Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de Pointes

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Circulation

• Publication date

  2002-04-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000014448.19052.4CPMID 11997281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gating-Dependent Mechanisms for Flecainide Action in SCN5A-Linked Arrhythmia Syndromes

  2001cited by this paper
• Drug Block of I Kr : Model Systems and Relevance to Human Arrhythmias

  2001cited by this paper
• Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population

  2000cited by this paper
• A common polymorphism associated with antibiotic-induced cardiac arrhythmia.

  2000cited by this paper
• Survey of the coding region of the HERG gene in long QT syndrome reveals six novel mutations and an amino acid polymorphism with possible phenotypic effects

  2000cited by this paper
• Pharmacogenetics and the practice of medicine

  2000cited by this paper
• Spectrum of Mutations in Long-QT Syndrome Genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

  2000cited by this paper
• Evidence for a Cardiac Ion Channel Mutation Underlying Drug‐Induced QT Prolongation and Life‐Threatening Arrhythmias

  2000cited by this paper
• Acquired Long QT Syndromes and the Risk of Proarrhythmia

  2000cited by this paper
• MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.

  1999cited by this paper
• Exaggerated QT prolongation after cardioversion of atrial fibrillation.

  1999cited by this paper
• Long QT syndromes and torsade de pointes.

  1999cited by this paper
• Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current.

  1999cited by this paper
• Genomic organization of the KCNQ1 K+ channel gene and identification of C-terminal mutations in the long-QT syndrome.

  1999cited by this paper
• Genetic and molecular basis of cardiac arrhythmias; impact on clinical management. Study group on molecular basis of arrhythmias of the working group on arrhythmias of the european society of cardiology.

  1999cited by this paper
• Low penetrance in the long-QT syndrome: clinical impact.

  1999cited by this paper
• Genetic and molecular basis of cardiac arrhythmias : Impact on clinical management

  1999cited by this paper
• Electrocardiographic and Clinical Predictors of Torsades de Pointes Induced by Almokalant Infusion in Patients with Chronic Atrial Fibrillation or Flutter: A Prospective Study

  1998cited by this paper
• Genomic organization and mutational analysis of KVLQT1, a gene responsible for familial long QT syndrome

  1998cited by this paper
• Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers

  1998cited by this paper
• A DNA polymorphism discovery resource for research on human genetic variation.

  1998cited by this paper
• Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome

  1998cited by this paper
• Taking the “Idio” out of “Idiosyncratic”: Predicting Torsades de Pointes

  1998cited by this paper
• Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1.

  1998cited by this paper
• Properties of KvLQT1 K+ channel mutations in Romano–Ward and Jervell and Lange‐Nielsen inherited cardiac arrhythmias

  1997cited by this paper
• KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome.

  1997cited by this paper
• A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

  1997cited by this paper
• Molecular basis of the long-QT syndrome associated with deafness.

  1997cited by this paper
• Age-gender influence on the rate-corrected QT interval and the QT-heart rate relation in families with genotypically characterized long QT syndrome.

  1997cited by this paper
• Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole.

  1996cited by this paper
• Genomic organization of the human SCN5A gene encoding the cardiac sodium channel.

  1996cited by this paper
• Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.

  1993cited by this paper
• Mechanism of the cardiotoxic actions of terfenadine.

  1993cited by this paper
• The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome.

  1992cited by this paper
• Torsade de pointes during administration of pentamidine isethionate.

  1987cited by this paper
• Delayed repolarization (QT or QTU prolongation) and malignant ventricular arrhythmias.

  1982cited by this paper

• Mutation-specific roles of sustained sodium current (INa) in guiding precision medicine for long QT syndrome type 3

  2025cites this paper
• Targeting Nav1.5 with DKK678 attenuates NF-κB-driven inflammatory injury in skeletal muscle.

  2025cites this paper
• A synonymous KCNH2 polymorphism and methadone trough level influence QTc prolongation in Kelantanese Malay recipients of methadone maintenance therapy (MMT) in Malaysia

  2025cites this paper
• Analysis of Slow Inactivation of Nav1.5 Channels in the Development of Hereditary Heart Pathology

  2024influential citation
• Electrocardiographic Findings in Children Treated with Leuprolide Acetate for Precocious Puberty: Does it Cause Prolonged QT?

