Regulation of immune cell entry into the central nervous system.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Results and problems in cell differentiation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/400_020PMID 17068976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

  2005cited by this paper
• Mouse syngenic in vitro blood–brain barrier model: a new tool to examine inflammatory events in cerebral endothelium

  2005cited by this paper
• The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis

  2005cited by this paper
• P-Selectin Glycoprotein Ligand 1 Is Not Required for the Development of Experimental Autoimmune Encephalomyelitis in SJL and C57BL/6 Mice1

  2005cited by this paper
• Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact

  2005cited by this paper
• Neuropathology associated with feline immunodeficiency virus infection highlights prominent lymphocyte trafficking through both the blood-brain and blood-choroid plexus barriers

  2005cited by this paper
• Immunology of multiple sclerosis.

  2005cited by this paper
• PSGL-1 is not required for development of experimental autoimmune encephalomyelitis.

  2005cited by this paper
• Efficient Recruitment of Lymphocytes in Inflamed Brain Venules Requires Expression of Cutaneous Lymphocyte Antigen and Fucosyltransferase-VII1

  2005cited by this paper
• Junctional adhesion molecules (JAMs): more molecules with dual functions?

  2004cited by this paper
• Intravital microscopy: visualizing immunity in context.

  2004cited by this paper
• Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis

  2004cited by this paper
• Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.

  2004cited by this paper
• Chronic relapsing experimental allergic encephalomyelitis: its value as an experimental model for multiple sclerosis

  2004cited by this paper
• Mouse CD99 participates in T-cell recruitment into inflamed skin.

  2004cited by this paper
• In vivo imaging of leukocyte trafficking in blood vessels and tissues.

  2004cited by this paper
• The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion.

  2004cited by this paper
• A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

  2004cited by this paper
• T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells.

  2003cited by this paper
• A controlled trial of natalizumab for relapsing multiple sclerosis.

  2003cited by this paper
• T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules : a critical role for P-selectin glycoprotein ligand-1

  2003cited by this paper
• Lymphoid Chemokines CCL19 and CCL21 are Expressed in the Central Nervous System During Experimental Autoimmune Encephalomyelitis: Implications for the Maintenance of Chronic Neuroinflammation

  2003cited by this paper
• Regulation and Functional Effects of Monocyte Migration across Human Brain‐Derived Endothelial Cells

  2003cited by this paper
• Intracellular Domain of Brain Endothelial Intercellular Adhesion Molecule-1 Is Essential for T Lymphocyte-Mediated Signaling and Migration1

  2003cited by this paper
• Development of the blood-brain barrier

  2003cited by this paper
• Forging the endothelium during inflammation: pushing at a half-open door?

  2003cited by this paper
• Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin

  2003cited by this paper
• A real time in vitro assay for studying leukocyte transendothelial migration under physiological flow conditions.

  2003cited by this paper
• Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE.

  2003cited by this paper
• Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.

  2003cited by this paper
• The chemokine system in neuroinflammation: an update.

  2002cited by this paper
• Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood‐brain barrier suggests their involvement in G‐protein‐dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis

  2002cited by this paper
• CD99 plays a major role in the migration of monocytes through endothelial junctions

  2002cited by this paper
• Molecular Mechanisms Involved in Lymphocyte Recruitment in Inflamed Brain Microvessels: Critical Roles for P-Selectin Glycoprotein Ligand-1 and Heterotrimeric Gi-Linked Receptors1

  2002cited by this paper
• Interferon-β directly influences monocyte infiltration into the central nervous system

  2002cited by this paper
• Overlapping Roles of P-Selectin and α4 Integrin to Recruit Leukocytes to the Central Nervous System in Experimental Autoimmune Encephalomyelitis1

  2002cited by this paper
• Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice.

  2002cited by this paper
• Encephalitogenic T cells use LFA‐1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo

  2002cited by this paper
• Interferon-beta directly influences monocyte infiltration into the central nervous system.

  2002cited by this paper
• Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels.

  2001cited by this paper
• Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis.

