Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Blood

• Publication date

  1997-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V89.8.2986PMID 9108419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bax-independent inhibition of apoptosis by Bcl-XL

  1996cited by this paper
• Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia.

  1996cited by this paper
• bcl-2 expression in myelodysplastic syndromes and its correlation with hematological features, p53 mutations and prognosis.

  1995cited by this paper
• Bcl-XL and Bcl-2 repress a common pathway of cell death

  1995cited by this paper
• Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

  1995cited by this paper
• Bclx regulates the survival of double-positive thymocytes.

  1995cited by this paper
• Primitive human hematopoietic precursors express Bcl-x but not Bcl-2.

  1995cited by this paper
• Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone.

  1995cited by this paper
• Bcl-XL protects cancer cells from p53-mediated apoptosis.

  1995cited by this paper
• Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer.

  1995cited by this paper
• Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.

  1995cited by this paper
• Expression of bcl-xL can confer a multidrug resistance phenotype.

  1995cited by this paper
• Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death.

  1995cited by this paper
• Human gliomas with wild-type p53 express bcl-2.

  1995cited by this paper
• Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation.

  1995cited by this paper
• Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia.

  1995cited by this paper
• Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.

  1995cited by this paper
• Apoptosis in cancer therapy: crossing the threshold.

  1994cited by this paper
• Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways.

  1994cited by this paper
• BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

  1994cited by this paper
• Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines.

  1994cited by this paper
• Bcl-2 blocks p53-dependent apoptosis

  1994cited by this paper
• Down-regulation of bcl-2 by p53 in breast cancer cells.

  1994cited by this paper
• bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria.

  1994cited by this paper
• Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

  1994cited by this paper
• Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

  1994cited by this paper
• High expression of bcl-2 is the rule in acute lymphoblastic leukemia, except in Burkitt subtype at presentation, and is not correlated with the prognosis

  1994cited by this paper
• Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

  1994cited by this paper
• p53 status and the efficacy of cancer therapy in vivo.

  1994cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Immunohistochemical detection of p53 and bcl‐2 proteins in non‐Hodgkin's lymphoma

  1993cited by this paper
• Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line.

  1993cited by this paper
• bcl-2 protein in non-small-cell lung carcinoma.

  1993cited by this paper
• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

  1993cited by this paper
• High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy.

  1993cited by this paper
• Bcl-2 initiates a new category of oncogenes: regulators of cell death.

  1992cited by this paper
• Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.

  1992cited by this paper
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

  1991cited by this paper
• Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.

  1991cited by this paper
• Effect of tumor necrosis factor-alpha on the proliferation of leukemic cells from children with B-cell precursor-acute lymphoblastic leukemia (BCP-ALL): studies of primary leukemic cells and BCP-ALL cell lines.

  1991cited by this paper
• Drug-target interactions: only the first step in the commitment to a programmed cell death?

  1991cited by this paper
• Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

  1990cited by this paper
• Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes.

  1982cited by this paper
• Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes

  1982cited by this paper

• Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era

  2025cites this paper
• Biomarkers of Response to Venetoclax Therapy in Acute Myeloid Leukemia

  2024cites this paper
• Time-Dependent Molecular Changes Following MDMA-Induced Nephrotoxicity

  2024cites this paper
• IKZF1 and BTG1 silencing reduces glucocorticoid response in B-cell precursor acute leukemia cell line

  2024cites this paper
• The interaction of interferon gamma and gaillardin and the formation of a nanocomplex with improved anti-melanoma effects.

  2024cites this paper
• Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy

  2024cites this paper
• The Cytotoxicity Effect of Recombinant Arazyme on Breast and Ovarian Cancer Cells

  2023cites this paper
• Role of reactive oxygen species: in the cytotoxicity and apoptosis on colon cancer cell line due to green lead nanoparticles

  2023cites this paper
• Cannabis sativa a Potential Anticancer Treatment in Melanoma Cancer Cells

  2023cites this paper
• Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR ^L858R/T790M as antiproliferative and apoptotic agents

  2023cites this paper
• Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

  2022cites this paper
• The Cytotoxicity and Anticancer Effects of Propolis against the Oral Squamous Cell Carcinoma: In Vitro Study

  2022cites this paper
• PRODUCTION AND CHARACTERIZATION OF GALLIC ACID WITH Streptomyces olivochromogenes ISOLATED FROM CASHEW NUT SHELL LIQUID (CNSL) DEPOSITED SOIL

  2022cites this paper
• Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells

  2022cites this paper
• Inhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy.

  2022cites this paper
• Targeting the Mitochondrial Permeability Transition Pore for Drug Discovery: Challenges and Opportunities.

