Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

As shown by analyses of morphology, gene expression, antigen-presenting function, and Flt3 dependence, the steady-state mouse brain contains a population of DCs that exhibits similarities to splenic DCs and differences from microglia.

• Publication year

  2011

• Venue

  Journal of Experimental Medicine

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20102657PMID 21788405PMCID 3149213
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity.

  2011cited by this paper
• Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

  2010cited by this paper
• Unravelling mononuclear phagocyte heterogeneity

  2010cited by this paper
• Regulation of learning and memory by meningeal immunity: a key role for IL-4

  2010cited by this paper
• Disentangling the complexity of the skin dendritic cell network

  2010cited by this paper
• Dendritic cell subsets in primary and secondary T cell responses at body surfaces

  2009cited by this paper
• Gaining entry to an uninflamed brain

  2009influential reference
• Localizing central nervous system immune surveillance: Meningeal antigen‐presenting cells activate T cells during experimental autoimmune encephalomyelitis

  2009influential reference
• Acute in vivo exposure to interferon-γ enables resident brain dendritic cells to become effective antigen presenting cells

  2009cited by this paper
• The origin and development of nonlymphoid tissue CD103+ DCs

  2009cited by this paper
• Intestinal lamina propria dendritic cell subsets have different origin and functions.

  2009cited by this paper
• In Vivo Analysis of Dendritic Cell Development and Homeostasis

  2009cited by this paper
• Origin of the lamina propria dendritic cell network.

  2009cited by this paper
• Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

  2009influential reference
• C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

  2009influential reference
• The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis.

  2009cited by this paper
• Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis1

  2009cited by this paper
• Dendritic cells in intestinal homeostasis and disease.

  2009cited by this paper
• CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis1

  2009cited by this paper
• Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?

  2008cited by this paper
• FMS-like tyrosine kinase 3 is required for dendritic cell development in peripheral lymphoid tissues

  2008cited by this paper
• Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI

  2008cited by this paper
• Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity

  2008cited by this paper
• Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

  2007cited by this paper
• Chemotherapy-related change in cognitive function: a conceptual model.

  2007cited by this paper
• CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE

  2007cited by this paper
• Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

  2007cited by this paper
• Origin of dendritic cells in peripheral lymphoid organs of mice

  2007cited by this paper
• Differential Antigen Processing by Dendritic Cell Subsets in Vivo

  2007cited by this paper
• Erratum: Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo (Nature Immunology (2007) 10.1038/ni1522)

  2007cited by this paper
• Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen

  2007cited by this paper
• Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

  2007cited by this paper
• Innate and adaptive immune responses of the central nervous system.

  2006cited by this paper
• Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology.

  2006cited by this paper
• A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

  2006cited by this paper
• Dendritic Cells in Multiple Sclerosis Lesions: Maturation Stage, Myelin Uptake, and Interaction With Proliferating T Cells

  2006cited by this paper
• Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology.

  2006cited by this paper
• Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

  2006cited by this paper
• Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

  2005cited by this paper
• Multiple sclerosis: trapped in deadly glue

  2005cited by this paper
• Visualizing dendritic cell networks in vivo

  2004cited by this paper
• From the Cover: Critical roles of interferon regulatory factor 4 in CD11bhighCD8- dendritic cell development

  2004cited by this paper
• Transcriptional profiling identifies Id2 function in dendritic cell development

  2003cited by this paper
• Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin

  2003cited by this paper
• CD8α+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity 1

  2003cited by this paper
• Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

  2003cited by this paper
• Blood monocytes consist of two principal subsets with distinct migratory properties.

  2003cited by this paper
• Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy

  2003cited by this paper
• CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity.

  2003cited by this paper
• T-cell engagement of dendritic cells rapidly rearranges MHC class II transport

  2002cited by this paper
• In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.

  2002cited by this paper
• Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations

  1999cited by this paper
• From the Guest Editor- Two Photon Microscopy

  1999cited by this paper
• Dendritic cells and the control of immunity

  1998cited by this paper
• The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system.