  2001cited by this paper
• The Chemokine Receptor CCR2 Mediates the Binding and Internalization of Monocyte Chemoattractant Protein-1 along Brain Microvessels

  2001cited by this paper
• Development of the choroid plexus

  2001cited by this paper
• Inhibition of Antigen‐Specific T Cell Trafficking into the Central Nervous System via Blocking PECAM1/CD31 Molecule

  2001cited by this paper
• Involvement of the choroid plexus in central nervous system inflammation

  2001cited by this paper
• Cc Chemokine Receptor 2 Is Critical for Induction of Experimental Autoimmune Encephalomyelitis

  2000cited by this paper
• Cytokine-induced modulation of cellular adhesion to human cerebral endothelial cells is mediated by soluble vascular cell adhesion molecule-1.

  2000cited by this paper
• Tight Junctions of the Blood–Brain Barrier

  2000cited by this paper
• Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro

  2000cited by this paper
• Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment.

  2000cited by this paper
• Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection.

  2000cited by this paper
• Beta7 integrins contribute to demyelinating disease of the central nervous system.

  2000cited by this paper
• A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-&agr;–Induced Leukocyte Recruitment in the Brain Microvasculature

  2000cited by this paper
• Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

  2000cited by this paper
• β7 integrins contribute to demyelinating disease of the central nervous system

  2000cited by this paper
• Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

  1999cited by this paper
• In vitro model for evaluating drug transport across the blood-brain barrier.

  1999cited by this paper
• In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1.

  1999cited by this paper
• Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway.

  1999cited by this paper
• Lymphocyte trafficking and regional immunity.

  1999cited by this paper
• Chemokines and chemokine receptors in CNS pathology.

  1999cited by this paper
• Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

  1998cited by this paper
• The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.

  1998cited by this paper
• T cell interaction with ICAM‐1‐deficient endothelium in vitro: essential role for ICAM‐1 and ICAM‐2 in transendothelial migration of T cells

  1998cited by this paper
• Is the pial microvessel a good model for blood-brain barrier studies?

  1997cited by this paper
• The tight junctions of the leptomeningeal blood-cerebrospinal fluid barrier during development.

  1997cited by this paper
• E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis.

  1997cited by this paper
• Mechanisms of CNS response to systemic immune challenge: the febrile response.

  1997cited by this paper
• Evidence for a prolonged role of alpha sub 4 integrin throughout active experimental allergic encephalomyelitis

  1996cited by this paper
• Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions.

  1996cited by this paper
• ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro.

  1996cited by this paper
• Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion.

  1996cited by this paper
• A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis

  1995cited by this paper
• Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis.

  1995cited by this paper
• Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.

  1995cited by this paper
• Lymphocytes infiltrating the CNS during inflammation display a distinctive phenotype and bind to VCAM-1 but not to MAdCAM-1.

  1995cited by this paper
• The adhesion molecule and cytokine profile of multiple sclerosis lesions

  1995cited by this paper
• A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis.

  1995cited by this paper
• The blood-retinal barrier in experimental autoimmune uveoretinitis. Leukocyte interactions and functional damage.

  1994cited by this paper
• Leukocyte-endothelial adhesion molecules.

  1994cited by this paper
• Modulation of tight junction structure in blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes.

  1994cited by this paper
• Animal models

  1994cited by this paper
• Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse.

  1994cited by this paper
• Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA-1 alpha.

  1993cited by this paper
• Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma

  1993cited by this paper
• ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system.

  1993cited by this paper
• Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice.

  1993cited by this paper
• Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis.

  1993cited by this paper
• Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM‐1

  1993cited by this paper
• Ultrastructural pathology of experimental autoimmune uveitis. Quantitative evidence of activation and possible high endothelial venule-like changes in retinal vascular endothelium.

  1992cited by this paper
• The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues.

  1992cited by this paper
• Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system

  1992cited by this paper
• Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

  1992cited by this paper
• Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

  1992cited by this paper
• Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

  1991cited by this paper
• Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.

  1991cited by this paper
• Interaction of T Lymphocytes with Cerebral Endothelial Cells in vitro

  1991cited by this paper
• A cell culture model of the blood-brain barrier

  1991cited by this paper
• Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse.

