Effect of Momordica charantia, Camellia sinensis and Cinnamon Specieson Insulin Resistance

Insulin resistance is a serious challenge in diabetes treatment. Around the world, several plants are used in the treatment of diabetes and experimental studies clearly demonstrated that insulin resistance can be reduced by some antidiabetic plants. More than 100 plants have been reported to improve insulin sensitivity. The aim of this study was to review the effect of three popular medicinal plants that have generated broad interest during the past decade and used traditionally in the management of diabetes on insulin resistance. These plants are: Momordica charantia, Camellia sinensis and Cinnamomum species. We demonstrated that these plants effectively reduced insulin resistance in animal models involving different molecular mechanisms. However, clinical investigation remains needed to clearly affirm the effect of these plants on insulin resistance.

• Publication year

  2014

• Venue

  Medicinal and Aromatic plants

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.4172/2167-0412.1000182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Thiazolidinedione compounds: a patent review (2010 – present)

  2015cited by this paper
• Green tea changes serum and liver metabolomic profiles in mice with high-fat diet-induced obesity.

  2015cited by this paper
• Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome

  2015cited by this paper
• A novel insulin receptor-binding protein from Momordica charantia enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway.

  2014cited by this paper
• Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

  2014cited by this paper
• Having a promising efficacy on type II diabetes, it's definitely a green tea time.

  2014cited by this paper
• Green tea extracts reduce adipogenesis by decreasing expression of transcription factors C/EBPα and PPARγ.

  2014cited by this paper
• Effect of green tea extract microencapsulation on hypertriglyceridemia and cardiovascular tissues in high fructose-fed rats

  2013cited by this paper
• Wild bitter gourd extract up-regulates mRNA expression of PPARα, PPARγ and their target genes in C57BL/6J mice.

  2011cited by this paper
• Relationship between resistin and aPAI‐1 levels with insulin resistance in Saudi children

  2010cited by this paper
• Effects of C358A missense polymorphism of the degrading enzyme fatty acid amide hydrolase on weight loss, adipocytokines, and insulin resistance after 2 hypocaloric diets.

  2010cited by this paper
• NOX3‐derived reactive oxygen species promote TNF‐α‐induced reductions in hepatocyte glycogen levels via a JNK pathway

  2010cited by this paper
• Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation

  2010cited by this paper
• Implications of Magnesium Deficiency in Type 2 Diabetes: A Review

  2010cited by this paper
• Independent effects of weight gain and fetal programming on metabolic complications in adults born small for gestational age

  2010cited by this paper
• Therapeutic Options that Provide Glycemic Control and Weight Loss for Patients with Type 2 Diabetes

  2010cited by this paper
• Improved myocardial perfusion in chronic diabetic mice by the up‐regulation of pLKB1 and AMPK signaling

  2010cited by this paper
• Nonalcoholic Fatty Liver Disease: A Review and Update

  2010cited by this paper
• Mitochondrial DNA copy number in peripheral blood is associated with cognitive function in apparently healthy elderly women.

  2010cited by this paper
• Spiroindenes and spiroindanes as antagonists of CC chemokine receptor 2: WO 2009023754

  2010cited by this paper
• The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest

  2010cited by this paper
• The developmental origins, mechanisms, and implications of metabolic syndrome.

  2010cited by this paper
• Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat

  2010cited by this paper
• Common Genetic Variants in Fatty Acid–Binding Protein‐4 (FABP4) and Clinical Diabetes Risk in the Women's Health Initiative Observational Study

  2010cited by this paper
• Time-Resolved and Tissue-Specific Systems Analysis of the Pathogenesis of Insulin Resistance

  2010cited by this paper
• Autophagy and adipogenesis: Implications in obesity and type II diabetes

  2010cited by this paper
• Inflammation and the Incidence of Type 2 Diabetes

  2010cited by this paper
• Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats.

  2010cited by this paper
• Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression.

