Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  2000-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JCEM.85.10.6915PMID 11061527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Parental origin of the extra chromosome in prenatally diagnosed fetal trisomy 21

  2000cited by this paper
• Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro.

  1999cited by this paper
• Integrated screening for Down's syndrome based on tests performed during the first and second trimesters.

  1999cited by this paper
• Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro.

  1998cited by this paper
• hCG, its free subunits and its metabolites. Roles in pregnancy and trophoblastic disease.

  1998cited by this paper
• Hyperglycosylated hcg, a potential alternative to hcg in Down syndrome screening

  1998cited by this paper
• Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans

  1997cited by this paper
• The effect of hypoxia on human trophoblast in culture: morphology, glucose transport and metabolism.

  1997cited by this paper
• Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation

  1996cited by this paper
• Use of sonographic markers to determine the risk of Down syndrome in second-trimester fetuses.

  1996cited by this paper
• Gene expression of human pregnancy-associated plasma protein-A in placenta from trisomic pregnancies.

  1996cited by this paper
• Dexamethasone stimulates gap junctional communication, peptide hormones production and differentiation in human term trophoblast

  1996cited by this paper
• Screening of fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation

  1996influential reference
• Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation.

  1996cited by this paper
• Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro

  1996influential reference
• A novel method for real time quantitative RT-PCR.

  1996cited by this paper
• Molecular interactions during pregnancy: Placental expression of α and β subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome

  1995cited by this paper
• Glucose inhibits human placental GH secretion, in vitro.

  1995cited by this paper
• High maternal serum chorionic gonadotropin level in Downs' syndrome pregnancies is caused by elevation of both subunits messenger ribonucleic acid level in trophoblasts.

  1995influential reference
• Placental expression of alpha and beta subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome.

  1995cited by this paper
• Placental expression of α and β subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome

  1995cited by this paper
• Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin.

  1994cited by this paper
• Regulation of chorionic gonadotropin gene expression.

  1993cited by this paper
• Prospective maternal serum human chorionic gonadotropin screening for the risk of fetal chromosome anomalies and of subsequent fetal and neonatal deaths

  1993cited by this paper
• Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts.

  1993cited by this paper
• Improved performance in a prenatal screening programme for Down's syndrome incorporating serum‐free hCG subunit analyses

  1992cited by this paper
• Human placental growth hormone.

  1992influential reference
• Clinical counterpoint: the physiology of placental lactogen in human pregnancy.

  1991cited by this paper
• Transforming growth factor beta 1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion.

  1991cited by this paper
• Parathyroid hormone increases epidermal growth factor receptors in cultured human trophoblastic cells from early and term placenta.

  1991influential reference
• Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms. Down Syndrome Collaborative Group.

  1991cited by this paper
• Maternal serum unconjugated oestriol as an antenatal screening test for Down's syndrome

  1988cited by this paper
• Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities

  1987cited by this paper
• Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae.

  1986influential reference
• An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities

  1984cited by this paper
• An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities.

  1984cited by this paper
• Le placenta des trisomies dans le dernier trimestre de la gestation

  1983cited by this paper
• The Placenta Found in Trisomies in the Last Trimester of Pregnancy

  1983cited by this paper
• [The placenta in trisomy in the last trimester of pregnancy].

  1983cited by this paper

• The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome

  2025cites this paper
• Placental somatic mutation in human stillbirth and live birth: A pilot case-control study of paired placental, fetal, and maternal whole genomes.

  2024cites this paper
• Biochemical Screening for Fetal Trisomy 21: Pathophysiology of Maternal Serum Markers and Involvement of the Placenta

  2023cites this paper
• Does the interplay between human endogenous retrovirus K and extracellular vesicles contribute to aging?

  2023cites this paper
• Embryonic Statistical Analyses Reveal Two Growth Phenotypes in Mouse Models of Down Syndrome.

  2023cites this paper
• Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta

  2022cites this paper
• Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

  2022cites this paper
• Impact of fetal trisomy 21 on umbilical artery Doppler indices

  2021cites this paper
• Characterization of methylation signatures in spontaneous preterm birth

  2021cites this paper
• Title : Characterization of methylation signatures in spontaneous preterm birth

  2021cites this paper
• Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes.

