VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Blood

• Publication date

  2002-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V99.7.2532PMID 11895790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

  2001cited by this paper
• High levels of vascular endothelial growth factor receptor-2 correlate with shortened survival in chronic lymphocytic leukemia.

  2001cited by this paper
• Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through Phosphatidylinositol 3-Kinase-dependent Pathways*

  2001cited by this paper
• Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes.

  2000cited by this paper
• Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase*

  2000cited by this paper
• Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration.

  2000cited by this paper
• Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

  2000cited by this paper
• Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines.

  2000cited by this paper
• Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis.

  2000cited by this paper
• Hsp27 negatively regulates cell death by interacting with cytochrome c

  2000cited by this paper
• Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation*

  2000cited by this paper
• Human myeloid and lymphoid malignancies in the non-obese diabetic/severe combined immunodeficiency mouse model: frequency of apoptotic cells in solid tumors and efficiency and speed of engraftment correlate with vascular endothelial growth factor production.

  2000cited by this paper
• Heat-shock proteins inhibit induction of prostate cancer cell apoptosis.

  2000cited by this paper
• Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90

  2000cited by this paper
• Vascular endothelial growth factor (VEGF) and its receptors

  1999cited by this paper
• Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia.

  1999cited by this paper
• Hsp60 accelerates the maturation of pro‐caspase‐3 by upstream activator proteases during apoptosis

  1999cited by this paper
• Regulation of Transendothelial Migration of Hematopoietic Progenitor Cells

  1999cited by this paper
• The Role of Phosphatidylinositol 3-Kinase in Vascular Endothelial Growth Factor Signaling*

  1999cited by this paper
• Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression.

  1999cited by this paper
• Prothymosin alpha.

  1999cited by this paper
• Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor.

  1998cited by this paper
• Vascular endothelial growth factor (VEGF) activates Raf‐1, mitogen‐activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes

  1998cited by this paper
• Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells*

  1998cited by this paper
• The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase*

  1997cited by this paper
• Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia.

  1997cited by this paper
• Angiogenesis and angiogenesis inhibition: an overview.

  1997cited by this paper
• The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase.

  1997cited by this paper

• Implementation of Natural Products and Derivatives in Acute Myeloid Leukemia Management: Current Treatments, Clinical Trials and Future Directions

  2026cites this paper
• Beneficial Handling of Molecular Chaperones (Chaperonotherapy) in Glioblastoma and Neuroblastoma: Novel Therapeutic Targets or Potential Agents?

  2025cites this paper
• HSP90 and the cancer transcriptome: a comprehensive review of inhibitors and mechanistic insights

  2025cites this paper
• Single nuclear‐spatial transcriptomic sequencing reveals distinct puncture‐induced cell subpopulations in the intervertebral disc of a rat model

  2025cites this paper
• Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond

  2025cites this paper
• Necrosis as a fundamental driver of loss of resilience and biological decline: what if we could intervene?

  2025cites this paper
• Ang-1 and VEGF: central regulators of angiogenesis

  2024cites this paper
• Immunogenic cell death mediated TLR3/4-activated MSCs in U87 GBM cell line

  2024cites this paper
• [α2-macroglobulin alleviates glucocorticoid-induced avascular necrosis of the femoral head in mice by promoting proliferation, migration and angiogenesis of vascular endothelial cells].

  2024cites this paper
• Mesenchymal Stem Cells in Cancer Therapy.

  2024cites this paper
• Role of heat shock proteins in oncogenesis and strategy for treating cancers using Drosophila model

  2023cites this paper
• Aerobic training and vitamin E administration ameliorates cardiac apoptosis markers in rats exposed to methamphetamine

  2023cites this paper
• Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

  2023cites this paper
• Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment.

