The antithrombotic potential of selective blockade of talin-dependent integrin αIIbβ3 (platelet GPIIb-IIIa) activation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Clinical Investigation

• Publication date

  2007-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI31024PMCID PMC1906732
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• Regulation of integrin alphaIIbbeta3 activation by distinct regions of its cytoplasmic tails.

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• The molecular basis of filamin binding to integrins and competition with talin.

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• Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin

  2005cited by this paper
• Integrin regulation.

  2005cited by this paper
• PTP-1B is an essential positive regulator of platelet integrin signaling

  2005cited by this paper
• Integrins: dynamic scaffolds for adhesion and signaling in platelets.

  2004cited by this paper
• Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

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• The talin-tail interaction places integrin activation on FERM ground.

  2004cited by this paper
• Scientific and therapeutic advances in antiplatelet therapy

  2003cited by this paper
• Structural determinants of integrin recognition by talin.

  2003cited by this paper
• Integrin alphaIIbbeta3 and its antagonism.

  2003cited by this paper
• Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

  2003cited by this paper
• Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

  2003cited by this paper
• Faculty Opinions recommendation of Talin binding to integrin beta tails: a final common step in integrin activation.

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• Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries.

  2002cited by this paper
• Integrin activation takes shape

  2002cited by this paper
• The Phosphotyrosine Binding-like Domain of Talin Activates Integrins*

  2002cited by this paper
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  2001cited by this paper
• Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains.

  2001cited by this paper
• Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms.

  2001cited by this paper
• NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution.

  2001cited by this paper
• Anti-GPIIb/IIIa Drugs: Current Strategies and Future Directions

  2001cited by this paper
• Integrin cytoplasmic domain-binding proteins.

  2000cited by this paper
• Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets.

  1999cited by this paper
• Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function.

  1999cited by this paper
• Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

  1999influential reference
• Integrin cytoplasmic tyrosine motif is required for outside-in αIIbβ3 signalling and platelet function

  1999cited by this paper
• The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*

  1999cited by this paper
• Integrin β Cytoplasmic Domains Differentially Bind to Cytoskeletal Proteins*

  1998cited by this paper
• SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

  1997cited by this paper
• The Role of Conserved Amino Acid Motifs within the Integrin β3 Cytoplasmic Domain in Triggering Focal Adhesion Kinase Phosphorylation*

  1997cited by this paper
• Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.

  1997cited by this paper
• Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

  1996cited by this paper
• A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa).

  1994cited by this paper
• Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions

  1993cited by this paper
• Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor.

  1992cited by this paper
• Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.

  1992cited by this paper
• Glanzmann's thrombasthenia: the spectrum of clinical disease.

  1990cited by this paper
• Site-directed mutagenesis by overlap extension using the polymerase chain reaction.

  1989influential reference
• Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol.

  1983cited by this paper

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  2020cites this paper
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  2020cites this paper
• Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation.

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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019influential citation
• Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

  2019cites this paper
• Filamin A: key actor in platelet biology.

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017influential citation
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  2017cites this paper
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  2017cites this paper
• Integrin αIIbβ3 outside-in signaling.

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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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