  1996cited by this paper
• On the complexity of self

  1991cited by this paper
• Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

  1991cited by this paper
• The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.

  1988cited by this paper
• Brief Definitive Report Identifi Cation of Antigen-presenting Dendritic Cells in Mouse Aorta and Cardiac Valves

  year unknowncited by this paper

• Decoding brain border immunity to enable future therapeutic avenues.

  2026cites this paper
• Activation and Long‐Term Maintenance of Adaptive Immunity in the Central Nervous System: A Double‐Edged Sword?

  2025cites this paper
• Single-cell analysis reveals a longitudinal trajectory of meningioma evolution and heterogeneity

  2025cites this paper
• Follicle on the Roof: Tertiary Lymphoid Structures in Central Nervous System Autoimmunity

  2025cites this paper
• Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and meningioma.

  2025cites this paper
• Strategies to overcome tumour relapse caused by antigen escape after CAR T therapy

  2025cites this paper
• Meningeal lymphatics as a therapeutic target for neurodegenerative disorders

  2025cites this paper
• Interplay of Zeb2a, Id2a, and Batf3 regulates microglia and dendritic cell development in the zebrafish brain.

  2024cites this paper
• Best practices and novel approaches for the preclinical development of drug-radiotherapy combinations for cancer treatment.

  2024cites this paper
• Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages

  2024cites this paper
• Dendritic cells in Parkinson's disease: regulatory role and therapeutic potential.

  2024cites this paper
• The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury

  2024cites this paper
• Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?

  2024cites this paper
• Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment

  2024cites this paper
• Optimizing the synergy between stereotactic radiosurgery and immunotherapy for brain metastases

  2023cites this paper
• IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma

  2023cites this paper
• Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

  2023influential citation
• Ready for Prime Time? Dendritic Cells in High-Grade Gliomas

  2023cites this paper
• Immunity in the brain and surrounding tissues.

  2023cites this paper
• Targeting the tumor microenvironment: Potential strategy for cancer therapeutics.

  2023cites this paper
• Effects of repeated binge intake of the pyrovalerone cathinone derivative 3,4-methylenedioxypyrovalerone on prefrontal cytokine levels in rats – a preliminary study

  2023cites this paper
• Interplay Between the Immune and Nervous Cognitive Systems in Homeostasis and in Malaria

  2023influential citation
• Immune compartments at the brain’s borders in health and neurovascular diseases

  2023cites this paper
• Dendritic Cells as a Nexus for the Development of Multiple Sclerosis and Models of Disease

  2023cites this paper
• The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations

  2023cites this paper
• Cellular microenvironment as an object of targeted therapy for malignant neoplasms

  2023cites this paper
• Microglial diversity in neuropathic pain.

  2023cites this paper
• Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis

  2022cites this paper
• DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential

  2022cites this paper
• Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers

  2022cites this paper
• The meningeal lymphatic vasculature in neuroinflammation

  2022cites this paper
• The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases

  2022cites this paper
• A spinal microglia population involved in remitting and relapsing neuropathic pain

  2022cites this paper
• Role of Dendritic Cells in Viral Brain Infections

  2022influential citation
• Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

  2022cites this paper
• Immunological defense of CNS barriers against infections

  2022cites this paper
• Met/HGFR triggers detrimental reactive microglia in TBI.

  2022cites this paper
• Metabolism in the progression and metastasis of brain tumors

  2022cites this paper
• Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response

  2021cites this paper
• Immunology of Multiple Sclerosis

  2021cites this paper
• Therapeutic Targeting of the Tumor Microenvironment.

  2021cites this paper
• Immune cell compartmentalization for brain surveillance and protection

  2021cites this paper
• Efficient Roles of miR-146a in Cellular and Molecular Mechanisms of Neuroinflammatory Disorders: An Effectual Review in Neuroimmunology.

