Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Diabetes

• Publication date

  2005-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/DIABETES.54.2.570PMID 15677517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Response of the alternative complement pathway to an oral fat load in first-degree relatives of subjects with type II diabetes

  2005cited by this paper
• Reference distributions for complement proteins C3 and C4: A practical, simple and clinically relevant approach in a large cohort

  2004cited by this paper
• Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo.

  2004cited by this paper
• Critical review of acylation-stimulating protein physiology in humans and rodents.

  2003cited by this paper
• C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998.

  2003cited by this paper
• High expression of complement components in omental adipose tissue in obese men.

  2003cited by this paper
• The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones.

  2003cited by this paper
• Inflammation-sensitive plasma proteins are associated with future weight gain.

  2003cited by this paper
• Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.

  2002cited by this paper
• Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.

  2002cited by this paper
• Blood Pressure Increase and Incidence of Hypertension in Relation to Inflammation-Sensitive Plasma Proteins

  2002cited by this paper
• Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study.

  2002cited by this paper
• Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults.

  2002cited by this paper
• Effects of Cholesterol and Inflammation-Sensitive Plasma Proteins on Incidence of Myocardial Infarction and Stroke in Men

  2002cited by this paper
• C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study.

  2002cited by this paper
• Acylation-stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/obMice*

  2002cited by this paper
• The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study.

  2001cited by this paper
• Plasma Acylation Stimulating Protein Concentration and Subcutaneous Adipose Tissue C3 mRNA Expression in Nondiabetic and Type 2 Diabetic Men

  2001cited by this paper
• C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.

  2001cited by this paper
• Relationship of serum C3 to fasting insulin, risk factors and previous ischaemic events in middle-aged men.

  2000cited by this paper
• Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration.

  2000cited by this paper
• The role of TNFα and TNF receptors in obesity and insulin resistance

  1999cited by this paper
• Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies.

  1999cited by this paper
• Acylation Stimulating Protein (ASP) Deficiency Alters Postprandial and Adipose Tissue Metabolism in Male Mice*

  1999cited by this paper
• Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study.

  1999cited by this paper
• Mechanisms Involved in the Regulation of Free Fatty Acid Release from Isolated Human Fat Cells by Acylation-stimulating Protein and Insulin*

  1999cited by this paper
• The role of TNFalpha and TNF receptors in obesity and insulin resistance.

  1999cited by this paper
• C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

  1999cited by this paper
• Is Type II diabetes mellitus a disease of the innate immune system?

  1998cited by this paper
• Relation between plasma tumor necrosis factor-alpha and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus.

  1998cited by this paper
• Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus

  1998cited by this paper
• Cytokines and the hepatic acute phase response

  1997cited by this paper
• Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity

  1997cited by this paper
• ASP stimulates glucose transport in cultured human adipocytes

  1997cited by this paper
• Cardiovascular risk groups and mortality in an urban Swedish male population: the Malmö Preventive Project

  1996cited by this paper
• Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes.

  1995cited by this paper
• Association of serum C3 levels with the risk of myocardial infarction.

  1995cited by this paper
• Radioimmunoassay and related techniques.

  1993cited by this paper
• Plasma C3d Levels and Ischemic Heart Disease in Type II Diabetes

  1993cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• Electroimmuno assay.

  1972cited by this paper

• MAp44: Emerging Insights into Its Role in Disease Pathogenesis and Association with Various Diseases.

  2025cites this paper
• Plasma complement system markers and their association with cardiometabolic risk factors: an ethnic comparison of White European and Black African men.

  2025influential citation
• Complement at the crossroads of inflammation and metabolism: implications for diabetes and metabolic functions.

  2025cites this paper
• Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome

  2025cites this paper
• C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis

  2025cites this paper
• Proteomic Profiling Reveals Alterations in Metabolic and Cellular Pathways in Severe Obesity and Following Metabolic Bariatric Surgery.

  2025cites this paper
• Aging‐associated changes in immunological parameters: Implications for COVID‐19 immune response in the elderly

  2025cites this paper
• Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women

  2025cites this paper
• Identification of α2-macroglobulin as a biomarker for type 2 diabetes in human serum

  2025cites this paper
• Beta-cell-specific C3 deficiency exacerbates metabolic dysregulation and insulin resistance in obesity

  2025cites this paper
• Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients With Rheumatoid Arthritis

  2024cites this paper
• Association between PM2.5 constituents and cardiometabolic risk factors: exploring individual and combined effects, and mediating inflammation.

  2024cites this paper
• Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population

  2024cites this paper
• Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters

  2024cites this paper
• Association between inflammatory biomarkers and mortality in individuals with type 2 diabetes: NHANES 2005-2018.

  2024cites this paper
• DNA methylome analysis reveals epigenetic alteration of complement genes in advanced metabolic dysfunction-associated steatotic liver disease

  2024cites this paper
• Study on the Interaction Between C3 Gene Polymorphism and Environment in Patients with Type 2 Diabetes Combined with Coronary Artery Disease

  2024cites this paper
• The complement system in lipid-mediated pathologies

  2024cites this paper
• Sigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress

  2023cites this paper
• Bioinformatics and network biology approach to identifying type 2 diabetes genes and pathways that influence the progression of breast cancer

  2023cites this paper
• MASP‐2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes

  2023cites this paper
• Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

  2023cites this paper
• Healthy lifestyle linked to innate immunity and lipoprotein metabolism: a cross-sectional comparison using untargeted proteomics

  2023cites this paper
• Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation

  2023cites this paper
• From complement to complosome in non‐alcoholic fatty liver disease: When location matters

  2023cites this paper
• Study of the Levels of Immunoglobulin G and Complement 3 in Gestational Diabetes and Their Newborn

  2023cites this paper
• Plant-based dietary indices and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of adults in Ireland

  2023cites this paper
• The Youngbloods. Get Together. Hypercoagulation, Complement, and NET Formation in HIV/SIV Pathogenesis

  2022cites this paper
• Components of the Complement Cascade Differ in Polycystic Ovary Syndrome

  2022cites this paper
• Role of C-Reactive Protein in Diabetic Inflammation

  2022cites this paper
• Metabolomic Profile of Insulin Resistance Women with Systemic Lupus Erythematosus

  2022cites this paper
• SARS-CoV-2 infection and diabetes: Pathophysiological mechanism of multi-system organ failure

  2022cites this paper
• Changes in Specific Biomarkers Indicate Cardiac Adaptive and Anti-inflammatory Response of Repeated Recreational SCUBA Diving

  2022cites this paper
• The Complement System, Aging, and Aging-Related Diseases

  2022cites this paper
• Association of complement C3 with incident type 2 diabetes and the mediating role of BMI: A 10-year follow-up study.

  2022cites this paper
• Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows

  2022cites this paper
• Complement factors D and C3 cross-sectionally associate with arterial stiffness, but not independently of metabolic risk factors: The Maastricht Study

  2022cites this paper
• Exosome Proteomics Reveals the Deregulation of Coagulation, Complement and Lipid Metabolism Proteins in Gestational Diabetes Mellitus

  2022cites this paper
• Association of Complement C3 with Clinical Deterioration Among Hospitalized Patients with COVID-19

  2022cites this paper
• Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically.

  2021cites this paper
• Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.

  2021cites this paper
• Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity

  2021cites this paper
• Identification of potential pathways whereby dietary L-tryptophan ameliorates the glucose metabolic disorder of blunt snout bream through long non-coding RNAs

  2021cites this paper
• Maternal serum proteomic profiles of pregnant women with type 1 diabetes

  2021cites this paper
• Medical Records-Based Genetic Studies of the Complement System

  2021cites this paper
• Complement in metabolic disease: metaflammation and a two-edged sword

  2021cites this paper
• High serum complement component C4 as a unique predictor of unfavorable outcomes in diabetic stroke

  2021cites this paper
• Mechanisms of heart failure with preserved ejection fraction in the presence of diabetes mellitus

  2020cites this paper
• Prevalence and risk factors for gallstone disease: A population‐based cross‐sectional study

  2020cites this paper
• Early Pro-Inflammatory Remodeling of HDL Proteome in a Model of Diet-Induced Obesity: 2H2O-Metabolic Labeling-Based Kinetic Approach

  2020cites this paper
• Molecular pathophysiology of diabetes mellitus during pregnancy with antenatal complications

  2020cites this paper
• Immunological Profile of Type II Egyptian Diabetic Patients

  2020influential citation
• Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus

  2020cites this paper
• An Overview of Ozone Therapy for Treating Foot Ulcers in Patients With Diabetes.

  2020cites this paper
• Complement activation in polycystic ovary syndrome occurs in the postprandial and fasted state and is influenced by obesity and insulin sensitivity

  2020cites this paper
• Serum proteome assessment in nonalcoholic fatty liver disease in children: a preliminary study

  2020cites this paper
• Quantitative Comparative Proteomics Reveals Candidate Biomarkers for the Early Prediction of Gestational Diabetes Mellitus: A Preliminary Study

  2020cites this paper
• Assessment of immune response in patients with type 2 Diabetes mellitus

  2020cites this paper
• Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies

  2020cites this paper
• Association of thyroid hormones with resting energy expenditure and complement C3 in normal weight high body fat women

  2019cites this paper
• Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation.

  2019cites this paper
• Study of hemolytic activity and subfactors of complement in smokers intoxication

  2019cites this paper
• Identification of core genes and pathways in type 2 diabetes mellitus by bioinformatics analysis

  2019cites this paper
• Assesment of Inflammatory Markers and Epicardial Adipose Tissue Thickness in Women with Polycystic Ovary Syndrome

  2019influential citation
• Role of Complement and Complement-Related Adipokines in Regulation of Energy Metabolism and Fat Storage.

  2019cites this paper
• Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study

  2019cites this paper
• Ginkgo biloba Extract Modulates the Retroperitoneal Fat Depot Proteome and Reduces Oxidative Stress in Diet-Induced Obese Rats

  2019cites this paper
• Role of complement in diabetes.

  2019cites this paper
• Comparative Proteomics Analysis of Serum Proteins in Gestational Diabetes during Early and Middle Stages of Pregnancy

  2019cites this paper
• Serum complement C3 and islet β-cell function in patients with type 2 diabetes: A 4.6-year prospective follow-up study

  2019cites this paper
• EVALUATION OF C3 COMPLEMENT AND INFLAMMATORY MARKER (C-REACTIVE PROTEIN) IN TYPE 2 DIABETES SUBJECTS WITH INSULIN RESISTANCE

  2019cites this paper
• Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China.

  2019cites this paper
• Relationships of Complement Components C3 and C4 and their Genetics to Cardiometabolic Risk in Healthy, Non-Hispanic White Adolescents

  2019cites this paper
• Endogenous Roles of Mammalian Flavin-Containing Monooxygenases

  2019cites this paper
• Comparative Proteomic Analysis of Two Differently Extracted Coptis chinensis in the Treatment of Type 2 Diabetic Rats

  2018cites this paper
• Early detection of metabolic dysregulation using water T2 analysis of biobanked samples

  2018cites this paper
• Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals: a cross-sectional study

  2018cites this paper
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.

  2018cites this paper
• Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome

  2018cites this paper
• Circulating C3 and glucose metabolism abnormalities in patients with OSAHS

  2018cites this paper
• Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals.

  2018cites this paper
• Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the ‘common soil’ hypothesis

  2018cites this paper
• Association between Complement System, Inflammatory Cytokines and Glucose Control in Obese Subjects

  2018cites this paper
• Adipose tissue complement factor B promotes adipocyte maturation.

  2018cites this paper
• Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes

  2018cites this paper
• Non-traditional roles of complement in type 2 diabetes: Metabolism, insulin secretion and homeostasis.

  2017cites this paper
• Complement 3 serum levels as a pro-inflammatory biomarker for insulin resistance in obesity.

  2017cites this paper
• Inflammation and insulin resistance according to body composition in European adolescents: the HELENA study.

  2017cites this paper
• Inflammation and Type 2 Diabetes

  2017cites this paper
• Complement component 3 (C3) as a biomarker for insulin resistance after bariatric surgery.

  2017influential citation
• Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men

  2017influential citation
• Widely used commercial ELISA for human Zonulin reacts with Complement C3 rather than preHaptoglobin2

  2017cites this paper
• Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity

  2017cites this paper
• Elevated serum complement C3 levels are associated with prehypertension in an adult population

  2017cites this paper
• Association of endotoxaemia with serum free fatty acids in metabolically healthy and unhealthy abdominally obese individuals: a case–control study in northwest of Iran

  2017cites this paper
• C 3 aR and C 5 aR 1 act as key regulators of human and mouse β ‐ cell function

  2017cites this paper
• Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study

  2017cites this paper
• Clinical significance of serum complement factor 3 in patients with type 2 diabetes mellitus.

  2017cites this paper
• Enhanced differential expression statistics for data-independent acquisition proteomics

  2017cites this paper
• Association of serum complement C3 with metabolic syndrome components in normal weight obese women

  2017cites this paper