The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular Biology of the Cell

• Publication date

  2001-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.12.7.1911PMID 11451992PMCID PMC55639
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dissection of a Nuclear Localization Signal*

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  1999influential reference
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  1998influential reference
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