Gender differences in aging: cognition, emotions, and neuroimaging studies

Gender and aging moderate brain-behavior relationships. Advances in neuroscience enable integration of neurobehavioral, neuroanatomic, and neurophysiology measures. Here we present neurobehavioral studies thai examine cognitive and emotion processing in healthy men and women and highlight the effects of sex differences and aqinq. Neuroanatomic studies with maqnetic resonance imaging (MRI) indicate that the progressive decrease in brain volume affects froniotemporal brain regions in men more than in Vi/omen, Functional imaging methods suggest sex differences in rate of blood flow, pattern of glucose metabolism, and receptor activity. The role of ovarian hormones is important in elucidating the observed relationships. A life span perspective on gender differences through the integration of available methodologies will advance understanding healthy people and the effects of brain disorders.

• Publication year

  2002

• Venue

  Dialogues in Clinical Neuroscience

• Publication date

  2002-06-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.31887/DCNS.2002.4.2/rgurPMID 22033483PMCID 3181676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects

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• S E a R C H

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• What the Face Reveals

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• Computerized Neurocognitive Scanning: I. Methodology and Validation in Healthy People

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• Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging.

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• Striatal dopamine transporters and cognitive functioning in healthy men and women.

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• Sex Differences in Brain Gray and White Matter in Healthy Young Adults: Correlations with Cognitive Performance

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• Age effects on brain activity associated with episodic memory retrieval. An electrophysiological study.

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• Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging.

  1998influential reference
• Emotion in the perspective of an integrated nervous system.

  1998cited by this paper
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• Hemifacial Asymmetry in Emotion Expressions

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• From sensation to cognition.

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• Sex differences in brain aging: a quantitative magnetic resonance imaging study.

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• White matter changes with normal aging

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• The neurobiology of emotional experience.

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• Gender Differences in Human Cognition

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• Emotion and aging: experience, expression, and control.

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• Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life.

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