Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1207646PMID 15122328
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Electrical wound-healing assay for cells in vitro.

  2004cited by this paper
• Sprouty: how does the branch manager work?

  2003cited by this paper
• Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

  2003cited by this paper
• Tyrosine Phosphorylation of Sprouty2 Enhances Its Interaction with c-Cbl and Is Crucial for Its Function*

  2003cited by this paper
• Met, metastasis, motility and more

  2003cited by this paper
• Endosomal dynamics of Met determine signaling output.

  2003cited by this paper
• hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.

  2003cited by this paper
• Protein-tyrosine Phosphatase-1B (PTP1B) Mediates the Anti-migratory Actions of Sprouty*

  2003cited by this paper
• Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops.

  2003cited by this paper
• Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

  2002cited by this paper
• Application of cell adhesion to study signaling networks.

  2002cited by this paper
• The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

  2002influential reference
• Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

  2002cited by this paper
• The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

  2002cited by this paper
• Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf*

  2002influential reference
• Expression of Sprouty genes 1, 2 and 4 during mouse organogenesis.

  2001cited by this paper
• Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.

  2001cited by this paper
• Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.

  2001cited by this paper
• Inhibition of Angiogenesis by a Mouse Sprouty Protein*

  2001cited by this paper
• Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells

  2001cited by this paper
• Down-regulation of MET, the receptor for hepatocyte growth factor

  2001cited by this paper
• Mammalian Sprouty Proteins Inhibit Cell Growth and Differentiation by Preventing Ras Activation*

  2001influential reference
• ERK pathway positively regulates the expression of Sprouty genes.

  2001cited by this paper
• The von Hippel-Lindau Tumor Suppressor Gene Inhibits Hepatocyte Growth Factor/Scatter Factor-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells

  1999cited by this paper
• Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila.

  1999cited by this paper
• Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo.

  1999cited by this paper
• Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

  1999cited by this paper
• Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis.

  1999cited by this paper
• Sprouty, an intracellular inhibitor of Ras signaling.

  1999cited by this paper
• Sprouty is a general inhibitor of receptor tyrosine kinase signaling.

  1999cited by this paper
• sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

  1998influential reference
• Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway

  1997cited by this paper
• Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network

  1996cited by this paper
• Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

  1992cited by this paper
• Micromotion of mammalian cells measured electrically.

  1991cited by this paper

• Recent Advances in Pyridine and Pyrimidine Based Scaffolds as c-Met Kinase Inhibitors for Cancer Therapy: Biological Insights, Docking and SAR

  2026cites this paper
• Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.

  2022cites this paper
• Identification of two SPRY isoforms SPRY1 and SPRY3 by atomic force microscopy at the single-molecule level.

  2022cites this paper
• Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin

  2021cites this paper
• How metformin affects various malignancies by means of microRNAs: a brief review

  2021cites this paper
• Role of Tetraspanins in Hepatocellular Carcinoma

  2021cites this paper
• Overexpression of sprouty 1 protein in human oral squamous cell carcinogenesis

  2020cites this paper
• Impedance-Based Assays Along the Life Span of Adherent Mammalian Cells In Vitro: From Initial Adhesion to Cell Death

  2019cites this paper
• Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2

  2019cites this paper
• Spred negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation

  2019cites this paper
• C7 peptide inhibits hepatocellular carcinoma metastasis by targeting the HGF/c-Met signaling pathway

  2019cites this paper
• A Review of Osteosarcoma Therapeutics

  2018cites this paper
• HGF/c-MET Signaling in Melanocytes and Melanoma

  2018cites this paper
• miR-21 promotes EGF-induced pancreatic cancer cell proliferation by targeting Spry2

  2018cites this paper
• Dyrk1A promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis via down-regulating Spry2 and activating the ERK MAPK pathway.

  2018cites this paper
• Long non-coding RNA CASC2 regulates Sprouty2 via functioning as a competing endogenous RNA for miR-183 to modulate the sensitivity of prostate cancer cells to docetaxel.

  2018cites this paper
• SPRY2 is a novel MET interactor that regulates metastatic potential and differentiation in rhabdomyosarcoma

  2018cites this paper
• Overexpression of sprouty2 in human oral squamous cell carcinogenesis.

  2018cites this paper
• DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth

  2018cites this paper
• Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein

  2017cites this paper
• Chapter 8 MIG-6 and SPRY 2 in the Regulation of Receptor Tyrosine Kinase Signaling : Balancing Act via Negative Feedback Loops

  2017influential citation
• PHA665752 inhibits the HGF-stimulated migration and invasion of cells by blocking PI3K/AKT pathway in uveal melanoma.

  2017cites this paper
• MiR-122 promotes renal cancer cell proliferation by targeting Sprouty2

  2017cites this paper
• Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.

  2016cites this paper
• Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer‐Derived Cells

  2016cites this paper
• Modulation of ERK5 Is a Novel Mechanism by Which Cdc42 Regulates Migration of Breast Cancer Cells

  2015cites this paper
• Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts but Inhibits Proliferation of Gingival Epithelial Cells

  2015cites this paper
• Sprouty2 mediated tuning of signalling is essential for somite myogenesis

  2015cites this paper
• Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion

  2015cites this paper
• Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts

  2015cites this paper
• Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals.

  2015cites this paper
• Intraarticular gene transfer of SPRY2 suppresses adjuvant-induced arthritis in rats

  2015cites this paper
• Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity

  2015cites this paper
• Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer

  2015cites this paper
• The MET Receptor Family

  2015cites this paper
• MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility

  2015cites this paper
• Stem Cells in Tooth Development, Growth, Repair, and Regeneration.

  2015cites this paper
• Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.

