Nuclear factor‐κB as a molecular target for migraine therapy

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Annals of Neurology

• Publication date

  2002-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/ana.10159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• 5-HT2 receptor antagonists and migraine therapy

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  1999cited by this paper
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  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

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  1998cited by this paper
• Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins.

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• Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β*

  1998influential reference
• Inhibition by the JAK/STAT pathway of IFNgamma- and LPS-stimulated nitric oxide synthase induction in vascular smooth muscle cells.

  1998cited by this paper
• Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways

  1998cited by this paper
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  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Nitric oxide synthase inhibition in migraine.

  1997cited by this paper
• Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: a double‐blind placebo‐controlled study

  1997cited by this paper
• Neurobiology of nitric oxide.

  1996cited by this paper
• Herbal medicines in migraine prevention Randomized double-blind placebo-controlled crossover trial of a feverfew preparation.

  1996cited by this paper
• Exogenous nitric oxide regulates IFN-gamma plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages.

  1995cited by this paper
• The 5-hydroxytryptamine-nitric oxide connection: the key link in the initiation of migraine?

  1995cited by this paper
• Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB (*)

  1995cited by this paper
• Systemic nitroglycerin induces Fos immunoreactivity in brainstem and forebrain structures of the rat.

  1995cited by this paper
• Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

  1995cited by this paper
• Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B.

  1995cited by this paper
• Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide

  1995cited by this paper
• Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

  1994cited by this paper
• Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells.

  1994cited by this paper
• Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells

  1994cited by this paper
• Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain.

  1993cited by this paper
• Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

  1993cited by this paper
• Feedback inhibition of nitric oxide synthase activity by nitric oxide

  1993cited by this paper
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  1992cited by this paper
• 5-HT2 receptor antagonists and migraine therapy.

  1991cited by this paper
• Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells.

  1991cited by this paper
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  1991cited by this paper
• Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

  1990cited by this paper
• Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B.

  1990cited by this paper
• Randomised double-blind placebo-controlled trial of feverfew in migraine prevention.

  1988cited by this paper
• Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain

  1987cited by this paper
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  1986cited by this paper
• Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes.

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• Headaches in explosive magazine workers.

  1966cited by this paper

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