Pharmacokinetics and pharmacodynamics of the selective serotonin reuptake inhibitors, fluoxetine and paroxetine, during pregnancy and the nursing period

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.14288/1.0103834
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Paroxetine: pharmacokinetics, tolerance and depletion of blood 5-HT in man.

  2009cited by this paper
• Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation.

  2003cited by this paper
• Pharmacokinetics of selective serotonin reuptake inhibitors.

  2000cited by this paper
• Paroxetine in human breast milk and nursing infants.

  2000cited by this paper
• Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.

  2000cited by this paper
• CYP2D6 Inhibition by Fluoxetine, Paroxetine, Sertraline, and Venlafaxine in a Crossover Study: Intraindividual Variability and Plasma Concentration Correlations

  2000cited by this paper
• Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance.

  2000cited by this paper
• Safety of fluoxetine during the first trimester of pregnancy: a meta-analytical review of epidemiological studies

  2000cited by this paper
• The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine.

  1999cited by this paper
• Behavioral changes in developing mice after prenatal exposure to paroxetine (Paxil)

  1999cited by this paper
• Excretion of paroxetine into breast milk.

  1999cited by this paper
• Paroxetine in human milk.

  1999cited by this paper
• CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine, fluvoxamine, paroxetine, or sertraline.

  1999cited by this paper
• Distribution and excretion of fluoxetine and norfluoxetine in human milk.

  1999cited by this paper
• Prenatal exposure to fluoxetine (Prozac) produces site-specific and age-dependent alterations in brain serotonin transporters in rat progeny: evidence from autoradiographic studies.

  1998cited by this paper
• In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens.

  1998cited by this paper
• Placental Transfer and Fetal Metabolism of Zidovudine in the Baboon

  1998cited by this paper
• Managing psychiatric medications in the breast-feeding woman.

  1998cited by this paper
• Delayed ontogenesis of CYP1A2 in the human liver.

  1998cited by this paper
• Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity.

  1998cited by this paper
• Pharmacokinetics and antidepressant activity of fluoxetine in transgenic mice with elevated serum alpha-1-acid glycoprotein levels.

  1998cited by this paper
• Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies.

  1998cited by this paper
• Interactions between promazine and antidepressants at the level of cellular distribution.

  1997cited by this paper
• Examination of attendance patterns before and after introduction of south africa's policy of free health care for children aged under 6 years and pregnant women

  1997cited by this paper
• Pharmacokinetic Changes During Pregnancy and Their Clinical Relevance

  1997cited by this paper
• Determination of p-trifluoromethylphenol, a metabolite of fluoxetine, in tissues and body fluids using an electron-capture gas chromatographic procedure.

  1997cited by this paper
• Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS.

  1997cited by this paper
• Simultaneous measurement of serotonin and paroxetine in rat brain microdialysate by a single-pump column-switching technique.

  1997cited by this paper
• [Epidemiological research on incidence of atopic disease in infants and children in relation to their nutrition in infancy].

  1997cited by this paper
• Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.

  1997cited by this paper
• Single pump column switching technique employing a flow gradient and wavelength programmed fluorescence for simultaneous monitoring of serotonin, fluoxetine and norfluoxetine in rat brain microdialysate.

  1997cited by this paper
• The PEGASUS project--a prospective cohort study for the investigation of drug use in pregnancy. PEGASUS Study Group.

  1997cited by this paper
• Paroxetine withdrawal syndrome in a neonate

  1997cited by this paper
• Transplacental pharmacokinetics and fetal distribution of azidothymidine, its glucuronide, and phosphorylated metabolites in late-term rhesus macaques after maternal infusion.

  1997cited by this paper
• Direct analysis of fluoxetine and norfluoxetine in plasma by gas chromatography with nitrogen-phosphorus detection.

  1997cited by this paper
• In vivo induction and in vitro inhibition of hepatic cytochrome P450 activity by the benzodiazepine anticonvulsants clonazepam and diazepam.

  1997cited by this paper
• Birth outcomes in pregnant women taking fluoxetine.

  1997cited by this paper
• Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs.

  1997influential reference
• Changes in plasma alpha 1-acid glycoprotein and albumin concentrations during late pregnancy in rhesus monkeys.

  1997cited by this paper
• Potential fluoxetine chloride (Prozac) toxicity in a newborn.

  1997cited by this paper
• Effects of First‐Trimester Fluoxetine Exposure on the Newborn

  1997cited by this paper
• Determination of fluvoxamine and paroxetine in human serum with high-performance liquid chromatography and ultraviolet detection

  1997cited by this paper
• The Cost of Not Breastfeeding: A Commentary

  1997cited by this paper
• Effect of prenatal fluoxetine (Prozac) exposure on brain serotonin neurons in prepubescent and adult male rat offspring.

  1997cited by this paper
• Neurodevelopment of children exposed in utero to antidepressant drugs

  1997cited by this paper
• Induction of CYP2D6 in pregnancy

  1997cited by this paper
• Antidepressant treatment during breast-feeding.

  1996cited by this paper
• Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults.

  1996cited by this paper
• Pharmacological basis for hepatic drug metabolism in sheep.

  1996cited by this paper
• The safety of fluoxetine during pregnancy and lactation.

  1996cited by this paper
• Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry.

  1996cited by this paper
• Maternal-fetal pharmacokinetics of zidovudine in rats.