  2022cites this paper
• Neuroprotective effect of thiamine triethylorthoformate conjugate against Parkinson disease in a mouse model

  2021cites this paper
• The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line

  2021cites this paper
• Effect of Grape Seeds (Vitis vinifera L.) and Mandarin Peels (Citrus reticulate L.) Extracts on the Cardiotoxicity Induced by Cyclophosphamide in Rats

  2021cites this paper
• Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas

  2021cites this paper
• Effect of Mimic Hypoxia on the Proliferation and Expression of miR-27a, miR-9, miR-370 and their Target Genes in MOLT-4 and KG1a Cell Lines

  2021cites this paper
• BH3-mimetics: recent developments in cancer therapy

  2021cites this paper
• Alternative splicing of BCL-X and implications for treating hematological malignancies

  2021influential citation
• Assessment of Antitumor Activity of Vinca herbacea on Human Ovarian Cancer Cell Line

  2021cites this paper
• Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors

  2021cites this paper
• Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR.

  2021cites this paper
• Cell-Permeable Bak BH3 Peptide Induces Chemosensitization of Hematologic Malignant Cells

  2020cites this paper
• IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity inhigh-risk B-cell acute lymphoblastic leukemia.

  2020cites this paper
• A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment

  2020cites this paper
• A Mouse Model of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Parkinson Disease Shows that 2-Aminoquinoline Targets JNK Phosphorylation

  2020cites this paper
• An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties.

  2020cites this paper
• In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies.

  2020cites this paper
• Discovery of Novel 3-Cyanopyridines as Survivin Modulators and Apoptosis Inducers

  2020cites this paper
• Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives

  2020cites this paper
• Efficacy and molecular mechanisms of the BH3-mimetic venetoclax (ABT-199) in pediatric acute lymphoblastic leukemia

  2020influential citation
• Anti-cancer effects of recombinant arazyme from Serratia Proteomaculans.

  2020cites this paper
• Understanding the evolutionary trend of intrinsically structural disorders in cancer relevant proteins as probed by Shannon entropy scoring and structure network analysis

  2019cites this paper
• Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy.

  2019cites this paper
• The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells.

  2019cites this paper
• Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.

  2019cites this paper
• Design, synthesis, cytotoxicity screening and molecular docking of new 3-cyanopyridines as survivin inhibitors and apoptosis inducers.

  2019cites this paper
• Methotrexate induced cell death mechanisms in MCF-7 adenocarcinoma breast cancer cells: Enhanced cytotoxicity following dff45-siRNA pre-treatment

  2018cites this paper
• Vicenin‐2 acts as a radiosensitizer of the non‐small cell lung cancer by lowering Akt expression

  2018cites this paper
• The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation

  2018cites this paper
• Hepatic protective effect of grape seed proanthocyanidin extract against Gleevec-induced apoptosis, liver Injury and Ki67 alterations in rats

  2018cites this paper
• Evaluation of BAX and BCL-2 Gene Expression and Apoptosis Induction in Acute Lymphoblastic Leukemia Cell Line CCRF-CEM after High- Dose Prednisolone Treatment

  2018cites this paper
• A Lentinus edodes polysaccharide induces mitochondrial-mediated apoptosis in human cervical carcinoma HeLa cells.

  2017cites this paper
• Augmentation of the cytotoxic effects of zinc oxide nanoparticles by MTCP conjugation: Non-canonical apoptosis and autophagy induction in human adenocarcinoma breast cancer cell lines.

  2017cites this paper
• Effects of curcumin on growth of human cervical cancer xenograft in nude mice and underlying mechanism

  2017cites this paper
• Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea

  2017cites this paper
• Can Cystic Fibrosis Patients Finally Catch a Breath With Lumacaftor/Ivacaftor?

  2017cites this paper
• Alpha-integrin expression and function modify chemoresistance and immunogenicity of acute lymphoblastic leukemia

  2017influential citation
• A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O-α-L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells

  2017cites this paper
• Induction of Apoptosis with Moringa oleifera Fruits in HCT116 Human Colon Cancer Cells Via Intrinsic Pathway

  2017cites this paper
• L-Tetrahydropalmatine Induces Apoptosis in EU-4 Leukemia Cells by Down-Regulating X-Linked Inhibitor of Apoptosis Protein and Increases the Sensitivity Towards Doxorubicin.

  2017cites this paper
• Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes.

  2017cites this paper
• Anti-proliferation of MDA-MB-231 cells by Averrhoa bilimbi extract is associated with G0/G1 perturbation and mitochondria-mediated apoptosis independent of p53

  2017cites this paper
• Silencing of FANCD2 enhances the radiosensitivity of metastatic cervical lymph node-derived head and neck squamous cell carcinoma HSC-4 cells.