  2015influential citation
• Hepatic microRNA orchestra: a new diagnostic, prognostic and theranostic tool for hepatocarcinogenesis.

  2014cites this paper
• Frequency dependent impedimetric cytotoxic evaluation of anticancer drug on breast cancer cell.

  2014cites this paper
• The expression of the Sprouty 1 protein inversely correlates with growth, proliferation, migration and invasion of ovarian cancer cells

  2014cites this paper
• Electric cell–substrate impedance sensing technique to monitor cellular behaviours of cancer cells

  2014cites this paper
• Monitoring cellular activities of cancer cells using impedance sensing devices

  2014cites this paper
• Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform

  2014cites this paper
• The developing story of Sprouty and cancer

  2014cites this paper
• In non‐small cell lung cancer mitogenic signaling leaves Sprouty1 protein levels unaffected

  2014cites this paper
• Sprouty2 is associated with prognosis and suppresses cell proliferation and invasion in renal cell carcinoma.

  2013cites this paper
• AntagomiR-27 a Targets FOXO 3 a in Glioblastoma and Suppresses U 87 Cell Growth in Vitro and in Vivo

  2013cites this paper
• AntagomiR-27a targets FOXO3a in glioblastoma and suppresses U87 cell growth in vitro and in vivo.

  2013cites this paper
• MIG-6 and SPRY2 in the Regulation of Receptor Tyrosine Kinase Signaling: Balancing Act via Negative Feedback Loops

  2013influential citation
• c-MYC-regulated miR-23a/24-2/27a Cluster Promotes Mammary Carcinoma Cell Invasion and Hepatic Metastasis by Targeting Sprouty2*

  2013cites this paper
• Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.

  2013cites this paper
• Nanotopography induced contact guidance of the F11 cell line during neuronal differentiation: a neuronal model cell line for tissue scaffold development

  2012cites this paper
• Sprouty Is a Negative Regulator of Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Transition and Cataract

  2012cites this paper
• Interplay between microRNA-21 and Sprouty2 in non small cell lung cancer-derived cell lines

  2012cites this paper
• Progress in cancer therapy targeting c-Met signaling pathway

  2012cites this paper
• MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.

  2012cites this paper
• Cytogenetic and molecular cytogenetic profile of bone marrow-derived mesenchymal stromal cells in chronic and acute lymphoproliferative disorders

  2012cites this paper
• Characterization of Electrode/Electrolyte Interface of ECIS Devices

  2012cites this paper
• Progress in cancer therapy targeting c-Met signaling pathway

  2012cites this paper
• Initial Report on Differential Expression of Sprouty Proteins 1 and 2 in Human Epithelial Ovarian Cancer Cell Lines

  2012cites this paper
• Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver

  2012cites this paper
• A vertically aligned carbon nanotube-based impedance sensing biosensor for rapid and high sensitive detection of cancer cells.

  2012cites this paper
• CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia.

  2012cites this paper
• Differential expression of sprouty genes in hepatocellular carcinoma

  2012cites this paper
• Epigenomics in Environmental Health

  2011cites this paper
• Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease

  2011influential citation
• Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

  2011cites this paper
• Cell migration regulates the kinetics of cytokinesis

  2011cites this paper
• Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.

  2011cites this paper
• MicroRNAs in development and disease.

  2011cites this paper
• The C-terminus of Hsp70-Interacting Protein Promotes Met Receptor Degradation

  2011cites this paper
• FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size

  2011cites this paper
• Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells

  2010cites this paper
• Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene.

  2010cites this paper
• Bimodal expression of Sprouty2 during the cell cycle is mediated by phase-specific Ras/MAPK and c-Cbl activities

  2010cites this paper
• Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2

  2010influential citation
• Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon

  2010cites this paper
• Expression and functional role of negative signalling regulators in tumour development and progression

  2010cites this paper
• Sprouty-2 Controls c-Met Expression and Metastatic Potential of Colon Cancer Cells: Sprouty/c-Met Upregulation in Human Colonic Adenocarcinomas

  2010cites this paper
• miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2.

  2010cites this paper
• Synergistic role of sprouty2 inactivation and c‐Met up‐regulation in mouse and human hepatocarcinogenesis

  2010cites this paper
• The Role of CtBP in Pituitary Development and Tumorigenesis

  2010cites this paper
• MET signalling: principles and functions in development, organ regeneration and cancer

  2010cites this paper
• Sprouty4 regulates the balance between pluripotency and trophectoderm differentiation in mouse embryonic stem cells

  2010cites this paper
• The Role of CtBP in Pituitary Tumorigenesis

  2010cites this paper
• Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

  2009cites this paper
• The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts

  2009cites this paper
• Sprouty 2 Regulates DNA Damage-induced Apoptosis in Ras-transformed Human Fibroblasts*

  2009cites this paper
• Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis.

  2009cites this paper
• Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.

  2009cites this paper
• Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

  2009influential citation
• Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.

  2009cites this paper
• HECT Domain-containing E3 Ubiquitin Ligase Nedd4 Interacts with and Ubiquitinates Sprouty2*

  2009cites this paper
• Sprouty proteins, masterminds of receptor tyrosine kinase signaling

  2008cites this paper
• Modulation of Endocrine Pancreas Development but not β-Cell Carcinogenesis by Sprouty4

  2008cites this paper
• Analysis of the sensitivity and frequency characteristics of coplanar electrical cell-substrate impedance sensors.

  2008cites this paper
• KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2

  2008cites this paper
• The Ins and Outs of Satellite Cell Myogenesis: The Role of the Ruling Growth Factors

  2008cites this paper
• The Interconnected Network of ESCRT and Non-ESCRT Cellular Proteins Required for Retroviral Release

  2008cites this paper