Mitochondria at the Base of Neuronal Innate Immunity in Alzheimer’s and Parkinson’s Diseases

Mitochondria are exceptionally primed to play a key role in neuronal cell survival since they are involved in energy production and function as the metabolic center of cells. Several findings provide evidence for the role of mitochondria in neurodegeneration associated with Alzheimer’s and Parkinson’s diseases (AD and PD). Recent data highlight the role of mitochondrial proteins and mitochondrial reactive oxygen species in the intracellular signaling that regulates innate immunity and inflammation. In this chapter, we will discuss the relevance of the interplay between mitochondria and innate immunity, focusing on mitochondrial damage-associated molecular patterns (DAMPs) and how they can activate innate immunity and elicit AD and PD neurodegenerative process.

• Publication year

  2018

• Venue

  Mitochondrial Diseases

• Publication date

  2018-08-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.5772/INTECHOPEN.72612
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer's and Parkinson's Diseases.

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• Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

  2017cited by this paper
• Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology

  2017influential reference
• Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson’s Disease Patients: Search for a Disease Indicator

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  2017cited by this paper
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  2017cited by this paper
• Mitochondria, Cybrids, Aging, and Alzheimer's Disease.

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• Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures.

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• Microglial activation in Parkinson’s disease using [18F]-FEPPA

  2017cited by this paper
• Alzheimer's disease: Innate immunity gone awry?

  2017cited by this paper
• Role of microtubule-associated protein tau phosphorylation in Alzheimer’s disease

  2017cited by this paper
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  2016cited by this paper
• The amyloid hypothesis of Alzheimer's disease at 25 years

  2016cited by this paper
• The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

  2016cited by this paper
• Evidence for neuroinflammation in Alzheimer's disease

  2016cited by this paper
• Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease: Is Inflammatory Signaling a Key Player?

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• Targeting neuroinflammation in Alzheimer’s disease

  2016cited by this paper
• Mitochondrial dysfunction in Parkinson's disease

  2016cited by this paper
• Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.

  2016cited by this paper
• Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

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• Transfer of mitochondria from astrocytes to neurons after stroke

  2016cited by this paper
• Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

  2016cited by this paper
• Alzheimer's disease: the role of mitochondrial dysfunction and potential new therapies

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• Mechanism and Regulation of NLRP3 Inflammasome Activation.

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• Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond.

  2016cited by this paper
• Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

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• Early alterations of mitochondrial morphology in dopaminergic neurons from Parkinson's disease-like pathology and time-dependent neuroprotection with D2 receptor activation.

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• Deciphering the Molecular Signals of PINK1/Parkin Mitophagy.

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• The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

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• PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

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• Mitochondria: diversity in the regulation of the NLRP3 inflammasome.

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• Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

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• Caspase-1: an integral regulator of innate immunity

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• Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

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• Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

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• Linking microtubules to Parkinson's disease: the case of parkin.

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• Mitochondrial Lysates Induce Inflammation and Alzheimer's Disease-Relevant Changes in Microglial and Neuronal Cells

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  2015cited by this paper
• Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

  2015cited by this paper
• Mechanisms of unconventional secretion of IL-1 family cytokines.

  2015cited by this paper
• Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.

  2015cited by this paper
• Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay.

  2015cited by this paper
• Oxidative stress and Parkinson’s disease

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• Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta

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• The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease

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• Immune attack: the role of inflammation in Alzheimer disease

  2015influential reference
• Relevance of chronic stress and the two faces of microglia in Parkinson’s disease

  2015influential reference
• Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α

  2015cited by this paper
• Neuroinflammation in Alzheimer's disease.

  2015cited by this paper
• Mitochondria: a target for bacteria.

  2015cited by this paper
• Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria

  2015cited by this paper
• Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy.

  2015cited by this paper
• Emerging concepts in Alzheimer's disease.

  2015cited by this paper
• Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

  2015cited by this paper
• Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

  2014cited by this paper
• Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

  2014cited by this paper
• LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

  2014cited by this paper
• Transcellular degradation of axonal mitochondria

  2014cited by this paper
• Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia.

  2014cited by this paper
• Parkin and PINK1: much more than mitophagy.

  2014cited by this paper
• Correlation between Serum RANTES Levels and the Severity of Parkinson's Disease

  2014cited by this paper
• Reversible 26S proteasome disassembly upon mitochondrial stress.

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• Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation

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• Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

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• Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice

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• Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer’s disease-relevant murine model

  2014cited by this paper
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• Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

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  2014cited by this paper
• Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

  2013cited by this paper
• Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

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• In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease.

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• CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

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• Innate immunity in the CNS: redefining the relationship between the CNS and Its environment.

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• Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.

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  2013cited by this paper
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• Prodromal metabolic phenotype in MCI cybrids: implications for Alzheimer's disease.

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• Heme binding induces dimerization and nitration of truncated β-amyloid peptide Aβ16 under oxidative stress.

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• Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.

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• The role of autophagy in neurodegenerative disease

  2013cited by this paper
• Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines.

  2013cited by this paper
• Biomarker modeling of Alzheimer's disease.

  2013cited by this paper
• Activation and regulation of the inflammasomes

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• Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease.

  2013cited by this paper
• The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

  2013cited by this paper
• Colonic inflammation in Parkinson's disease.

  2013cited by this paper
• Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention.

  2012cited by this paper
• Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

  2012cited by this paper

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