  2010cited by this paper
• The determinants of insulin sensitivity, β-cell function, and glucose tolerance are different in patients with polycystic ovary syndrome than in women who do not have hyperandrogenism.

  2010cited by this paper
• Antidiabetic effects of fermented soybean products on type 2 diabetes.

  2010cited by this paper
• Managing Highly Insulin-Resistant Diabetes Mellitus: Weight Loss Approaches and Medical Management

  2010cited by this paper
• Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation.

  2010cited by this paper
• Lipodystrophy, lipid profile changes, and low serum retinol and carotenoid levels in children and adolescents with acquired immunodeficiency syndrome.

  2010cited by this paper
• The antidiabetic plants Tecoma stans (L.) Juss. ex Kunth (Bignoniaceae) and Teucrium cubense Jacq (Lamiaceae) induce the incorporation of glucose in insulin-sensitive and insulin-resistant murine and human adipocytes.

  2010cited by this paper
• Amelioration of streptozotocin‐induced diabetes mellitus, oxidative stress and dyslipidemia in rats by tomato extract lycopene

  2009cited by this paper
• Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator‐activated receptor (PPAR), adipocyte differentiation and insulin‐stimulated glucose uptake

  2009cited by this paper
• [Homeostasis model assessment (HOMA) values in Chilean elderly subjects].

  2009cited by this paper
• St. John's Wort inhibits adipocyte differentiation and induces insulin resistance in adipocytes.

  2009cited by this paper
• Effect of Cinnamon (Cinnamomum Cassia) intervention on Blood Glucose of Middle Aged Adult Male with Non Insulin Dependent Diabetes Mellitus (NIDDM)

  2009cited by this paper
• Intestinal Drug Transport Enhancement by Aloe vera

  2009cited by this paper
• Garlic and its potential for prevention of colorectal cancer and other conditions

  2009cited by this paper
• Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients

  2009cited by this paper
• Preparation and antioxidant activity of green tea extract enriched in epigallocatechin (EGC) and epigallocatechin gallate (EGCG).

  2009cited by this paper
• [The metabolic syndrome: can nutrition influence rebellious organs?].

  2009cited by this paper
• Improved Insulin Sensitivity After Exercise: Focus on Insulin Signaling

  2009cited by this paper
• [Obesity and the metabolic syndrome: a new epidemic].

  2009cited by this paper
• Effect of flavonol glycosides from Cinnamomum osmophloeum leaves on adiponectin secretion and phosphorylation of insulin receptor-beta in 3T3-L1 adipocytes.

  2009cited by this paper
• [Effects and mechanisms of total flavonoids of Litsea coreana on insulin resistance in rats with hyperlipidemia].

  2009cited by this paper
• Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women.

  2009cited by this paper
• Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro.

  2009cited by this paper
• Primary pioglitazone failure in Asian Indian diabetics is not related to common Pro12Ala polymorph of PPAR-gamma gene.

  2009cited by this paper
• Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats.

  2009cited by this paper
• The effect of high-fructose corn syrup consumption on triglycerides and uric acid.

  2009cited by this paper
• Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice.

  2008cited by this paper
• Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain

  2008cited by this paper
• Saponins isolated from the root of Panax notoginseng showed significant anti-diabetic effects in KK-Ay mice.

  2008cited by this paper
• Dietary chia seed (Salvia hispanica L.) rich in α-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats

  2008cited by this paper
• [Effects of oligofructose containing diet in obese persons].

  2008cited by this paper
• Botanicals and the metabolic syndrome.

  2008cited by this paper
• Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats

  2008cited by this paper
• Bmc Complementary and Alternative Medicine Pharmacokinetic and Metabolic Effects of American Ginseng (panax Quinquefolius) in Healthy Volunteers Receiving the Hiv Protease Inhibitor Indinavir

  2008cited by this paper
• A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase.

  2008cited by this paper
• Effect of Withania somnifera on insulin sensitivity in non-insulin-dependent diabetes mellitus rats.

  2008cited by this paper
• Role of multi-component functional foods in the complex treatment of patients with advanced breast cancer.

  2007cited by this paper
• Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women.

  2007cited by this paper
• The metabolic syndrome and vascular disease in Asia.

  2007cited by this paper
• Resveratrol: From Basic Science to the Clinic

  2007cited by this paper
• Inflammation, obesity and comorbidities: the role of diet

  2007cited by this paper
• A review of the “mysterious” wasting disease in swedish moose (Alces alces L.) related to molybdenosis and disturbances in copper metabolism

  2007cited by this paper
• Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue

  2007cited by this paper
• Green tea attenuates diabetes induced Maillard-type fluorescence and collagen cross-linking in the heart of streptozotocin diabetic rats.

  2007cited by this paper
• Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma.

  2006cited by this paper
• Insulin resistance in children and adolescents after bone marrow transplantation for malignancies.

  2006cited by this paper
• The glycemic index. A current controversy.

  2006cited by this paper
• The glycemic index. A current controversy.

  2006cited by this paper
• Improvement of insulin resistance by miracle fruit (Synsepalum dulcificum) in fructose‐rich chow‐fed rats

  2006cited by this paper
• Green tea leaf extract improves lipid and glucose homeostasis in a fructose-fed insulin-resistant hamster model.

  2006cited by this paper
• A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes

  2006cited by this paper
• The Effects of Grapefruit on Weight and Insulin Resistance: Relationship to the Metabolic Syndrome

  2006cited by this paper
• Difference in dietary intake between women with polycystic ovary syndrome and healthy controls.

  2006cited by this paper
• Insulin sensitizing property of Indigofera mysorensis extract.

  2006cited by this paper
• Insulin and insulin resistance.

  2005cited by this paper
• Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats.

  2005cited by this paper
• “Agouti NOD”: identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells

  2005cited by this paper
• Effects of rice bran oil on plasma lipid concentrations, lipoprotein composition, and glucose dynamics in mares.

  2005cited by this paper
• Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana.

  2005cited by this paper
• Production of mouse adiponectin, an anti-diabetic protein, in transgenic sweet potato plants.

  2005cited by this paper
• Tea Catechin Suppresses Adipocyte Differentiation Accompanied by Down-regulation of PPARγ2 and C/EBPα in 3T3-L1 Cells

  2004cited by this paper
• Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells.

  2004cited by this paper
• [Xylitol production from corn cob hemicellulosic hydrolysate by Candida sp].

  2004cited by this paper
• Improvement of Insulin Resistance and Insulin Secretion by Water Extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% Pancreatectomized Rats

  2004cited by this paper
• Dietary PUFA and the metabolic syndrome in Indian Asians living in the UK

  2004cited by this paper
• Polyunsaturated Fatty Acids, Insulin Resistance, and Atherosclerosis: Is Inflammation the Connecting Link?

  2004cited by this paper
• Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model

  2004cited by this paper
• Dietary Flaxseed Meal is More Protective Than Soy Protein Concentrate Against Hypertriglyceridemia and Steatosis of the Liver in an Animal Model of Obesity

  2003cited by this paper
• Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet.

  2003cited by this paper
• Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats.

  2002cited by this paper
• Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

  2002cited by this paper
• Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats.

  2001cited by this paper

• Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

  2020cites this paper
• PHYTOCHEMICAL EVALUATION AND ANTIOXIDANT SCREENING STUDIES OF OCIMUM TENUIFLORUM LINN SEEDS

  2017cites this paper
• A Mini Review on Wheatgrass

  2016cites this paper
• Wheatgrass (Triticum aestivum); A Super Herb

  2015cites this paper
• New Interventions and Emerging Trends in the Treatment of Diabetes

  2015cites this paper
• Medicinal plant Tulasi and its Uses

  2015cites this paper
• Research and Reviews; Journal of Pharmaceutics and Nanotechnology

  2015cites this paper
• Commentary to: Transcriptomics in Aid to the Establishment of Secondary Metabolic Pathways in Non-Model Plants

  2015cites this paper