Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2010-04-08

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jm901757tPMID 20222671PMCID PMC2848690
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of the BCA2 ubiquitin E3 ligase in hormone responsive breast cancer.

  2010cited by this paper
• Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

  2009cited by this paper
• Carbon Tetrabromide Promoted Reaction of Amines with Carbon Disulfide: Facile and Efficient Synthesis of Thioureas and Thiuram Disulfides.

  2009cited by this paper
• Targeting Leukemic Stem Cells

  2009cited by this paper
• The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies.

  2008cited by this paper
• Inactivation of NF-κB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells

  2008cited by this paper
• Autoubiquitination of BCA2 RING E3 Ligase Regulates Its Own Stability and Affects Cell Migration

  2008cited by this paper
• Design and synthesis of BCA2 inhibitors

  2008cited by this paper
• Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells.

  2008cited by this paper
• Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients.

  2007cited by this paper
• ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

  2007cited by this paper
• Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

  2007cited by this paper
• Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.

  2007cited by this paper
• Novel Alternative for the N—S Bond Formation and Its Application to the Synthesis of Benzisothiazol-3-ones.

  2007cited by this paper
• Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram.

  2006cited by this paper
• Novel alternative for the N-S bond formation and its application to the synthesis of benzisothiazol-3-ones.

  2006cited by this paper
• Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.

  2006cited by this paper
• Novel RING E3 ubiquitin ligases in breast cancer.

  2006cited by this paper
• Straightforward and highly efficient catalyst-free one-pot synthesis of dithiocarbamates under solvent-free conditions.

  2006cited by this paper
• Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.

  2006cited by this paper
• Inhibition of proteasome activity, nuclear factor‐KB translocation and cell survival by the antialcoholism drug disulfiram

  2006cited by this paper
• Drug discovery in the ubiquitin–proteasome system

  2006cited by this paper
• One-pot synthesis of dithiocarbamates accelerated in water.

  2006cited by this paper
• 382 POSTER Disulfiram inhibits the E3 ligase activity of breast cancer associated gene 2 (BCA2) and the growth of BCA2-expressing breast cancers in vitro and in vivo

  2006cited by this paper
• Disulfiram inhibits the ubiquitin E3 ligase activity of the novel breast cancer associated gene BCA2 and the growth of BCA2 expressing breast cancer cell lines.

  2006cited by this paper
• A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.

  2005cited by this paper
• Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

  2005cited by this paper
• M(S)2(I)2 (M=Zn, Cd) and Hg(S)3I Coordination Environment of Transition Metal Complexes – Synthesis, Spectral, and Single Crystal X-ray Structural Investigations

  2005cited by this paper
• The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications.

  2004cited by this paper
• Development of the Proteasome Inhibitor Velcade™ (Bortezomib)

  2004cited by this paper
• The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1).

  2004cited by this paper
• Development of the Proteasome Inhibitor Velcade TM

  2004cited by this paper
• A Short, Novel, and Cheaper Procedure for Oligonucleotide Synthesis Using Automated Solid Phase Synthesizer

  2003cited by this paper
• Inhibition of invasion and angiogenesis by zinc-chelating agent disulfiram.

  2003cited by this paper
• Oxidation of Thiols to Disulfides with Molecular Bromine on Hydrated Silica Gel Support.

  2002cited by this paper
• Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism.

  2000cited by this paper
• Inactivation of the human papillomavirus-16 E6 oncoprotein by organic disulfides.

  2000cited by this paper
• RING finger proteins: mediators of ubiquitin ligase activity.

  2000cited by this paper
• The ubiquitin system

  2000cited by this paper
• The ubiquitin system.

  1998cited by this paper
• Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFκB c‐fos/c‐jun, and p53 proteins

  1998cited by this paper
• Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2'-dithiobis[benzamides] and benzisothiazolones.