  2021cites this paper
• Targeting Antigen-Presenting Cells in Multiple Sclerosis Treatment

  2021cites this paper
• Modification of Glial Cell Activation through Dendritic Cell Vaccination: Promises for Treatment of Neurodegenerative Diseases

  2021cites this paper
• Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation

  2021cites this paper
• Met/HGFR triggers detrimental reactive microglia in TBI

  2021cites this paper
• T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues *

  2021cites this paper
• The conventional dendritic cell 1 subset primes CD8+ T cells and traffics tumor antigen to drive anti-tumor immunity in the brain

  2021influential citation
• Transmigration across a Steady-State Blood–Brain Barrie Induces Activation of Circulating Dendritic Cells Partly Mediated by Actin Cytoskeletal Reorganization

  2021cites this paper
• Defining Immunogenic and Radioimmunogenic Tumors

  2021cites this paper
• Peripherally-sourced myeloid antigen presenting cells increase with advanced aging.

  2020cites this paper
• Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy

  2020cites this paper
• Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era

  2020cites this paper
• Antigen-Dependent T Cell Response to Neural Peptides After Human Ischemic Stroke

  2020cites this paper
• Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

  2020cites this paper
• Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain

  2020cites this paper
• Meningeal Lymphatics: From Anatomy to Central Nervous System Immune Surveillance

  2020cites this paper
• Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins

  2019influential citation
• The CNS Immune Landscape from the Viewpoint of a T Cell.

  2019cites this paper
• Immunologie de la sclérose en plaques

  2019cites this paper
• Parenchymal and non‐parenchymal immune cells in the brain: A critical role in regulating CNS functions

  2019cites this paper
• Myeloid Cells in Multiple Sclerosis

  2019cites this paper
• The anatomy and immunology of vasculature in the central nervous system

  2019cites this paper
• CD49d/CD29‐integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation

  2019cites this paper
• Acutely malnourished weanling mice administered Flt3 ligand can support a cell‐mediated inflammatory response

  2019cites this paper
• HTLV-1 infection of myeloid cells: from transmission to immune alterations

  2019cites this paper
• Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis

  2019cites this paper
• Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers

  2019cites this paper
• Dulaglutide Modulates the Development of Tissue-Infiltrating Th1/Th17 Cells and the Pathogenicity of Encephalitogenic Th1 Cells in the Central Nervous System

  2019cites this paper
• Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation

  2019cites this paper
• Neuroinflammation: Microglia and T Cells Get Ready to Tango

  2018cites this paper
• To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis

  2018cites this paper
• Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses

  2018cites this paper
• Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner

  2018cites this paper
• Dendritic Cells as an Alternate Approach for Treatment of Neurodegenerative Disorders

  2018influential citation
• High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

  2018influential citation
• NLR-Dependent Regulation of Inflammation in Multiple Sclerosis

  2018cites this paper
• Brain Inflammation and Endoplasmic Reticulum Stress

  2018cites this paper
• Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone‐induced demyelination

  2018cites this paper
• Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges

  2018influential citation
• MicroRNA signature of central nervous system‐infiltrating dendritic cells in an animal model of multiple sclerosis

  2018cites this paper
• Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

  2018cites this paper
• Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma

  2018cites this paper
• Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

  2018cites this paper
• CNS-resident classical DCs play a critical role in CNS autoimmune disease

  2018cites this paper
• Updates on immunity and inflammation in Parkinson disease pathology

  2018cites this paper
• CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ

  2018cites this paper
• The role of T cells in the pathogenesis of Parkinson’s disease

  2018cites this paper
• Macrophages, Microglia and Dendritic Cell Function

  2017cites this paper
• Cells of the Immune System

  2017cites this paper
• Myeloid Cells in the Central Nervous System.

  2017cites this paper
• T cell responses in the central nervous system

  2017cites this paper
• The role of peripheral immune cells in the CNS in steady state and disease

  2017cites this paper
• Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb

  2017cites this paper
• A Neuroprimer: Principles of CNS Immunity

  2017cites this paper
• P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

  2017cites this paper
• Immune responses in perinatal brain injury.

  2017cites this paper
• Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions.

  2017cites this paper
• Ontogeny and homeostasis of CNS myeloid cells

  2017cites this paper