Oxalate toxicity in LLC-PK1 cells: role of free radicals.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Kidney International

• Publication date

  1996-02-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1038/KI.1996.60PMID 8821825
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Determination of oxalic acid clearance and plasma concentration by radioisotope infusion. Results in a family with hyperoxaluria.

  2009cited by this paper
• Oxalate toxicity in LLC-PK1 cells, a line of renal epithelial cells.

  1996cited by this paper
• Oxalate Transport in LLC-PK1 Cells: Evidence for Oxalate Transport by Anion Exchange

  1994cited by this paper
• Oxalate transport in a line of porcine renal epithelial cells--LLC-PK1 cells.

  1994cited by this paper
• Oxalate-induced initiation of DNA synthesis in LLC-PK1 cells, a line of renal epithelial cells.

  1994cited by this paper
• Cytogenetic approaches to human cancer genes 1

  1994cited by this paper
• Polarized distribution of oxalate transport systems in LLC-PK1 cells, a line of renal epithelial cells.

  1994cited by this paper
• Oxalate-Induced Changes in Intracellular Calcium Levels in Renal Papillary Cells

  1994cited by this paper
• Superoxide anion production and phagocytosis of crystals by cultured endothelial cells.

  1993cited by this paper
• Hyperoxaluria, enzymuria and nephrolithiasis.

  1993cited by this paper
• Effects of formate and oxalate on chloride absorption in rat distal tubule.

  1993cited by this paper
• Dihydrorhodamine 123: a fluorescent probe for superoxide generation?

  1993cited by this paper
• Acute hyperoxaluria, renal injury and calcium oxalate urolithiasis.

  1992cited by this paper
• Cell polarity and calcium oxalate crystal adherence to cultured collecting duct cells.

  1992cited by this paper
• Hydrogen peroxide cytotoxicity in LLC-PK1 cells: a role for iron.

  1991cited by this paper
• Oxalate transport in renal tubular cells from normal and stone-forming animals.

  1991cited by this paper
• Membrane-associated crystallization of calcium oxalatein vitro

  1990cited by this paper
• Dietary intake, absorption, metabolism, and excretion of oxalate.

  1990cited by this paper
• Cell injury associated calcium oxalate crystalluria.

  1990cited by this paper
• Oxidative stress in isolated rat renal proximal and distal tubular cells.

  1990cited by this paper
• A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123.

  1990influential reference
• Effect of citrate on the urinary excretion of calcium and oxalate: relevance to calcium oxalate nephrolithiasis.

  1989cited by this paper
• Effect of oxalate on function of kidney mitochondria.

  1989cited by this paper
• Anion transport through the contraluminal cell membrane of renal proximal tubule. The influence of hydrophobicity and molecular charge distribution on the inhibitory activity of organic anions.

  1989cited by this paper
• Dihydrorhodamine 123: a new flow cytometric indicator for respiratory burst activity in neutrophil granulocytes

  1988cited by this paper
• Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.

  1988cited by this paper
• Anion exchange pathways for Cl- transport in rabbit renal microvillus membranes.

  1987cited by this paper
• An investigation into the mechanism of citrate-Fe2+-dependent lipid peroxidation.

  1987cited by this paper
• Membrane interactions with calcium oxalate crystals: variation in hemolytic potentials with crystal morphology.

  1986cited by this paper
• Polarized distribution of the Na+/H+ exchange system in a renal cell line (LLC-PK1) with characteristics of proximal tubular cells.

  1986cited by this paper
• EQUIL2: a BASIC computer program for the calculation of urinary saturation.

  1985cited by this paper
• Plasma oxalate concentration in chronic renal disease.

  1984cited by this paper
• The significance of oxalate in renal failure.

  1984cited by this paper
• Increased urinary excretion of renal enzymes in idiopathic calcium oxalate nephrolithiasis.

  1983cited by this paper
• The determination of oxalic acid in plasma and urine by means of capillary gas chromatography.

  1982cited by this paper
• Oxalate transport by proximal tubule of the rabbit kidney.

  1982cited by this paper
• Oxalate secretion in the rat proximal tubule.

  1981cited by this paper
• Respiratory burst enzyme in human neutrophils. Evidence for multiple mechanisms of activation.

