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Carbohydrate metabolism of the liver of the hypophysectomized rat.

R. Hill,J. W. Bauman,I. Chaikoff

Published 1957 in Journal of Biological Chemistry

ABSTRACT

The livers of hypophysectomized rats fed a diet adequate in all respects, and containing whole ground wheat as its main carbohydrate source, show an impaired ability to convert acetate carbon to fatty acids (1). This defect in lipogenesis can be readily overcome by feeding these rats, for a few days, a synthetic diet containing either 60 per cent glucose or 60 per cent starch. The importance, in this connection, of large amounts of available carbohydrate was further emphasized by the observation that feeding hypophysectomized rats a diet containing only 25 per cent glucose failed to restore to normal the capacity of their livers to convert acetate carbon to fatty acids. These observations on the carbohydrate content of the diet necessitate calling attention to the need for a careful evaluation of the nutritional state of the hypophysectomized rat. Such an evaluation must be made before concluding that a metabolic defect observed in this animal which was operated upon is the result of the absence, per se, of anterior pituitary hormones. From the above considerations, we concluded that the hypophysectomized rat is characterized by an increased sensitivity to glucose requirements for maintenance of hepatic lipogenesis. Apparently some change in the carbohydrate metabolism of the liver occurs after the rat is completely deprived of anterior pituitary hormones, and in the present investigation we have attempted to analyze the nature of this altered carbohydrate metabolism.

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