Invasive Disease Caused by Nontypeable Haemophilus influenzae

These infections are emerging worldwide, especially in young children and the elderly.

• Publication year

  2015

• Venue

  Emerging Infectious Diseases

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3201/eid2110.150004PMID 26407156PMCID 4593434
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
• Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011

  2014cited by this paper
• Non-typeable Haemophilus influenzae, an under-recognised pathogen.

  2014cited by this paper
• Shielding of a Lipooligosaccharide IgM Epitope Allows Evasion of Neutrophil-Mediated Killing of an Invasive Strain of Nontypeable Haemophilus influenzae

  2014cited by this paper
• Isolates of β-lactamase-negative ampicillin-resistant Haemophilus influenzae causing invasive infections in Spain remain susceptible to cefotaxime and imipenem.

  2014influential reference
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  2014cited by this paper
• Identification of a Haemophilus influenzae Factor H–Binding Lipoprotein Involved in Serum Resistance

  2014cited by this paper
• Clinical and Molecular Epidemiology of Haemophilus influenzae Causing Invasive Disease in Adult Patients

  2014cited by this paper
• Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure

  2014cited by this paper
• Pediatric Invasive Haemophilus influenzae Infections in Israel in the Era of Haemophilus influenzae Type b Vaccine: A Nationwide Prospective Study

  2014cited by this paper
• Effect of antibiotic streamlining on patient outcome in pneumococcal bacteraemia.

  2014cited by this paper
• Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients

  2014cited by this paper
• Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002–2010)

  2013cited by this paper
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  2013cited by this paper
• Resistance to complement-mediated killing and IgM binding to non-typeable Haemophilus influenzae is not altered when ascending from the nasopharynx to the middle ears in children with otitis media

  2013cited by this paper
• Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

  2012cited by this paper
• Long-Term Effects of Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis

  2012cited by this paper
• Evolving epidemiology of invasive Haemophilus infections in the post-vaccination era: results from a long-term population-based study.

  2012cited by this paper
• Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia.

  2012cited by this paper
• Invasive Haemophilus influenzae Serotype e and f Disease, England and Wales

  2012cited by this paper
• Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency.

  2012cited by this paper
• Modified Lipooligosaccharide Structure Protects Nontypeable Haemophilus influenzae from IgM-Mediated Complement Killing in Experimental Otitis Media

  2012cited by this paper
• Invasive Haemophilus influenzae in the United States, 1999-2008: epidemiology and outcomes.

  2012cited by this paper
• Use of bexB To Detect the Capsule Locus in Haemophilus influenzae

  2011cited by this paper
• Detection of bacterial pathogens in Mongolia meningitis surveillance with a new real-time PCR assay to detect Haemophilus influenzae.

  2011cited by this paper
• Current epidemiology and trends in invasive Haemophilus influenzae disease--United States, 1989-2008.

  2011cited by this paper
• Increasing Incidence of Invasive Haemophilus influenzae Disease in Adults, Utah, USA

  2011cited by this paper
• Nontypeable Haemophilus influenzae invasive disease in The Netherlands: a retrospective surveillance study 2001-2008.

  2011cited by this paper
• Molecular Basis of Increased Serum Resistance among Pulmonary Isolates of Non-typeable Haemophilus influenzae

  2011cited by this paper
• Epidemiology of Haemophilus influenzae bacteremia: a multi-national population-based assessment.

  2011influential reference
• Invasive disease caused by Haemophilus influenzae in Sweden 1997-2009; evidence of increasing incidence and clinical burden of non-type b strains.

  2011influential reference
• Binding of Complement Regulators to Invasive Nontypeable Haemophilus influenzae Isolates Is Not Increased Compared to Nasopharyngeal Isolates, but Serum Resistance Is Linked to Disease Severity

  2010cited by this paper
• Invasive Haemophilus influenzae Disease, Europe, 1996–2006

  2010cited by this paper
• Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination.

  2010influential reference
• Characterisation of invasive Haemophilus influenzae isolates in Slovenia, 1993–2008

  2010cited by this paper
• Invasive Haemophilus influenzae disease caused by non-type b strains in Northwestern Ontario, Canada, 2002-2008.

  2009cited by this paper
• Invasive Haemophilus influenzae disease in adults in Taiwan.

  2008cited by this paper
• Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005

  2008cited by this paper
• Capsule Gene Analysis of Invasive Haemophilus influenzae: Accuracy of Serotyping and Prevalence of IS1016 among Nontypeable Isolates

  2007cited by this paper
• Characterization of invasive Haemophilus influenzae disease in Manitoba, Canada, 2000-2006: invasive disease due to non-type b strains.