  2024cites this paper
• Prevalence and Risk Factors of Cardiac Arrhythmia in COVID-19 Patients

  2024cites this paper
• A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation

  2024cites this paper
• Variability in reported midpoints of (in)activation of cardiac INa

  2024cites this paper
• Population-specific variations in KCNH2 predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy

  2024cites this paper
• Biophysical mechanisms of myocardium sodium channelopathies

  2024cites this paper
• Genetic risk factors for drug-induced long QT syndrome: findings from a large real-world case-control study.

  2024cites this paper
• A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder

  2024cites this paper
• A method of identifying the high-risk mutations of sudden cardiac death at KCNQ1 and KCNH2 genes.

  2024cites this paper
• A novel mutation in hERG gene associated with azithromycin-induced acquired long QT syndrome

  2024cites this paper
• Electrocardiographic Abnormalities During and After Withdrawal in Patients Diagnosed with Opioid Use Disorder.

  2023cites this paper
• Does prolonged QTc predict pulmonary involvement in COVID-19 patients?

  2023cites this paper
• Torsades De Pointes Complicating Acute Myocardial Infarction, Twisting the Prognosis

  2023cites this paper
• Risk Stratification of QTc Prolongation in Critically Ill Patients Receiving Antipsychotics for the Management of Delirium Symptoms

  2023cites this paper
• Concurrent Deep T-Wave Inversions and QT Prolongation with Azithromycin Treatment

  2022cites this paper
• Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

  2022cites this paper
• Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond

  2022cites this paper
• Genetics of drug-induced QT prolongation: evaluating the evidence for pharmacodynamic variants.

  2022cites this paper
• Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome

  2022cites this paper
• Characteristic Electrocardiography Findings of COVID-19 Patients.

  2021cites this paper
• Torsades de pointes episode in a woman with high-grade fever and inflammatory activation: A case report

  2021cites this paper
• Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome

  2021cites this paper
• Genetics and genomics of arrhythmic risk: current and future strategies to prevent sudden cardiac death

  2021cites this paper
• A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants

  2020cites this paper
• Ventricular Arrhythmia Risk Based on Ethnicity in COVID-19 Patients on Hydroxychloroquine and Azithromycin Combination: Viewpoint

  2020cites this paper
• 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

  2020cites this paper
• SCN5A Gene

  2020cites this paper
• SARS-CoV-2, COVID-19, and inherited arrhythmia syndromes

  2020cites this paper
• Statistical algorithms for clinical decisions and prevention of genetic-related heart disease

  2020cites this paper
• Acquired Long QT Syndrome: A Review of the Literature

  2020cites this paper
• Guidelines for reporting case studies and series on drug-induced QT interval prolongation and its complications following acute overdose

  2020cites this paper
• Drug-induced long qt syndrome

  2020cites this paper
• Acquired Long QT Syndrome and Torsades de Pointes

  2020cites this paper
• 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

  2020cites this paper
• Cardiac Repolarization: Basic Science and Clinical Management

  2020influential citation
• Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know.

  2020cites this paper
• Torsades de Pointes During Myringotomy in a Child with Congenital Long QT Syndrome: A Case Report

  2020cites this paper
• Can HCQ Be Considered a “Safe Weapon” for COVID-19 in the Indian Population?

  2020cites this paper
• SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

  2019cites this paper
• Cardiovascular Pharmacogenomics: Does It Matter If You're Black or White?

  2019cites this paper
• Erratum to “Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients”

  2019cites this paper
• Genetic susceptibility in pharmacodynamic and pharmacokinetic pathways underlying drug-induced arrhythmia and sudden unexplained deaths.

  2019cites this paper
• Navigating the Minefield of QTc Interval‐Prolonging Therapy in Nursing Facility Residents

  2019influential citation
• A current understanding of drug-induced QT prolongation and its implications for anticancer therapy.

  2019cites this paper
• Drug-Induced QT Interval Prolongation: Mechanisms, Risk Factors, Genetics and Clinical Management

  2019cites this paper
• QT length during methadone maintenance treatment: gene × dose interaction

  2019influential citation
• Proarrhythmische Nebenwirkungen von Nicht-Antiarrhythmika

  2019cites this paper
• The Role of Inflammation and Autoimmunity in Long QT Syndrome

  2019cites this paper
• Deep Mutational Scan of a cardiac sodium channel voltage sensor

  2019cites this paper
• Reproducibility and diagnostic usefulness of repeated sodium channel blocker test at higher precordial electrocardiogram recording in a patient with Brugada syndrome

  2019cites this paper
• Title Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients

  2019cites this paper
• Multiple mechanisms underlie increased cardiac late sodium current.

