Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cold Spring Harbor Symposia on Quantitative Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/sqb.2011.76.010652PMID 21960527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Franklin H. Epstein Lecture: Sirtuins, aging, and medicine.

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• Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia

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• Regulation of mitochondrial biogenesis during myogenesis.

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• Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

  2010cited by this paper
• Mammalian sirtuins: biological insights and disease relevance.

  2010cited by this paper
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  2010cited by this paper
• Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice.

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  2010cited by this paper
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  2010cited by this paper
• Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways.

  2010cited by this paper
• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

  2010cited by this paper
• Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

  2010cited by this paper
• Regulation of muscle atrophy in aging and disease.

  2010cited by this paper
• Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

  2010cited by this paper
• Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.

  2010cited by this paper
• Inducible lineage tracing of Pax7‐descendant cells reveals embryonic origin of adult satellite cells

  2010cited by this paper
• Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity

  2009cited by this paper
• FoxO3 regulates neural stem cell homeostasis.

  2009cited by this paper
• The impact of sarcopenia and exercise training on skeletal muscle satellite cells.

  2009cited by this paper
• FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

  2009cited by this paper
• Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration.

  2009cited by this paper
• Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles.

  2008cited by this paper
• FoxO transcription factors in the maintenance of cellular homeostasis during aging.

  2008cited by this paper
• Self-renewal and expansion of single transplanted muscle stem cells

  2008cited by this paper
• Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

  2008cited by this paper
• Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-κB activation and expression

  2008cited by this paper
• Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated.

  2008cited by this paper
• Radiation effects on skeletal muscle

  2008cited by this paper
• Codependent activators direct myoblast-specific MyoD transcription.

  2008influential reference
• Regulation and function of skeletal muscle stem cells.

  2008cited by this paper
• Defining the transcriptional signature of skeletal muscle stem cells.

  2008cited by this paper
• A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

  2008cited by this paper
• The emerging biology of satellite cells and their therapeutic potential.

  2008cited by this paper
• Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis

  2007cited by this paper
• A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging

  2007cited by this paper
• FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

  2007cited by this paper
• Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle

  2007cited by this paper
• Impaired expression of Notch signaling genes in aged human skeletal muscle.

  2007cited by this paper
• Asymmetric self-renewal and commitment of satellite stem cells in muscle.

  2007cited by this paper
• AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES

  2007cited by this paper
• Diabetes Provides an Unfavorable Environment for Muscle Mass and Function after Muscle Injury in Mice

  2007influential reference
• Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo

  2007cited by this paper
• Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

  2006cited by this paper
• Mitochondria, oxidants, and aging.

  2005cited by this paper
• Muscle regeneration through myostatin inhibition

  2005cited by this paper
• Rejuvenation of aged progenitor cells by exposure to a young systemic environment

  2005cited by this paper
• Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis.

  2005cited by this paper
• Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy

  2005cited by this paper
• Inflammatory processes in muscle injury and repair.

  2005cited by this paper
• Telomeres, stem cells, senescence, and cancer.

  2004cited by this paper
• Myoblast transplantation: the current status of a potential therapeutic tool for myopathies

  2004cited by this paper
• Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

  2004cited by this paper
• Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.

  2004cited by this paper
• Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin.

  2003cited by this paper
• Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

  2003cited by this paper
• Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression*

  2002cited by this paper
• Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells.

  2002cited by this paper
• Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice

  2002cited by this paper
• Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

  2002cited by this paper
• Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

  2001cited by this paper
• Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

  2001cited by this paper
• Myostatin regulates cell survival during C2C12 myogenesis.

  2001cited by this paper
• Contraction-induced muscle fiber damage is increased in soleus muscle of streptozotocin-diabetic rats and is associated with elevated expression of brain-derived neurotrophic factor mRNA in muscle fibers and activated satellite cells.

  2000cited by this paper
• Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation*

  2000cited by this paper
• Transgenic mouse models of muscle aging.

  1999cited by this paper
• Effects of dexamethasone and anabolic agents on proliferation and protein synthesis and degradation in C2C12 myogenic cells.

  1996cited by this paper
• Effects of ageing on the motor unit.

  1995cited by this paper
• Satellite cell activation after muscle damage in young and adult rats

  1995cited by this paper
• An age-related type IIB to IIX myosin heavy chain switching in rat skeletal muscle.

  1993cited by this paper
• Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscle.

  1993cited by this paper
• Effects of age on physiological, immunohistochemical and biochemical properties of fast‐twitch single motor units in the rat.

