The Role of T cells In Mucosal Immunity against Mycobacterium tuberculosis (Mtb) Infection: A Review of Current Understanding

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains one of the most important infectious diseases globally. Because Bacille Calmette-Guerin (BCG) vaccine is short of preventing transmission, the search for an efficacious vaccine to either augment that of BCG or to replace has been intensified globally. Currently, there are many candidate vaccines in different stages of clinical trials but none of these has achieved the desired efficacy to control TB. One central issue in TB immunology is lack of clear understanding as to what leads to immune protection or development of clinical disease. Tuberculosis is primarily a disease of the lungs and the main portal of entry of Mtb to the lungs and systemic organs is the respiratory tract and its mucosal surfaces. Therefore, the role of mucosal immunity against Mtb infection has been the subject of several investigations quite for some time. There is emerging evidence that mucosal immunity against TB may be critical for the control of Mtb infection and development of an efficacious vaccine. Although it is generally believed that type helper T (Th1) cells are critical for protection against Mtb infection, emerging data show that non-conventional T cells could play a vital role in protection against TB, particularly in the respiratory mucosa. In this review, current understanding on the role of various T cell subsets, with focus on lymphocytes collectively called “innate-like lymphocytes”, including gammadelta (γδ) T cells, natural killer T (NKT) cells, and mucosal-associated invariant T (MAIT) cells will be presented.

• Publication year

  2014

• Venue

  Journal of clinical & cellular immunology

• Publication date

  2014-09-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4172/2155-9899.1000254
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Protective CD4 T Cells Targeting Cryptic Epitopes of Mycobacterium tuberculosis Resist Infection-Driven Terminal Differentiation

  2014cited by this paper
• B Cells Modulate Mucosal Associated Invariant T Cell Immune Responses

  2014cited by this paper
• iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis

  2014cited by this paper
• Immunology of Tuberculosis

  2014cited by this paper
• TLR-Induced Cytokines Promote Effective Proinflammatory Natural Th17 Cell Responses

  2014cited by this paper
• Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

  2014cited by this paper
• Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

  2014cited by this paper
• Mycobacterium Tuberculosis Infection

  2013cited by this paper
• The Contribution of Non-Conventional T Cells and NK Cells in the Mycobacterial-Specific IFNγ Response in Bacille Calmette-Guérin (BCG)-Immunized Infants

  2013cited by this paper
• TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines.

  2013influential reference
• Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection

  2013cited by this paper
• Interleukin-17-dependent CXCL-13 mediates mucosal vaccine-induced immunity against tuberculosis

  2013cited by this paper
• Immunization strategies against pulmonary tuberculosis: considerations of T cell geography.

  2013influential reference
• Devices and formulations for pulmonary vaccination

  2013cited by this paper
• MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

  2013cited by this paper
• Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells

  2013influential reference
• Identification of a New Tuberculosis Antigen Recognized by γδ T Cell Receptor

  2013cited by this paper
• Tripartite immune cell co‐operation in the Bacillus Calmette Guérin‐induced activation of γδ T cells

  2013cited by this paper
• Dysregulation in lung immunity — The protective and pathologic Th17 response in infection

  2013cited by this paper
• Th17 cell development: from the cradle to the grave

  2013cited by this paper
• MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

  2013cited by this paper
• Is interferon‐gamma the right marker for bacille Calmette–Guérin‐induced immune protection? The missing link in our understanding of tuberculosis immunology

  2012cited by this paper
• MR1 presents microbial vitamin B metabolites to MAIT cells

  2012cited by this paper
• Diversity of γδ T-cell antigens

  2012cited by this paper
• The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies*

  2012cited by this paper
• Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection

  2012cited by this paper
• IL‐17‐producing γδ T cells and innate lymphoid cells

  2012cited by this paper
• Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: A critical role of airway luminal T cells

  2012cited by this paper
• Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection

  2012cited by this paper
• Systemic BCG Immunization Induces Persistent Lung Mucosal Multifunctional CD4 TEM Cells which Expand Following Virulent Mycobacterial Challenge

  2011cited by this paper
• CD161-Expressing Human T Cells

  2011cited by this paper
• Induction of Lectin-like Transcript 1 (LLT1) Protein Cell Surface Expression by Pathogens and Interferon-γ Contributes to Modulate Immune Responses*

  2011cited by this paper
• Chimeric flagellin expressed by Salmonella typhimurium induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunization

  2011cited by this paper
• Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis.

  2011cited by this paper
• Progress Towards a Needle-Free Hepatitis B Vaccine

  2011cited by this paper
• IL-17 in protective immunity to intracellular pathogens

  2010cited by this paper
• Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

  2010cited by this paper
• Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB.

  2010cited by this paper
• Probing local innate immune responses after mucosal immunisation

  2010cited by this paper
• Hepatitis B vaccines: WHO position paper--recommendations.

  2010cited by this paper
• Antimicrobial activity of mucosal-associated invariant T cells

  2010influential reference
• Respiratory mucosal immunization with adenovirus gene transfer vector induces helper CD4 T cell‐independent protective immunity

  2010cited by this paper
• Heterogeneity and plasticity of T helper cells

  2010cited by this paper
• Stepwise Development of MAIT Cells in Mouse and Human

  2009influential reference
• Intranasal Immunization Promotes Th17 Immune Responses1

  2009cited by this paper
• Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

  2009cited by this paper
• Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation

  2009cited by this paper
• Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogens

  2009cited by this paper
• Mucosal immunization with recombinant heparin-binding haemagglutinin adhesin suppresses extrapulmonary dissemination of Mycobacterium bovis bacillus Calmette-Guerin (BCG) in infected mice

  2008cited by this paper
• Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis

  2008cited by this paper
• Only a Subset of Phosphoantigen-Responsive γ9δ2 T Cells Mediate Protective Tuberculosis Immunity1

  2008cited by this paper
• ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes

  2008influential reference
• Human Innate Mycobacterium tuberculosis–Reactive αβTCR+ Thymocytes

  2008cited by this paper
• 7. Immunologic lung disease.

  2008cited by this paper
• Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs

  2008influential reference
• Photoaffinity Antigens for Human γδ T Cells1

  2008cited by this paper
• Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice

  2008cited by this paper
• Photoaffinity antigens for human gammadelta T cells.

  2008cited by this paper
• Airway Delivery of Soluble Mycobacterial Antigens Restores Protective Mucosal Immunity by Single Intramuscular Plasmid DNA Tuberculosis Vaccination: Role of Proinflammatory Signals in the Lung1

  2008cited by this paper
• Mucosal immunization with recombinant heparin-binding haemagglutinin adhesin suppresses extrapulmonary dissemination of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in infected mice.

  2008cited by this paper
• The biological functions of T helper 17 cell effector cytokines in inflammation.

  2008cited by this paper
• Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity.

  2008influential reference
• IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

  2007cited by this paper
• The biology of NKT cells.

  2007cited by this paper
• Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza

  2007cited by this paper
• INTERLEUKIN-17 IN PULMONARY HOST DEFENSE

  2007cited by this paper
• Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia

  2007cited by this paper
• IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1

  2006cited by this paper
• Mucosal Administration of Ag85B-ESAT-6 Protects against Infection with Mycobacterium tuberculosis and Boosts Prior Bacillus Calmette-Guérin Immunity1

  2006cited by this paper
• Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses1

  2006cited by this paper
• Intranasal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances Protection by Parenteral Mycobacterium bovis BCG Immunization against Pulmonary Tuberculosis

  2006cited by this paper
• IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection.

  2006cited by this paper
• Mucosal vaccines: the promise and the challenge

  2006cited by this paper
• Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Th1 responses of CD4+ and CD8+ T cells to nasal killed-bacillus calmette-guerin in mice.

  2006cited by this paper
• The Combined CTA1-DD/ISCOMs Vector Is an Effective Intranasal Adjuvant for Boosting Prior Mycobacterium bovis BCG Immunity to Mycobacterium tuberculosis

  2006cited by this paper
• TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells1

  2006cited by this paper
• Lymphocyte development in fetal piglets: facts and surprises.

  2005cited by this paper
• Mechanisms of Mucosal and Parenteral Tuberculosis Vaccinations: Adenoviral-Based Mucosal Immunization Preferentially Elicits Sustained Accumulation of Immune Protective CD4 and CD8 T Cells within the Airway Lumen1

  2005cited by this paper
• Immunization without needles

  2005cited by this paper
• Pulmonary Interleukin-23 Gene Delivery Increases Local T-Cell Immunity and Controls Growth of Mycobacterium tuberculosis in the Lungs

  2005cited by this paper
• Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice

  2005cited by this paper
• IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available1

  2005cited by this paper
• Faculty Opinions recommendation of IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available.

  2005cited by this paper
• Cytolytic CD8 T Cells Recognizing CFP10 Are Recruited to the Lung after Mycobacterium tuberculosis Infection

  2004cited by this paper
• Single Mucosal, but Not Parenteral, Immunization with Recombinant Adenoviral-Based Vaccine Provides Potent Protection from Pulmonary Tuberculosis1

  2004cited by this paper
• Interleukin-17 family members and inflammation.

  2004cited by this paper
• HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase

  2004cited by this paper
• NKT cells: what's in a name?

  2004cited by this paper
• Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

  2003cited by this paper
• Cutting Edge: Major CD8 T Cell Response to Live Bacillus Calmette-Guérin Is Mediated by CD1 Molecules1

  2003cited by this paper
• Enhanced Immunogenicity and Protective Efficacy Against Mycobacterium tuberculosis of Bacille Calmette-Guérin Vaccine Using Mucosal Administration and Boosting with a Recombinant Modified Vaccinia Virus Ankara1

  2003cited by this paper
• Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present1

  2002cited by this paper
• Classically Restricted Human CD8+ T Lymphocytes Derived from Mycobacterium tuberculosis-Infected Cells: Definition of Antigenic Specificity1

  2001cited by this paper
• Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.

  2000cited by this paper
• Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells

  2000cited by this paper
• BCG vaccination against tuberculosis: past disappointments and future hopes.

  1995cited by this paper
• Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65.

  1994cited by this paper
• Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

  1992cited by this paper
• TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

  1989cited by this paper
• The dynamics of infection following BCG and Mycobacterium tuberculosis challenge in T-cell-deficient mice.

  1987cited by this paper

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  2020cites this paper
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  2020cites this paper
• Tuberculosis: Notifiable Disease in India

  2016cites this paper
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  2015cites this paper