Human Embryonic Stem Cell-Derived Cardiomyocytes Migrate in Response to Gradients of Fibronectin and Wnt5a: Implications for cardiac repair & congenital heart defects

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Unknown venue

• Publication date

  2013-11-14

• Fields of study

  Biology, Medicine

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013influential reference
• Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.

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  2012influential reference
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  2012influential reference
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  2011influential reference
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