  1996cited by this paper
• Exchange and other reactions associated with zinc(II) dithiocarbamate oxidation and reduction processes observed at mercury and platinum electrodes in dichloromethane

  1990cited by this paper
• Dialkylcarbamoyl(diaryl)iodanes

  1987cited by this paper
• Human mitochondrial aldehyde dehydrogenase inhibition by diethyldithiocarbamic acid methanethiol mixed disulfide: a derivative of disulfiram

  1985cited by this paper
• The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver.

  1976cited by this paper
• The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.

  1975cited by this paper
• Organic disulfides and related substances. XXV. Thiocarbamoyl and imidocarbamoyl disulfides

  1968cited by this paper

• Newtonioside, a new cytotoxic cerebroside and other constituents from the stem bark of Newtonia buchananii (Fabaceae) and their chemophenetic significance

  2026cites this paper
• Design, synthesis and activity evaluation of dithiocarbamate-based L-homoserine lactone derivatives as Gram-negative bacteria quorum sensing inhibitors.

  2025cites this paper
• Advances in cross-coupling and oxidative coupling reactions of NH-sulfoximines - a review.

  2025cites this paper
• Catalyst/Metal/Solvent-Free Markovnikov Hydrothiolation of Unactivated Alkenes with Dithiocarbamic Acids.

  2024cites this paper
• Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

  2024cites this paper
• Cytotoxic clerodane diterpenoids from the roots of Casearia barteri Mast.

  2024cites this paper
• Aframomumlabdane, a new bislabdane diterpenoid from Aframomum arundinaceum (zingiberaceae)

  2024cites this paper
• Copolymer-Coated Au–Pt Nanomotors for Delivery of Disulfiram Prodrug

  2024cites this paper
• 2‐Cyanoethyl dimethyldithiocarbamate, a new contact allergen found in accelerator‐free nitrile gloves

  2024cites this paper
• Anti-proliferative activity of dithiocarbamate salts: Synthesis and in vitro study

  2024cites this paper
• Regioselective Markovnikov hydrothiolation of 1-aryl-1,3-butadienes with dithiocarbamic acid to allyl dithiocarbamates.

  2024cites this paper
• Photoinduced Decarboxylative Thioacylation of N-Hydroxyphthalimide Esters with Tetraalkylthiuram Disulfides.

  2024cites this paper
• An electron donor–acceptor photoactivation strategy for the synthesis of S-aryl dithiocarbamates using thianthrenium salts under mild aqueous micellar conditions

  2023cites this paper
• Cytotoxicity, acute and sub-chronic toxicities of the leaves of Bauhinia thonningii (Schumach.) Milne-Redh. (Caesalpiniaceae)

  2023cites this paper
• Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines

  2023cites this paper
• Structure-activity relationship of anticancer drug candidate quinones

  2023cites this paper
• RNF115 Inhibits the Post‐ER Trafficking of TLRs and TLRs‐Mediated Immune Responses by Catalyzing K11‐Linked Ubiquitination of RAB1A and RAB13

  2022cites this paper
• Molecular Dynamics Simulations of Reduced and Oxidized TFIIIA Zinc Fingers Free and Interacting with 5S RNA

  2022cites this paper
• Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

  2022influential citation
• Programming Hydrogels with Complex Transient Behaviors via Autocatalytic Cascade Reactions.

  2022cites this paper
• Phthalimide Analogs Enhance Genotoxicity of Cyclophosphamide and Inhibit Its Associated Hypoxia

  2022cites this paper
• Synthesis, characterization, and antifungal activity of novel chromene oxadiazole based dithiocarbamates

  2022cites this paper
• Condensation of α-Chloroethers of Unsaturated C3-Alcohols with Thioacetamide and Thioureas

  2022cites this paper
• Antimicrobial and Cytotoxic Potential of Helminthosporin from Rumex abyssiniscus Jacq. Discovered as a Novel Source of Syringic Acid and Bis(2-ethyloctyl) Phthalate

  2022cites this paper
• Disulfiram Oxy-Derivatives Suppress Protein Retrotranslocation across the ER Membrane to the Cytosol and Initiate Paraptosis-like Cell Death

  2022cites this paper
• Chemical constituents and cytotoxic activity of Ocimum gratissimum L.