  1981cited by this paper
• Calcium oxalate crystal-induced cytolysis in polymorphonuclear leukocytes and erythrocytes

  1980cited by this paper
• Histopathological occurrence and characterisation of calcium oxalate: a review.

  1977cited by this paper
• Oxalic acid in biology and medicine

  1977cited by this paper
• The origin and characteristics of a pig kidney cell strain, LLC-PK1

  1976cited by this paper
• Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

  1975cited by this paper

• Antioxidant and anti–inflammatory effects of Helichrysum plicatum DC. subsp. plicatum extract in an experimental model of acute urolithiasis

  2025cites this paper
• Dietary oxalate-calcium balance and the incidence of hypertension and chronic kidney disease: a prospective study among an Asian population

  2022cites this paper
• Tomato Oxalyl-CoA Synthetase Degrades Oxalate and Affects Fruit Quality

  2022cites this paper
• Application of Quercus salicina extract in the management of urolithiasis

  2022cites this paper
• Dietary oxalate to calcium ratio and incident cardiovascular events: a 10-year follow-up among an Asian population

  2022cites this paper
• Dietary Oxalate Loading Impacts Monocyte Metabolism and Inflammatory Signaling in Humans

  2021cites this paper
• Quercus salicina Blume: Research Progress in Chemistry and Pharmacodynamics (1959–2021)

  2021cites this paper
• An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants

  2021cites this paper
• Primary hyperoxaluria type 1

  2020cites this paper
• Cellular injury leading to oxidative stress in acute poisoning with potassium permanganate/oxalic acid, paraquat, and glyphosate surfactant herbicide.

  2020cites this paper
• Calcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation

  2020cites this paper
• Nephrolithiasis in Chronic Kidney Disease

  2019cites this paper
• Nutritional and Medical Management of Kidney Stones

  2019cites this paper
• Oxalate induces type II epithelial to mesenchymal transition (EMT) in inner medullary collecting duct cells (IMCD) in vitro and stimulate the expression of osteogenic and fibrotic markers in kidney medulla in vivo

  2019cites this paper
• Mitochondria and Kidney Disease

  2018cites this paper
• Modulation of lithiatic injury to renal epithelial cells by aqueous extract of Terminalia arjuna

  2018cites this paper
• Renal Allograft With Calcium Oxalate Deposition: Association with Urinary Tract Infection and Development of Interstitial Fibrosis.

  2018cites this paper
• Hyperoxaluria Induces Oxidative DNA Damage and Results in Renal Tubular Epithelial Cell Apoptosis: A Clue to the Pathogenesis of Urolithiasis

  2017cites this paper
• Serum creatinine and cystatin C provide conflicting evidence of acute kidney injury following acute ingestion of potassium permanganate and oxalic acid

  2017cites this paper
• Protective impact of resveratrol in experimental rat model of hyperoxaluria

  2017cites this paper
• Does green tea consumption increase urinary oxalate excretion? Results of a prospective trial in healthy men

  2017cites this paper
• Do “inhibitors of crystallisation” play any role in the prevention of kidney stones? A critique

  2017cites this paper
• An Oxalyl-CoA Synthetase Is Involved in Oxalate Degradation and Aluminum Tolerance1[OPEN]

  2016cites this paper
• N-acetylcysteine protects against star fruit-induced acute kidney injury

  2016cites this paper
• Original Article Genetic variants in renal interstitial inflammation-related genes CSF-1 and CD44 are associated with susceptibility of nephrolithiasis

  2016cites this paper
• An Oxalyl-CoA Dependent Pathway of Oxalate Catabolism Plays a Role in Regulating Calcium Oxalate Crystal Accumulation and Defending against Oxalate-Secreting Phytopathogens in Medicago truncatula

  2016cites this paper
• Tunicate‐Inspired Gallic Acid/Metal Ion Complex for Instant and Efficient Treatment of Dentin Hypersensitivity

  2016cites this paper
• Evaluation of urinary KIM-1, NGAL, and IL-18 levels in determining early renal injury in pediatric cases with hypercalciuria and/or renal calculi.

