Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding

No abstract is available for this paper.

• Publication year

  2003

• Venue

  The Journal of comparative neurology

• Publication date

  2003-03-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/cne.10550PMID 12561075
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• EMXl homeoprotein is expressed in cell nuclei of the developing cortex and in the axons of the olfactory sensory neurons cerebral

  2003cited by this paper
• Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles.

  2002cited by this paper
• Distinct Actions of Emx1, Emx2, andPax6 in Regulating the Specification of Areas in the Developing Neocortex

  2002cited by this paper
• Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon.

  2002cited by this paper
• Role of Emx2 in the development of the reciprocal connectivity between cortex and thalamus

  2002cited by this paper
• Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.

  2002influential reference
• Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex.

  2002cited by this paper
• Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage

  2002cited by this paper
• Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: Evidence that cortical and thalamic axons interact and guide each other

  2002cited by this paper
• Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium.

  2002cited by this paper
• A role for cingulate pioneering axons in the development of the corpus callosum

  2001cited by this paper
• Cortical Axon Guidance by the Glial Wedge during the Development of the Corpus Callosum

  2001cited by this paper
• Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.

  2001cited by this paper
• A long, remarkable journey: Tangential migration in the telencephalon

  2001cited by this paper
• Cell-Cycle Kinetics of Neocortical Precursors Are Influenced by Embryonic Thalamic Axons

  2001cited by this paper
• Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles.

  2001cited by this paper
• Combinatorial Expression Patterns of LIM-Homeodomain and Other Regulatory Genes Parcellate Developing Thalamus

  2001cited by this paper
• Emx1 is a marker for pyramidal neurons of the cerebral cortex.

  2001cited by this paper
• Tbr1 regulates differentiation of the preplate and layer 6.

  2001cited by this paper
• Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway.

  2001cited by this paper
• Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain

  2001cited by this paper
• Differential Expression of COUP-TFI, CHL1, and Two Novel Genes in Developing Neocortex Identified by Differential Display PCR

  2000cited by this paper
• Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx‐2, Emx‐1, Nkx‐2.1, Pax‐6, and Tbr‐1

  2000cited by this paper
• The Lack of Emx2 Causes Impairment ofReelin Signaling and Defects of Neuronal Migration in the Developing Cerebral Cortex

  2000influential reference
• Emx homeogenes and mouse brain development.

  2000cited by this paper
• Regulation of area identity in the mammalian neocortex by Emx2 and Pax6.

  2000cited by this paper
• Morphology and Growth Patterns of Developing Thalamocortical Axons

  2000cited by this paper
• Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice

  2000influential reference
• Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).

  2000cited by this paper
• Normal corpus callosum in Emx1 mutant mice with C57BL/6 background.

  2000cited by this paper
• The origin and migration of cortical neurones: new vistas.

  2000cited by this paper
• Emx2 Is Required for Growth of the Hippocampus But Not for Hippocampal Field Specification

  2000cited by this paper
• Genetic control of cortical regionalization and connectivity.

  1999cited by this paper
• Defects in thalamocortical axon pathfinding correlate with altered cell domains in Mash-1-deficient mice.

  1999cited by this paper
• Thalamocortical axons are influenced by chemorepellent and chemoattractant activities localized to decision points along their path.

  1999cited by this paper
• The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons.

  1999cited by this paper
• Early neocortical regionalization in the absence of thalamic innervation.

  1999cited by this paper
• Gli3 is required for Emx gene expression during dorsal telencephalon development.

  1999influential reference
• Regional differences in the developing cerebral cortex revealed by ephrin-A5 expression.

  1999cited by this paper
• Graded and Areal Expression Patterns of Regulatory Genes and Cadherins in Embryonic Neocortex Independent of Thalamocortical Input

  1999cited by this paper
• Beauty is skin deep: the fascinating biology of the epidermis and its appendages.

  1998cited by this paper
• Mechanisms Underlying the Early Establishment of Thalamocortical Connections in the Rat

  1998cited by this paper
• Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes.

  1998cited by this paper
• Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse

  1998cited by this paper
• EMX2 protein in the developing mouse brain and olfactory area.

  1998cited by this paper
• Immunohistochemical localization of neurocan and L1 in the formation of thalamocortical pathway of developing rats

  1997cited by this paper
• Neuronal circuits are subdivided by differential expression of type-II classic cadherins in postnatal mouse brains.

  1997cited by this paper
• Emx1 and Emx2 functions in development of dorsal telencephalon.

  1997influential reference
• Directed Growth of Early Cortical Axons Is Influenced by a Chemoattractant Released from an Intermediate Target

  1997cited by this paper
• Emx1 and Emx2 Show Different Patterns of Expression During Proliferation and Differentiation of the Developing Cerebral Cortex in the Mouse

  1996cited by this paper
• Dentate gyrus formation requires Emx2.

  1996influential reference
• Mutation of the Emx-1 homeobox gene disrupts the corpus callosum.

  1996cited by this paper
• How do thalamic axons find their way to the cortex?

  1995cited by this paper
• Constructing the cerebral cortex: neurogenesis and fate determination.