  2022cites this paper
• In Vitro Growth Inhibition, Caspase-Dependent Apoptosis, and S and G2/M Phase Arrest in Breast Cancer Cells Induced by Fluorine-Incorporated Gold I Compound, Ph3PAu[SC(OMe)=NC6H4F-3]

  2022cites this paper
• Multifaceted Roles of the E3 Ubiquitin Ligase RING Finger Protein 115 in Immunity and Diseases

  2022cites this paper
• Aerobic Visible‐Light Induced Intermolecular S−N Bond Construction: Synthesis of 1,2,4‐Thiadiazoles from Thioamides under Photosensitizer‐Free Conditions

  2021cites this paper
• E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability

  2021cites this paper
• Bioactivity of fractions and constituents of Piper capense fruits towards a broad panel of cancer cells.

  2021cites this paper
• Design, synthesis, characterization, and anticancer activity of a novel series of O-substituted chalcone derivatives.

  2021cites this paper
• HETEROCYCLES 45. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-INDOLYL-1-PYRIDYL-2- PROPENONES AS ANTICANCER AGENTS

  2020cites this paper
• Cytotoxic Constituents of the Bark of Hypericum roeperianum towards Multidrug-Resistant Cancer Cells

  2020cites this paper
• Ubiquitin-specific protease 7 downregulation suppresses breast cancer in vitro

  2020cites this paper
• Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

  2020cites this paper
• N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic cell death.

  2020cites this paper
• A new Mumm-type rearrangement with dithiocarbamates via isocyanide-based multicomponent reaction under ultrasound irradiation: synthesis of polysubstituted pyrrolidine compounds

  2020cites this paper
• Cytotoxicity of a naturally occuring spirostanol saponin, progenin III, towards a broad range of cancer cell lines by induction of apoptosis, autophagy and necroptosis.

  2020cites this paper
• 8,8-bis-(Dihydroconiferyl)-diferulate displayed impressive cytotoxicity towards a panel of human and animal cancer cells.

  2020cites this paper
• Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy.

  2020cites this paper
• Radiosynthesis of [thiocarbonyl-11C]disulfiram and its first PET study in mice.

  2020cites this paper
• Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)

  2020cites this paper
• Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells.

  2020cites this paper
• The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis.

  2020cites this paper
• Cytotoxicity of botanicals and isolated phytochemicals from Araliopsis soyauxii Engl. (Rutaceae) towards a panel of human cancer cells.

  2020cites this paper
• Botanicals from the leaves of Acacia sieberiana had better cytotoxic effects than isolated phytochemicals towards MDR cancer cells lines

  2020cites this paper
• N−H and C−H Functionalization of Sulfoximine: Recent Advancement and Prospects

  2020cites this paper
• Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors

  2019cites this paper
• Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy.

  2019cites this paper
• Synthesis of alkyl dithiocarbamates by using thiuram disulfide reagents: A metal-free C(sp3)-S bond formation

  2019cites this paper
• Two new polyhydroxylated pentacyclic triterpenes with cytotoxic activities from Manilkara pellegriniana (Sapotaceae)

  2019cites this paper
• Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer.

  2019cites this paper
• Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multi-factorial drug resistant cancer cells.

  2019cites this paper
• Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.

  2019cites this paper
• Cytotoxic flavonoids from two Lonchocarpus species

  2019cites this paper
• Cytotoxicity of Crude Extract and Isolated Constituents of the Dichrostachys cinerea Bark towards Multifactorial Drug-Resistant Cancer Cells

  2019cites this paper
• Deubiquitinase ubiquitin‐specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells

  2019cites this paper
• Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells

  2018cites this paper
• Heterocycles 44. Synthesis, characterization and anticancer activity of new thiazole ortho-hydroxychalcones

  2018cites this paper
• Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.

