Multiple regioselective functionalizations of quinolines via magnesiations.

A wide range of polyfunctionalized quinolines was prepared via chemo- and regioselective magnesiation reactions using appropriate Mg reagents, such as i-PrMgCl.LiCl, MesMgBr.LiCl, Mes2Mg.2LiBr, TMPMgCl.LiCl, and TMP2Mg.2LiCl. An application to the total synthesis of the biologically active compound talnetant was performed (six steps, 28%).

• Publication year

  2007

• Venue

  Organic Letters

• Publication date

  2007-11-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/OL702494KPMID 18027959
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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