  2007influential reference
• The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons > or = 65 years old.

  2007cited by this paper
• Invasive nontypeable Haemophilus influenzae infections in Germany: a case report of a previously healthy 7-year-old boy with an intracranial abscess, and epidemiological data from 2001 to 2004

  2006influential reference
• Epidemiology of invasive Haemophilus influenzae type A disease among Navajo and White Mountain Apache children, 1988-2003.

  2005cited by this paper
• Changes in Frequency and Pathogens Causing Acute Otitis Media in 1995–2003

  2004cited by this paper
• Community-Wide Vaccination with the Heptavalent Pneumococcal Conjugate Significantly Alters the Microbiology of Acute Otitis Media

  2004cited by this paper
• Invasive Disease Due to Nontypeable Haemophilus influenzae among Children in Arkansas

  2003cited by this paper
• Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM.

  2003cited by this paper
• Invasive Haemophilus influenzae disease in Alaskan residents aged 10 years and older before and after infant vaccination programs.

  2000cited by this paper
• Vaccination against colonizing bacteria with multiple serotypes.

  1997cited by this paper
• The molecular basis of pathogenicity in Haemophilus influenzae: comparative virulence of genetically-related capsular transformants and correlation with changes at the capsulation locus cap.

  1989cited by this paper
• Invasive Haemophilus influenzae disease in adults.

  1987cited by this paper
• Differential Complement Resistance Mediates Virulence of Haemophilus influenzae Type b

  1982cited by this paper

• Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018–2023

  2026cites this paper
• Incidence and bacterial etiology of acute otitis media in children in the pneumococcal conjugate vaccine era: A systematic literature review and meta-analysis.

  2026cites this paper
• Characteristics of 241 invasive and non-invasive Haemophilus influenzae isolated from patients under 14 years old, Hebei Province, China

  2025cites this paper
• Epidemiology of Bacterial Meningitis in the Lombardy Region, Italy, from 2014 to 2024: An Observational, Retrospective Study

  2025cites this paper
• A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report

  2025cites this paper
• Haemophilus influenzae

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• Purulent Pericarditis and Septic Shock Caused by Nontypeable Haemophilus Influenzae in an Immunocompromised Patient: A Case Report

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• A Haemophilus influenzae-associated mycotic aneurysm months after treated bacteremia

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• Application of novel biosensors for detecting biomarkers of community-acquired pneumonia in children

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• The epidemiology of bacterial meningitis in the United States during 2008–2023: an analysis of active, laboratory, population-based, multistate surveillance data

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• Sialic Acids in Health and Disease

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• Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland

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• Inflammatory Responses to Non-Typeable Haemophilus influenzae Clinical Isolates from Invasive and Non-Invasive Infections

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• Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children’s Hospital: a cross-sectional study

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• Articulating What Makes Sense: An Exercise in Clinical Reasoning

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• Comparing sputum, nasopharyngeal swabs, and combined samples for respiratory bacterial detection using multiplex PCR

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• A Case of Lumbar Spinal Epidural Abscess and Facet Joint Septic Arthritis Caused by Haemophilus influenzae in an Immunocompetent Host

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• Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children

  2024cites this paper
• Comparative genomic study of non-typeable Haemophilus influenzae in children with pneumonia and healthy controls

  2024cites this paper
• Whole-genome sequencing of non-typeable Haemophilus influenzae isolated from a tertiary care hospital in Surabaya, Indonesia

  2024cites this paper
• Bioreceptor modified electrochemical biosensors for the detection of life threating pathogenic bacteria: a review

  2024cites this paper
• Impact of the COVID-19 pandemic on Haemophilus influenzae infections in pediatric patients hospitalized with community acquired pneumonia

  2024cites this paper
• Meningitis in Children: Still a Can't-Miss Diagnosis.

  2024cites this paper
• Changing Landscape of Haemophilus influenzae Meningitis and Implication on Public Health

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  2024cites this paper
• Multiplatform Metabolomics Characterization Reveals Novel Metabolites and Phospholipid Compositional Rules of Haemophilus influenzae Rd KW20

  2023cites this paper
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  2023cites this paper
• Antibiotic susceptibility profiles of Haemophilus influenzae isolates collected in Dakar between 2018 and 2022

  2023cites this paper
• Phase variable acetylation of lipooligosaccharide modifies antibody production and opsonophagocytic killing of non-typeable Haemophilus influenzae

  2023cites this paper
• Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs

  2023cites this paper
• Progress in laboratory-based Haemophilus influenzae surveillance of bacterial meningitis and pneumonia, by real-time PCR, in Sao Paulo State (2010-2019)

  2023cites this paper
• Non-typeable Haemophilus influenzae Osteomyelitis and Discitis of the Cervical Vertebrae in an Elderly Adult: A Case Report and Literature Review

  2023cites this paper
• Molecular Epidemiology of Haemophilus influenzae Strains with Reduced Susceptibility and Genetic Profiles of Resistance in the Postvaccination Period

  2023cites this paper
• Epidemiology of invasive nontypeable Haemophilus influenzae disease-United States, 2008-2019.