  2018cites this paper
• Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses

  2018cites this paper
• A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.

  2018cites this paper
• Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana.

  2018cites this paper
• Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells

  2018cites this paper
• Role of Ubiquitin E 3 Ligase Breast Cancer Associated Gene 2 ( BCA 2 ) in SUMOylation Thesis

  2018cites this paper
• Cytotoxicity of Lupeol from the Stem Bark of Zanthoxylum gilletii against Multi-factorial Drug Resistant Cancer Cell Lines

  2018cites this paper
• Efficient, straightforward, catalyst-free synthesis of medicinally important S-alkyl/benzyl dithiocarbamates under green conditions

  2018cites this paper
• Green and Efficient Synthesis of N-Sulfenyl Sulfoximines in Water

  2018cites this paper
• Benign One‐Pot Synthesis of Carbamo(dithioperoxo)thioate Compounds in Water Medium Using N ‐(Arylthio)phthalimides as the Electrophilic Sulfur Source

  2018cites this paper
• Transition-Metal-Free C(sp3 )-S Coupling in Water: Synthesis of Benzyl Dithiocarbamates Using Thiuram Disulfides as an Organosulfur Source

  2018cites this paper
• Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells

  2017cites this paper
• Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells.

  2017cites this paper
• Antimicrobial, anti-inflammatory activity and cytotoxicity of Funtumia africana leaf extracts, fractions and the isolated methyl ursolate

  2017cites this paper
• Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

  2017cites this paper
• Targeting Protein Synthesis, Folding, and Degradation Pathways in Cancer

  2017cites this paper
• A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O-α-L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells

  2017cites this paper
• In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines

  2017cites this paper
• Induction of apoptosis in response to improved gedunin by liposomal nano-encapsulation in human non-small-cell lung cancer (NCI-H292) cell line

  2017cites this paper
• Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone towards multi-factorial drug-resistant cancer cells.

  2017cites this paper
• Development of mass spectrometric methods to understand the mechanism of action of transition metal-based anticancer compounds

  2016influential citation
• Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

  2016cites this paper
• Cyclic ammonium salts of dithiocarbamic acid: stable alternative reagents for the synthesis of S-alkyl carbodithioates from organyl thiocyanates in water

  2016cites this paper
• The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer

  2016cites this paper
• An efficient approach to construct benzisothiazol-3(2H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide.

  2016cites this paper
• Using an Old Drug to Target a New Drug Site: Application of Disulfiram to Target the Zn-Site in HCV NS5A Protein.

  2016cites this paper
• Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines.

  2016cites this paper
• Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone

  2016cites this paper
• Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells.

  2016cites this paper
• Synthesis, Biological Evaluation, Docking and QSAR Studies of Some Novel Naphthalimide Dithiocarbamate Analogs as Antitumor and Anti-Inflammatory Agents

  2016cites this paper
• Advances in Synthetic Applications of Hypervalent Iodine Compounds.

  2016cites this paper
• Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells

  2015cites this paper
• Cytotoxicity of anthraquinones from the roots of Pentas schimperi towards multi-factorial drug-resistant cancer cells

  2015cites this paper
• Investigation into the effects of zinc on the anti-breast cancer properties of disulfiram

  2015cites this paper
• Synthesis of Dithiocarbamates Containing Disulfide Linkage Using Cyclic Trithiocarbonate and Amines under Solvent–Catalyst Free Condition

  2015cites this paper
• Oxidative Heterocycle Formation Using Hypervalent Iodine(III) Reagents.

  2015cites this paper
• Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents

  2015cites this paper
• Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells.

  2015cites this paper
• Effects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates

  2015cites this paper
• Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells.

  2015cites this paper