Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Experimental Neurology

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/EXNR.2002.7980PMID 12429228
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Beyond the Glial Scar: Cellular and Molecular Mechanisms by which Glial Cells Contribute to CNS Regenerative Failure

  1999cited by this paper
• CNS regeneration : basic science and clinical advances

  1999cited by this paper
• Robust Regeneration of Adult Sensory Axons in Degenerating White Matter of the Adult Rat Spinal Cord

  1999cited by this paper
• Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function

  1999influential reference
• Survival of chronically-injured neurons can be prolonged by treatment with neurotrophic factors.

  1999cited by this paper
• Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury.

  1998cited by this paper
• Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord

  1998cited by this paper
• Local application of collagen containing brain-derived neurotrophic factor decreases the loss of function after spinal cord injury in the adult rat.

  1998cited by this paper
• Neurotrophin gene therapy in CNS models of trauma and degeneration.

  1998cited by this paper
• Transplants and neurotrophic factors prevent atrophy of mature CNS neurons after spinal cord injury.

  1998cited by this paper
• Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons.

  1997cited by this paper
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  1997cited by this paper
• Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord.

  1997cited by this paper
• The cellular and molecular basis of peripheral nerve regeneration

  1997cited by this paper
• Endogenous repair after spinal cord contusion injuries in the rat.

  1997cited by this paper
• Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.

  1997cited by this paper
• Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat.

  1997cited by this paper
• Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats.

  1997cited by this paper
• Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

  1997cited by this paper
• Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury.

  1996cited by this paper
• Axonal regeneration by chronically injured supraspinal neurons can be enhanced by exposure to insulin-like growth factor, basic fibroblast growth factor or transforming growth factor beta

  1996cited by this paper
• Axonal regeneration into Schwann cell‐seeded guidance channels grafted into transected adult rat spinal cord

  1995cited by this paper
• A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord.

  1995cited by this paper
• Response of rubrospinal and corticospinal neurons to injury and neurotrophins.

  1994cited by this paper
• Chronic spinal cord injury.

  1994cited by this paper
• Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord.

  1994cited by this paper
• Sprouting and Regeneration of Lesioned Corticospinal Tract Fibres in the Adult Rat Spinal Cord

  1993cited by this paper
• Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system.

  1992cited by this paper
• The structural integrity of glial scar tissue associated with a chronic spinal cord lesion can be altered by transplanted fetal spinal cord tissue

  1992cited by this paper
• Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats

  1992cited by this paper
• Demonstration of the potential for chronically injured neurons to regenerate axons into intraspinal peripheral nerve grafts.

  1991cited by this paper
• Regrowth of calcitonin gene-related peptide (CGRP) immunoreactive axons from the chronically injured rat spinal cord into fetal spinal cord tissue transplants.

  1989cited by this paper
• Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.

  1988cited by this paper
• Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression.

  1988cited by this paper
• Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord

  1988cited by this paper
• The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair.

  1988cited by this paper
• Chronic regenerative changes in the spinal cord after cord compression injury in rats.

  1987cited by this paper
• Peripheral nerve autografts to the rat spinal cord: studies with axonal tracing methods.

  1982cited by this paper
• Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.

  1981cited by this paper
• Degeneration and regeneration of the nervous system

  1960cited by this paper

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  2025cites this paper
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  2025cites this paper
• BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications

  2024cites this paper
• Spinal cord stimulation for spinal cord injury - Where do we stand? A narrative review.

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Neurotrophic factors-based therapeutic strategies in the spinal cord injury: an overview of recent preclinical studies in rodent models

  2023cites this paper
• Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

  2023cites this paper
• Role of Axon Guidance Molecules in Ascending and Descending paths in Spinal Cord Regeneration.

  2023cites this paper
• Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives

  2023cites this paper
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  2022cites this paper
• Growth Factor Gene-Modified Cells in Spinal Cord Injury Recovery; a Systematic Review.

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Sustained cell body reactivity and loss of NeuN in a subset of axotomized bulbospinal neurons after a chronic high cervical spinal cord injury

  2017influential citation
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  2017influential citation
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
• [Pathogenesis of spinal cord injuries and mechanisms of repair induced by olfactory ensheathing cells].

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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