Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression.

No abstract is available for this paper.

• Publication year

  1983

• Venue

  Journal of Lipid Research

• Publication date

  1983-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 6644183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cholesterol turnover in lipid phases of human atherosclerotic plaque.

  1982cited by this paper
• Isolation and and partial characterization of the lipid phases of human atherosclerotic plaques.

  1980cited by this paper
• The Mass Uptake of Cholesterol Ester from Low Density Lipoproteins by Cultured Smooth Muscle and Adventitial Cells of Human Aortas

  1980cited by this paper
• The phase behavior of hydrated cholesterol.

  1979cited by this paper
• Heterozygous familial hypercholesterolemia. Relationship between plasma lipids, lipoproteins, clinical manifestations and ischaemic heart disease in men and women.

  1979cited by this paper
• Achilles tendon thickness and ischemic heart disease in familial hypercholesterolemia.

  1978cited by this paper
• Interaction of collagen with the lipids of tendon xanthomata.

  1978cited by this paper
• Cellular Mechanisms for Lipid Deposition in Atherosclerosis

  1977cited by this paper
• Cellular mechanisms for lipid deposition in atherosclerosis (first of two parts).

  1977cited by this paper
• Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques.

  1976cited by this paper
• Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of dietary manipulation.

  1975cited by this paper
• Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

  1975cited by this paper
• Separation of polyunsaturated fatty acids by argentation thin layer chromatography

  1975cited by this paper
• The development of essential fatty acid deficiency in healthy men fed fat-free diets intravenously and orally.

  1975cited by this paper
• Mechanisms of cholesterol accumulation in the arterial wall.

  1975cited by this paper
• Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency. Further studies of very low and low density lipoprotein abnormalities.

  1973cited by this paper
• Ultrastructural and lipid biochemical comparisons of human eruptive, tuberous and planar xanthomas.

  1973cited by this paper
• The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis. 2. Studies on "nile blue" cells.

  1972cited by this paper
• The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis. 1. The lipids in the isolated fractions.

  1972cited by this paper
• Lipid droplets in atherosclerotic fatty streaks of human aorta.

  1970cited by this paper
• The lipids in raised fatty and fibrous lesions in human aorta. A comparison of the changes at different stages of development.

  1968cited by this paper
• Simultaneous Statistical Inference

  1967cited by this paper
• QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL DIETARY AND FECAL NEUTRAL STEROIDS.

  1965cited by this paper
• THE FORMATION OF CHOLESTEROL ESTERS WITH RAT LIVER ENZYMES.

  1964cited by this paper
• Rabbit local tissue response to triglycerides, cholesterol, and its ester.

  1962cited by this paper
• CHAPTER 5 – THE PHYSIOLOGY OF THE CIRCULATING CHOLESTEROL AND LIPOPROTEINS

  1958cited by this paper
• Response of Arterial Wall to Intramural Cholesterol.∗ †

  1958cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: implications for atherogenic, tumorigenic, and obesogenic processes.

  2025cites this paper
• Rethinking Statin Dosage in Coronary Disease

  2025cites this paper
• Nuclear Magnetic Resonance (NMR)-Based Lipidomics Reveal the Association of Altered Red Blood Cell (RBC) Membrane Lipidome with the Presence and the Severity of Coronary Artery Stenosis

  2024cites this paper
• An In Vitro Study of 355‐nm Laser Ablation of Atherosclerotic Lesions Model

  2024cites this paper
• Cholesterol-load evokes robust calcium response in macrophages: An early event toward cholesterol-induced macrophage death.

  2023cites this paper
• In Situ Raman Study of Neurodegenerated Human Neuroblastoma Cells Exposed to Outer-Membrane Vesicles Isolated from Porphyromonas gingivalis

  2023cites this paper
• The Role of Lipid Subcomponents in the Development of Atherosclerotic Plaques

  2023cites this paper
• Serum esterified cholesterol subfractions as a risk marker for coronary artery disease

  2022cites this paper
• Palmar Striated Xanthomas in Clinical Practice

  2022cites this paper
• Spatial metabolomics identifies lipid profiles of human carotid atherosclerosis.