  2020cites this paper
• Placental development and function in trisomy 21 and mouse models of Down syndrome: Clues for studying mechanisms underlying atypical development.

  2019cites this paper
• The significance of the placental genome and methylome in fetal and maternal health

  2019cites this paper
• Study of Human T21 Placenta Suggests a Potential Role of Mesenchymal Spondin-2 in Placental Vascular Development.

  2019cites this paper
• Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome

  2019cites this paper
• Role of Maternal Serum Human Placental Lactogen in First Trimester Screening

  2018cites this paper
• Spontaneous and IVF pregnancies have comparable first trimester screening profiles for Down syndrome

  2018cites this paper
• The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimester screening test results

  2018cites this paper
• Human Placental Growth Hormone Variant in Pathological Pregnancies.

  2018cites this paper
• Эндокринные аспекты функционирования фетоплацентарного комплекса (обзор литературы)

  2017cites this paper
• Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology

  2017cites this paper
• Contribution of Syncytins and Other Endogenous Retroviral Envelopes to Human Placenta Pathologies.

  2017cites this paper
• The role of cellular senescence in ageing of the placenta.

  2017cites this paper
• Differentially expressed miRNAs in trisomy 21 placentas

  2016cites this paper
• First trimester combined screening – focus on early biochemistry

  2016cites this paper
• Expression and function of endogenous retroviruses in the placenta

  2016influential citation
• Detecting Down syndrome pregnancies and preeclampsia

  2015cites this paper
• A novel regulator of human villous trophoblast fusion: the Krüppel-like factor 6.

  2015cites this paper
• Changes in first trimester screening test parameters in pregnancies complicated by placenta previa and association with hyperemesis gravidarum.

  2014cites this paper
• Pattern of secretion of pregnancy-associated plasma protein-A (PAPP-A) during pregnancies complicated by fetal aneuploidy, in vivo and in vitro

  2014cites this paper
• Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation

  2014cites this paper
• Review: Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta.

  2012cites this paper
• Distal villous immaturity

  2012cites this paper
• Comparative expression of hCG β-genes in human trophoblast from early and late first-trimester placentas.

  2012cites this paper
• EG-VEGF controls placental growth and survival in normal and pathological pregnancies: case of fetal growth restriction (FGR)

  2012cites this paper
• Homeobox gene Distal-Less 3 is a regulator of villous cytotrophoblast differentiation and its expression is increased in human idiopathic foetal growth restriction

  2012cites this paper
• First trimester prenatal screening among women pregnant after IVF/ICSI.

  2012cites this paper
• Interaction between the ovine Bst-2 paralogs and sheep Betaretroviruses

  2012cites this paper
• hCG, five independent molecules.

  2012cites this paper
• Endokrinologie der humanen Plazenta

  2012cites this paper
• Growth in Individuals with Down Syndrome

  2012cites this paper
• Extragonadal actions of chorionic gonadotropin

  2011cites this paper
• Mesenchymal activin-A overcomes defective human trisomy 21 trophoblast fusion.

  2011cites this paper
• 2D DIGE analysis of maternal plasma for potential biomarkers of Down Syndrome

  2011cites this paper
• Innovations in Down Syndrome Screening

  2011cites this paper
• Abnormal spiral artery remodelling in the decidual segment during pregnancy: from histology to clinical correlation

  2011cites this paper
• Noninvasive Prenatal Nucleic Acid Diagnostics of Down Syndrome

  2011cites this paper
• Syncytins expression in cultured trophoblast cells according to differentiation status

  2011cites this paper
• New insights into the mechanisms and roles of cell-cell fusion.

  2011cites this paper
• Hyperglycosylated hCG, a review.

  2010cites this paper
• Possible Effect of Histamine in Physiology of Female Reproductive Function: An Updated Review

  2010cites this paper
• Proteomics and Down syndrome screening: a validation study

  2010cites this paper
• Down syndrome screening: imagining the screening test of the future

  2010cites this paper
• Trisomy 21- affected placentas highlight prerequisite factors for human trophoblast fusion and differentiation.

  2010cites this paper
• Hyperglycosylated hCG is a marker of early human trophoblast invasion.

  2010cites this paper
• hCG, Hyperglycosylated hCG, and Free ß-Subunit in Predicting Down Syndrome Pregnancies and Preeclampsia

  2010cites this paper
• ZO-1 is involved in trophoblastic cell differentiation in human placenta.

