The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell Metabolism

• Publication date

  2015-07-07

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.cmet.2015.06.001PMID 26154056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
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  2006cited by this paper
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  2006cited by this paper
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  2001cited by this paper

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