  1995cited by this paper
• A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

  1995cited by this paper
• The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons.

  1995cited by this paper
• Development of cairetinin immunoreactivity in the neocortex of the rat

  1995cited by this paper
• Longitudinal organization of the anterior neural plate and neural tube.

  1995cited by this paper
• Glutamate-like immunoreactivity and fate of Cajal-Retzius cells in the murine cortex as identified with calretinin antibody.

  1995cited by this paper
• Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain.

  1994cited by this paper
• Regulation of the POU domain gene SCIP during cerebral cortical development

  1994cited by this paper
• Axons of early generated neurons in cingulate cortex pioneer the corpus callosum

  1994cited by this paper
• Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

  1992cited by this paper
• Growth and targeting of subplate axons and establishment of major cortical pathways [published erratum appears in J Neurosci 1993 Mar;13(3):following table of contents]

  1992cited by this paper
• Nested expression domains of four homeobox genes in developing rostral brain

  1992cited by this paper
• Role of the early epithelium in the patterning of the teeth and Meckel's cartilage.

  1991cited by this paper
• Developmental expression of neural cell adhesion molecules in the mouse neocortex and olfactory bulb

  1991cited by this paper
• Requirement for subplate neurons in the formation of thalamocortical connections

  1990cited by this paper
• Carbocyanine dyes. Novel markers for labelling neurons.

  1989cited by this paper
• Subplate neurons pioneer the first axon pathway from the cerebral cortex.

  1989cited by this paper
• Dil and diO: versatile fluorescent dyes for neuronal labelling and pathway tracing.

  1989cited by this paper
• Pattern formation in the molar dentition of the mouse.

  1979cited by this paper
• The development of the cerebral cortex

  1912cited by this paper

• Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus

  2025cites this paper
• Transferring Mouse Emx1 and Emx2 Lentiviruses into the Chicken Embryonic Brain and Their Implication to the Organization and Evolution of the Amniote Pallium

  2025influential citation
• Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1

  2024cites this paper
• Indirect neurogenesis in space and time

  2024cites this paper
• Comparison of genes involved in brain development: insights into the organization and evolution of the telencephalic pallium

  2024influential citation
• Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder.

  2024cites this paper
• Identification of novel microRNAs in the embryonic mouse brain using deep sequencing

  2023cites this paper
• Identifying enhancer properties associated with genetic risk for complex traits using regulome-wide association studies

  2022cites this paper
• Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes

  2022cites this paper
• Disease Modeling of Rare Neurological Disorders in Zebrafish

  2022cites this paper
• Modeling Axonal Plasticity in Artificial Neural Networks

  2021cites this paper
• Correction to: Modeling Axonal Plasticity in Artificial Neural Networks

  2021cites this paper
• Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala

  2021cites this paper
• Regulome-wide association study identifies enhancer properties associated with risk for schizophrenia

  2021cites this paper
• Evolving Views on the Pallium

  2021cites this paper
• Transcriptional network orchestrating regional patterning of cortical progenitors

  2020cites this paper
• Neuronal migration of guidepost cells

  2020cites this paper
• Morphogens, patterning centers, and their mechanisms of action

  2020cites this paper
• Ciliopathies and hedgehog-related forebrain developmental disorders.

  2020cites this paper
• Anatomy and development of the human taste system.

  2019cites this paper
• Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox

  2019cites this paper
• Metabolic regulation and glucose sensitivity of cortical radial glial cells

  2018cites this paper
• Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury

  2018cites this paper
• Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation

  2017cites this paper
• Emx1 Is Required for Neocortical Area Patterning

  2016cites this paper
• Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach

  2016cites this paper
• TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons

  2016cites this paper
• Étude de la neuroinflammation suite à la lésion et la transplantation corticale

  2016cites this paper
• The First Nervous System

  2016cites this paper
• The Role of Sonic Hedgehog in the Specification of Human Cortical Progenitors In Vitro.

  2016cites this paper
• Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development

  2016cites this paper
• Patterning, morphogenesis, and neurogenesis of zebrafish cranial sensory placodes.

  2016cites this paper
• Insights into the Biology and Therapeutic Applications of Neural Stem Cells

  2016cites this paper
• Genetic analyses of thalamocortical axon guidance and subpallial development

  2016influential citation
• The complex genetic basis of congenital hypogonadotropic hypogonadism.

  2016cites this paper
• Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal‐Retzius cells

  2016influential citation
• Brain and Cognitive Development

  2015cites this paper
• Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex

  2015cites this paper
• EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex

  2015cites this paper
• EMX 1 regulates NRP 1-mediated wiring of the mouse anterior cingulate cortex

  2015cites this paper
• Neuronal and microglial regulators of cortical wiring: usual and novel guideposts

  2015cites this paper
• Building the Olfactory System: Morphogenesis and Stem Cell Specification in the Olfactory Epithelium and Olfactory Bulb

  2015cites this paper
• A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene

  2015cites this paper
• Computational and mathematical methods for morphogenetic gradient analysis, boundary formation and axonal targeting.