  2023cites this paper
• A potential area of use for immune checkpoint inhibitors: Targeting bone marrow microenvironment in acute myeloid leukemia

  2023cites this paper
• Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment

  2022cites this paper
• Tumor microenvironment antigens

  2022cites this paper
• Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance

  2022cites this paper
• Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells

  2022cites this paper
• BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma

  2022cites this paper
• High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model

  2021cites this paper
• Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

  2021cites this paper
• Effect of mesenchymal stem cell in liver regeneration and clinical applications

  2021cites this paper
• Evaluation of molecular mechanisms of heparin-induced angiogenesis, in human umbilical vein endothelial cells

  2021cites this paper
• Genetically-Modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era.

  2021cites this paper
• Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities

  2021cites this paper
• Modulating Angiogenesis by Proteomimetics of Vascular Endothelial Growth Factor.

  2021cites this paper
• Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

  2021cites this paper
• Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

  2021cites this paper
• Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

  2020cites this paper
• A Review of Bioactive Peptides: Chemical Modification, Structural Characterization and Therapeutic Applications.

  2020cites this paper
• Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors

  2020cites this paper
• Mesenchymal Stem Cells in the Tumor Microenvironment.

  2020cites this paper
• Mesenchymal stem cells to treat liver diseases

  2020cites this paper
• Angiocrine endothelium: from physiology to cancer

  2020cites this paper
• The molecular chaperone Hsp90α deficiency causes retinal degeneration by disrupting Golgi organization and vesicle transportation in photoreceptors

  2019cites this paper
• Profiling of functional intercellular interactions in a model of the leukemia microenvironment

  2019cites this paper
• NDT_A_229296 3041..3050

  2019cites this paper
• Stress and catecholamines modulate the bone marrow microenvironment to promote tumorigenesis

  2019cites this paper
• Bidirectional and Opposite Effects of Naïve Mesenchymal Stem Cells on Tumor Growth and Progression

  2019cites this paper
• Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model

  2019cites this paper
• HSP90: A Key Player in Metal-Induced Carcinogenesis?

  2019cites this paper
• Adipose tissue-derived mesenchymal stem cells cultured at high density express IFN-β and TRAIL and suppress the growth of H460 human lung cancer cells.

  2019cites this paper
• Human Amniotic Membrane and Its Anti-cancer Mechanism: a Good Hope for Cancer Therapy

  2019cites this paper
• Multifunctional Magnetic Nanoplatform Eliminates Cancer Stem Cells via Inhibiting the Secretion of Extracellular Heat Shock Protein 90

  2019cites this paper
• VEGFR2 survival and mitotic signaling depends on joint activation of associated C3ar1/C5ar1 and IL-6R–gp130

  2019cites this paper
• VEGFR2-Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy.

  2018cites this paper
• Effect of recombinant vascular endothelial growth factor and translationally controlled tumor protein on 2‑hydroxyethyl methacrylate‑treated pulp cells.

  2018cites this paper
• Heat‐shock protein B1 upholds the cytoplasm reduced state to inhibit activation of the Hippo pathway in H9c2 cells

  2018cites this paper
• VEGF signaling in acute leukemia: mitochondrial connections

  2018cites this paper
• Apoptosis of colon cancer cells under the effect of geldanamycin derivate.

  2017cites this paper
• Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells

  2017cites this paper
• Vascular endothelial growth receptor 1 acts as a stress-associated protein in the therapeutic response to thalidomide

  2017cites this paper
• miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.

  2017cites this paper
• Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells

  2017influential citation
• In vitro investigation of the effect of matrix molecules on the behavior of colon cancer cells under the effect of geldanamycin derivative

  2017cites this paper
• MicroRNA-370 suppresses the retinal capillary endothelial cell growth by targeting KDR gene.

  2017cites this paper
• Angiogenesis Status in Patients with Acute Myeloid Leukemia: From Diagnosis to Post-hematopoietic Stem Cell Transplantation

  2017cites this paper
• Protein network related to unfavorable prognosis in Acute Myeloid Leukemia

  2017cites this paper
• Myeloid malignancies and the microenvironment.

  2017cites this paper
• MYELOID NEOPLASIA miR-125 b promotes MLL-AF 9 – driven murine acute myeloid leukemia involving a VEGFA-mediated non – cell-intrinsic mechanism

  2017cites this paper
• Advances in understanding the pathogenesis of CNS acute lymphoblastic leukaemia and potential for therapy

  2017cites this paper
• Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells.