  2017cites this paper
• Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines.

  2017cites this paper
• Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells

  2017cites this paper
• In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

  2017cites this paper
• Flavonoids isolated from Citrus platymamma induced G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells

  2016cites this paper
• Multiple Pharmacological Properties of a Novel Parthenin Analog P16 as Evident by its Cytostatic and Antiangiogenic Potential Against Pancreatic Adenocarcinoma PANC -1 Cells.

  2016cites this paper
• A new approach to high risk pediatric acute lymphoblastic leukemia

  2016cites this paper
• Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies

  2016cites this paper
• BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells

  2016cites this paper
• Apoptosis-Mediated Chemoprevention by Different Ratios of Fish Oil in Experimental Colon Carcinogenesis

  2016cites this paper
• Radiation response of head and neck squamous cell carcinoma using early markers of apoptosis and proliferation, utilising a microfluidic approach

  2016cites this paper
• A study of the potential anticancer activity of Mangifera zeylanica bark: Evaluation of cytotoxic and apoptotic effects of the hexane extract and bioassay-guided fractionation to identify phytochemical constituents

  2016cites this paper
• Cytotoxic effect of Cuscuta reflexa Roxb. and induction of apoptosis in human promyelocytic leukemia HL-60 cells

  2015cites this paper
• NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells

  2015cites this paper
• Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis resulting in B-cell lymphoma

  2015cites this paper
• Multiple outcomes for PI3K/Akt/mTOR targeting in non-Hodgkin lymphoma

  2015cites this paper
• Isoflavones Extracted from Chickpea Cicer arietinum L. Sprouts Induce Mitochondria‐Dependent Apoptosis in Human Breast Cancer Cells

  2015cites this paper
• The Simultaneous Effect of Valproic Acid and Gamma Radiation on Telomerase Activity and Bax and Bcl-2 Protein Levels in MCF-7 Breast Cancer Cell Line

  2015cites this paper
• (90)Y-labelled anti-CD22 epratuzumab tetraxetan in adults with refractory or relapsed CD22-positive B-cell acute lymphoblastic leukaemia: a phase 1 dose-escalation study.

  2015cites this paper
• Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells.

  2015cites this paper
• Antiproliferative potential of a novel parthenin analog P16 as evident by apoptosis accompanied by down-regulation of PI3K/AKT and ERK pathways in human acute lymphoblastic leukemia MOLT-4 cells.

  2014cites this paper
• Antiproliferative effects of Plumbago rosea and its purified constituent plumbagin on SK-MEL 28 melanoma cell lines

  2014cites this paper
• The Effect of Alisma orientale Extract on Free Fatty Acid-induced Lipoapoptosis in HepG2 Cells

  2014cites this paper
• Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells.

  2014cites this paper
• Leukemic Relapse Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of

  2013cites this paper
• Expression of Ki67, BCL-2, and COX-2 in Canine Cutaneous Mast Cell Tumors

  2013cites this paper
• Berberine Induces Apoptosis in p53-Null Leukemia Cells by Down-Regulating XIAP at the Post-Transcriptional Level

  2013cites this paper
• Breaking T-cell tolerance in chronic lymphocytic leukaemia

  2013cites this paper
• Chemopreventive effects of Ginkgo biloba extract in estrogen-negative human breast cancer cells

  2013cites this paper
• Assessing the effects of radiotherapy on head and neck squamous cell carcinoma using microfluidic techniques

  2013cites this paper
• Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production

  2012cites this paper
• ABERRANT EXPRESION OF TAL-1 INCREASES RESISTANCE TO APOPTOSIS IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA A THESIS SUBMITTED TO THE GRADUATE SCHOOL IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE MASTER OF SCIENCE BY GAVIN

  2012influential citation
• Drug Resistance in Leukemia and Lymphoma III

  2012cites this paper
• Triptolide Inhibits MDM2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p53-Independent Pathway

  2012cites this paper
• Triptolide Inhibits MDM 2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p 53-Independent Pathway

  2012cites this paper
• The mechanisms of anticancer agents by genistein and synthetic derivatives of isoflavone.

  2012cites this paper
• BCL 2 L 1 ( BCL 2-like 1 )

  2012cites this paper
• Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.

  2012cites this paper
• Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer.

  2012cites this paper
• Vitamin C induces apoptosis in AGS cells by down-regulation of 14-3-3σ via a mitochondrial dependent pathway.

  2012cites this paper
• APOLIPROTEIN(A)-INDUCED APOPTOSIS IN VASCULAR ENDOTHELIAL CELLS

  2011cites this paper
• Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells

  2011cites this paper
• Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis.

  2011cites this paper