  2014cites this paper
• Analyse von Wechselwirkungen der Homeodomäninteragierenden Proteinkinase (Hipk) in Drosophila melanogaster unter besonderer Berücksichtigung des Interaktionspartners Spenito (Nito)

  2014cites this paper
• The role of HuD, a post-transcriptional regulator, in the development and function of the murine neocortex

  2014cites this paper
• Olfactory sensory system develops from coordinated movements within the neural plate

  2014cites this paper
• Gli3 controls subplate formation and growth of cortical axons.

  2013cites this paper
• The zinc finger transcription factor Jing is required for dendrite/axonal targeting in Drosophila antennal lobe development.

  2013cites this paper
• EMX2 is Downregulated in Endometrial Cancer and Correlated With Tumor Progression

  2013cites this paper
• Etude de la fonction du facteur de transcription Dmrt5 dans le développement du système olfactif

  2013cites this paper
• Transcriptional Regulation of Olfactory Bulb Neurogenesis

  2013cites this paper
• Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.

  2013cites this paper
• The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.

  2013cites this paper
• Neocortical arealization: Evolution, mechanisms, and open questions

  2013cites this paper
• RORβ induces barrel-like neuronal clusters in the developing neocortex.

  2012cites this paper
• The effects of injury to dynamic neural networks in the mature and developing brain.

  2012cites this paper
• DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67‐positive neurons in the GAD67‐GFP mouse brain

  2012cites this paper
• Genomics of mature and immature olfactory sensory neurons

  2012cites this paper
• Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain

  2012cites this paper
• From tetrapods to primates: conserved developmental mechanisms in diverging ecological adaptations.

  2012cites this paper
• Scaling Proprioceptor Gene Transcription by Retrograde NT3 Signaling

  2012cites this paper
• Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation

  2011cites this paper
• Regionalized gene expression during human neocorticogenesis

  2011cites this paper
• Development of the Auditory Cortex

  2011cites this paper
• The role of Gsx homeobox genes in the specification and differentiation of mouse lateral ganglionic eminence progenitors

  2011cites this paper
• FEATURE ARTICLE RORb Induces Barrel-like Neuronal Clusters in the Developing Neocortex

  2011cites this paper
• A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype

  2011cites this paper
• EBF factors drive expression of multiple classes of target genes governing neuronal development

  2011cites this paper
• The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels

  2011cites this paper
• Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing

  2011cites this paper
• Molecular bases of cortico-cerebral regionalization.

  2011cites this paper
• The transcription factor Foxg 1 regulates telencephalic progenitor proliferation cell autonomously , in part by controlling Pax 6 expression levels

  2011cites this paper
• Development of axonal pathways in the human fetal fronto‐limbic brain: histochemical characterization and diffusion tensor imaging

  2010cites this paper
• Murine Embryonic Stem Cell-Derived Pyramidal Neurons Integrate into the Cerebral Cortex and Appropriately Project Axons to Subcortical Targets

  2010cites this paper
• Prominent periventricular fiber system related to ganglionic eminence and striatum in the human fetal cerebrum

  2010influential citation
• WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.

  2010cites this paper
• Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells

  2010cites this paper
• Maturation of “Neocortex Isolé” In Vivo in Mice

  2010cites this paper
• Expression and function of the empty spiracles gene in olfactory sense organ development of Drosophila melanogaster

  2010cites this paper
• Emx3 is required for the differentiation of dorsal telencephalic neurons

  2009cites this paper
• Genes and signaling events that establish regional patterning of the mammalian forebrain.

  2009cites this paper
• Evolutionary conservation of mechanisms for neural regionalization, proliferation and interconnection in brain development

  2009cites this paper
• Layer-specific expression of multiple cadherins in the developing visual cortex (V1) of the ferret.

  2009cites this paper
• Patterns and consequences of vertebrate Emx gene duplications

  2009cites this paper
• Targeted knockdown of CREB1 in brain nuclei critically involved in drug-seeking behaviour

  2009cites this paper
• Molecular mechanisms of projection neuron production and maturation in the developing cerebral cortex.

  2009cites this paper
• Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue

  2009cites this paper
• The roles of EMX2 in odorant receptor gene expression and olfactory sensory neuron axon growth

  2009cites this paper
• Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2

  2008cites this paper
• COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.

  2008cites this paper
• empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila

  2008cites this paper
• Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene

  2008cites this paper
• Morphogenetic Gradients and the Stability of Boundaries Between Neighboring Morphogenetic Regions

  2008cites this paper
• Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development

  2008cites this paper
• Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype.

  2008cites this paper
• Altered Molecular Regionalization and Normal Thalamocortical Connections in Cortex-Specific Pax6 Knock-Out Mice

  2008cites this paper
• Homeobox genes in vertebrate forebrain development and disease

  2008cites this paper
• Reelin and Cajal-Retzius Cells

  2008cites this paper
• The age of plasticity: developmental regulation of synaptic plasticity in neocortical microcircuits.

  2008cites this paper