  1991cited by this paper
• Regeneration of skeletal muscle in streptozotocin‐induced diabetic rats

  1991cited by this paper
• The molecular basis of muscular dystrophy in the mdx mouse: a point mutation.

  1989cited by this paper
• A model of myogenesis in vivo, derived from detailed autoradiographic studies of regenerating skeletal muscle, challenges the concept of quantal mitosis

  1987cited by this paper
• Initiation and duration of muscle precursor replication after mild and severe injury to skeletal muscle of mice

  1987cited by this paper
• Myogenic cell formation in regenerating rat skeletal muscle injured by mincing II. An autoradiographic study

  1977cited by this paper
• The structure of the satellite cells in skeletal muscle.

  1965cited by this paper
• SATELLITE CELL OF SKELETAL MUSCLE FIBERS

  1961cited by this paper
• Transforming Growth Factor-(cid:2) 1 Induces the Differentiation of Myogenic Cells into Fibrotic Cells in Injured Skeletal Muscle A Key Event in Muscle Fibrogenesis

  year unknowncited by this paper

• Targeting telomere dynamics with plant-derived compounds: Molecular strategies against aging

  2025influential citation
• Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice

  2025cites this paper
• Soluble RAGE enhances muscle regeneration after cryoinjury in aged and diseased mice

  2025cites this paper
• The Roles of myomiRs in the Pathogenesis of Sarcopenia: From Literature to In Silico Analysis.

  2025cites this paper
• Regulatory Landscapes of Muscle Satellite Cells: From Mechanism to Application

  2025cites this paper
• Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration

  2025cites this paper
• Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies

  2025cites this paper
• The Role of FNDC4 in Inflammation and Metabolism for Various Diseases

  2024cites this paper
• The Current Landscape of Pharmacotherapies for Sarcopenia

  2024cites this paper
• Inhibition of MAT2A Impairs Skeletal Muscle Repair Function

  2024cites this paper
• Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events

  2024cites this paper
• Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle

  2023influential citation
• Age‐related nitration/dysfunction of myogenic stem cell activator HGF

  2023cites this paper
• Effect of fermented sarco oyster extract on age induced sarcopenia muscle repair by modulating regulatory T cells

  2023cites this paper
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  2023cites this paper
• The Role of Mitochondria in Mediation of Skeletal Muscle Repair

  2023cites this paper
• Atrophic skeletal muscle fibre‐derived small extracellular vesicle miR‐690 inhibits satellite cell differentiation during ageing

  2022cites this paper
• The effect of hypoxia on myogenic differentiation and multipotency of the skeletal muscle-derived stem cells in mice

  2022cites this paper
• Carm1 and the Epigenetic Control of Stem Cell Function

  2022cites this paper
• Could sarcopenia-related mortality in end-stage renal disease be underpinned by the number of hospitalizations and cardiovascular diseases?

  2022cites this paper
• Ferroptosis and its role in skeletal muscle diseases

  2022cites this paper
• Enhancing health span: muscle stem cells and hormesis

  2022cites this paper
• Cellular Senescence in Acute and Chronic Wound Repair.

  2022cites this paper
• The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells

  2021cites this paper
• Stem Cell Quiescence versus Senescence: The Key for Healthy Aging

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• LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming

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• Bioengineered Skeletal Muscle as a Model of Muscle Aging and Regeneration

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  2020cites this paper
• Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase

  2020cites this paper
• Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

  2020cites this paper
• Sarcopenia: Current treatments and new regenerative therapeutic approaches

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• Isolation and culturing myogenic satellite cells from ovine skeletal muscle

  2020cites this paper
• Skeletal Muscle Stem Cell Niche from Birth to Old Age

  2020cites this paper
• Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

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• Low birth weight influences the postnatal abundance and characteristics of satellite cell subpopulations in pigs

  2020cites this paper
• No effect of the endurance training status on senescence despite reduced inflammation in skeletal muscle of older individuals.

  2020cites this paper
• Adiponectin promotes muscle regeneration through binding to T-cadherin

  2019cites this paper
• Urethral function and histopathology in aged female rats as a stress urinary incontinence model

  2019cites this paper
• Oxytocin is involved in steroid hormone-stimulated bovine satellite cell proliferation and differentiation in vitro.