  2022cites this paper
• Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging

  2021cites this paper
• An Implantable Artificial Atherosclerotic Plaque as a Novel Approach for Drug Transport Studies on Drug‐Eluting Stents

  2021cites this paper
• Cardiovascular diseases: Altering apoptosis for a healthy heart

  2021cites this paper
• The Complex Tail of Circulating Sphingolipids in Atherosclerosis and Cardiovascular Disease

  2021cites this paper
• A lipid atlas of human carotid atherosclerosis

  2020cites this paper
• Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging.

  2020cites this paper
• Regulation and Functions of 15-Lipoxygenases in Human Macrophages

  2019cites this paper
• Data Processing Pipeline for Lipid Profiling of Carotid Atherosclerotic Plaque with Mass Spectrometry Imaging

  2019cites this paper
• Free cholesterol, cholesterol precursor and plant sterol levels in atherosclerotic plaques are independently associated with symptomatic advanced carotid artery stenosis.

  2019cites this paper
• Strategies Towards Soft Functional Supramolecular Materials

  2018cites this paper
• Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome.

  2018cites this paper
• Novel Lipidomic Biomarkers in Hyperlipidemia and Cardiovascular Diseases: An Integrative Biology Analysis

  2017cites this paper
• Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols

  2017cites this paper
• Tendon Homeostasis in Hypercholesterolemia.

  2016cites this paper
• Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients.

  2016cites this paper
• How lipids hurt tendons: Current understanding

  2016cites this paper
• Intermittent hypoxia induces murine macrophage foam cell formation by IKK-β-dependent NF-κB pathway activation.

  2016cites this paper
• In a Western Dietary Context Excess Oxidised Linoleic Acid of Dietary and Endogenous Origin by Over-Activation of PPAR Gamma so Immune and Inflammatory Pathways, and through Cardiolipin Damage, Increases Cardiovascular Risk

  2016cites this paper
• Celery Seed Extract Blocks Peroxide Injury in Macrophages via Notch1/NF-κB Pathway.

  2015cites this paper
• Role of Macrophage Apoptosis in Atherosclerosis

  2015cites this paper
• Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice

  2015cites this paper
• Raman spectroscopy of lipids: a review

  2015cites this paper
• The role of the lymphatic system in cholesterol transport

  2015cites this paper
• Concentration-Dependent Diversifcation Effects of Free Cholesterol Loading on Macrophage Viability and Polarization

  2015cites this paper
• Targeting Cholesterol Crystal-Induced Inflammation for the Secondary Prevention of Cardiovascular Disease

  2014cites this paper
• IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1

  2014cites this paper
• A novel selective lipid uptake pathway contributing to LDL-induced macrophage foam cell formation

  2013cites this paper
• Impact of artificial plaque composition on drug transport.

  2013cites this paper
• Noninvasive detection of intimal xanthoma using combined ultrasound, strain rate and photoacoustic imaging.

  2012cites this paper
• Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting

  2012cites this paper
• Melittin stimulates fatty acid release through non-phospholipase-mediated mechanisms and interacts with the dopamine transporter and other membrane-spanning proteins.

  2011cites this paper
• Methodical study on plaque characterization using integrated vascular ultrasound, strain and spectroscopic photoacoustic imaging

  2011cites this paper
• Comparative Lipidomics Profiling of Human Atherosclerotic Plaques

  2011cites this paper
• Cholesterol in human atherosclerotic plaque is a marker for underlying disease state and plaque vulnerability

  2010cites this paper
• The effects of sterol structure upon sterol esterification.

  2010cites this paper
• The role of red blood cells in the progression and instability of atherosclerotic plaque.

  2010cites this paper
• Skin manifestations in familial heterozygous hypercholesterolemia.

