Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy

Inflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. The interaction between tumor cells and macrophages provides opportunities for therapy. This paper will discuss secreted proteins as targets for intervention.

• Publication year

  2011

• Venue

  Clinical and Developmental Immunology

• Publication date

  2011-11-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2011/565187PMID 22162712PMCID 3227419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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