  2019cites this paper
• Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System

  2019cites this paper
• Update on long QT syndrome

  2019cites this paper
• Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients

  2019cites this paper
• Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest.

  2018cites this paper
• IN PHARMACOLOGY OF ION CHANNEL AND CHANNELOPATHIES Stereoselective inhibition of the hERG 1 potassium channel

  2018influential citation
• Pharmacogenetics of Adverse Drug Reactions.

  2018cites this paper
• Clinical Reviews: Drugs and Devices

  2018cites this paper
• SCN5A Variants: Association With Cardiac Disorders

  2018cites this paper
• 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death.

  2018cites this paper
• Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing

  2018cites this paper
• Comprehensive Review on Methadone-Induced QT Prolongation and Torsades

  2018cites this paper
• Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT

  2018cites this paper
• Perioperative management of patients with congenital or acquired disorders of the QT interval

  2018cites this paper
• Exploiting ion channel structure to assess rare variant pathogenicity.

  2018cites this paper
• An in Vitro Assay of hERG K+ Channel Potency for a New EGFR Inhibitor FHND004

  2018cites this paper
• Dysfunctional Nav1.5 channels due to SCN5A mutations

  2018cites this paper
• Fatal Drowning Associated with QT Prolongation Caused by Alcohol, Some Drugs, and Congenital Long QT Syndrome: The Role of the Diving Reflex

  2018influential citation
• An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation

  2018cites this paper
• 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.

  2018cites this paper
• 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.

  2017cites this paper
• Implantable cardioverter defibrillator therapy in repaired tetralogy of Fallot after pulmonary valve replacement: Implications for the mechanism of ventricular arrhythmia.

  2017cites this paper
• Torsade de Pointes Induced by Hypokalemia from Imipenem and Piperacillin

  2017cites this paper
• Automated T‐wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome

  2017cites this paper
• Long QT Syndrome Unveiled by a Fatal Combination of Medications and Electrolyte Abnormalities

  2017cites this paper
• An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes

  2017cites this paper
• Genomics of Cardiac Arrhythmias

  2017cites this paper
• Impact of Variant Reclassification in the Clinical Setting of Cardiovascular Genetics

  2017cites this paper
• Association between SCN 5 A gene variant H 558 R and arrhythmias : a systemic review and meta-analysis

  2017cites this paper
• Torsade de pointes and systemic azole antifungal agents: Analysis of global spontaneous safety reports

  2017cites this paper
• Red Bull®: Red flag or red herring?

  2017cites this paper
• Latent pathogenicity of the G38S polymorphism of KCNE1 K+ channel modulator

  2017cites this paper
• A novel KCNQ1 nonsense variant in the isoform-specific first exon causes both jervell and Lange-Nielsen syndrome 1 and long QT syndrome 1: a case report

  2017cites this paper
• Effect of GWAS-Identified Genetic Variants on Maximum QT Interval in Patients With Schizophrenia Receiving Antipsychotic Agents: A 24-Hour Holter ECG Study

  2017cites this paper
• Personalized Medicine Applied to Forensic Sciences: New Advances and Perspectives for a Tailored Forensic Approach.

  2017cites this paper
• Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

  2017cites this paper
• GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, “GENEREPOL study”: Lack of common variants with large effect sizes

  2017cites this paper
• Update to Practice Standards for Electrocardiographic Monitoring in Hospital Settings: A Scientific Statement From the American Heart Association

  2017cites this paper
• Multi-scale modeling and variability in cardiac cellular electrophysiology

  2017cites this paper
• Syndrome sélectif du QT long sous le traitement de risperidone

  2017cites this paper
• The regulation of trafficking and function of KCNQ1 potassium channels by phosphatidylinositol-4,5-bisphosphate

  2017cites this paper
• Drug-Induced Torsades de Pointes and Genetic Screening--Reply.

  2016cites this paper
• hERG long QT syndrome type 2 mutants need more than a chaperone to dance

  2016cites this paper
• Pharmacogenetics of Potassium Channel Blockers.

  2016cites this paper
• Editorial to "Disturbances of cardiac wavelength and repolarization precede torsade de pointes and ventricular fibrillation in langendorff perfused rabbit hearts" by Luc Hondeghem: It is difficult to make predictions, especially about the future∗: Thoughts about forecasting cardiotoxicity of pharmac

  2016cites this paper