Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biochemistry

• Publication date

  2005-11-12

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI051618UPMID 16331995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Highly prevalent putative quadruplex sequence motifs in human DNA

  2005cited by this paper
• Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands

  2005cited by this paper
• Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.

  2005cited by this paper
• Prevalence of quadruplexes in the human genome

  2005cited by this paper
• Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators.

  2005cited by this paper
• The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

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• Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes

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• Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.

  2005cited by this paper
• Functional Integrity of Nuclear Factor κB, Phosphatidylinositol 3′-Kinase, and Mitogen-Activated Protein Kinase Signaling Allows Tumor Necrosis Factor α-Evoked Bcl-2 Expression to Provoke Internal Ribosome Entry Site-Dependent Translation of Hypoxia-Inducible Factor 1α

  2004cited by this paper
• Hypoxia inducible factor-1alpha as a cancer drug target.

  2004cited by this paper
• Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha.

  2004cited by this paper
• Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase.

  2004cited by this paper
• Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.

  2004cited by this paper
• Vascular endothelial growth factor: basic science and clinical progress.

  2004cited by this paper
• Intramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobing.

  2004cited by this paper
• Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance

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• Renal cell carcinoma: rationale and development of therapeutic inhibitors of angiogenesis.

  2004cited by this paper
• The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.

  2004cited by this paper
• Interaction of Telomestatin with the Telomeric Single-strand Overhang*

  2004cited by this paper
• Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.

  2003cited by this paper
• Hoechst 33258 binds to G-quadruplex in the promoter region of human c-myc.

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.

  2003cited by this paper
• The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.

  2003cited by this paper
• Telomere inhibition and telomere disruption as processes for drug targeting.

  2003cited by this paper
• HIF hydroxylation and the mammalian oxygen-sensing pathway.

  2003cited by this paper
• Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry.

  2003cited by this paper
• Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

  2002cited by this paper
• Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

  2002cited by this paper
• Crystal structure of parallel quadruplexes from human telomeric DNA

  2002cited by this paper
• Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications.

  2002cited by this paper
• Tiny telomere DNA.

  2002cited by this paper
• The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo.

  2002cited by this paper
• Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

  2002cited by this paper
• Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway*

  2002cited by this paper
• Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia.

  2002cited by this paper
• c-myc Suppression in Burkitt's lymphoma cells.

  2002cited by this paper
• Selective interactions of cationic porphyrins with G-quadruplex structures.

  2001cited by this paper
• HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

  2001cited by this paper
• HIF-1 and mechanisms of hypoxia sensing.

  2001cited by this paper
• REGULATION OF GENE EXPRESSION BY GC‐RICH DNA CIS ‐ELEMENTS

  2001cited by this paper
• Functional and dysfunctional roles of quadruplex DNA in cells.

  2001cited by this paper
• In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

  2001cited by this paper
• Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.

  2000cited by this paper
• Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ.

  2000cited by this paper
• Quadruplex structures in nucleic acids

  2000cited by this paper
• Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

  2000cited by this paper
• A DNA polymerase stop assay for G-quadruplex-interactive compounds.

  1999cited by this paper
• Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

  1999cited by this paper
• HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5'UTR.

  1999cited by this paper
• The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G(4)T(4)G(4)).

  1999cited by this paper
• Accelerated assembly of G-quadruplex structures by a small molecule.

  1999cited by this paper
• The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation.

  1998cited by this paper
• DNA tetraplex formation in the control region of c-myc.

  1998cited by this paper
• The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution.

  1997cited by this paper
• Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level.

  1997cited by this paper
• Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses.

  1997cited by this paper
• Structural and functional analysis of hypoxia-inducible factor 1.

  1997cited by this paper
• Structure-function correlations of the insulin-linked polymorphic region.

  1996cited by this paper
• Synapsable DNA.

  1996cited by this paper
• In vivo expression of mRNAs encoding hypoxia-inducible factor 1.

  1996cited by this paper
• The Development and Use of a DNA Polymerase Arrest Assay for the Evaluation of Parameters Affecting Intrastrand Tetraplex Formation*

  1996cited by this paper
• CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.

  1995cited by this paper
• Solution structure of the Na+ form of the dimeric guanine quadruplex [d(G3T4G3)]2.

  1995cited by this paper
• Solution structure of the Oxytricha telomeric repeat d[G4(T4G4)3] G-tetraplex.

  1995cited by this paper
• Structure and stability of human telomeric sequence.

  1994cited by this paper
• The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.

  1994cited by this paper
• The high-resolution crystal structure of a parallel-stranded guanine tetraplex.

  1994cited by this paper
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  1993cited by this paper
• Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA.

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• Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex.

  1993cited by this paper
• Structure and stability of sodium and potassium complexes of dT4G4 and dT4G4T.

  1992cited by this paper
• Hairpin and parallel quartet structures for telomeric sequences.

  1992cited by this paper
• Guanine residues in d(T2AG3) and d(T2G4) form parallel-stranded potassium cation stabilized G-quadruplexes with anti glycosidic torsion angles in solution.

  1992cited by this paper
• Telomere G-strand structure and function analyzed by chemical protection, base analogue substitution, and utilization by telomerase in vitro.

  1990cited by this paper
• A sodium-potassium switch in the formation of four-stranded G4-DNA

  1990cited by this paper
• Four-stranded nucleic acid structures 25 years later: from guanosine gels to telomer DNA.

  1990cited by this paper
• Monovalent cation-induced structure of telomeric DNA: the G-quartet model.

  1989cited by this paper
• Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

  1989cited by this paper
• Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

  1988cited by this paper
• Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs.

  1987cited by this paper

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