  1991cited by this paper
• Central nervous system endothelial cell-polymorphonuclear cell interactions during autoimmune demyelination.

  1991cited by this paper

• CNS-Specific and Coagulation Biomarkers in Traumatic Brain Injury: Beyond the Reach of the Scalpel—A Scoping Review

  2026cites this paper
• Gut-brain axis in health and brain disease.

  2026cites this paper
• Metabolomic Markers and Pathways of Blood–Brain Barrier Damage: A Systematic Review

  2025influential citation
• The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes

  2025cites this paper
• Enterococcus faecium L-3 Ameliorates the Severity of Experimental Allergic Encephalomyelitis in Rats by Influencing Gut Microbiota, Enterocytes, and Immune Functions

  2025cites this paper
• Bloodstream Infection-induced Neuroinflammation: from Systemic Infection To Brain Invasion

  2025cites this paper
• Evolution of Microglia.

  2024cites this paper
• Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population

  2024cites this paper
• Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis

  2024cites this paper
• Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease

  2024cites this paper
• Chimeric antigen receptor adoptive immunotherapy in central nervous system tumors: state of the art on clinical trials, challenges, and emerging strategies to addressing them

  2024cites this paper
• Natural Killer Cell-Based Immunotherapy against Glioblastoma

  2023cites this paper
• The role of the blood–brain barrier during neurological disease and infection

  2023cites this paper
• The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors

  2023influential citation
• mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism

  2023cites this paper
• Open Research Online MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium

  2022cites this paper
• Strategies for delivering therapeutics across the blood–brain barrier

  2021cites this paper
• Pro- and Anti-inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium

  2021cites this paper
• Comparative Review of Microglia and Monocytes in CNS Phagocytosis

  2021cites this paper
• Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma

  2020cites this paper
• Critical Neurotransmitters in the Neuroimmune Network

  2020cites this paper
• The Cytokine Interleukin 6 (IL-6) as a Neural and Endocrine Regulator

  2020cites this paper
• CAR T-Cell Therapy for CNS Malignancies

  2020cites this paper
• Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome

  2020cites this paper
• Oxidative stress in the choroid plexus contributes to blood-cerebrospinal fluid barrier disruption during sepsis development.

  2019cites this paper
• Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy

  2019cites this paper
• RARRES1 is a novel immune-related biomarker in GBM.

  2019cites this paper
• Macrophages at CNS interfaces: ontogeny and function in health and disease

  2019cites this paper
• Recording Leukocyte Rolling and Adhesion on Meningeal Vessels by Intravital Microscopy

  2018cites this paper
• The role of neutrophil granulocytes in immune-to-brain communication

  2018cites this paper
• NK Cell-Based Glioblastoma Immunotherapy

  2018cites this paper
• Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions.

  2017cites this paper
• Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

  2017cites this paper
• MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium

  2017cites this paper
• Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas.

  2017cites this paper
• NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings.

  2017cites this paper
• Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease.

  2016cites this paper
• Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases.

  2016cites this paper
• Role of nitric oxide in the regulation of immune responses during rabies virus infection in mice

  2016cites this paper
• Effects of olanzapine on LPS-induced inflammation in rat primary glia cells

  2016cites this paper
• Potential new complication in drug therapy development for amyotrophic lateral sclerosis

  2016cites this paper
• Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis.

  2015cites this paper
• [Neuropeptides, Cytokines and Thymus Peptides as Effectors of Interactions Between Thymus and Neuroendocrine System].

  2015cites this paper
• Adaptive immune response to viral infections in the central nervous system.

  2014influential citation
• Multiple Sclerosis: An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options

  2014cites this paper
• POST-POLIO SYNDROME - ANALYSIS OF INFLAMMATION AND IMMUNE MODULATION

  2014cites this paper
• Potential Roles for the Neurotrophic Molecules Agrin and Neuregulin in Regulating Aspects of the Inflammatory Response

  2014cites this paper
• Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

  2014influential citation
• Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System

  2014cites this paper
• The Application of Novel Positron Emission Tomography (PET) Radioligands as Imaging Biomarkers of Neurochemical Changes in the Brain: Relevance in Schizophrenia and Alzheimer's disease

  2014cites this paper
• The proinflammatory peptide substance P promotes blood–brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions

  2014cites this paper
• The Role And Molecular Mechanism of Flt3 Over-expression In A Murine Model Of Precursor-B Acute Lymphoblastic Leukemia

  2013cites this paper
• Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production

  2013cites this paper
• Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain

  2013cites this paper
• Crossing the wall: the opening of endothelial cell junctions during infectious diseases.

  2013cites this paper
• Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid

  2013cites this paper
• CSF markers in amyotrophic lateral sclerosis

  2012cites this paper
• Tumour necrosis FA cTor - ALPHA mediAT ed mecHAnisms oF cogniT ive dysF unc Tion 1 Discipline of Psychiatry, School of Medicine,

  2012cites this paper
• Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models

  2012cites this paper
• CD49d-specific Single Domain Antibodies for the Treatment of Multiple Sclerosis

  2012cites this paper
• Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction

  2012cites this paper
• Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats.

  2012cites this paper
• Rituximab combination therapy in relapsing multiple sclerosis

  2012cites this paper
• Neurovascular development in the embryonic zebrafish hindbrain.

  2011cites this paper
• The induction of traumatic brain injury by blood brain barrier disruption

  2011cites this paper
• Perpheral autoimmunity induces central neuro-inflammation and hippocampal neurogenesis impairment in a murine model of collagen induced Rheumatoid Arthritis

  2011influential citation
• Molecular heterogeneity in the choroid plexus epithelium: the 22‐member γ‐protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation

  2011cites this paper
• Disruption of central nervous system barriers in multiple sclerosis.

  2011cites this paper
• α4β1 Integrin Mediates the Recruitment of Immature Dendritic Cells across the Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis

  2010cites this paper
• The effects of parenteral or dietary omega-3 polyunsaturated fatty acids in rat models of spinal cord injury

  2010cites this paper
• A small‐molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease

  2010cites this paper
• Pathogenesis and pathophysiology of bacterial CNS infections.

  2010cites this paper
• Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

  2010cites this paper
• This information is current as Autoimmune Encephalomyelitis Blood-Brain Barrier during Experimental Immature Dendritic Cells across the Integrin Mediates the Recruitment of 1 β 4 α Rottapel and

  2010cites this paper
• Interleukin-6: A Cytokine with a Pleiotropic Role in the Neuroimmunoendocrine Network

  2010cites this paper
• Tetravalent Abeta1-15 vaccine reduces TCR-positive cell infiltration and up-regulates p75 in Tg2576 brains compared to Abeta42 vaccine.

  2010influential citation
• Molecular intervention in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease -- Neuropathology and behavior

  2009cites this paper
• The choroid plexus response to a repeated peripheral inflammatory stimulus

  2009cites this paper
• NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.

  2009cites this paper
• Interactions cellules souches/progénitrices neurales – lymphocytes T : étude in vitro et perspectives pour la transplantation

  2009cites this paper
• Lectures

  2008cites this paper
• New approaches to the immunotherapy of Alzheimer’s disease with the synthetic fragments of α7 subunit of the acetylcholine receptor

  2008cites this paper
• Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

  2008cites this paper
• On the mechanisms and putative pathways involving neuroimmune interactions.

  2008cites this paper
• Time‐course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrow

  2008cites this paper
• Divergent roles for tumor necrosis factor-alpha in the brain.

  2007cites this paper
• GENETIC ANALYSIS OF IL7R AND OTHER IMMUNE- REGULATORY GENES IN MULTIPLE SCLEROSIS

  2007cites this paper
• Divergent Roles for Tumor Necrosis Factor-α in the Brain

  2007cites this paper
• Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS

  2007cites this paper
• Neurotrophins - More than Neurotrophic

  2007cites this paper
• Spirulina, Aging, and Neurobiology

  2007cites this paper