Insights into the Molecular Basis of Human Hereditary Breast Cancer from Studies of the BRCA1 BRCT Domain

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Familial Cancer

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10689-005-2579-zPMID 16528612
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

  2005cited by this paper
• Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

  2004influential reference
• Interactions between BRCT repeats and phosphoproteins: tangled up in two.

  2004cited by this paper
• Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

  2004cited by this paper
• Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase*

  2004cited by this paper
• Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

  2004cited by this paper
• Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains*

  2003cited by this paper
• Detection of Protein Folding Defects Caused by BRCA1-BRCT Truncation and Missense Mutations*

  2003influential reference
• Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

  2003cited by this paper
• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

  2003cited by this paper
• The BRCT Domain Is a Phospho-Protein Binding Domain

  2003cited by this paper
• Structural Consequences of a Cancer-causing BRCA1-BRCT Missense Mutation*

  2003cited by this paper
• The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair.

  2003cited by this paper
• BRCA1 RING Domain Cancer-predisposing Mutations

  2001cited by this paper
• Structure of a BRCA1–BARD1 heterodimeric RING–RING complex

  2001cited by this paper
• Functional analysis of BRCA1 C-terminal missense mutations identified in breast and ovarian cancer families.

  2001cited by this paper
• Direct DNA binding by Brca1

  2001cited by this paper
• Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

  2001cited by this paper
• Functional assay for BRCA1: mutagenesis of the COOH-terminal region reveals critical residues for transcription activation.

  2000cited by this paper
• Mapping the Functional Domains of BRCA1

  1999cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• BRCA1 mutations in primary breast and ovarian carcinomas.

  1994cited by this paper
• The BRCT Domain Is a PhosphoProtein Binding Domain

  year unknowncited by this paper

• The Role of BRCT Domain from LmjPES in Leishmania major Pathogenesis

  2025cites this paper
• Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays

  2023cites this paper
• In Silico and Structure-Based Assessment of Similar Variants Discovered in Tandem Repeats of BRCT Domains of BRCA1 and BARD1 To Characterize the Folding Pattern

  2022cites this paper
• The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

  2022cites this paper
• BRCA1/2 variants of unknown significance in hereditary breast and ovarian cancer (HBOC) syndrome: looking for the hidden meaning.

  2022cites this paper
• Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice

  2022cites this paper
• BRCA1-BRCT Mutations Alter the Subcellular Localization of BRCA1 In Vitro

  2021cites this paper
• Epigenetics in toxicology and drug development

  2021cites this paper
• Screening of BRCA1 variants c.190T>C, 1307delT, g.5331G>A and c.2612C>T in breast cancer patients from North India

  2020cites this paper
• 15 TopBP 1 in DNA Damage Response

  2018influential citation
• Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11

  2018cites this paper
• Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation

  2018cites this paper
• Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk

  2018cites this paper
• Systematic analysis of heterochromatin modification readout

  2017cites this paper
• The Impact of M1775K Variant in BRCA1 Regulation

  2017cites this paper
• Toxicology and Epigenetics

  2016cites this paper
• Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes

  2016cites this paper
• Petasis-Ugi ligands: New affinity tools for the enrichment of phosphorylated peptides.

  2016cites this paper
• Development of a Community-Based Palliative Care Model for Advance Cancer Patients in Public Health Centers in Busan, Korea

  2016cites this paper
• Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients

  2016cites this paper
• University of Groningen A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history Garcia,

  2015influential citation
• The Role of BRCT-Containing Proteins BRCA1 and PAXIP1 in Cancer

  2015cites this paper
• Opportunities and hurdles in the treatment of BRCA1-related breast cancer

  2014cites this paper
• Analiza molekularna kompleksu genów MRE11/RAD50/NBS1 w rodzinach z agregacją zachorowań na raki piersi i/lub jajnika

  2014cites this paper
• The role of the BARD1 BRCT domains in the DNA damage response

  2014cites this paper
• Pathogenicity evaluation of BRCA1 and BRCA2 unclassified variants identified in Portuguese breast/ovarian cancer families.

  2014cites this paper
• Organizing the Ubiquitin-dependent Response to DNA Double-Strand Breaks

  2014cites this paper
• The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.

  2014cites this paper
• Functional and Structural Analysis of C-Terminal BRCA1 Missense Variants

  2013cites this paper
• A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

  2013cites this paper
• Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer

  2013influential citation
• Extending the Interaction Repertoire of FHA and BRCT Domains

  2013cites this paper
• Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

  2013cites this paper
• Association between the c.*229C>T polymorphism of the topoisomerase IIb binding protein 1 (TopBP1) gene and breast cancer

  2013cites this paper
• BRCA1 tumor suppressor network: focusing on its tail

  2012cites this paper
• Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation

  2012cites this paper
• [Molecular basis of gynecological oncology--TopBP1 protein and its participation in the transcription process].

  2012cites this paper
• Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition

  2011cites this paper
• A novel role for BRCA1 in regulating breast cancer cell spreading and motility

  2011cites this paper
• Cancer predisposing mutations in BRCT domains

  2011influential citation
• TopBP1 in DNA Damage Response

  2011cites this paper
• Structure-Function Relationship of DNA Repair Proteins: Lessons from BRCA1 and RAD51 Studies

  2011cites this paper
• Breast cancer and genetics.

  2011cites this paper
• Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach

  2010cites this paper
• Targeting the DNA double strand breaks repair for cancer therapy.

  2010cites this paper
• Identification of a Danish breast/ovarian cancer family double heterozygote for BRCA1 and BRCA2 mutations

  2010cites this paper
• Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer

  2010cites this paper
• The BRCA1 c.5434C→G (p.Pro1812Ala) variant induces a deleterious exon 23 skipping by affecting exonic splicing regulatory elements

  2010cites this paper
• Recent Advances in Understanding the Cellular Functions of BRCA1

  2009cites this paper
• Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.

  2009cites this paper
• UvA-DARE ( Digital Academic Repository ) A method to assess the clinical significance of unclassified variants in the BRCA 1 and BRCA 2 genes based on cancer family history

  2009influential citation
• Regulatory ubiquitylation in response to DNA double-strand breaks.

  2009cites this paper
• Characterization of cancer‐linked BRCA1‐BRCT missense variants and their interaction with phosphoprotein targets

  2009cites this paper
• A common Greenlandic Inuit BRCA1 RING domain founder mutation

  2009cites this paper
• A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history

  2009influential citation
• The role of BACH1 , BARD1 and TOPBP1 genes in familial breast cancer

  2009cites this paper
• Evidence for a Structural Relationship between BRCT Domains and the Helicase Domains of the Replication Initiators Encoded by the Polyomaviridae and Papillomaviridae Families of DNA Tumor Viruses

  2008cites this paper
• Greek BRCA1 and BRCA2 mutation spectrum: two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients

  2008cites this paper
• RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.

  2008cites this paper
• G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history

  2008cites this paper
• RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205.

  2008cites this paper
• Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicans.

  2007cites this paper
• Biology of BRCA1- and BRCA2-Associated Carcinogenesis

  2007cites this paper
• Pharmacogenomics and Personalized Medicine Dovepress Microrna Binding Site Polymorphisms as Biomarkers in Cancer Management and Research

  year unknowncites this paper