Genetics of primary hypertension: the clinical impact of adducin polymorphisms.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbadis.2010.03.014PMID 20382219
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study

  2010influential reference
• Lack of association between α-adducin G460W polymorphism and hypertension: evidence from a case–control study and a meta-analysis

  2010cited by this paper
• Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension.

  2010cited by this paper
• Making the right connections: biological networks in the light of evolution

  2009cited by this paper
• Sex-specific effect of the α-adducin (G460W) and AGTR1 (A1166C) polymorphism on carotid intima–media thickness

  2009cited by this paper
• What are genes “for” or where are traits “from”? What is the question?

  2009cited by this paper
• A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

  2009cited by this paper
• Shadows of complexity: what biological networks reveal about epistasis and pleiotropy

  2009cited by this paper
• Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study.

  2009cited by this paper
• Arterial properties in relation to genetic variation in α-adducin and the renin–angiotensin system in a White population

  2009influential reference
• Genome-wide association study of blood pressure and hypertension

  2009cited by this paper
• From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

  2009cited by this paper
• The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age

  2009cited by this paper
• Pressure-Induced Renal Injury in Angiotensin II Versus Norepinephrine-Induced Hypertensive Rats

  2009cited by this paper
• Finding the missing heritability of complex diseases

  2009cited by this paper
• Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics.

  2009cited by this paper
• Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array

  2009cited by this paper
• Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure.

  2009cited by this paper
• Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.

  2009cited by this paper
• Endogenous ouabain in cardiovascular function and disease

  2009cited by this paper
• Faculty Opinions recommendation of Genome-wide association study identifies eight loci associated with blood pressure.

  2009cited by this paper
• The evolution of hierarchical gene regulatory networks

  2009cited by this paper
• The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication

  2009cited by this paper
• Mapping complex disease traits with global gene expression

  2009cited by this paper
• Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations

  2009cited by this paper
• Dietary salt intake, salt sensitivity, and cardiovascular health.

  2009cited by this paper
• [Association of the polymorphisms of sodium transport related genes with essential hypertension].

  2009cited by this paper
• A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species

  2009cited by this paper
• Mendelian randomization: nature's randomized trial in the post-genome era.

  2009cited by this paper
• The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project

  2009cited by this paper
• The dilemma of placebo controlled studies: scientific evidence, guidelines, ethics and regulatory recommendations.

  2009cited by this paper
• Interaction between the Gly460Trp α-adducin gene variant and diuretics on the risk of myocardial infarction

  2009cited by this paper
• Phenotype–genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling

  2009cited by this paper
• Relationships among endogenous ouabain, α-adducin polymorphisms and renal sodium handling in primary hypertension

  2008cited by this paper
• Network pharmacology: the next paradigm in drug discovery.

  2008cited by this paper
• Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population

  2008cited by this paper
• Evolutionary plasticity of genetic interaction networks

  2008cited by this paper
• Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis.

  2008cited by this paper
• Salt intake, blood pressure and clinical outcomes

  2008cited by this paper
• Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

  2008cited by this paper
• Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats.

  2008cited by this paper
• Endogenous digitalis: pathophysiologic roles and therapeutic applications

  2008cited by this paper
• Targeting and tinkering with interaction networks.

  2008cited by this paper
• Homology and the hierarchy of biological systems.

  2008cited by this paper
• Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

  2008cited by this paper
• [Association of alpha-adducin and angiotensin converting enzyme gene polymorphisms with salt-sensitive hypertension and early renal injury].

  2008cited by this paper
• &agr;-Adducin Gly460Trp Variant Increases the Risk of Stroke in Hypertensive Dutch Women

  2008cited by this paper
• Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?

  2008cited by this paper
• Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES).

  2008cited by this paper
• Variations in DNA elucidate molecular networks that cause disease

  2008cited by this paper
• Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

  2008cited by this paper
• Arterial properties in relation to genetic variations in the adducin subunits in a white population.

  2008cited by this paper
• Physiological Interaction Between &agr;-Adducin and WNK1-NEDD4L Pathways on Sodium-Related Blood Pressure Regulation

  2008cited by this paper
• Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice.

  2008cited by this paper
• High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.

  2007cited by this paper
• Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action

  2007cited by this paper
• Both angiotensinogen M235T and α-adducin G460W polymorphisms are associated with hypertension in the Japanese population

  2007cited by this paper
• Antihypertensive therapy, the α-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment Study

  2007cited by this paper
• Diuretic–gene interaction and the risk of myocardial infarction and stroke

  2007cited by this paper
• Convergent adaptation of human lactase persistence in Africa and Europe

  2007cited by this paper
• Drug Discovery and Development in the Age of Molecular Medicine

  2007cited by this paper
• Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes

  2007cited by this paper
• Association of α-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population

  2007cited by this paper
• Angiotensin-Converting Enzyme I/D and &agr;-Adducin Gly460Trp Polymorphisms: From Angiotensin-Converting Enzyme Activity to Cardiovascular Outcome

  2007cited by this paper
• Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension.

  2006cited by this paper
• &agr;-Adducin Polymorphism, Atherosclerosis, and Cardiovascular and Cerebrovascular Risk

  2006cited by this paper
• The Calcium Paradoxon of Renin Release: Calcium Suppresses Renin Exocytosis by Inhibition of Calcium-Dependent Adenylate Cyclases AC5 and AC6

  2006cited by this paper
• The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes

  2006cited by this paper
• The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure

  2006cited by this paper
• The alpha-adducin gene is associated with macrovascular complications and mortality in patients with type 2 diabetes.