  2016cites this paper
• Hyperoxaluria: The role of N-acetyl-L-cysteine and Vitamin E on lithogenic factors and urinary markers in ameliorating calcium oxalate crystallization

  2016cites this paper
• An investigation of antioxidant and antidiabetic effect of aqueous leaf extracts of Mucuna pruriens

  2016cites this paper
• Mechanistic Insights into the Antilithiatic Proteins from Terminalia arjuna: A Proteomic Approach in Urolithiasis

  2016cites this paper
• Antioxidant and Renoprotective Effects of Mushroom Extract: Implication in Prevention of Nephrolithiasis

  2016cites this paper
• Genetic variants in renal interstitial inflammation-related genes CSF-1 and CD 44 are associated with susceptibility of nephrolithiasis

  2016cites this paper
• Nox and renal disease.

  2015cites this paper
• Oral Manifestations of Chronic Renal Failure Complicating a Systemic Genetic Disease: Diagnostic Dilemma. Case Report and Literature Review.

  2015cites this paper
• Studying inhibition of calcium oxalate stone formation: an in vitro approach for screening hydrogen sulfide and its metabolites

  2015cites this paper
• Oligomeric proanthocyanidins protect against HK-2 cell injury induced by oxalate and calcium oxalate monohydrate crystals

  2015cites this paper
• Involvement of renin–angiotensin–aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury

  2015cites this paper
• Protective effects of N-acetylcysteine against hyperoxaluria induced mitochondrial dysfunction in male wistar rats

  2015cites this paper
• Limitation of apoptotic changes and crystal deposition by Tutukon following hyperoxaluria-induced tubular cell injury in rat model

  2015cites this paper
• High Sodium-Induced Oxidative Stress and Poor Anticrystallization Defense Aggravate Calcium Oxalate Crystal Formation in Rat Hyperoxaluric Kidneys

  2015cites this paper
• Effect of mitochondrial potassium channel on the renal protection mediated by sodium thiosulfate against ethylene glycol induced nephrolithiasis in rat model

  2015cites this paper
• Modulation of NADPH oxidase activity by known uraemic retention solutes

  2014cites this paper
• C-Phycocyanin Confers Protection against Oxalate-Mediated Oxidative Stress and Mitochondrial Dysfunctions in MDCK Cells

  2014cites this paper
• Potential role of fluctuations in the composition of renal tubular fluid through the nephron in the initiation of Randall’s plugs and calcium oxalate crystalluria in a computer model of renal function

  2014cites this paper
• Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria

  2014cites this paper
• Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin.

  2014cites this paper
• An oxalyl‐CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae

  2014cites this paper
• Oxalate at physiological urine concentrations induces oxidative injury in renal epithelial cells: effect of α‐tocopherol and ascorbic acid

  2014cites this paper
• Pathomechanisms of nephrolithiasis.

  2013cites this paper
• The Scientific Basis of Urinary Stone Formation

  2013cites this paper
• Hiperoxaluria primaria con pancitopenia: a propósito de un caso.

  2013cites this paper
• Klotho gene polymorphism of rs3752472 is associated with the risk of urinary calculi in the population of Han nationality in Eastern China.

  2013cites this paper
• Preventive effect of specific antioxidant on oxidative renal cell injury associated with renal crystal formation.

  2013cites this paper
• Antiurolithiatic Activity of Aqueous and Methanolic Extracts of Tecoma stans Flowers in Rats

  2013cites this paper
• Diosmin Reduces Calcium Oxalate Deposition and Tissue Degeneration in Nephrolithiasis in Rats: A Stereological Study

  2013cites this paper
• Oxalate: From the Environment to Kidney Stones

  2013cites this paper
• Role of TNF-associated cytokines in renal tubular cell apoptosis induced by hyperoxaluria

  2013cites this paper
• Effects of vitamin E ingestion on plasma and urinary risk factors for calcium oxalate urolithiasis in two population groups having different stone-risk profiles: evidence of different physiological handling mechanisms

  2012cites this paper
• Human umbilical vein endothelial cells accelerate oxalate-induced apoptosis of human renal proximal tubule epithelial cells in co-culture system which is prevented by pyrrolidine dithiocarbamate

  2012cites this paper
• Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury

  2012cites this paper
• The impact of metaphylaxis of kidney stone disease in the renal function at long term in active kidney stone formers patients

  2012cites this paper
• Evaluation and Medical Management of Kidney Stones

  2012cites this paper
• Hyperoxaluria-induced tubular ischemia: the effects of verapamil and vitamin E on apoptotic changes with an emphasis on renal papilla in rat model

  2012cites this paper
• Modulation of Antioxidant Enzyme Expression and Activity by Paraquat in Renal Epithelial NRK-52E Cells

  2011cites this paper
• Renal cell carcinomas in haemodialysis patients: does haemodialysis duration influence pathological cell types and prognosis?