  1996cited by this paper
• Bruising Associated with the Use of Fluoxetine

  1996cited by this paper
• The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

  1996cited by this paper
• The maternal-fetal transfer of lamivudine in the ex vivo human placenta.

  1996cited by this paper
• Paroxetine level in breast milk.

  1996cited by this paper
• Drug-protein binding sites. New trends in analytical and experimental methodology.

  1996cited by this paper
• Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes.

  1996cited by this paper
• Pharmacokinetics of selective serotonin reuptake inhibitors: clinical relevance.

  1996cited by this paper
• Models for Placental Transfer Studies of Drugs

  1995cited by this paper
• Cytochrome P450 Monooxygenases and Interactions of Psychotropic Drugs: A Five-Year Update

  1995cited by this paper
• Effects of third trimester fluoxetine exposure on the newborn.

  1995cited by this paper
• Protein binding of propranolol and verapamil enantiomers in maternal and foetal serum.

  1995cited by this paper
• Simultaneous quantification of fluoxetine, norfluoxetine, and desipramine using gas chromatography with nitrogen-phosphorus detection.

  1995cited by this paper
• Determinants of placental drug transfer: studies in the isolated perfused human placenta.

  1995cited by this paper
• The pharmacokinetics of valproic acid in pregnant sheep after maternal and fetal intravenous bolus administration.

  1995cited by this paper
• Oxygen consumption, acid-base status, and behavior during and after acute, severe hemorrhage in fetal lambs.

  1995cited by this paper
• Antidepressant Drug Interactions and the Cytochrome P450 System: A Critical Appraisal

  1995influential reference
• The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine.

  1994cited by this paper
• Clinical Pharmacokinetics of Fluoxetine

  1994cited by this paper
• Pharmacokinetics of the newer antidepressants: clinical relevance.

  1994cited by this paper
• The Clinical Pharmacology and Use of Paroxetine, a New Selective Serotonin Reuptake Inhibitor

  1994cited by this paper
• Prevention of recurrent postpartum major depression.

  1994cited by this paper
• Drug therapy during pregnancy and lactation.

  1994cited by this paper
• Column liquid chromatographic determination of paroxetine in human serum using solid-phase extraction.

  1994cited by this paper
• Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver.

  1994cited by this paper
• Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care.

  1994cited by this paper
• Automated Determination of Paroxetine and Its Main Metabolite by Column Switching and On‐Line High‐Performance Liquid Chromatography

  1994cited by this paper
• In vivo 19F spin relaxation and localized spectroscopy of fluoxetine in human brain

  1994cited by this paper
• Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450.

  1993cited by this paper
• Human brain fluoxetine concentrations.

  1993cited by this paper
• Prescription drug use in lactating mothers: an experience at a referral hospital and in a community in India.

  1993cited by this paper
• Transfer of cocaine by the perfused human placenta: the effect of binding to serum proteins.

  1993cited by this paper
• Determination of fluoxetine and norfluoxetine in human plasma by capillary gas chromatography with electron-capture detection.

  1993cited by this paper
• Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain

  1993cited by this paper
• Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac)

  1993cited by this paper
• Possible association between fluoxetine hydrochloride and colic in an infant.

  1993cited by this paper
• Fluoxetine hydrochloride (Prozac) toxicity in a neonate.

  1993cited by this paper
• A Controlled Study of the Onset, Duration and Prevalence of Postnatal Depression

  1993cited by this paper
• Protein Binding and Stereoselectivity of Nonsteroidal Anti-Inflammatory Drugs

  1993cited by this paper
• Tricyclic dose requirements across pregnancy.

  1993cited by this paper
• In utero exposure to fluoxetine HCl increases hematoma frequency at birth.

  1993cited by this paper
• Fetal effects.

  1993cited by this paper
• Transplacental and nonplacental clearances, metabolism and pharmacodynamics of labetalol in the fetal lamb after direct intravenous administration.

  1993cited by this paper
• Breast-feeding and cognitive development.

  1993cited by this paper
• Low-dose aspirin therapy to prevent preeclampsia.

  1993cited by this paper
• Venous placental reactivity to serotonin in normal and preeclamptic gestants.

  1993cited by this paper
• Inhibition by fluoxetine of cytochrome P450 2D6 activity

  1993cited by this paper
• The effects of renal and hepatic disease on the pharmacokinetics, renal tolerance, and risk‐benefit profile of fluoxetine

  1993cited by this paper
• The comparative pharmacology of new antidepressants.

  1993cited by this paper

• Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy

  2020cites this paper
• An in vivo evaluation of the ontogeny of stereoselective fluoxetine metabolism and disposition in lambs from birth to one year of age

  2019influential citation
• Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women

  2017cites this paper
• Stereoselective pharmacokinetics and placental transfer of fluoxetine and norfluoxetine in pregnant sheep under steady-state conditions

  2004influential citation
• Chronic Maternal Fluoxetine Infusion in Pregnant Sheep: Effects on the Maternal and Fetal Hypothalamic-Pituitary-Adrenal Axes

  2004cites this paper
• Clearance and disposition of indometacin in chronically instrumented fetal lambs following a 3‐day continuous intravenous infusion

  2002cites this paper
• Physiologic responses of the fetal lamb to eight day fluoxetine exposure during late gestation

  2001cites this paper