  2009cites this paper
• Cholesterol composition of erythrocyte membranes and its association with clinical presentation of coronary artery disease

  2008cites this paper
• Macrophages: An elusive yet emerging therapeutic target of atherosclerosis

  2008cites this paper
• Overview of Imaging Atherosclerosis

  2007cites this paper
• Pivotal Advance: Macrophages become resistant to cholesterol‐induced death after phagocytosis of apoptotic cells

  2007cites this paper
• The inflammatory cytokine response of cholesterol‐enriched macrophages is dampened by stimulated pinocytosis

  2007cites this paper
• Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages*

  2006cites this paper
• Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor*

  2006cites this paper
• Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages

  2006cites this paper
• NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs Published, JLR Papers in Press, June 28, 2006.

  2006cites this paper
• The in teraction of melitt in with membrane fatt y acids and the dopamine transporter

  2006cites this paper
• Intestinal Absorption of Cholesterol by Patients with Smith-Lemli-Opitz Syndrome

  2005cites this paper
• Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.

  2005cites this paper
• Pathogenesis, detection and treatment of Achilles tendon xanthomas

  2005cites this paper
• Vessel wall apoptosis and atherosclerotic plaque instability

  2005cites this paper
• Magnetic resonance imaging of high-risk plaque

  2005cites this paper
• Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids

  2004cites this paper
• CMR atherothrombotic plaque imaging

  2004cites this paper
• Role of Macrophage Apoptosis in Atherosclerosis.

  2004cites this paper
• Removal of cholesteryl esters from diet-induced atherosclerotic lesions in two long-term studies in rhesus monkeys.

  2003cites this paper
• The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

  2003influential citation
• Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

  2003cites this paper
• MR imaging for the noninvasive assessment of atherothrombotic plaques.

  2003cites this paper
• Lipid composition in atheromatous plaque: evaluation of the lipid three-phase percentage.

  2003cites this paper
• ABCA1-mediated Cholesterol Efflux Is Defective in Free Cholesterol-loaded Macrophages

  2002cites this paper
• Atherothrombotic plaques and the need for imaging.

  2002cites this paper
• Familial apolipoprotein A-I and CIll deficiency , variant IV

  2002cites this paper
• Clinical Imaging of the High-Risk or Vulnerable Atherosclerotic Plaque

  2001cites this paper
• Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway*

  2001cites this paper
• Macrophage foam cells and atherosclerosis.

  2001cites this paper
• Acid Sphingomyelinase-deficient Macrophages Have Defective Cholesterol Trafficking and Efflux*

  2001cites this paper
• Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is

  2000cites this paper
• Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway*

  2000cites this paper
• Cholesterol and phospholipid metabolism in macrophages.

  2000cites this paper
• Mechanisms and Consequences of Cholesterol Loading in Macrophages

  1998cites this paper
• Quantitative analysis of cholesterol and cholesteryl esters in human atherosclerotic plaques using near-infrared Raman spectroscopy.

  1998cites this paper
• Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm.

  1998cites this paper
• Intracellular Cholesterol Trafficking

  1998cites this paper
• Free cholesterol-induced cytotoxicity a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions.

  1997cites this paper
• Sperm abnormalities in retinitis pigmentosa.

  1997cites this paper
• Degranulation of cutaneous mast cells induces transendothelial transport and local accumulation of plasma LDL in rat skin in vivo.

  1997cites this paper
• Cholesterol deposition in atherosclerotic lesions.

  1997cites this paper
• Phospholipid metabolism in cholesterol-loaded macrophages

  1997cites this paper
• Cholesterol

  1997cites this paper
• Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats.

  1996cites this paper
• Oxidized lipids in the diet accelerate the development of fatty streaks in cholesterol-fed rabbits.

  1996cites this paper
• Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis

  1996cites this paper
• Quantitative Analysis of Cholesterol and Cholesterol Ester Mixtures Using Near-Infrared Fourier Transform Raman Spectroscopy

  1996cites this paper
• Quantitative determination of free and esterified cholesterol concentrations in cholesterol-fed rabbit aorta using near-infrared- Fourier transform-Raman spectroscopy

  1996cites this paper
• Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.

  1995cites this paper
• Stimulation of CTP:Phosphocholine Cytidylyltransferase by Free Cholesterol Loading of Macrophages Involves Signaling through Protein Dephosphorylation (*)

  1995cites this paper
• Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase.

  1994cites this paper
• Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.

  1994cites this paper
• Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

  1994cites this paper