  2016cites this paper
• MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma.

  2016cites this paper
• Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma.

  2016cites this paper
• COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo

  2016cites this paper
• CRYOIMAGING-MICROSCOPY IMPLEMENTATION FOR 3 D OPTICAL IMAGING by

  2016cites this paper
• Molecular Chaperones and Ubiquitin Proteasome System in Tumor Biogenesis: An Overview

  2016cites this paper
• Selective Toxicity and Angiogenic Inhibition by Euglenophycin: A Role in Cancer Therapy?

  2016cites this paper
• Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90

  2016cites this paper
• Anti-cancer activity of withaferin A in B-cell lymphoma

  2015influential citation
• MicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma.

  2015cites this paper
• BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma.

  2015cites this paper
• Up-regulation of VEGF and its receptor in refractory leukemia cells.

  2015cites this paper
• Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression

  2015cites this paper
• Endothelium Expression of Bcl-2 Is Essential for Normal and Pathological Ocular Vascularization

  2015cites this paper
• Optical cryoimaging of mitochondrial redox state in bronchopulmonary-dysplasia injury models in mice lungs.

  2015cites this paper
• A phase II study of AZD2171 (cediranib) in the treatment of patients with acute myeloid leukemia or high-risk myelodysplastic syndrome

  2015cites this paper
• Role of tumour angiogenesis in haematological malignancies.

  2014cites this paper
• Advances in understanding the leukaemia microenvironment

  2014cites this paper
• Upregulated autocrine vascular endothelial growth factor (VEGF)/VEGF receptor‐2 loop prevents apoptosis in haemangioma‐derived endothelial cells

  2014cites this paper
• VEGF-VEGFR Signals in Health and Disease

  2014cites this paper
• L'hyperthermie provoque l'agrégation de FLIP et restaure l'apoptose induite par TRAIL

  2014cites this paper
• 1+1=? Combinations and combination strategies in early cancer-drug development

  2014cites this paper
• (Lymph)angiogenic influences on hematopoietic cells in acute myeloid leukemia

  2014cites this paper
• Treatment patterns, outcomes, and resource utilization of patients with metastatic melanoma in the U.K.: the MELODY study

  2014cites this paper
• Production of functional human vascular endothelial growth factor(165) in transgenic rice cell suspension cultures.

  2014cites this paper
• Crosstalk Between VEGF and Bcl-2 in Tumor Progression and Angiogenesis

  2013cites this paper
• in therapy Farnesyltransferase inhibitors in hematologic malignancies: new horizons

  2013cites this paper
• Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF

  2013cites this paper
• Antiangiogenic approach in soft-tissue sarcomas

  2013cites this paper
• Inhibition of leukemic U937 cell growth by induction of apoptosis, cell cycle arrest and suppression of VEGF, MMP-2 and MMP-9 activities by cytotoxin protein NN-32 purified from Indian spectacled cobra (Naja naja) venom.

  2013cites this paper
• One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment

  2013cites this paper
• against apoptosis VEGF induces MCL-1 upregulation and protects multiple myeloma cells

  2013cites this paper
• erythroleukemic cells inflammatory mediators accelerating the expansion of murine The splenic microenvironment is a source of pro-angiogenesis /

  2013cites this paper
• Inhibition of HSP90 molecular chaperones: moving into the clinic.

  2013cites this paper
• Factor plasma level in patients with Chronic Myeloid Leukemia Imatinib Mesylate (STI571) decreases the Vascular Endothelial Growth

  2013cites this paper
• Water soluble Pleurotus ostreatus polysaccharide down-regulates the expression of MMP-2 and MMP-9 in Caco-2 cells.

  2013cites this paper
• Contribution of the intracellular cholesterol levels for the expression of VEGF-C and VEGFR-3 in acute myeloid leukemia

  2013cites this paper
• Angiogenesis as a treatment target in leukemia

  2013cites this paper