  2019cites this paper
• Changes in Redox Signaling in the Skeletal Muscle with Aging

  2019cites this paper
• Small molecule nicotinamide N‐methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

  2019cites this paper
• Loss of Muscle Mass Induced by Aging Pérdida de masa muscular inducida por el envejecimiento Perda de massa muscular induzida por envelhecimento

  2019cites this paper
• A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

  2019cites this paper
• Can Proprioceptive Training Reduce Muscle Fatigue in Patients With Motor Neuron Diseases? A New Direction of Treatment

  2019cites this paper
• The NAD+-Dependent Histone Deacetylase Sirtuin-2 is Upregulated during Myogenesis and Promotes the Differentiation of C2C12 Myoblasts

  2019cites this paper
• Effects of physical exercise on the prevention of stem cells senescence

  2019cites this paper
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  2018cites this paper
• Aging Hallmarks: The Benefits of Physical Exercise

  2018cites this paper
• Cellular function of satellite cells does not play a role in muscle weakness of adult Ts1Cje mice

  2018cites this paper
• CRISPR-Cas 9 mutagenesis of the zebrafish foxm 1

  2018cites this paper
• Role of accelerated aging in limb muscle wasting of patients with COPD

  2018cites this paper
• The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

  2018cites this paper
• MicroRNAs in Skeletal Muscle Aging: Current Issues and Perspectives.

  2018cites this paper
• Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction

  2018cites this paper
• AGING-RELATED MOROLOPHGICAL CHANGES IN TASTE BUDS OF AGED RATS: AMELIORATIVE ROLE OF GREEN TEA AND GARLIC

  2018cites this paper
• α‐Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice

  2018cites this paper
• A review of telomere length in sarcopenia and frailty

  2018cites this paper
• Effect of photobiomodulation on connective tissue remodeling and regeneration of skeletal muscle in elderly rats

  2018cites this paper
• ‘Repair’ Treg Cells in Tissue Injury

  2017cites this paper
• In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells.

  2017cites this paper
• EFFECT OF EIGHT WEEKS SPRINT INTERVAL TRAINING ON MYOGENIN RATE IN AGED RATS SKELETAL MUSCLE TISSUE

  2017cites this paper
• Murine myoblast migration: influence of replicative ageing and nutrition

  2017cites this paper
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  2017cites this paper
• Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice

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• Effects of exercise‐induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats

  2017cites this paper
• MicroRNA-434-3p regulates age-related apoptosis through eIF5A1 in the skeletal muscle

  2017cites this paper
• Plasticity of the Muscle Stem Cell Microenvironment.

  2017cites this paper
• Systemic Regulators of Skeletal Muscle Regeneration in Obesity

  2017cites this paper
• The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging.

  2017cites this paper
• NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

  2016cites this paper
• Expression of FOXO6 is Associated With Oxidative Stress Level and Predicts the Prognosis in Hepatocellular Cancer

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• Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

  2016cites this paper
• Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

  2016cites this paper
• Metabolic control of muscle and muscle stem cell function

  2016cites this paper
• The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis

  2016cites this paper
• Ectopic Fat Accumulation and Glucose Homeostasis: Role of Leptin in Glucose and Lipid Metabolism and Mass Maintenance in Skeletal Muscle

  2016cites this paper
• Reduced Expression of MYC Increases Longevity and Enhances Healthspan

  2016cites this paper
• Skeletal muscle regeneration and impact of aging and nutrition.

  2016cites this paper
• Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia

  2016cites this paper
• Anti-aging pharmacology: Promises and pitfalls.

  2016cites this paper
• KLF7 Regulates Satellite Cell Quiescence in Response to Extracellular Signaling

  2016cites this paper
• Tissue Tregs.

  2016cites this paper
• Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies.

  2016cites this paper
• miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice.

  2016cites this paper
• The quasi-parallel lives of satellite cells and atrophying muscle

  2015cites this paper
• Reduced expression of MYC increases longevity and enhances healthspan.

  2015cites this paper
• miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4

  2015cites this paper
• The Relationship Between Adiponectin Levels and Appendicular Lean Mass in Postmenopausal Women

  2015cites this paper
• Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

  2015cites this paper
• Forever young: rejuvenating muscle satellite cells

  2015cites this paper
• Exercise Attenuates the Major Hallmarks of Aging

  2015cites this paper
• The Role of Apoptosis Repressor with Caspase Recruitment Domain in Aging Mouse Skeletal Muscle Morphology and Apoptotic Signaling

  2015cites this paper
• Aging of Muscle Stem Cells

  2015cites this paper
• Blockade of TGF-ß Signaling Through the Activin Type IIB Receptor with the Small Molecule, SGI-1252

  2015cites this paper
• Cellular senescence in aging and age-related disease: from mechanisms to therapy

  2015cites this paper