  2006cited by this paper
• Interactions between five candidate genes and antihypertensive drug therapy on blood pressure

  2006cited by this paper
• The genetic dissection of essential hypertension

  2006cited by this paper
• Are the beta-adducin C1797T polymorphism and gamma-adducin A386G polymorphism associated with essential hypertension in Yi and Hani populations?

  2006cited by this paper
• [Association of polymorphism in alpha-adducin gene with antihypertensive effect of Hydrochlorothiazide].

  2005cited by this paper
• Combined Analysis of Polymorphisms in Angiotensinogen and Adducin Genes and Their Effects on Hypertension in a Japanese Sample: The Shigaraki Study

  2005influential reference
• [Association of peripheral and central blood pressure with the alpha-adducin Gly460Trp polymorphism in a Chinese population].

  2005cited by this paper
• OASIS-HT: design of a pharmacogenomic dose-finding study.

  2005cited by this paper
• Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.

  2005cited by this paper
• Sodium pump α2 subunits control myogenic tone and blood pressure in mice

  2005cited by this paper
• ERNEST H. STARLING DISTINGUISHED LECTURESHIP OF THE WATER AND ELECTROLYTE HOMEOSTASIS SECTION, 2005 Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms

  2005influential reference
• Cardiovascular Risk in Relation to α-Adducin Gly460Trp Polymorphism and Systolic Pressure: A Prospective Population Study

  2005cited by this paper
• Assessing the impact of population stratification on genetic association studies

  2004cited by this paper
• Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study.

  2004cited by this paper
• [Alpha-adducin gene G/W460 polymorphism is associated with intracerebral hemorrhage in Chinese].

  2004cited by this paper
• Hypertension-Linked Mutation in the Adducin &agr;-Subunit Leads to Higher AP2-&mgr;2 Phosphorylation and Impaired Na+,K+-ATPase Trafficking in Response to GPCR Signals and Intracellular Sodium

  2004cited by this paper
• Organ Hypertrophic Signaling within Caveolae Membrane Subdomains Triggered by Ouabain and Antagonized by PST 2238*

  2004cited by this paper
• Alpha-adducin G460W polymorphism, urinary sodium excretion, and blood pressure in community-based samples.

  2004cited by this paper
• Multilocus Analysis of Hypertension: A Hierarchical Approach

  2004cited by this paper
• The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.

  2004cited by this paper
• Epistatic interaction between α- and γ-adducin influences peripheral and central pulse pressures in white Europeans

  2004cited by this paper
• Alpha-Adducin Gly460Trp Polymorphism and Essential Hypertension in Korea

  2004cited by this paper
• The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?

  2004cited by this paper
• Present status of genetic mechanisms in hypertension.

  2004cited by this paper
• Blood pressure in relation to three candidate genes in a Chinese population

  2004influential reference
• Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study.

  2004cited by this paper
• Population stratification and spurious allelic association.

  2003cited by this paper
• Interaction Between ACE and ADD1 Gene Polymorphisms in the Progression of IgA Nephropathy in Japanese Patients

  2003cited by this paper
• Blood pressure phenotypes in relation to the &bgr;-adducin C1797T polymorphism in the European Project on Genes in Hypertension (EPOGH)

  2003cited by this paper
• Salt, endogenous ouabain and blood pressure interactions in the general population

  2003cited by this paper
• Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case–control and family-based study

  2003cited by this paper

• Klotho Gene in Human Salt-Sensitive Hypertension.

  2020cites this paper
• Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes

  2020cites this paper
• Hypertension in High School Students: Genetic and Environmental Factors: The HYGEF Study.

  2019cites this paper
• α-Adducin nsSNPs affect mRNA secondary structure, protein modification and stability

  2018cites this paper
• Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases

  2018cites this paper
• ADDing a piece to the puzzle of cognition in schizophrenia.

  2016cites this paper
• Gene and dietary calcium interaction effects on brachial-ankle pulse wave velocity.

  2016cites this paper
• Personalized Therapy of Hypertension: the Past and the Future

  2016cites this paper
• Post-Genomics Appraisal of Systemic and Pulmonary Hypertension

  2014cites this paper
• The effects of both single-locus and multi-locus interaction on the clinical manifestations of IgA nephropathy in Southern Han Chinese.

  2014cites this paper
• SNP Interactions in the Genetic Architecture of Blood Pressure

  2013cites this paper
• Asociación y efectos de interacción en los genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2 sobre la hipertensión en la población antioqueña

  2013cites this paper
• [Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population].

  2013cites this paper
• Salt sensitivity, endogenous ouabain and hypertension

  2012cites this paper
• Current world literature.

  2012cites this paper
• Between Candidate Genes and Whole Genomes: Time for Alternative Approaches in Blood Pressure Genetics

  2012cites this paper
• Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation.

  2012cites this paper
• Altered expression of renal aquaporins and α-adducin polymorphisms may contribute to the establishment of salt-sensitive hypertension.

  2011cites this paper
• Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies

  2011cites this paper
• The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin–angiotensin–aldosterone system, oxidative stress and endogenous digitalis in the brain

  2011cites this paper
• THE REGULATION AND F UNCTION OF HU -LI TAI SHAO (HTS) AT THE DROSOPHILA NEUROMUSCULAR JUNCTI ON

  2011cites this paper
• Polymorphisms, hypertension and thiazide diuretics.

  2011cites this paper
• Genes Involved in Vasoconstriction and Vasodilation System Affect Salt-Sensitive Hypertension

  2011cites this paper
• Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls

  2010cites this paper
• Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies

  2010cites this paper
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  year unknowncites this paper