  2023cites this paper
• Establishment and Clinical Application of a RPA-LFS Assay for Detection of Capsulated and Non-Capsulated Haemophilus influenzae

  2022cites this paper
• Evolução na vigilância laboratorial do Haemophilus influenzae nas meningites e pneumonias bacterianas, por PCR em tempo real, no Estado de São Paulo (2010-2019)

  2022cites this paper
• Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells

  2022cites this paper
• Molecular epidemiology and antibiotic resistance profiles of invasive Haemophilus influenzae from Norway 2017–2021

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• Atypical Presentation of Haemophilus influenzae Septic Arthritis: A Case Report

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• Understanding the Biology of Non-typeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease Through the Lens of Genomics

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• The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

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• Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and nontypeable Haemophilus influenzae in children attending daycare centers: Nationwide population-based study, South Korea 2014 and 2019.

  2021cites this paper
• Nontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance

  2021cites this paper
• Haemophilus influenzae Prevalence, Proportion of Capsulated Strains and Antibiotic Susceptibility During Colonization and Acute Otitis Media in Children, 2019–2020

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• Respiratory Viral and Bacterial Factors That Influence Early Childhood Asthma

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• Cloning and Characterization of Immunological Properties of Haemophilus influenzae Enolase

  2021cites this paper
• Deacetylated sialic acids modulates immune mediated cytotoxicity via the sialic acid-Siglec pathway.

  2021cites this paper
• A Narrative Review of the Molecular Epidemiology and Laboratory Surveillance of Vaccine Preventable Bacterial Meningitis Agents: Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae and Streptococcus agalactiae

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• Community-acquired Haemophilus influenzae meningitis in adults.

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• Structure–Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation

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• Structural Characterization of Haemophilus influenzae Enolase and Its Interaction with Human Plasminogen by In Silico and In Vitro Assays

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• Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influenzae Isolates from Spain, Portugal, and the Netherlands

  2020cites this paper
• Respiratory Virus Co-infection in Acute Respiratory Infections in Children

  2020cites this paper
• In Vitro Probiotic Potential of Hemophilin-producing Strains of Haemophilus haemolyticus

  2020cites this paper
• Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children

  2020cites this paper
• Molecular Epidemiology and Antimicrobial Resistance of Haemophilus influenzae in Adult Patients in Shanghai, China

  2020cites this paper
• In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of Haemophilus haemolyticus

  2020cites this paper
• Unraveling Haemophilus influenzae virulence mechanisms enable discovery of new targets for antimicrobials and vaccines.

  2020cites this paper
• The non-typeable Haemophilus influenzae major adhesin Hia is a dual function lectin that binds to human-specific respiratory tract sialic acid glycan receptors

  2020cites this paper
• Pediatric Bacterial Pericarditis

  2020cites this paper
• Presence of antibodies against Haemophilus influenzae serotype a in Alaska prior to and after the emergence of invasive infections.

  2020cites this paper
• Gradenigo's Syndrome and Bacterial Meningitis in a Patient with a Petrous Apex Cholesterol Granuloma

  2020cites this paper
• Carriage of Haemophilus influenzae among children attending childcare centres in Kuala Lumpur, Malaysia in the post vaccination era: A cross-sectional study.

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  2019cites this paper
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• Invasive Nontypeable Haemophilus influenzae Infection Among Adults With HIV in Metropolitan Atlanta, Georgia, 2008-2018.

  2019cites this paper
• Bacterial pericarditis: A pediatric case report.

  2019cites this paper
• Phase variable glycosylation in non-typeable Haemophilus influenzae

  2019influential citation
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• Imipenem Heteroresistance in Nontypeable Haemophilus influenzae

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• The epidemiology of Haemophilus influenzae in healthy carriers and infected in Iceland following the introduction of Protein D conjugated vaccine

  2019influential citation
• Infections à « Haemophilus influenzae »

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• Metabolic analyses reveal common adaptations in two invasive Haemophilus influenzae strains

  2019cites this paper
• Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China

  2019cites this paper
• Using quality improvement approach to address missed opportunities for vaccination in Kano Metropolis, Nigeria

  2019cites this paper
• Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper