-hook motifs identified in a wide variety of DNA-binding proteins.

  1998cited by this paper
• Replication origins in yeast versus metazoa: separation of the haves and the have nots.

  1998cited by this paper
• Replication conrol: choreographing replication origins.

  1998cited by this paper
• Discrete start sites for DNA synthesis in the yeast ARS1 origin.

  1998cited by this paper
• Human Minichromosome Maintenance Proteins and Human Origin Recognition Complex 2 Protein on Chromatin*

  1998cited by this paper
• Cell cycle modulation of protein–DNA interactions at a human replication origin

  1998cited by this paper
• Emerging mechanisms of eukaryotic DNA replication initiation.

  1998cited by this paper
• Cell cycle control of chorion gene amplification.

  1998cited by this paper
• Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

  1998cited by this paper
• Identification of Primary Initiation Sites for DNA Replication in the Hamster Dihydrofolate Reductase Gene Initiation Zone

  1998cited by this paper
• Genetic dissection of a mammalian replicator in the human beta-globin locus.

  1998cited by this paper
• Identification of a Preinitiation Step in DNA Replication That Is Independent of Origin Recognition Complex and cdc6, but Dependent on cdk2

  1998cited by this paper
• Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.

  1997cited by this paper
• Putting It All Together: Building a Prereplicative Complex

  1997cited by this paper
• Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs.

  1997cited by this paper
• The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2.

  1997cited by this paper
• Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.

  1997cited by this paper
• The replication origin decision point is a mitogen-independent, 2-aminopurine-sensitive, G1-phase event that precedes restriction point control

  1997cited by this paper
• Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.

  1997cited by this paper
• Architecture of the yeast origin recognition complex bound to origins of DNA replication

  1997cited by this paper
• Functional equivalency and diversity of cis-acting elements among yeast replication origins

  1997cited by this paper
• Initiation of DNA replication in eukaryotic cells.

  1997cited by this paper
• Mapping replication origins, pause sites, and termini by neutral/alkaline two-dimensional gel electrophoresis.

  1997cited by this paper
• Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.

  1997cited by this paper
• Mapping replication origins by quantifying relative abundance of nascent DNA strands using competitive polymerase chain reaction.

  1997cited by this paper
• Replication initiation point mapping.

  1997cited by this paper
• Mechanisms for Priming DNA Synthesis

  1996cited by this paper
• A Distinct G1 Step Required to Specify the Chinese Hamster DHFR Replication Origin

  1996cited by this paper
• At the heart of the budding yeast cell cycle.

  1996cited by this paper
• Role for a Xenopus Orc2-related protein in controlling DNA replication

  1996cited by this paper
• In vivo protein-DNA interactions at human DNA replication origin.

  1996cited by this paper
• Multivalent DNA-binding properties of the HMG-1 proteins.

  1996cited by this paper
• Multiple DNA elements in ARS305 determine replication origin activity in a yeast chromosome.

  1996cited by this paper
• 32 DNA Replication in Yeast

  1996cited by this paper
• On the nature of replication origins in higher eukaryotes.

  1995cited by this paper
• Autonomous replication in Drosophila melanogaster tissue culture cells

  1995cited by this paper
• [47] Specific labeling of newly replicated DNA

  1995cited by this paper
• Specific labeling of newly replicated DNA.

  1995cited by this paper
• Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

  1995cited by this paper
• The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.

  1995cited by this paper
• Genetic analysis of an ARS element from the fission yeast Schizosaccharomyces pombe.

  1995cited by this paper
• Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function

  1994cited by this paper
• Analysis of an origin of DNA amplification in Sciara coprophila by a novel three-dimensional gel method

  1994cited by this paper
• Two steps in the assembly of complexes at yeast replication origins in vivo.

  1994cited by this paper
• cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

  1994cited by this paper
• Regulation of eukaryotic DNA replication.

  1994cited by this paper
• Fine mapping of a replication origin of human DNA.

  1994cited by this paper
• Functional conservation of multiple elements in yeast chromosomal replicators

  1994cited by this paper
• A DNA unwinding element and an ARS consensus comprise a replication origin within a yeast chromosome.

  1993cited by this paper
• The structure and function of yeast ARS elements.

  1993cited by this paper
• Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A.

  1993cited by this paper
• DNA amplification in DNA puff II/9A of Sciara coprophila.

  1993cited by this paper
• A yeast chromosomal origin of DNA replication defined by multiple functional elements.

  1992cited by this paper
• ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

  1992cited by this paper
• Protein-DNA interactions at a yeast replication origin

  1992cited by this paper
• Assembly of simian virus 40 Okazaki pieces from DNA primers is reversibly arrested by ATP depletion

  1992cited by this paper
• Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation.

  1991cited by this paper

• RNF4 prevents genomic instability caused by chronic DNA under-replication.

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• RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication

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• The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2

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• Spatial regulation and organization of DNA replication within the nucleus

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