  2010cites this paper
• Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes

  2010cites this paper
• Reference centile chart for fetal nuchal translucency, maternal serum PAPP-A and free beta hCG.

  2010cites this paper
• Maternal Serum Placental Protein 13 at Eleven to Thirteen Weeks in Chromosomally Abnormal Pregnancies

  2010cites this paper
• Maternal serum human placental growth hormone at 11 to 13 weeks in trisomy 21 and trisomy 18 pregnancies

  2010influential citation
• Dépistage de la trisomie 21 fœtale par les marqueurs sériques maternels

  2009cites this paper
• Involvement of MAPK signalling in human villous trophoblast differentiation.

  2009cites this paper
• Gestational related morphological abnormalities in placental villous trophoblast turnover in compromised pregnancies

  2009influential citation
• [Human trophoblast differentiation].

  2009cites this paper
• Placental weight in pregnancies with trisomy confined to the placenta.

  2009cites this paper
• Expression and regulation by PPARgamma of hCG alpha- and beta-subunits: comparison between villous and invasive extravillous trophoblastic cells.

  2009cites this paper
• Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene

  2009cites this paper
• Comparative Methylation of ERVWE1/Syncytin-1 and Other Human Endogenous Retrovirus LTRs in Placenta Tissues

  2009cites this paper
• Placental protein 13 as a first trimester screening marker for aneuploidy

  2009cites this paper
• Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome

  2009cites this paper
• Increased levels of human placental growth hormone in the amniotic fluid of pregnancies affected by Down syndrome.

  2009cites this paper
• Maternal serum screening in cases of mosaic and translocation Down syndrome

  2008cites this paper
• PLAC4 and β‐HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21

  2008cites this paper
• Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights.

  2008cites this paper
• Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta

  2008cites this paper
• Oxygen, the Janus gas; its effects on human placental development and function

  2008influential citation
• Vitamins C and E inhibit apoptosis of cultured human term placenta trophoblast.

  2008cites this paper
• Human Placental Growth Hormone Is Increased in Maternal Serum in Pregnancies Affected by Down Syndrome

  2008cites this paper
• Analysis of the promoter region of human placenta-specific DSCR4 gene.

  2008cites this paper
• HISTOLOGICAL ABNORMALITIES OF THE PLACENTA

  2007cites this paper
• Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.

  2007cites this paper
• Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-gamma.

  2007cites this paper
• Rôle de PPARγ dans le développement du placenta humain

  2007cites this paper
• Human chorionic gonadotropin expression in human trophoblasts from early placenta: comparative study between villous and extravillous trophoblastic cells.

  2007cites this paper
• Hyperglycosylated hCG.

  2007cites this paper
• Human placental lactogen is a first‐trimester maternal serum marker of Down syndrome

  2007cites this paper
• Biochemical characterization and modulation of LH/CG—receptor during human trophoblast differentiation

  2007cites this paper
• Hyperglycosylated hCG: a variant with separate biological functions to regular hCG.

  2007cites this paper
• Therapies and rehabilitation in Down syndrome

  2007cites this paper
• Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells.

  2007cites this paper
• Stratégie d'exploration fonctionnelle et de suivi thérapeutique Les raisons de l'élévation de l'hCG dans le sérum de mères porteuses d'un fœtus trisomique Reasons of increased level of hCG in the serum of mothers bearing a trisomic fœtus

  2006cites this paper
• Les raisons de l'élévation de l'hCG dans le sérum de mères porteuses d'un fœtus trisomique

  2006influential citation
• CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues.

  2006cites this paper
• ADAM12‐s in coelomic fluid and maternal serum in early pregnancy

  2006cites this paper
• Localized expression of histamine H1 receptors in syncytiotrophoblast cells of human placenta.

  2006cites this paper
• Increased human placental growth hormone at midtrimester pregnancies may be an index of intrauterine growth retardation related to preeclampsia.

  2006cites this paper
• Aspects of placental growth hormone physiology.

  2006cites this paper
• Perinatal Loss of Ts65Dn Down Syndrome Mice

  2006cites this paper
• Validating a rapid method for detecting common polymorphisms in the APOA5 gene by melting curve analysis using LightTyper.

  2005cites this paper