  2011cites this paper
• TEMPOL protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell toxicity.

  2011cites this paper
• Blood Pressure, Urinary Protein Creatinine Ratio and Oxidative Stress in Dogs with Urolithiasis

  2010cites this paper
• Hepatocyte Molecular Cytotoxic Mechanism Study of Fructose and its Metabolites Involved in Nonalcoholic Steatohepatitis and Hyperoxaluria

  2010influential citation
• Severe periodontitis in a patient with hyperoxaluria and oxalosis: a case report and review of the literature.

  2010cites this paper
• Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

  2010cites this paper
• Renal toxicity of ethylene glycol results from internalization of calcium oxalate crystals by proximal tubule cells.

  2010cites this paper
• Regressive course of oxalate deposition in primary hyperoxaluria after kidney transplantation

  2010cites this paper
• Early Renal Failure After Domino Liver Transplantation Using Organs From Donors With Primary Hyperoxaluria Type 1

  2010cites this paper
• First Prize (Tie): Oxidative Renal Cell Injury Induced by Calcium Oxalate Crystal and Renoprotection with Antioxidants: A Possible Role of Oxidative Stress in Nephrolithiasis

  2010cites this paper
• Inflammation and Organ Failure

  2010cites this paper
• Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition

  2009cites this paper
• Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?

  2009cites this paper
• Oxalate-induced activation of PKC- and-regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells

  2009cites this paper
• Low-vitamin E diet exacerbates calcium oxalate crystal formation via enhanced oxidative stress in rat hyperoxaluric kidney.

  2009cites this paper
• Mechanism underlying the low prevalence of pediatric calcium oxalate urolithiasis.

  2009cites this paper
• Role of scanning electron microscopy in identifying drugs used in medical practice

  2009cites this paper
• The effect of indomethacin on hyperoxaluria-induced renal tubular epithelial injury

  2009cites this paper
• Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy.

  2009cites this paper
• Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells.

  2009cites this paper
• Robot-Assisted Partial Adrenalectomy for Isolated Adrenal Metastasis

  2009cites this paper
• Two‐step transplantation for primary hyperoxaluria: Cadaveric liver followed by living donor related kidney transplantation

  2009cites this paper
• Idiopathic recurrent calcium urolithiasis (IRCU): an acid meal challenge uncovers inappropriate pH of postprandial, fasting and daily urine: a cross-sectional study of male patients providing insight into post- and pre-load urinary stone substances, crystallization risk, presence of stones, renal tr

  2008cites this paper
• Reduction of paraquat-induced renal cytotoxicity by manganese and copper complexes of EGTA and EHPG.

  2008influential citation
• Oxalate exposure provokes HSP 70 response in LLC-PK1 cells, a line of renal epithelial cells: protective role of HSP 70 against oxalate toxicity

  2008cites this paper
• Screening for Anti-crystallisation Calcium Oxalate Urolithiasis Activity in Algerian Plants

  2008cites this paper
• Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties

  2008cites this paper
• Mitochondrial dysfunction in an animal model of hyperoxaluria: a prophylactic approach with fucoidan.

  2008cites this paper
• Mechanism of calcium oxalate renal stone formation and renal tubular cell injury

  2008cites this paper
• The Effects of Lipopolysaccharide-Induced Reactive Oxygen Species Were Blunted by Calcium Oxalate in Renal Tubular Epithelial Cells

  2008cites this paper
• Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria.

  2008cites this paper
• Inhibition of calcium oxalate monohydrate crystal growth using Algerian medicinal plants

  2008cites this paper
• Second Prize: Comprehensive Proteomic Analysis of Human Calcium Oxalate Monohydrate Kidney Stone Matrix

  2008cites this paper
• Management of Patients With Hyperoxaluria

  2007cites this paper
• Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals

  2007cites this paper