Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization

Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) alpha/beta i-IEL, but little effect in the pool size or characteristics of gamma/delta i-IEL. In young athymic mice, virtually no alpha/beta i-IEL are detected, while considerable numbers of gamma/delta i-IEL remain, though reduced in GF animals.

• Publication year

  1990

• Venue

  Journal of Experimental Medicine

• Publication date

  1990-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.172.1.239PMID 2141628PMCID 2188170
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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